8 research outputs found
De novo protecting-group-free total synthesis of (+)-muricadienin, (+)-ancepsenolide and (+)-3-hexadecyl-5-methylfuran-2(5H)-one
A de novo protecting-group-free total synthesis of (+)-muricadienin, (+)-ancepsenolide and (+)-3-hexadecyl-5-methylfuran-2(5H)-one has been achieved. Ring-closing-metathesis has been the key step in the synthesis. In (+)-muricadienin synthesis, a long chain alkyl group has been installed by an sp-sp(3) Sonogashira type reaction followed by a cis-selective Lindlar reduction. The total synthesis is achieved in 7 steps and in excellent 43.5% overall yield. Similarly, (+)-ancepsenolide and (+)-3-hexadecyl-5-methylfuran-2(5H)-one synthesis is completed in 5 steps each and in 48 and 68% overall yields, respectively
Total Synthesis of Neuritogenic Alkynes: Lembehyne B and Key Intermediate of Lembehyne A
The first total synthesis of the marine acetylenic alcohol, lembehyne B – a selective inducer of early apoptosis in leukemia cancer cells
Copper(II) Triflate Catalyzed Regioselective and Enantioselective Propargylation of Isatin Derivatives by Using Allenylboronic Acid Pinacol Ester
Six-membered ring systems: with O and/or S atoms
This chapter is dedicated to the synthesis of O- and S-6-membered heterocycles, covering
the literature published during 2019. Highlights include the most interesting chemistry
dedicated of these heterocyclic ring systems, from our personal point of view,
with special emphasis to the synthesis of natural oxygen derivatives.
Reviews on the isolation, biological properties, biosynthesis, and total synthesis of
benzannulated spiroketal natural products (19OBC8272) and of diterpene pyran-
2-ones (19OBC8943), on the natural occurrence, pharmacological properties, and
structureeactivity relationships of quassinoids, a kind of triterpenoid bearing a tetrahydropyran
bridge (19CPB654), on the biosynthesis of Monascus azaphilone pigment
congeners containing chromene frameworks (19NPR561), and on naturally occurring
3-aryl-4H-chromen-4-ones isolated after 2012 (19NPR1156), have appeared.info:eu-repo/semantics/publishedVersio