Validating Dose Uncertainty Estimates Produced by AUTODIRECT: An Automated Program to Evaluate Deformable Image Registration Accuracy.

Deformable image registration is a powerful tool for mapping information, such as radiation therapy dose calculations, from one computed tomography image to another. However, deformable image registration is susceptible to mapping errors. Recently, an automated deformable image registration evaluation of confidence tool was proposed to predict voxel-specific deformable image registration dose mapping errors on a patient-by-patient basis. The purpose of this work is to conduct an extensive analysis of automated deformable image registration evaluation of confidence tool to show its effectiveness in estimating dose mapping errors. The proposed format of automated deformable image registration evaluation of confidence tool utilizes 4 simulated patient deformations (3 B-spline-based deformations and 1 rigid transformation) to predict the uncertainty in a deformable image registration algorithm's performance. This workflow is validated for 2 DIR algorithms (B-spline multipass from Velocity and Plastimatch) with 1 physical and 11 virtual phantoms, which have known ground-truth deformations, and with 3 pairs of real patient lung images, which have several hundred identified landmarks. The true dose mapping error distributions closely followed the Student t distributions predicted by automated deformable image registration evaluation of confidence tool for the validation tests: on average, the automated deformable image registration evaluation of confidence tool-produced confidence levels of 50%, 68%, and 95% contained 48.8%, 66.3%, and 93.8% and 50.1%, 67.6%, and 93.8% of the actual errors from Velocity and Plastimatch, respectively. Despite the sparsity of landmark points, the observed error distribution from the 3 lung patient data sets also followed the expected error distribution. The dose error distributions from automated deformable image registration evaluation of confidence tool also demonstrate good resemblance to the true dose error distributions. Automated deformable image registration evaluation of confidence tool was also found to produce accurate confidence intervals for the dose-volume histograms of the deformed dose

The relationship between the use of social networking sites and student spectator behaviour: A case of university sport in the Western Cape

Magister Artium (Sport, Recreation and Exercise Science) - MA(SRES)Social networking sites are important communication tools used in different industries including the sports industry. Professional athletes, coaches, spectators, journalists, and broadcasters from nearly every sports code maintain a social media presence. The rapid growth in the use of social networks in sport and the challenging economic climate launched an urgent need for sport administration departments at universities to understand SNSs and how student spectators use these sites in the realm of university sport. This understanding serves as an attempt to enhance spectator attendance at university sports games through the use of SNSs by integrating these sites into marketing strategies. Sports spectators are key constituents of sports event attendance, however, little is known regarding whether a relationship exists between students’ activities on SNSs and their spectator behaviour. Subsequently, the purpose of this study was to examine and describe the relationship between the use of SNSs and student spectator behaviour in university sport by considering attendance, loyalty, trust, and commitment as determinants of behaviour. A quantitative methodological approach was adopted to collect data, using a cross-sectional research design. By applying a random sampling method, 540 full-time registered university students provided consent to participate in this study. An online survey was distributed to the entire student population, N=24000. All significance levels were set at p<0.05. Data were analyzed using the Statistical Package for Social Science (SPSS) V.25 software. Results showed statistical significance, p<0.00, for the relationship between the use of SNSs and student spectator behaviour during student spectator attendance of university sports games. No statistical significance was found in the relationship between the use of SNSs and student spectator behaviour before and after student spectator attendance of university sports games. These results suggest that greater investment should be placed in marketing through SNSs in order to develop, increase, and retain longstanding relationships of loyalty, trust, and commitment with student spectators in the fast-growing segment of social media and spectatorship

Substrate-Assisted Catalysis Unifies Two Families of Chitinolytic Enzymes

Hen egg-white lysozyme has long been the paradigm for enzymatic glycosyl hydrolysis with retention of configuration, with a protonated carboxylic acid and a deprotonated carboxylate participating in general acid-base catalysis. In marked contrast, the retaining chitin degrading enzymes from glycosyl hydrolase families 18 and 20 all have a single glutamic acid as the catalytic acid but lack a nucleophile on the enzyme. Both families have a catalytic (βα)8-barrel domain in common. X-ray structures of three different chitinolytic enzymes complexed with substrates or inhibitors identify a retaining mechanism involving a protein acid and the carbonyl oxygen atom of the substrate’s C2 N-acetyl group as the nucleophile. These studies unambiguously demonstrate the distortion of the sugar ring toward a sofa conformation, long postulated as being close to that of the transition state in glycosyl hydrolysis.

Interview with Kirby Phillips

Kirby Phillips talks about his involvement with the 4H Clubhttps://digital.kenyon.edu/ps_interviews/1020/thumbnail.jp

Strong CH+ J=1-0 emission and absorption in DR21

We report the first detection of the ground-state rotational transition of the methylidyne cation CH+ towards the massive star-forming region DR21 with the HIFI instrument onboard the Herschel satellite. The line profile exhibits a broad emission line, in addition to two deep and broad absorption features associated with the DR21 molecular ridge and foreground gas. These observations allow us to determine a CH+ J=1-0 line frequency of 835137 +/- 3 MHz, in good agreement with a recent experimental determination. We estimate the CH+ column density to be a few 1e13 cm^-2 in the gas seen in emission, and > 1e14 cm^-2 in the components responsible for the absorption, which is indicative of a high line of sight average abundance [CH+]/[H] > 1.2x10^-8. We show that the CH+ column densities agree well with the predictions of state-of-the-art C-shock models in dense UV-illuminated gas for the emission line, and with those of turbulent dissipation models in diffuse gas for the absorption lines.Comment: Accepted for publication in A&

Neurovisceral phenotypes in the expression of psychiatric symptoms

This review explores the proposal that vulnerability to psychological symptoms, particularly anxiety, originates in constitutional differences in the control of bodily state, exemplified by a set of conditions that include Joint Hypermobility, Postural Tachycardia Syndrome and Vasovagal Syncope. Research is revealing how brainbody mechanisms underlie individual differences in psychophysiological reactivity that can be important for predicting, stratifying and treating individuals with anxiety disorders and related conditions. One common constitutional difference is Joint Hypermobility, in which there is an increased range of joint movement as a result of a variant of collagen. Joint hypermobility is over-represented in people with anxiety, mood and neurodevelopmental disorders. It is also linked to stress-sensitive medical conditions such as irritable bowel syndrome, chronic fatigue syndrome and fibromyalgia. Structural differences in 'emotional' brain regions are reported in hypermobile individuals, and many people with joint hypermobility manifest autonomic abnormalities, typically Postural Tachycardia Syndrome. Enhanced heart rate reactivity during postural change and as recently recognised factors causing vasodilatation (as noted post prandially, post exertion and with heat) is characteristic of Postural Tachycardia Syndrome, and there is a phenomenological overlap with anxiety disorders, which may be partially accounted for by exaggerated neural reactivity within ventromedial prefrontal cortex. People who experience Vasovagal Syncope, a heritable tendency to fainting induced by emotional challenges (and needle/blood phobia), are also more vulnerable to anxiety disorders. Neuroimaging implicates brainstem differences in vulnerability to faints, yet the structural integrity of the caudate nucleus appears important for the control of fainting frequency in relation to parasympathetic tone and anxiety. Together there is clinical and neuroanatomical evidence to show that common constitutional differences affecting autonomic responsivity are linked to psychiatric symptoms, notably anxiety

3D Integral Field Observations of Ten Galactic Winds - I. Extended phase (>10 Myr) of mass/energy injection before the wind blows

We present 3D spectroscopic observations of a sample of 10 nearby galaxies with the AAOmega-SPIRAL integral field spectrograph on the 3.9m AAT, the largest survey of its kind to date. The double-beam spectrograph provides spatial maps in a range of spectral diagnostics: [OIII] 5007, H-beta, Mg-b, NaD, [OI] 6300, H-alpha, [NII] 6583, [SII] 6717, 6731. All of the objects in our survey show extensive wind-driven filamentation along the minor axis, in addition to large-scale disk rotation. Our sample can be divided into either starburst galaxies or active galactic nuclei (AGN), although some objects appear to be a combination of these. The total ionizing photon budget available to both classes of galaxies is sufficient to ionise all of the wind-blown filamentation out to large radius. We find however that while AGN photoionisation always dominates in the wind filaments, this is not the case in starburst galaxies where shock ionisation dominates. This clearly indicates that after the onset of star formation, there is a substantial delay (> 10 Myr) before a starburst wind develops. We show why this behavior is expected by deriving ``ionisation'' and dynamical timescales for both AGNs and starbursts. We establish a sequence of events that lead to the onset of a galactic wind. The clear signature provided by the ionisation timescale is arguably the strongest evidence yet that the starburst phenomenon is an impulsive event. A well-defined ionisation timescale is not expected in galaxies with a protracted history of circumnuclear star formation. Our 3D data provide important templates for comparisons with high redshift galaxies.[Abridged]Comment: 43 pages, 30 figures, Accepted for publication in ApJ Jan-2010, Full resolution figures available from: http://www.aao.gov.au/AAO/local/www/rgs/work/winds/public/papers/SPIRAL_WINDS_hi-res.htm

Identity From Variation : Representations of Faces Derived From Multiple Instances

Research in face recognition has tended to focus on discriminating between individuals, or "telling people apart." It has recently become clear that it is also necessary to understand how images of the same person can vary, or "telling people together." Learning a new face, and tracking its representation as it changes from unfamiliar to familiar, involves an abstraction of the variability in different images of that person's face. Here, we present an application of principal components analysis computed across different photos of the same person. We demonstrate that people vary in systematic ways, and that this variability is idiosyncratic-the dimensions of variability in one face do not generalize well to another. Learning a new face therefore entails learning how that face varies. We present evidence for this proposal and suggest that it provides an explanation for various effects in face recognition. We conclude by making a number of testable predictions derived from this framework

Differences in the semantics of prosocial words: an exploration of compassion and kindness

The study of prosocial behaviour has accelerated greatly in the last 20 years. Researchers are exploring different domains of prosocial behaviour such as compassion, kindness, caring, cooperation, empathy, sympathy, love, altruism and morality. While these constructs can overlap, and are sometimes used interchangeably, they also have distinctive features that require careful elucidation. This paper discusses some of the controversies and complexities of describing different (prosocial) mental states, followed by a study investigating the differences between two related prosocial concepts: compassion and kindness. For the study, a scenario-based questionnaire was developed to assess the degree to which a student (N = 222) and a community (N = 112) sample judged scenarios in terms of compassion or kindness. Subsequently, participants rated emotions (e.g. sadness, anxiety, anger, disgust, joy) associated with each scenario. Both groups clearly distinguished kindness from compassion in the scenarios on the basis of suffering. In addition, participants rated compassion-based scenarios as significantly higher on sadness, anger, anxiety and disgust, whereas kindness-based scenarios had higher levels of joy. As a follow-up, a further sample (29 male, 63 female) also rated compassionate scenarios as involving significantly more suffering compared to the kindness scenarios. Although overlapping concepts, compassion and kindness are clearly understood as different processes with different foci, competencies and emotion textures. This has implications for research in prosocial behaviour, and the cultivation of kindness and compassion for psychotherapy and in general.N/