7 research outputs found
Clinical and cytopathological characteristics of HTLVâ1 +
Abstract Background Human Tâlymphotropic virusâ1 (HTLVâ1)+ Hodgkin lymphoma (HL) is difficult to differentiate from adult Tâcell leukemia/lymphoma (ATLL) with HLâlike histology (HLâlike ATLL). Methods Cytological and immunohistological features, HTLVâ1 proviral DNA integration, and rearrangements of the Tâcell receptor (TCR) Cβ1 gene were examined in 11 HTLVâ1+ patients with HLâlike disease. Results Six patients were classified as HTLVâ1+ HL and five as HLâlike ATLL in accordance with genetic findings of HTLVâ1 proviral DNA integration and rearrangements of the TCR Cβ1 gene. Small ordinary looking lymphocytes with round nuclei were detected in the background of six patients with HTLVâ1+ HL, which were immunohistochemically negative for CD25 and CC chemokine receptor (CCR)4 and had a low MIB1 labeling index (mean: 28.3%). In the HLâlike ATLL specimens, smallâ and mediumâsized atypical lymphocytes with indented and irregularâshaped nuclei were found, and were diffusely positive for CD25 and CCR4, with high MIB1 labeling (mean: 76%). Both groups had scattered CD30+ and CD15+ Hodgkin and Reed Sternberg (RS) giant cells, with or without CD20 expression and EpsteinâBarr virus infection. The 50% overall survival period was significantly longer for the HTLVâ1+ HL group (180 months) than for the HLâlike ATLL group (7.8 months; P = .004). Conclusions HTLVâ1+ HL showed typical small lymphoid cells with a low MIB1 labeling index in a background of Hodgkin and RS cells, with some scattered CD25+ and CCR4+ lymphocytes. In HTLVâ1 endemic areas, distinguishing HTLVâ1+ HL from HLâlike ATLL is important because of their differing treatment strategies and prognoses