Partial parametrized presentability and the universal property of equivariant spectra

We introduce a notion of partial presentability in parametrized higher category theory and investigate its interaction with the concepts of parametrized semiadditivity and stability from arXiv:2301.08240. In particular, we construct the free partially presentable $T$-categories in the unstable, semiadditive, and stable contexts and explain how to exhibit them as full subcategories of their fully presentable analogues. Specializing our results to the setting of (global) equivariant homotopy theory, we obtain a notion of equivariant presentability for the global categories of arXiv:2301.08240, and we show that the global category of genuine equivariant spectra is the free global category that is both equivariantly presentable and equivariantly stable. As a consequence, we deduce the analogous result about the $G$-category of genuine $G$-spectra for any finite group $G$, previously formulated by Nardin.Comment: 56 page

Design of the VISITOR Tool: A Versatile ImpulSive Interplanetary Trajectory OptimizeR

The design of trajectories for interplanetary missions represents one of the most complex and important problems to solve during conceptual space mission design. To facilitate conceptual mission sizing activities, it is essential to obtain sufficiently accurate trajectories in a fast and repeatable manner. To this end, the VISITOR tool was developed. This tool modularly augments a patched conic MGA-1DSM model with a mass model, launch window analysis, and the ability to simulate more realistic arrival and departure operations. This was implemented in MATLAB, exploiting the built-in optimization tools and vector analysis routines. The chosen optimization strategy uses a grid search and pattern search, an iterative variable grid method. A genetic algorithm can be selectively used to improve search space pruning, at the cost of losing the repeatability of the results and increased computation time. The tool was validated against seven flown missions: the average total mission (Delta)V offset from the nominal trajectory was 9.1%, which was reduced to 7.3% when using the genetic algorithm at the cost of an increase in computation time by a factor 5.7. It was found that VISITOR was well-suited for the conceptual design of interplanetary trajectories, while also facilitating future improvements due to its modular structure

Antiphospholipid antibodies in patients with COVID-19 : a relevant observation?

Background: High incidence of thrombosis in COVID‐19 patients indicates a hypercoagulable state. Hence, exploring the involvement of antiphospholipid antibodies (aPL) in these patients is of interest. Objectives: To illustrate the incidence of criteria (lupus anticoagulant [LAC], anticardiolipin [aCL] immunoglobulin G [IgG]/IgM, antibeta2‐glycoprotein I antibodies [aβ2GPI] IgG/IgM) and noncriteria (anti‐phosphatidyl serine/prothrombin [aPS/PT], aCL, and aβ2GPI IgA) aPL in a consecutive cohort of critically ill SARS‐CoV‐2 patients, their association with thrombosis, antibody profile and titers of aPL. Patients/Methods: Thirty‐one consecutive confirmed COVID‐19 patients admitted to the intensive care unit were included. aPL were measured at one time point, with part of the aPL‐positive patients retested after 1 month. Results: Sixteen patients were single LAC‐positive, two triple‐positive, one double‐positive, one single aCL, and three aCL IgG and LAC positive. Seven of nine thrombotic patients had at least one aPL. Sixteen of 22 patients without thrombosis were aPL positive, amongst them two triple positives. Nine of 10 retested LAC‐positive patients were negative on a second occasion, as well as the double‐positive patient. Seven patients were aPS/PT‐positive associated to LAC. Three patients were aCL and aβ2GPI IgA‐positive. Conclusion: Our observations support the frequent single LAC positivity during (acute phase) observed in COVID‐19 infection; however, not clearly related to thrombotic complications. Triple aPL positivity and high aCL/aβ2GPI titers are rare. Repeat testing suggests aPL to be mostly transient. Further studies and international registration of aPL should improve understanding the role of aPL in thrombotic COVID‐19 patients

Orthofibrations and monoidal adjunctions

We study various types of fibrations over a product of two $\infty$-categories, and show how they can be dualised over one of the two factors via an explicit construction in terms of spans. Among other things, we use this to prove that given an adjunction between monoidal $\infty$-categories, there is an equivalence between lax monoidal structures on the right adjoint and oplax monoidal structures on the left adjoint functor.Comment: 48 page

Two-variable fibrations, factorisation systems and categories of spans

Open Access via the CUP agreement Funding statement During the preparation of this text, FH and SL were members of the Hausdorff Center for Mathematics at the University of Bonn funded by the German Research Foundation (DFG), and FH was furthermore a member of the cluster ‘Mathematics Münster: Dynamics-Geometry-Structure’ at the University of Münster under grant nos. EXC 2047 and EXC 2044, respectively. FH would also like to thank the Mittag-Leffler Institute for its hospitality during the research program ‘Higher Algebraic Structures in Algebra, Topology and Geometry’, supported by the Swedish Research Council (VR) under grant no. 2016-06596. FH and JN were further supported by the European Research Council (ERC) through the grants ‘Moduli Spaces, Manifolds and Arithmetic’, grant no. 682922, and ‘Derived Symplectic Geometry and Applications’, grant no. 768679, respectively. SL was supported by the DFG Schwerpunktprogramm 1786 ‘Homotopy Theory and Algebraic Geometry’ (project ID SCHW 860/1-1).Peer reviewedPublisher PD

Prenatal screening in twin pregnancies

Vugt, J.M.G. van [Promotor]Blankenstein, M.A. [Promotor

Both recombinant African catfish LH and FSH are able to activate the African catfish FSH receptor

LH and FSH are heterodimeric glycoprotein hormones, composed of a common alpha-subunit non-covalently associated with a hormone-specific beta-subunit. Repeated efforts to isolate catfish FSH (cfFSH) have not been successful and only catfish LH (cfLH) has been purified from catfish pituitaries. Recently, however, we succeeded in cloning the cDNA encoding the putative cfFSHbeta; the cDNAs for the alpha- and beta-subunit of cfLH have been cloned before. Here we report the expression of biologically active cfLH and cfFSH in the soil amoeba, Dictyostelium discoideum. The biological activity of the recombinant hormones was analyzed using cell lines transiently expressing either the cfLH receptor or the cfFSH receptor. Moreover, a primary testis tissue culture system served to study the steroidogenic potency of the recombinant hormones. Our results demonstrated that Dictyostelium produced biologically active, recombinant catfish gonadotropins, with recombinant cfLH being almost indistinguishable from its native counterpart, purified from pituitaries. Although recombinant cfFSH has significant effects in the bioassays used in this study, the specific function of native cfFSH in the control of reproduction and its expression patterns are not yet understood

The omnivorous Tyrolean Iceman: colon contents (meat, cereals, pollen, moss and whipworm) and stable isotope analyses

The contents of the colon of the Tyrolean Iceman who lived Ga. 5300 years ago include muscle fibres, cereal remains, a diversity of pollen, and most notably that of the hop hornbeam (Ostrya carpinifolia) retaining cellular contents, as well as a moss leaf (Neckera complanata) and eggs of the parasitic whipworm (Trichuris trichiura). Based almost solely on stable isotope analyses and ignoring the work on the colon contents, two recently published papers on the Iceman's diet draw ill- founded conclusions about vegetarianism and even veganism. Neither the pollen nor the moss is likely to have been deliberately consumed as food by the Iceman. All the available evidence concerning the Iceman's broad-based diet is reviewed and the significance of the colon contents for matters other than assessment of food intake is outlined