Advancing airborne Doppler lidar wind profiling in turbulent boundary layer flow – an LES-based optimization of traditional scanning-beam versus novel fixed-beam measurement systems

There is a need for improved wind measurements inside the planetary boundary layer (PBL), including the capability to sample turbulent flow. Airborne Doppler lidar (ADL) provides unique capabilities for spatially resolved and targeted wind measurements in the PBL. However, ADL wind profiling in the PBL is challenging, as turbulence violates the flow homogeneity assumption used in wind profile retrieval and thereby introduces error in the retrieved wind profiles. As turbulence is a dominant source of error it is necessary to investigate and optimize ADL wind profiling capabilities in turbulent PBL flow. This study investigates the potential of a novel multiple-fixed-beam ADL system design to provide improved wind information in turbulent PBL flow compared to traditional single-scanning-beam ADL systems. To achieve this, an LES-based (LES: large eddy simulation) airborne Doppler lidar simulator presented in Gasch et al. (2020) is employed and extended in this study. Results show that a multiple-fixed-beam system with settings comparable to those of commonly used single-scanning-beam systems offers distinct advantages. Advantages include overall reduced wind profile retrieval error due to turbulence and improved spatial representation alongside higher wind profile availability. The study also offers insight into the dependence of the retrieval error on system setup parameters and retrieval parameters for both fixed-beam and scanning-beam systems. When using a fixed-beam system, an order of magnitude higher wind profile resolution appears possible compared to traditional scanning systems at comparable retrieval accuracy. Thus, using multiple-fixed-beam systems opens the door to better sampling of turbulent PBL flow. Overall, the simulator provides a cost-effective tool to investigate and optimize wind profile error characteristics due to turbulence and to optimize system setup and retrieval strategies for ADL wind profiling in turbulent flow

Advancing airborne Doppler lidar wind profiling in turbulent boundary layer flow – an LES-based optimization of traditional scanning-beam versus novel fixed-beam measurement systems

There is a need for improved wind measurements inside the planetary boundary layer (PBL), including the capability to sample turbulent flow. Airborne Doppler lidar (ADL) provides unique capabilities for spatially resolved and targeted wind measurements in the PBL. However, ADL wind profiling in the PBL is challenging, as turbulence violates the flow homogeneity assumption used in wind profile retrieval and thereby introduces error in the retrieved wind profiles. As turbulence is a dominant source of error it is necessary to investigate and optimize ADL wind profiling capabilities in turbulent PBL flow. This study investigates the potential of a novel multiple-fixed-beam ADL system design to provide improved wind information in turbulent PBL flow compared to traditional single-scanning-beam ADL systems. To achieve this, an LES-based (LES: large eddy simulation) airborne Doppler lidar simulator presented in Gasch et al. (2020) is employed and extended in this study. Results show that a multiple-fixed-beam system with settings comparable to those of commonly used single-scanning-beam systems offers distinct advantages. Advantages include overall reduced wind profile retrieval error due to turbulence and improved spatial representation alongside higher wind profile availability. The study also offers insight into the dependence of the retrieval error on system setup parameters and retrieval parameters for both fixed-beam and scanning-beam systems. When using a fixed-beam system, an order of magnitude higher wind profile resolution appears possible compared to traditional scanning systems at comparable retrieval accuracy. Thus, using multiple-fixed-beam systems opens the door to better sampling of turbulent PBL flow. Overall, the simulator provides a cost-effective tool to investigate and optimize wind profile error characteristics due to turbulence and to optimize system setup and retrieval strategies for ADL wind profiling in turbulent flow.</p

Mie-resonances, infrared emission and band gap of InN

Mie resonances due to scattering/absorption of light in InN containing clusters of metallic In may have been erroneously interpreted as the infrared band gap absorption in tens of papers. Here we show by direct thermally detected optical absorption measurements that the true band gap of InN is markedly wider than currently accepted 0.7 eV. Micro-cathodoluminescence studies complemented by imaging of metallic In have shown that bright infrared emission at 0.7-0.8 eV arises from In aggregates, and is likely associated with surface states at the metal/InN interfaces.Comment: 4 pages, 5 figures, submitted to PR

Strain-free bulk-like GaN grown by hydride-vapor-phase-epitaxy on two-step epitaxial lateral overgrown GaN template

Crack-free bulk-like GaN with high crystalline quality has been obtained by hydride-vapor-phase-epitaxy (HVPE)growth on a two-step epitaxial lateral overgrown GaN template on sapphire. During the cooling down stage, the as-grown 270-μm-thick GaN layer was self-separated from the sapphire substrate. Plan-view transmission electron microscopyimages show the dislocation density of the free-standing HVPE-GaN to be ∼2.5×10 exp 7  cm exp −2 on the Ga-polar face. A low Ga vacancy related defect concentration of about 8×10 exp 15 cm exp−3 is extracted from positron annihilation spectroscopy data. The residual stress and the crystalline quality of the material are studied by two complementary techniques. Low-temperature photoluminescence spectra show the main neutral donor bound exciton line to be composed of a doublet structure at 3.4715 (3.4712) eV and 3.4721 (3.4718) eV for the Ga- (N-) polar face with the higher-energy component dominating. These line positions suggest virtually strain-free material on both surfaces with high crystalline quality as indicated by the small full width at half maximum values of the donor bound exciton lines. The E1(TO) phonon mode position measured at 558.52 cm exp −1 (Ga face) by infrared spectroscopic ellipsometry confirms the small residual stress in the material, which is hence well suited to act as a lattice-constant and thermal-expansion-coefficient matched substrate for further homoepitaxy, as needed for high-quality III-nitride device applications.Peer reviewe

Boosting antitumor responses of T lymphocytes infiltrating human prostate cancers

Immunotherapy may provide valid alternative therapy for patients with hormone-refractory metastatic prostate cancer. However, if the tumor environment exerts a suppressive action on antigen-specific tumor-infiltrating lymphocytes (TIL), immunotherapy will achieve little, if any, success. In this study, we analyzed the modulation of TIL responses by the tumor environment using collagen gel matrix–supported organ cultures of human prostate carcinomas. Our results indicate that human prostatic adenocarcinomas are infiltrated by terminally differentiated cytotoxic T lymphocytes that are, however, in an unresponsive status. We demonstrate the presence of high levels of nitrotyrosines in prostatic TIL, suggesting a local production of peroxynitrites. By inhibiting the activity of arginase and nitric oxide synthase, key enzymes of L-arginine metabolism that are highly expressed in malignant but not in normal prostates, reduced tyrosine nitration and restoration of TIL responsiveness to tumor were achieved. The metabolic control exerted by the tumor on TIL function was confirmed in a transgenic mouse prostate model, which exhibits similarities with human prostate cancer. These results identify a novel and dominant mechanism by which cancers induce immunosuppression in situ and suggest novel strategies for tumor immunotherapy

Free carrier effects in gallium nitride epilayers: the valence band dispersion

The dispersion of the A-valence-band in GaN has been deduced from the observation of high-index magneto-excitonic states in polarised interband magneto-reflectivity and is found to be strongly non-parabolic with a mass in the range 1.2-1.8 m_{e}. It matches the theory of Kim et al. [Phys. Rev. B 56, 7363 (1997)] extremely well, which also gives a strong k-dependent A-valence-band mass. A strong phonon coupling leads to quenching of the observed transitions at an LO-phonon energy above the band gap and a strong non-parabolicity. The valence band was deduced from subtracting from the reduced dispersion the electron contribution with a model that includes a full treatment of the electron-phonon interaction.Comment: Revtex, 4 pages, 5 figure

Raman scattering by longitudinal optical phonons in InN nanocolumns grown on Si(111) and Si(001) substrates

Raman measurements in high-quality InN nanocolumns and thin films grown on both Si(1 1 1) and Si(1 0 0) substrates display a low-energy coupled LO phonon–plasmon mode together with uncoupled longitudinal optical (LO) phonons. The coupled mode is attributed to the spontaneous accumulation of electrons on the lateral surfaces of the nanocolumns, while the uncoupled ones originates from the inner part of the nanocolumns. The LO mode in the columnar samples appears close to the E1(LO) frequency. This indicates that most of the incident light is entering through the lateral surfaces of the nanocolumns, resulting in pure longitudinal–optical mode with quasi-E1 symmetry. For increasing growth temperature, the electron density decreases as the growth rate increases. The present results indicate that electron accumulation layers do not only form on polar surfaces of InN, but also occur on non-polar ones. According to recent calculations, we attribute the electron surface accumulation to the temperature dependent In-rich surface reconstruction on the nanocolumns sidewalls

Effects of modified Restricted Environmental Stimulation Therapy on relaxation, heart rate, blood pressure and flexibility

Background: Restricted Environmental Stimulation Therapy (REST) promotes physiological and behavioral changes that reduce the deleterious effects of stress. However, it requires expensive equipment and is accessible to a limited number of professionals and patients. We aimed to evaluate the physiological and behavioral effects of modified REST (mREST) in healthy young women. Method: Twenty-one healthy young women (20-25 yrs) participated. mREST consists of positioning the patient floating in the pool with 32oC for about 15 minutes, for twelve sessions, with blindfolded and wearing earplugs. The evaluation was performed before and after the intervention. The analysis of the state of relaxation was investigated by a questionnaire and the self-reports were categorized. Measures of heart rate and blood pressure were used as indicators of the cardiovascular response. Flexibility, measured by the finger-to-floor test, was used as an indicator of muscle relaxation. Results: Heart rate and blood pressure significantly decreased while flexibility and relaxation increased after the sessions (p&lt;0.001 for all comparisons). Self-reports of relaxation were consistent with the blood pressure measures and indicated that the participants showed states of relaxation associated with the decrease of blood pressure and the increase of flexibility (p&lt;0.001 for all comparisons). Conclusion: Healthy women undergoing mREST reported relaxation, with effects on muscular and cardiovascular systems. mREST is a simple, practical and affordable option for therapy in the aquatic environment

Genetic regulation of pituitary gland development in human and mouse

Normal hypothalamopituitary development is closely related to that of the forebrain and is dependent upon a complex genetic cascade of transcription factors and signaling molecules that may be either intrinsic or extrinsic to the developing Rathke’s pouch. These factors dictate organ commitment, cell differentiation, and cell proliferation within the anterior pituitary. Abnormalities in these processes are associated with congenital hypopituitarism, a spectrum of disorders that includes syndromic disorders such as septo-optic dysplasia, combined pituitary hormone deficiencies, and isolated hormone deficiencies, of which the commonest is GH deficiency. The highly variable clinical phenotypes can now in part be explained due to research performed over the last 20 yr, based mainly on naturally occurring and transgenic animal models. Mutations in genes encoding both signaling molecules and transcription factors have been implicated in the etiology of hypopituitarism, with or without other syndromic features, in mice and humans. To date, mutations in known genes account for a small proportion of cases of hypopituitarism in humans. However, these mutations have led to a greater understanding of the genetic interactions that lead to normal pituitary development. This review attempts to describe the complexity of pituitary development in the rodent, with particular emphasis on those factors that, when mutated, are associated with hypopituitarism in humans