296 research outputs found
Standard Model Higgs boson production in association with a top anti-top pair at NLO with parton showering
We present predictions for the production cross section of a Standard Model
Higgs boson in association with a top-antitop pair at next-to-leading order
accuracy using matrix elements obtained from the HELAC-Oneloop package. The NLO
prediction was interfaced to the PYTHIA and HERWIG shower Monte Carlo programs
with the help of POWHEG-Box, allowing for decays of massive particles,
showering and hadronization, thus leading to final results at the hadron level.Comment: 14 pages, 9 figure
t \bar{t} W production and decay at NLO
We present results for the production of a top pair in association with a
W-boson at next-to-leading order. We have implemented this process into the
parton-level integrator MCFM including the decays of both the top quarks and
the W-bosons with full spin correlations. Although the cross section for this
process is small, it is a Standard Model source of same-sign lepton events that
must be accounted for in many new physics searches. For a particular analysis
of same-sign lepton events in which b-quarks are also present, we investigate
the effect of the NLO corrections as a function of the signal region cuts.Comment: 10 pages, 7 figure
Top Partner Discovery in the channel at the LHC
In this paper we study the discovery potential of the LHC run II for heavy
vector-like top quarks in the decay channel to a top and a boson. Despite
the usually smaller branching ratio compared to charged-current decays, this
channel is rather clean and allows for a complete mass reconstruction of the
heavy top. The latter is achieved in the leptonic decay channel of the
boson and in the fully hadronic top channel using boosted jet and jet
substructure techniques. To be as model-independent as possible, a simplified
model approach with only two free parameters has been applied. The results are
presented in terms of parameter space regions for evidence or
discovery for such new states in that channel.Comment: 24 pages, 8 figures, version 2 updated to JHEP 01 (2015) 08
Les Houches 2013: Physics at TeV Colliders: Standard Model Working Group Report
This Report summarizes the proceedings of the 2013 Les Houches workshop on
Physics at TeV Colliders. Session 1 dealt primarily with (1) the techniques for
calculating standard model multi-leg NLO and NNLO QCD and NLO EW cross sections
and (2) the comparison of those cross sections with LHC data from Run 1, and
projections for future measurements in Run 2.Comment: Proceedings of the Standard Model Working Group of the 2013 Les
Houches Workshop, Physics at TeV Colliders, Les houches 3-21 June 2013. 200
page
New Physics from the Top at the LHC
The top quark may hold the key to new physics associated with the electroweak
symmetry-breaking sector, given its large mass and enhanced coupling to the
Higgs sector. We systematically categorize generic interactions of a new
particle that couples to the top quark and a neutral particle, which is assumed
to be heavy and stable, thus serving as a candidate for cold dark matter. The
experimental signatures for new physics involving top quarks and its partners
at the Large Hadron Collider (LHC) may be distinctive, yet challenging to
disentangle. We optimize the search strategy at the LHC for the decay of the
new particle to a top quark plus missing energy and propose the study of its
properties, such as its spin and couplings. We find that, at 14 TeV with an
integrated luminosity of 100 fb^-1, a spin-zero top partner can be observed at
the 5-sigma level for a mass of 675 GeV. A spin-zero particle can be
differentiated from spin-1/2 and spin-1 particles at the 5-sigma level with a
luminosity of 10 fb^-1.Comment: 19 pages, 7 figures; v2: journal versio
Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector
A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results
Glutamate Uptake Triggers Transporter-Mediated GABA Release from Astrocytes
Background: Glutamate (Glu) and c-aminobutyric acid (GABA) transporters play important roles in regulating neuronal activity. Glu is removed from the extracellular space dominantly by glial transporters. In contrast, GABA is mainly taken up by neurons. However, the glial GABA transporter subtypes share their localization with the Glu transporters and their expression is confined to the same subpopulation of astrocytes, raising the possibility of cooperation between Glu and GABA transport processes. Methodology/Principal Findings: Here we used diverse biological models both in vitro and in vivo to explore the interplay between these processes. We found that removal of Glu by astrocytic transporters triggers an elevation in the extracellular level of GABA. This coupling between excitatory and inhibitory signaling was found to be independent of Glu receptor-mediated depolarization, external presence of Ca2+ and glutamate decarboxylase activity. It was abolished in the presence of non-transportable blockers of glial Glu or GABA transporters, suggesting that the concerted action of these transporters underlies the process. Conclusions/Significance: Our results suggest that activation of Glu transporters results in GABA release through reversal of glial GABA transporters. This transporter-mediated interplay represents a direct link between inhibitory and excitatory neurotransmission and may function as a negative feedback combating intense excitation in pathological conditions such as epilepsy or ischemia
Development of a risk score for early saphenous vein graft failure: An individual patient data meta-analysis
Objectives: Early saphenous vein graft (SVG) occlusion is typically attributed to technical factors. We aimed at exploring clinical, anatomical, and operative factors associated with the risk of early SVG occlusion (within 12 months postsurgery). Methods: Published literature in MEDLINE was searched for studies reporting the incidence of early SVG occlusion. Individual patient data (IPD) on early SVG occlusion were used from the SAFINOUS-CABG Consortium. A derivation (n = 1492 patients) and validation (n = 372 patients) cohort were used for model training (with 10-fold cross-validation) and external validation respectively. Results: In aggregate data meta-analysis (48 studies, 41,530 SVGs) the pooled estimate for early SVG occlusion was 11%. The developed IPD model for early SVG occlusion, which included clinical, anatomical, and operative characteristics (age, sex, dyslipidemia, diabetes mellitus, smoking, serum creatinine, endoscopic vein harvesting, use of complex grafts, grafted target vessel, and number of SVGs), had good performance in the derivation (c-index = 0.744; 95% confidence interval [CI], 0.701-0.774) and validation cohort (c-index = 0.734; 95% CI, 0.659-0.809). Based on this model. we constructed a simplified 12-variable risk score system (SAFINOUS score) with good performance for early SVG occlusion (c-index = 0.700, 95% CI, 0.684-0.716). Conclusions: From a large international IPD collaboration, we developed a novel risk score to assess the individualized risk for early SVG occlusion. The SAFINOUS risk score could be used to identify patients that are more likely to benefit from aggressive treatment strategies
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