1,310 research outputs found

    Governance capacity and collaborative action in Hong Kong : the structure and dynamics of district level community building

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    published_or_final_versionPolitics and Public AdministrationMasterMaster of Public Administratio

    PLASER: Pronunciation Learning via Automatic Speech Recognition

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    PLASER is a multimedia tool with instant feedback designed to teach English pronunciation for high-school students of Hong Kong whose mother tongue is Cantonese Chinese. The objective is to teach correct pronunciation and not to assess a student's overall pronunciation quality. Major challenges related to speech recognition technology include: allowance for non-native accent, reliable and corrective feedbacks, and visualization of errors

    The photometric observation of the quasi-simultaneous mutual eclipse and occultation between Europa and Ganymede on 22 August 2021

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    Mutual events (MEs) are eclipses and occultations among planetary natural satellites. Most of the time, eclipses and occultations occur separately. However, the same satellite pair will exhibit an eclipse and an occultation quasi-simultaneously under particular orbital configurations. This kind of rare event is termed as a quasi-simultaneous mutual event (QSME). During the 2021 campaign of mutual events of jovian satellites, we observed a QSME between Europa and Ganymede. The present study aims to describe and study the event in detail. We observed the QSME with a CCD camera attached to a 300-mm telescope at the Hong Kong Space Museum Sai Kung iObservatory. We obtained the combined flux of Europa and Ganymede from aperture photometry. A geometric model was developed to explain the light curve observed. Our results are compared with theoretical predictions (O-C). We found that our simple geometric model can explain the QSME fairly accurately, and the QSME light curve is a superposition of the light curves of an eclipse and an occultation. Notably, the observed flux drops are within 2.6% of the theoretical predictions. The size of the event central time O-Cs ranges from -14.4 to 43.2 s. Both O-Cs of flux drop and timing are comparable to other studies adopting more complicated models. Given the event rarity, model simplicity and accuracy, we encourage more observations and analysis on QSMEs to improve Solar System ephemerides.Comment: 23 pages, 5 appendixes, 16 figures, 7 table

    Inhibitory role of peroxisome proliferator-activated receptor gamma in hepatocarcinogenesis in mice and in vitro

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    Although peroxisome proliferator-activated receptor gamma (PPARγ) agonist have been shown to inhibit hepatocellular carcinoma (HCC) development, the role of PPARγ in hepatocarcinogenesis remains unclear. We investigated the therapeutic efficacy of PPAR

    照顧者實用資訊手冊

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    手冊源起 香港面對人口高齡化,醫療和福利系統無可避免面臨持續的挑戰。照顧者因壓力問題而引發的家庭悲劇時有發生,反映照顧者自身亦極需要社會的重視和支援。 現時照顧者人數眾多,當中不乏配偶、父母、子女、女婿、媳婦,對長者照顧及社會無酬的付出,確實值得社會的認同和肯定。然而,儘管本港為長者及照顧者提供不少支援服務,由於不同的原因,照顧者似乎未有善用現有的服務,常常需要一力承擔所有照顧的責任,這無疑增加了他們的壓力。 照顧者需求多樣性 照顧者有不同種類,所需要的服務或支援亦有所不同。例如:「新手照顧者」剛開始接觸照顧工作,需要盡快提升日常護理和相關的疾病知識,以及獲得合適的離院/復康服務支援。「隱蔽照顧者」一直承擔照顧工作但沒有接受任何支援,因此,他們需要的是服務提供者/鄰里的主動接觸,並被轉介合適的照顧服務,以分擔他們部分照顧工作。「高危照顧者」幾乎長時間被照顧的工作佔據了其生活,他們需要的是喘息空間和暫託服務,甚至可能是情緒支援。即使「資深的照顧者」也可能需要喘息或暫託的支援服務去減輕壓力;而結束了照顧工作的「畢業照顧者」,無論是情緒的支援,還是重新規劃財務與就業的安排,都有非常實際的需求。基於照顧者的不同需要,照顧者的支援和服務也是多樣化,如何讓不同種類的照顧者能夠輕易了解現有的社區支援服務、可考慮甚麼因素選取相關服務、如何獲取所需的支援包括申領經濟支援或預早準備長期護理開支、如何自強增值等,都是這本手冊希望解答的問題。 手冊的目的 編製這本手冊的目的就是要減少照顧者四處尋找資訊的麻煩,提供一個整全且易於瀏覽的資訊來源。本手冊主要有兩大目標:其一,幫助照顧者認識不同的服務和資源,積極尋求援助;其二是一站式提供豐富的資訊服務,提升照顧者的能力和平衡身心健康。 手冊的意義 此手冊的社會意義是期望提高大眾對照顧者需要的關注,並引導更多的行動以支援照顧者。如果您的親友是照顧者,又或您認識的朋友甚至鄰居正面對照顧家人的困難,您可以主動伸出援手,又或利用這本手冊作為啟示,向他們介紹相關的服務。 另外,這本手冊可以視作為支援照顧者的工具,讓照顧者明白在承擔照顧家人的重任時並不需要孤軍奮戰,也可以善用社區提供的各種資源和服務。 手冊架構 本手冊由四個主要部分組成,每部分都專注於特定的主題,旨在提供照顧者的全方位支援和資訊,幫助他們在面對挑戰時能夠有所依賴,並從中獲得力量: 第一部分主要提供基礎知識,其中包括不同種類的照顧者的介紹、四種長者常見疾病(包括認知障礙、中風、老年抑鬱和癌症)的病徵說明、以及照顧者可能面臨的壓力與「喘息服務」的重要性。第二部分專注介紹長者常用的社區及健康服務。我們按照地區將服務機構進行了分類,羅列「認知障礙、中風、老年抑鬱、癌症」常用的服務機構,此外,我們還提供家居安全、樂齡科技租賃服務,以及財務支援等相關建議。第三部分將焦點重新放回照顧者身上,提供了支援照顧者的社福機構介紹、照顧者同路人的心得分享,以及照顧者的培訓資訊,旨在幫助照顧者在面對困難時能自強不息。最後,在本手冊的結尾部分,我們特別邀請了四位專家學者就照顧者政策提出見解和建議,為加強照顧者支援服務提供新思路。 如果按持份者來分類,手冊的四個部分的重點如下: 第一部分:照顧者的基礎知識 ◎ 針對預備照顧者、新手以及隱蔽照顧者,讓他們了解照顧者的角色和需要;照顧體弱長者的基礎知識,並提供應對壓力的建議,包括自我照顧和喘息服務等。 第二部分:照顧者支援 ◎ 針對所有護老者,提供長者常用的社區服務、健康服務和支援計劃,包括暫託、住宿、護送及陪診、善別支援、情緒支援、復康用品津貼及租賃的支援計劃,以及財務策劃師提供的理財貼士。 第三部分:照顧者自強 ◎ 針對照顧者,資訊包括不同的照顧者支援組織、同路人和畢業照顧者的經驗心得、培訓課程,以及實用的電子資訊平台推介。 第四部分:對照顧者支援政策的看法和展望 ◎ 針對服務提供者、政策倡議者及制定者,提供專家學者對照顧者服務及政策的未來發展方向的看法和建議,以期引發更多關於「如何為照顧者提供更好支持」的討論。 給讀者的使用指引 本手冊內容十分豐富,讀者可以先瀏覽目錄,選擇與您相關的部分進行細讀。對於新手照顧者或剛接觸/關注護老服務的人士(例如:學生、社區人士),我們建議您可以參考手冊第24-33頁「給照顧者的智慧錦囊」的個案,了解不同照顧者可能面對的情境,這可能會給您一點概念,讓您可以考慮尋求哪些支援服務,又或您身邊照顧者朋友有哪些需要,以及如何協助他們獲取所需要的支援。我們深知閱讀本手冊時,您可能會遇到一些不明白的地方,請不必感到困惑。您可以嘗試找身邊的朋友、鄰居或社會服務機構的工作人員一起閱讀,或者向本中心的職員進行查詢。 此外,為方便讀者可以隨時隨地閱讀而不需要攜帶整本手冊,我們為本手冊設立了一個專屬網頁,免費下載整本手冊或某些章節內容。 希望您在閱讀的過程中能找到有用的資訊,並能從中獲得實際的幫助。https://commons.ln.edu.hk/apias_guide/1009/thumbnail.jp

    Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

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    BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

    Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study

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    Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world. Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231. Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001). Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication
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