Creación de ocasiones de gol en fútbol de élite. Diferencias tácticas entre Real Madrid CF y FC Barcelona

The aim of this study was to compare the playing tactics used to create scoring opportunities between Real Madrid C.F. (RMCF) and F.C. Barcelona (FCB). All team possessions which achieved scoring opportunity (n=945) during 64 matches (32 per team) corresponding to the 2011-2012 Spanish BBVA League were analyzed through systematical observation. Possessions were grouped according to the start-up type of possession into «recoveries» (n=526), «restarts» (n=199), and «set-plays» (n=175). Multidimensional data from nine categorical variables related to playing tactics were analyzed using chi-square analysis. In recoveries, RMCF registered higher initial penetration (p<0.01), higher percentage of counterattacks (p<0.01), fewer passes (p<0.01), higher percentage of penetrative passes (p<0.001) and greater number of scoring opportunities outside the score pentagon (p<0.01) than FCB. In restarts, the single difference was that RMCF registered greater number of scoring opportunities outside the score pentagon than FCB (p<0.001). The main differences between RMCF and FCB occurred in the transition between defense to attack, where RMCF was more penetrative immediately gaining the ball, progressed faster and used more frequently the counterattack. In contrast, FCB finished nearer the goal than RMCF.El objetivo de este estudio fue comparar los indicadores tácticos utilizados en la creación de ocasiones de gol entre Real Madrid C.F. (RMCF) y F.C. Barcelona (FCB). Todas las posesiones finalizadas en ocasión de gol (n=945) durante 64 partidos (32 por equipo) de la Liga BBVA 2011-2012 fueron analizadas a través de observación sistemática. Las posesiones fueron agrupadas según el tipo de inicio en «recuperaciones» (n=526), «reanudaciones» (n=199), y «acciones a balón parado» (n=175). 9 dimensiones relacionadas con indicadores tácticos fueron analizadas utilizando análisis chicuadrado. En recuperaciones, RMCF registró más penetración inicial (p<0.01), mayor porcentaje de contraataques (p<0.01), menor número de pases (p<0.01), más pases penetrativos (p<0.001), y mayor número de ocasiones de gol fuera del pentágono de finalización (p<0.01) que el FCB. En reanudaciones, la única diferencia fue el mayor número de ocasiones de gol fuera del pentágono de finalización del RMCF con respecto al FCB (p<0.001). Las mayores diferencias entre RMCF y FCB tuvieron lugar en la transición entre el momento defensivo y el ofensivo, donde el RMCF fue más penetrativo inmediatamente después de recuperar el balón, progresando más rápido y usando con mayor frecuencia el contraataque. En cambio, el FCB finalizó sus ocasiones de gol más cerca de la portería rival que el RMCF

Creation of Goal Scoring Opportunities by Means of Different Types of Offensive Actions in US Major League Soccer

Purpose. The aim of the study was to describe how scoring opportunities emerge and finish in Major League Soccer, taking into account offensive and defensive tactical indicators. Methods. The total of 360 team possessions that led to scoring opportunities during 30 random matches from Major League Soccer were analysed. For each possession, 14 dimensions were evaluated by means of observational methodology. Results. The scoring opportunities were created in 52.8% by organized attacks, in 25.3% by counterattacks, and in 21.9% by set pieces. Organized attacks were characterized by starting in non-invasive zones (57.1%), performing a non-penetrative action (72.6%), and making 4 or more passes (70.1%), while counterattacks started primarily in invasive zones (87.9%) and were bound with performing a penetrative action (96.7%) and making 3 or less passes (70.3%). Chi-square analysis showed that scoring opportunities created by organized attacks had more proportion of previous actions in wide areas (p = 0.034), while counterattacks showed more passes in behind the defence from central areas (p = 0.001). As for the final action, counterattacks achieved more penetration over the opponent defence than organized attacks (p = 0.036) but for both types of attacks, the opponent defensive zone was the space majorly used to finish. For set pieces, corner kicks created 46.8% and free kicks 45.6% of the scoring opportunities. Conclusions. Goal scoring opportunities from organized attacks started more frequently in non-invasive zones, showed a greater proportion of non-penetrative actions, were built up by means of longer passing sequences, used more the wide areas of the pitch, and achieved less penetration over the opponent than those from counterattacks.We acknowledge the support of a Spanish government project (Ministerio de Economía y Competitividad): La actividad física y el deporte como potenciadores del estilo de vida saludable: Evaluación del comportamiento deportivo desde metodologías no intrusivas [Grant number DEP2015-66069-P]

IFE Plant Technology Overview and contribution to HiPER proposal

HiPER is the European Project for Laser Fusion that has been able to join 26 institutions and signed under formal government agreement by 6 countries inside the ESFRI Program of the European Union (EU). The project is already extended by EU for two years more (until 2013) after its first preparatory phase from 2008. A large work has been developed in different areas to arrive to a design of repetitive operation of Laser Fusion Reactor, and decisions are envisioned in the next phase of Technology Development or Risk Reduction for Engineering or Power Plant facilities (or both). Chamber design has been very much completed for Engineering phase and starting of preliminary options for Reactor Power Plant have been established and review here

Immunological predictors of CD4+ T cell decline in antiretroviral treatment interruptions

<p>Abstract</p> <p>Background</p> <p>The common response to stopping anti-HIV treatment is an increase of HIV-RNA load and decrease in CD4⁺, but not all the patients have similar responses to this therapeutic strategy. The aim was to identify predictive markers of CD4⁺cell count declines to < 350/μL in CD4-guided antiretroviral treatment interruptions.</p> <p>Methods</p> <p>27 HIV-infected patients participated in a prospective multicenter study in with a 24 month follow-up. Patients on stable highly active antiretroviral therapy (HAART), with CD4⁺count > 600/μL, and HIV-RNA < 50 copies/ml for at least 6 months were offered the option to discontinue antiretroviral therapy. The main outcome was a decline in CD4⁺cell count to < 350/μL.</p> <p>Results</p> <p>After 24 months of follow-up, 16 of 27 (59%) patients (who discontinued therapy) experienced declines in CD4⁺cell count to < 350/μL. Patients with a CD4⁺nadir of < 200 cells/μL had a greater risk of restarting therapy during the follow-up (RR (CI95%): 3.37 (1.07; 10.36)). Interestingly, lymphoproliferative responses to <it>Mycobacterium tuberculosis </it>purified protein derivative (PPD) below 10000 c.p.m. at baseline (4.77 (1.07; 21.12)), IL-4 production above 100 pg/mL at baseline (5.95 (1.76; 20.07)) in PBMC cultured with PPD, and increased IL-4 production of PBMC with p24 antigen at baseline (1.25 (1.01; 1.55)) were associated to declines in CD4⁺cell count to < 350/μL.</p> <p>Conclusion</p> <p>Both the number (CD4⁺nadir) and the functional activity of CD4⁺(lymphoproliferative response to PPD) predict the CD4⁺decrease associated with discontinuation of ART in patients with controlled viremia.</p

Enfrentando los riesgos socionaturales

El objetivo del libro es comprender la magnitud de los Riesgos Socionaturales en México y Latinoamérica, para comprender el peligro que existe por algún tipo de desastre, ya sea inundaciones, sismos, remoción en masa, entre otros, además conocer qué medidas preventivas, correctivas y de contingencias existen para estar atentos ante alguna señal que la naturaleza esté enviando y así evitar alguna catástrofe. El libro se enfoca en los aspectos básicos de análisis de los peligros, escenarios de riesgo, vulnerabilidad y resiliencia, importantes para la gestión prospectiva o preventiva

Isotemporal substitution of inactive time with physical activity and time in bed: cross-sectional associations with cardiometabolic health in the PREDIMEDPlus study

Background: This study explored the association between inactive time and measures of adiposity, clinical parameters, obesity, type 2 diabetes and metabolic syndrome components. It further examined the impact of reallocating inactive time to time in bed, light physical activity (LPA) or moderate-to-vigorous physical activity (MVPA) on cardio-metabolic risk factors, including measures of adiposity and body composition, biochemical parameters and blood pressure in older adults. Methods: This is a cross-sectional analysis of baseline data from 2189 Caucasian men and women (age 55-75 years, BMI 27-40 Kg/m2) from the PREDIMED-Plus study (http://www.predimedplus.com/). All participants had ≥3 components of the metabolic syndrome. Inactive time, physical activity and time in bed were objectively determined using triaxial accelerometers GENEActiv during 7 days (ActivInsights Ltd., Kimbolton, United Kingdom). Multiple adjusted linear and logistic regression models were used. Isotemporal substitution regression modelling was performed to assess the relationship of replacing the amount of time spent in one activity for another, on each outcome, including measures of adiposity and body composition, biochemical parameters and blood pressure in older adults. Results: Inactive time was associated with indicators of obesity and the metabolic syndrome. Reallocating 30 min per day of inactive time to 30 min per day of time in bed was associated with lower BMI, waist circumference and glycated hemoglobin (HbA1c) (all p-values < 0.05). Reallocating 30 min per day of inactive time with 30 min per day of LPA or MVPA was associated with lower BMI, waist circumference, total fat, visceral adipose tissue, HbA1c, glucose, triglycerides, and higher body muscle mass and HDL cholesterol (all p-values < 0.05). Conclusions: Inactive time was associated with a poor cardio-metabolic profile. Isotemporal substitution of inactive time with MVPA and LPA or time in bed could have beneficial impact on cardio-metabolic health

Towards precision medicine: defining and characterizing adipose tissue dysfunction to identify early immunometabolic risk in symptom-free adults from the GEMM family study

Interactions between macrophages and adipocytes are early molecular factors influencing adipose tissue (AT) dysfunction, resulting in high leptin, low adiponectin circulating levels and low-grade metaflammation, leading to insulin resistance (IR) with increased cardiovascular risk. We report the characterization of AT dysfunction through measurements of the adiponectin/leptin ratio (ALR), the adipo-insulin resistance index (Adipo-IRi), fasting/postprandial (F/P) immunometabolic phenotyping and direct F/P differential gene expression in AT biopsies obtained from symptom-free adults from the GEMM family study. AT dysfunction was evaluated through associations of the ALR with F/P insulin-glucose axis, lipid-lipoprotein metabolism, and inflammatory markers. A relevant pattern of negative associations between decreased ALR and markers of systemic low-grade metaflammation, HOMA, and postprandial cardiovascular risk hyperinsulinemic, triglyceride and GLP-1 curves was found. We also analysed their plasma non-coding microRNAs and shotgun lipidomics profiles finding trends that may reflect a pattern of adipose tissue dysfunction in the fed and fasted state. Direct gene differential expression data showed initial patterns of AT molecular signatures of key immunometabolic genes involved in AT expansion, angiogenic remodelling and immune cell migration. These data reinforce the central, early role of AT dysfunction at the molecular and systemic level in the pathogenesis of IR and immunometabolic disorders

Multicentre, randomised, single-blind, parallel group trial to compare the effectiveness of a Holter for Parkinson's symptoms against other clinical monitoring methods: study protocol

Introduction In recent years, multiple studies have aimed to develop and validate portable technological devices capable of monitoring the motor complications of Parkinson's disease patients (Parkinson's Holter). The effectiveness of these monitoring devices for improving clinical control is not known. Methods and analysis This is a single-blind, cluster-randomised controlled clinical trial. Neurologists from Spanish health centres will be randomly assigned to one of three study arms (1:1:1): (a) therapeutic adjustment using information from a Parkinson?s Holter that will be worn by their patients for 7 days, (b) therapeutic adjustment using information from a diary of motor fluctuations that will be completed by their patients for 7 days and (c) therapeutic adjustment using clinical information collected during consultation. It is expected that 162 consecutive patients will be included over a period of 6 months. The primary outcome is the efficiency of the Parkinson?s Holter compared with traditional clinical practice in terms of Off time reduction with respect to the baseline (recorded through a diary of motor fluctuations, which will be completed by all patients). As secondary outcomes, changes in variables related to other motor complications (dyskinesia and freezing of gait), quality of life, autonomy in activities of daily living, adherence to the monitoring system and number of doctor?patient contacts will be analysed. The noninferiority of the Parkinson's Holter against the diary of motor fluctuations in terms of Off time reduction will be studied as the exploratory objective. Ethics and dissemination approval for this study has been obtained from the Hospital Universitari de Bellvitge Ethics Committee. The results of this study will inform the practical utility of the objective information provided by a Parkinson's Holter and, therefore, the convenience of adopting this technology in clinical practice and in future clinical trials. We expect public dissemination of the results in 2022.Funding This work is supported by AbbVie S.L.U, the Instituto de Salud Carlos III [DTS17/00195] and the European Fund for Regional Development, 'A way to make Europe'

Evolutionary Heritage Influences Amazon Tree Ecology

Lineages tend to retain ecological characteristics of their ancestors through time. However, for some traits, selection during evolutionary history may have also played a role in determining trait values. To address the relative importance of these processes requires large-scale quantification of traits and evolutionary relationships among species. The Amazonian tree flora comprises a high diversity of angiosperm lineages and species with widely differing life-history characteristics, providing an excellent system to investigate the combined influences of evolutionary heritage and selection in determining trait variation. We used trait data related to the major axes of life-history variation among tropical trees (e.g. growth and mortality rates) from 577 inventory plots in closed-canopy forest, mapped onto a phylogenetic hypothesis spanning more than 300 genera including all major angiosperm clades to test for evolutionary constraints on traits. We found significant phylogenetic signal (PS) for all traits, consistent with evolutionarily related genera having more similar characteristics than expected by chance. Although there is also evidence for repeated evolution of pioneer and shade tolerant life-history strategies within independent lineages, the existence of significant PS allows clearer predictions of the links between evolutionary diversity, ecosystem function and the response of tropical forests to global change