Conditions for detecting CP violation via neutrinoless double beta decay

Neutrinoless double beta decay data together with information on the absolute neutrino masses obtained from the future KATRIN experiment and/or astrophysical measurements give a chance to find CP violation in the lepton sector with Majorana neutrinos. We derive and discuss necessary conditions which make discovery of such CP violation possible for the future neutrino oscillation and mass measurements data.Comment: 15 pages, 4 figures, RevTe

Bound on the mass of Majorana neutrinos after SNO and KamLAND

Presently the best terrestrial limit on light neutrino masses (m<2.2 eV) are given by the tritium beta decay experiments. Not maximal mixing of solar neutrinos following from the SNO and KamLAND together with neutrinoless double beta decay (( )0 ) data open the chance for better determination of the lightest of Majorana neutrino mass. We combine all available fits for the solar neutrino parameters and collect all Nuclear Matrix Elements (NME) calculations for the 76Ge, nucleus for which presently the most stringent limit on the ( )0 decay half-life time exist. We have shown that for some NME smaller bound on (m )min can be found. Unfortunately one order of magnitude discrepancies in NME calculations do not allow to give the final answer

Compliance with pharmacological treatment among patients after minimally invasive coronary bypass grafting

Background: We sought to evaluate patients’ adherence to optimal pharmacotherapy as recommended by the European Society of Cardiology, together with the assessment of potential clinical determinants of medical non-compliance in a large cohort of patients after endoscopic atraumatic coronary artery bypassing (EACAB).Methods: This cross sectional study was conducted in a group of 706 individuals who underwent EACAB between April 1998 and December 2010. Data covering current pharmacological treatment with antiplatelet agents, beta-blockers (BB) (or heart rate lowering calcium channel blockers [CCB] in case of intolerance and/or poor efficacy of beta-blockade), angiotensin-converting enzyme (ACE) inhibitors (or angiotensin receptor blockers [ARB]) and statins was acquired. Mean duration of observation after the surgery was 2132 ± 1313 days.Results: Complete follow-up data has been obtained from 415 living patients (341 males). Amongst them, 353 (85%) received antiplatelet agents, while BB or CCB were routinely ingested by 349 (84%) patients. Statins were used by 310 (74.7%) individuals and 274 (66%) subjects took ACE inhibitors or ARB. Baseline demographic and clinical features, including major co-morbidities had no impact on patients’ compliance with all investigated medications. There was no clear association between adherence to treatment and risk of rehospitalization or occurrence of major cerebral and cardiovascular events.Conclusions: EACAB patients’ compliance with pharmacotherapy guidelines is insufficient and is unrelated to demographic and clinical features of the subjects. Multidisciplinary approach involving health education, enhancement in prescription drug affordability and a better rapport between doctors and patients should be incorporated into clinical practice to overcome therapeutic disobedience

Personal protective measures

With the financial support of Internal Security Fund Police Programme European Commission Directorate General Home Affairs. This project has been founded with support from the European Commission. This publication reflects the views only of the authors, and European Commission cannot be held responsible for any use which may be made of the information contained therein

A new class of invariants in the lepton sector

We construct a new set of combinations from the mass matrices of the charged leptons and neutrinos that are invariant under basis transformation, hereafter {\it the} invariants. We use these invariants to study various symmetries and neutrino mass textures in a basis independent way. In particular, we show that by using these invariants the ansatz such as $\mu-\tau$ exchange and reflection symmetries, various texture zeros and flavor symmetries can be expressed in a general basis.Comment: 19 pages, Version appeared in Nuclear Physics

Transport of dangerous biological materials

With the financial support of Internal Security Fund Police Programme European Commission Directorate General Home Affairs. This project has been founded with support from the European Commission. This publication reflects the views only of the authors, and European Commission cannot be held responsible for any use which may be made of the information contained therein

The Absolute Neutrino Mass Scale, Neutrino Mass Spectrum, Majorana CP-Violation and Neutrinoless Double-Beta Decay

Assuming 3-$\nu$ mixing, massive Majorana neutrinos and neutrinoless double-beta (\betabeta-) decay generated only by the (V-A) charged current weak interaction via the exchange of the three Majorana neutrinos, we briefly review the predictions for the effective Majorana mass \meff in \betabeta-decay and reanalyse the physics potential of future \betabeta-decay experiments to provide information on the type of neutrino mass spectrum, the absolute scale of neutrino masses, and Majorana CP-violation in the lepton sector. Using as input the most recent experimental results on neutrino oscillation parameters and the prospective precision that can be achieved in future measurements of the latter, we perform a statistical analysis of a \betabeta-decay half-life measurement taking into account experimental and theoretical errors, as well as the uncertainty implied by the imprecise knowledge of the corresponding nuclear matrix element (NME). We show, in particular, how the possibility to discriminate between the different types of neutrino mass spectra and the constraints on the absolute neutrino mass scale depend on the mean value and the experimental error of \meff and on the NME uncertainty. The constraints on Majorana CP-violation phases in the neutrino mixing matrix, which can be obtained from a measurement of \meff and additional data on the sum of neutrino masses, are also investigated in detail. We estimate the required experimental accuracies on both types of measurements, and the required precision in the NME permitting to address the issue of Majorana CP-violation in the lepton sector.Comment: 29 pages, 7 figures, minor improvements on the text, fig. 4 improved graphically, version to appear in Nucl. Phys.

Interferon-ß regulates the production of IL-10 by toll-like receptor-activated microglia

Pattern recognition receptors, such as toll-like receptors (TLRs), perceive tissue alterations and initiate local innate immune responses. Microglia, the resident macrophages of the brain, encode TLRs which primary role is to protect the tissue integrity. However, deregulated activation of TLRs in microglia may lead to chronic neurodegeneration. This double role of microglial responses is often reported in immune-driven neurologic diseases, as in multiple sclerosis (MS). Consequently, strategies to manipulate microglia inflammatory responses may help to ameliorate disease progression. In this context, the anti-inflammatory cytokine interleukin (IL)-10 appears as an attractive target. In this study, we investigated how activation of microglia by TLRs with distinct roles in MS impacts on IL-10 production. We found that activation of TLR2, TLR4, and TLR9 induced the production of IL-10 to a greater extent than activation of TLR3. This was surprising as both TLR3 and IL-10 play protective roles in animal models of MS. Interestingly, combination of TLR3 triggering with the other TLRs, enhanced IL-10 through the modulation of its transcription, via interferon (IFN)-beta, but independently of IL-27. Thus, in addition to the modulation of inflammatory responses of the periphery described for the axis TLR3/IFN-beta, we now report a direct modulation of microglial responses. We further show that the presence of IFN-gamma in the microenvironment abrogated the modulation of IL-10 by TLR3, whereas that of IL-17 had no effect. Considering the therapeutic application of IFN-beta in MS, our study bears important implications for the understanding of the cytokine network regulating microglia responses in this setting.Portuguese Foundation for Science and Technology (FCT), Grant/Award Numbers: SFRH/BD/88081/2012 and SFRH/BPD/72710/2010; FEDER - Competitiveness Factors Operational Programme (COMPETE), Grant/Award Numbers: POCI-01-0145-FEDER-007038 and NORTE-01-0145-FEDER-000013; Norte Portugal Regional Operational Programme, PORTUGAL 2020, European Regional Development Fund (ERDF), Grant/Award Number: NORTE 2020; FCT-ANR, Grant/Award Number: FCT-ANR/BIM-MEC/0007/2013; FEDER - Fundo Europeu de Desenvolvimento Regional; COMPETE 2020 - Operacional Programme for Competitiveness and Internationalisation (POCI), Portugal 2020; Institute for Research and Innovation in Health Sciences, Grant/Award Number: POCI-01-0145-FEDER-007274info:eu-repo/semantics/publishedVersio