12 research outputs found
Working in the Public Interest Law Conference
- Author
- Adams Chris
- Ansley Fran
- Berkowitz Susan
- Bondurant Emmet
- Brisman Avi
- Browne Judith
- Caftel Brad
- Casey Tim
- Colussy Sue
- Costello Andrea
- Diallo Dazon Dixon
- Edwards John
- Egemonye Uche
- Ehr Tom
- Emanuel Anne S.
- Gonzalez Jerry
- Gottlieb Steve
- Gresser Edward
- Hatcher Dan
- Hunter William
- Jamieson Sue
- Jones Bryan
- Jones Steve C.
- Knapp Jackie
- Kocher Eric
- Lindbloom Nancy
- Little John
- Lyle David
- McDonald Laughlin
- Mears Mike
- Morgan Alisha
- Munzenmaier John
- Norman Ajulo Othow
- Owens Jennifer
- Pierce Joe
- Price Mary
- Prittie Joan
- Quinn Mae C.
- Roseborough Teresa
- Scott Kay
- StipeMaas Skipper
- Stoops Michael
- Wang Cindy
- Wasline Michele
- Weber Gerald
- Williams Jeffrey
- Yoon Joan M.
- Zaremba Amy
- Publication venue
- Digital Commons @ University of Georgia School of Law
- Publication date
- 07/04/2006
- Field of study
Entirely student organized, WIPI seeks to bring together eminent practitioners in their respective fields, students, and faculty to discuss practical approaches to lawyering which can best serve the poor. Practical methods of challenging poverty are often not covered in traditional law school courses. This conference seeks to remedy that and provide dynamic, creative ways to combat poverty through the vehicle of the law
Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial
- Author
- Abab Julie
- Abbas Ali
- Abbassi Sara
- Abd Alazeez Mohamed
- Abdulwahid Danya
- Abdulwahid Danya
- Abed Jessy
- Adab Fawzi
- Adams Marion
- Adamson Vanessa
- Addison Anglise
- Adeyoju Adebanji
- Adinkra Victoria
- Adnaan Jamila
- Afzal Naveed
- Agdiran Didem
- Aggarwal Ajay
- Ahamadali Sheefa
- Ahmad Belal
- Ahmed Ilyas
- Ahmed Imtiaz
- Ahmed Shahida
- Aiku Abimbola
- Ainsworth Sarah
- Ainsworth Sarah
- Aitken Katherine
- Ajzensztejn Daniel
- Akhtar Naeem
- Al-Chamali Hiba
- Al-hasso Abdulla
- Al-hasso Abdulla
- Al-Samarraie Amir
- Albrecht Virginia
- Alcock Christopher
- Alder Leanne
- Alderton Kate
- Aldous Mary
- Ali Jennyfa
- Ali Maryam
- Ali Zulfiqer
- Ali Zulfiqer
- Allan Elaine
- Allan Elaine
- Allen Julie
- Allen Kirsten
- Allen Rachael
- Allen Susan
- Allison Joanna
- Allison Michele
- Alonzi Roberto
- AlRashdan Abdulla
- Alzouebi Mymoona
- Amanie John Oliver
- Ammeter Barb
- Amoaten Thomas
- Amos Claire
- Anderson Beverley
- Anderson Chris
- Anderson Jim
- Anderson John
- Anderson John
- Anderson Juliette
- Anderson Juliette
- Anderson Leanne
- Anderson Naomi
- Anderson Susan
- Anderson Susan
- Andrade Gerard
- Andrews (nee Moore) Eleanor
- Andrews Kelly
- Andrews Stephen
- Ang Daniel
- Ann Taehee
- Annan Lynda
- Ansari Jawaher
- Ansari Jawaher
- Anscombe Eleanor
- Anyamene Nicola
- Appleby Bonny
- Appleby Rowan
- Archer Denise
- Archer Denise
- Archer Simon
- Archer Simon
- Arnott Seonaid
- Arsanious Nasr
- Ashcroft Jan
- Ashworth Sue
- Ashworth Sue
- Askew Sarah
- Aslam Natasha
- Atkinson Jane
- Atkinson Lorraine
- Attlee Julie
- Auladin Raidah
- Austin (nee Glover) Gemma
- Austin Mandy
- Avery Alison
- Avis Joanne
- Aya Viviana
- Azirar Hanna
- Bachand Francois
- Bahary JeanPaul
- Bahl Amit
- Bahl Amit
- Bailey Laura
- Bailey Linda
- Baines Kizzy
- Baird Noelle
- Bak Dagmara
- Bakawala Rehana
- Baker Erin
- Baker Ivanna
- Bakija Zeljka
- Bakker Piet
- Balderson Jane
- Ball Julie
- Balogun Shaki
- Bamford Linda
- Banda Laillah-Crystal
- Barber Dave
- Baria Karin
- Barkati Maroie
- Barkati Maroie
- Barke Nyssa
- Barlow David
- Barnbrooke Sarah
- Barnes Alison
- Barnes Nicky
- Barnett Christian
- Barnett Debra
- Barron Chris
- Barron Claire
- Barter Elisa
- Barwell Lorraine
- Bashir Bashir
- Bashir Faheem
- Basu Devy
- Bateman Samantha
- Bates Emma
- Batish Cheryl
- Batz Margaret
- Bauman Glenn
- Baumber Shelley
- Baxter Matt
- Bayley Andrew J
- Beamish Neal
- Beaney Katherine
- Beaney Ronald
- Beard Karen
- Beard Karen
- Beaton Heather
- Beaton Kirsty
- Beattie Louise
- Beauchemin MarieClaude
- Beaumont Erica
- Beausoleil Rachelle
- Beazer Sarah
- Bech-Nielsen Nanette
- Bech-Nielsen Nanette
- Bedoya Luis Diaz de
- Beech Darren
- Beer Nigel
- Beesley Kate
- Beesley Katherine
- Beesley Sharon
- Beety Jane
- Bekulart Sylwia
- Belcher Rebecca
- Bell Karen
- Bellenger Katharine
- Benjaminson Patricia
- Bennett Molly
- Bennett Sarah
- Bennion Carole
- Benson Richard
- Benson Richard
- Benth Silvine
- Benton Louise
- Benton Richard
- Bentzen Lise
- Beresford Mark
- Beresford Mark
- Beresford Mark
- Bergen Leah
- Berghout Koralee
- Berlin Alejandro
- Bermingham Nicola
- Betts Chris
- Bhana Rajanee
- Bhatnagar Adityanarayan
- Bhatnagar Gagan
- Bici Julia
- Bier Bianca
- Binks Colin
- Binns Louise
- Birch Richard
- Bird Stephanie
- Birtle Alison
- Bishop Emma
- Bissa Caterina
- Bissett Donald
- Bisson MarieEve
- Blackwood Geoffrey
- Blaney Hilary
- Blight Kathy
- Blood Paul A
- Bloomfield David
- Bloomfield David
- Bloomfield Mark
- Blundell Martyn
- Blythe Tracy
- Boam Samantha
- Boardman John
- Bohra Vikram
- Bois (nee Harris) Elizabeth
- Bolger Annette
- Bolton Olivia
- Bolton Olivia
- Bond Brittany
- Bone Linzi
- Bonner Scott
- Bonner-Shand Shelagh
- Bonsu Nicole
- Boon Ian
- Borgaonkar Sudhir
- Borre Michael
- Borynec Carol
- Bott Trevor
- Bottomley David
- Bottomley David
- Bottomley David M.
- Bottomley Ian
- Bouchard Myriam
- Bourke Amie
- Bourque JeanMarc
- Boutflower Jane
- Bowen Jo
- Bowen Jo
- Bowen Katie
- Bower Lorna
- Bower Lorna C.
- Bowers Dawn
- Bowers Richard
- Bowes-Cavanagh Jeanette
- Bowling Lorna
- Bowman Sue
- Bowmer Amanda
- Bownie-Mukumbu Godfrey
- Brady Joanne
- Brady Joanne
- Brain Carol
- Branagan Jennifer
- Branagan Jenny
- Brander Mike
- Branson (née Dineen) Amy
- Brasso Klaus
- Braun Michael W
- Brawley Chris
- Breakspear Sally
- Breckin Edmund
- Breen Vivienne
- Brennan Maria
- Brewster Simon
- Briand Wayne
- Briggs Maxine
- Bristow Robert
- Brittain Paul
- Broadley Eve
- Brock Sue
- Brock Sue
- Brogan (nee Roddie) Stephanie
- Brookes Claire
- Brookman Catherine
- Broom Jane
- Broomfield Barbara
- Brough Richard
- Brough Richard
- Brough WA
- Brown Emmanuel
- Brown Grace
- Brown Joanne
- Brown Maggie
- Brown Rebecca
- Brown Richard B
- Brown Richard B
- Brown Sandra
- Brown Simon
- Brown Stephen CW
- Brown Teddy
- Brownless Caroline
- BrucePayne Kim
- Brulinski Patryk
- Brulinski Patryk
- Brundage Michael
- Bryan Rachel
- Bryant Hanna
- Brydon-Hill Ruth
- Bucci Catherine
- Buchan Jonathan
- Buckley Jon
- Buckley Julie
- Bujold Rachel
- Bunn Sarah
- Burbridge Susan
- Burgoyne Jamie-Rae
- Burlace Barbara
- Burlace Barbara
- Burns Rebecca
- Burrage Su
- Bursey Kara
- Butler-Barnes Jenny
- Butt Zainab
- Butterfield Anne
- Butterworth Caryl
- Buus Simon
- Byrne Mary Marg
- Caballes Mark
- Cadiz Lovely
- Callam Sara
- Calvert Clare
- Camara Mary Jane
- Camburn Sister Tracey
- Camilleri Philip
- Camilleri Philip
- Camilleri Philip
- Camilleri Philip
- Campbell Allister
- Campbell Audrey
- Campbell Hilary
- Campbell Yvonne
- Campos Monica
- Canavan Joycelin
- Cannon Philip
- Capaldi Lisa
- Capaldi Lisa
- Capaldi Lisa
- Carbonaro Adriana
- Carefoot Layton
- Carini Serrafina
- Carkner Amy
- Carlino Giulia
- Carlson Cindy
- Carmel Michel
- Carpenter Janice
- Carpenter Janice
- Carpio Viviana
- Carr Philippa
- Carroll Weronika
- Carruthers Ross
- Carter Adam
- Carter Vanda
- Cartwright Debbie
- Carvery Lane
- Casanova Nathalie
- Casanova Nathalie
- Casey Linda
- Casey Sue
- Catt Natalie
- Catton Charles
- Catton Charles N.
- Caumont Tom
- Cavanagh Kerrie
- Chadwick David
- Chadwick Eliot
- Chahal Rohit
- Chahine Jacqueline
- Chakraborti Prabir
- Challipalli Amarnath
- Challipalli Amarnath
- Chamberlain Shelley
- Chambers Carla
- Chan Andrew
- Chan Andrew
- Chan Heidi
- Chan Hin Fan
- Chan Olivia
- Chandrashekara Madhura
- Charnley Natalie
- Chatelain AnneMarie
- Chatfield Jenny
- Chauhan Zainab
- Chedham Alison
- Chennattukungu Indukala
- Cherepak Kathy
- Chetiyawardana Samantha
- Chetiyawardana Samantha
- Chettle Judith
- Cheung Arthur
- Cheung Patrick CF
- Chikkamuniyappa Bindu
- Chikkamuniyappa Bindu
- Chikopela Loveness
- Chilcott Helen
- Chipman Penny
- Chivers Rachael
- Chornopyski Tracy
- Choudhury Ananya
- Choudhury Ananya
- Choudhury Ananya
- Chowdhury Amitava D
- Christensen Anne Juel
- Christensen Tine
- Christmas Sallyanne
- Chrystal Melanie
- Chu William
- Chui Amadeus
- Chung Christina
- Chung Hans T
- Chung Peter
- Chung Peter W.M.
- Churn Mark
- Churn Mark
- Clancy Joanna
- Clapp Felicity
- Clark Alison
- Clark Diane
- Clark Helen
- Clark Katy
- Clark Su
- Clarke Elizabeth
- Clarke Jude
- Clarke Maria
- Clarke Noel
- Clarke Noel W.
- Clarke Peter
- Clarke Rachael
- Clarke Samantha
- Cleary Kristy
- Clements Colette
- Clements Mia AnnaMaria
- Clitheroe Pat
- Cobos-Arrivabene Marta
- Cocks Tracie
- Coe Marc
- Coffin Teresa
- Cogley Lyn
- Cogley Lyn
- Cole Aiden
- Cole David J
- Cole David J
- Collard Susan
- Colligan Steve
- Collins Gerald
- Collins Gerald
- Collins Lucy
- Commisso Angela
- Conibear John
- Connolly nee McKenna Sarah
- Connor Marie
- Conroy Ruth
- Conroy Ruth
- Conway Lisa-Jane
- Conway Rachel
- Cook Adrian
- Cook Adrian D.
- Cook Audrey
- Cook Audrey
- Cook Wendy
- Cooke Jill
- Cooke Juniebel
- Cooke Peter
- Coomber Kristy
- Coombs Sarah
- Cooper Adele
- Cooper Sophie
- Coppins Helen
- Corbett Thomas B
- Corcoran Sam
- Corderoy Helen
- Cordwell Amanda
- Corkery Danylle
- Corless Rebecca
- Cormack Margaret
- Cornaby Andrew
- Corner Victoria
- Cornthwaite Stephanie
- Corwin Charlotte
- Cossette Danielle
- Cote Genevieve
- Cotterill Lauren
- Cotts Shannon
- Coubrough Claudia
- Couch Ellie
- Coughlan Tricia
- Cousins Jane
- Cousins Rebecca
- Coutts Tim
- Coventry Thomas
- Cowan Chloe
- Cowan Chloe
- Cowan Richard
- Cowan Richard
- Cowley Sue
- Cox Adam
- Cox Christine
- Coyle Catherine
- Coyle Catherine
- Crawford Melanie
- Crawford Sister Denise
- Creelman Brianna
- Crellin Perric
- Crellin Perric
- Crook Juanita
- Cross Vanessa
- Cross William R.
- Crossley Lin
- Crowe (nee Hughes) Dawn
- Crowley Claire
- Crundwell M
- Cserbane Anita
- Cuffe Donna
- Cumming Kirsty
- Cunningham Amy
- Curtis Samantha
- Curtis Sandra
- Cusan Leonello
- Custins Laura
- Cyriac Abby
- Dabbs Marianne
- Dahar Nazeer
- Dahmane Rafika
- Dallas Nicola
- Dalton-Short Ross
- Dalton-Short Ross
- Daly Deirdre
- Danaswamy Patricia
- Danaswamy Patricia
- Daniel Amelia
- Danielson Brita
- Danjoux Cyril
- Darby Helen
- Darch Flora
- Daruwala Pallon
- Das Prantik
- Davda Reena
- Davey Alison
- Davey Elizabeth
- Davidson Cathy
- Davies Emily
- Davies Flor
- Davies Heather
- Davies Joe
- Davies Joseph
- Davies Julie-Ann
- Davies Kirstin
- Davies Llinos
- Davies Stacey
- Davies Sue
- Davies Tracey
- Davison Alison
- Davison Sue
- Dawe David
- Dawson Elizabeth
- Dawson Louise
- Dawson-Athey Linda
- Dayes Ian S
- De Silva-Minor Shiroma
- Dean Lynsey
- Dearnaley David
- Deenihan Emma
- Degendorfer Sarah
- Dekaj Fatjon
- Dell Gillian
- Dellar Conor
- Delouya Guila
- Dent Kathleen
- Desai Parth
- Desai Parth
- Desrosiers Isabelle
- Dewar Lorna
- Dharmaprasad Soney
- Dhinakaran Kathirvelu
- Di Maria Fabio
- Dias Heather
- Dickinson Peter
- Dickson Jeanette
- Dill Kendra
- DiLullo Elenor
- DiMarco Christine
- Din Omar
- Ding Ian
- Dion Helene
- Ditchfield Julie
- Dixit Sanjay
- Dixit Sanjay
- Dlodlo Jessica
- Dobson Tracey
- Dodds David
- Dodge Sister Jan
- Doherty A
- Donaghey Sally
- Donaldson David
- Donnison Michelle
- Douch Emma
- Doughty Victoria
- Dover Serena
- Downs Nichola
- Doyle Kerrie
- Drachenberg Darrel E
- Drakeley Susan
- Drew Ellen
- Drew Mary (Ellen)
- Driscoll Celine
- DSouza David
- Dubey Arbind
- Dubey Arbind
- Duckett Tracey
- Duclos Marie
- Duffy Annie
- Dufour Nathalie
- Dugas Stevie
- Duley Emma
- DuMontier Joelle
- Duncan (nee Keatley) Claire
- Duncan Graeme
- Duncan Ian
- Dunn Sharon
- Dunne Emma
- Durkan Garret
- Durrant Lisa
- Dymond Harvey
- E Choan
- Eady Robin
- Eapen Libni
- Ebacher Annie
- Eccleson Helen
- Edwards Abigail
- Edwards Albert
- Edwards Jackie
- Edwards Steve
- Edwards Steve
- Egan Lisa
- Eichenberger Lois
- El-Modir Ahmed
- El-Saghir Mohammed
- Eleftheriadis Symeon
- ElKerdawy Hala
- Ellard Rose
- Elliott Mark
- Elliott Tony
- Elliott Tony
- ElSokhn Nidale
- Elwell Christine
- Elwell Christine
- Elwell Sue
- Embleton Andrew
- Ennis Dawn
- Erskine Susan
- Escueta Vivette
- Eska Tiffani
- Etheridge Charlotte
- Evans Angela
- Evans Clary
- Evans Elizabeth
- Evans Marion
- Evans Melanie
- Evans Richard
- Eze Nancy
- Fair Kim
- Fairfax Claire
- Falconer Alison
- Fallah Fereshteh
- Fallaize Adrian
- Faria Sergio Luiz
- Farnworth Christine
- Farrar Michelle
- Farrell Helen
- Fawcitt Sara
- Fazekasne Fulep Adrienn
- Fearnley Mark
- Featherstone Wendy
- Fellows Kathryn
- Fennelly Ruth
- Ferguson Catherine
- Ferguson Catherine
- Fernandez Claire
- Ferreira Miguel
- Fiddes Kathleen
- Fielding Bethany
- Fielding Bethany
- Fildes Diane
- Finnegan Niall
- Firth Alexandra
- Firth Alexandra
- Firth Alexandra
- Firth Elizabeth
- Fish Matt
- Fish Nathan
- Flaherty Jan
- Flaherty Jan
- Flanagan Laura
- Flavin Aileen
- Fletcher Joanne
- Fletcher Julie
- Fletcher Mandy
- Flynn-Batham Marian
- Fode Kirsten
- Folkes Linda
- Follows Josh
- Foo Maxine
- Foot Jayne
- Forcat Silvia
- Forcat Silvia
- Ford Amanda
- Ford Amy
- Ford Chris
- Ford Daniel
- Ford Daniel
- Ford Nicky
- Ford Victoria
- Ford Victoria
- Forkes Janet
- Forkes Janet
- Forkes Janet
- Forman Susan
- Forrest Diane
- Forrest Diane
- Fortin Jacqueline
- Fosker Chris
- Fossey Gavin
- Foster Emma
- Foster William
- Fourt Monica
- Fox Shirley
- Foxwell Sue
- Francis Olesya
- Francis Peggy
- Francisco Cristina
- Frankland Helen
- Frankland Helen
- Franklin Alex
- Frattaroli Paul
- Frazzi Alexandra
- Frew John
- Frim Olivera
- Froese Jane
- Froude Nancy
- Funnell Sarah
- Gagne Vanessa
- Galante Joao
- Gallimore Elizabeth
- Galloway Lucy
- Galway Denise
- Gamble Tina
- Gamble Tina
- Gamez Raquel
- Ganabady Malavika
- Gao Annie
- Garcia Leni Santiago
- Gardiner Fiona
- Garner Victoria
- Garrett Gina
- Garrido-Perez Sandra
- Gauntlett Monica
- Gauthier Isabelle C
- Gearing Jennifer
- George Siny
- GeorgeChayka Danielle
- Geraghty Kerry
- Ghoul Mokhtar
- Gibbins Andrew
- Gibbins Jackie
- Gibbins Kate
- Gibbs Stephanie
- Gibson Sian
- Giddings Emma
- Gilbert Duncan
- Gilbert Duncan
- Gilbert Jeanette
- Gilby Lisa
- Gilchrist Gail
- Gill Lisa
- Gill Shafiq
- Gillatt David
- Gillatt David
- Gillesen Annelies
- Gillespie Sally
- Gillian Andrew
- Gilmartin Claire
- Gilmour Christina
- Ginnelly Helen
- Ginnelly Helen
- Giovannini Julia
- Gipson Anna
- Girolametto Carla
- Gladwell Louise
- Gladwish Adam
- Glaholm John
- Glaholm John
- Gleave Martin E
- Glen Hilary
- Glen Tracy
- Glick Daniel
- Goel Roshni
- Goh Chee
- Goh Chee L.
- Golden Sophie
- Goldenberg S Larry
- Goldstein Cindy
- Goldstein Cindy
- Goldsworthy Simon
- Gollapothu Srilakshmi
- Gomez JoseLuis
- Gomez-Marcos Raquel
- Gonzalez Celia
- Gooch Carol
- Goodhind Frances
- Goodsell Josie
- Goodsell Josie
- Goodwin Emma
- Gopaul Darindra
- Gordon Hussain
- Gore Alexandra
- Gospodarowicz Mary
- Goss Vanessa
- Gough Jessica
- Gould Aaron
- Goulden Kay
- Goulding James
- Goyena Ruby
- Grabey Jenna
- Graham Janet
- Graham Jeffrey
- Graham John
- Graham Susan
- Gramlich Colin
- Grant Anna
- Grant Cordelia
- Grant Judith
- Grant Susan
- Grant Warren
- Gratton Albert
- Grau Isabel
- Gray Emma
- Gray Emma
- Grayland Sarah
- Greedus Helen
- Green James
- Green Sara
- Green Sarah
- Green Sue
- Green Trish
- Greenland Jonathan
- Gregg Jane
- Gregorcic Emily
- Gregory Debbie
- Grieve Sylvia
- Griffen Ailsa
- Griffin Hannah
- Griffiths Dorothy
- Griffiths Leyshon
- Griffiths Theresa
- Griffiths Theresa
- Gruschy Lisa
- Guarino Robyn
- Gudelis Susan O
- Guerrero-Urbano Teresa
- Guerrero-Urbano Teresa
- Guerrero-Urbano Teresa
- Gujral Sandeep
- Gumapac Nicole
- Gunn Melanie
- Gupta Kamalnayan
- Gupta Nishi
- Gurzanski Christina
- Guy Peter
- Gwilt Julie
- Gwilt Julie
- Gwilt Julie
- Haddad Alain
- Hagan Chris
- Hague Dominic
- Haidar Imran
- Haidar Imran
- Haigh Steve
- Haldeos Anne
- Hale Jennifer
- Hall Jane
- Hall Julia
- Hall Julia
- Halperin Ross
- Hamid Abdel
- Hamill Maureen
- Hamilton Beatrice
- Hamilton Joanna
- Hamilton Ronald
- Hammonds John Christopher
- Hanna Emma
- Hannaford Zeta
- Happle Liz
- Hardie Maryon
- Harding Claudia
- Harding Joshua
- Hardman John
- Hardstaff Lisa
- Hare Jennifer A
- Hargreaves Carolyn
- Hargreaves Jeanette
- Hargreaves Jeanette
- Harinarayanan Sathish
- Harinarayanan Sathish
- Harland Keith
- Harney Jackie
- Harnwell Juliette
- Harpell Rhonda
- Harris (n. Marchant) Emily
- Harris Catherine
- Harris Sarah
- Harris-Burland Angie
- Harrison Alison
- Harrow Sister Kath
- Hart Amber
- Hart Andrew
- Harter Leah
- Hartley Jasmine
- Hartman Carrie
- Hartt Nancy
- Hartwell Lyn
- Harvey Julie
- Harvey Sally
- Harving Niels
- Haskell Annelise
- Hassall Alison
- Hassan Nebah
- Hassan Nebah
- Hathout Lara
- Hatimy Umi
- Haydock Helen
- Haydock Helen
- Hayes Jill A
- Hayward Lesley
- Healey Gail
- Healey-Mariano Jennifer
- Healey-Mariano Jennifer
- Heasley Karen
- Heath Catherine
- Heckford Louise
- Hedges Andy
- Heeley Janine
- Hefferon Billy
- Hegarty Gemma
- Hejlesen Finn
- Helou Joelle
- Hendel Debra
- Henry Ann
- Henry Ann
- Henry Ann
- Henry Ann
- Henry Joanne
- Henry Joanne
- Henson (nee Savidge) Verity
- Henson Helen
- Herasimtschuk Anna
- Herbert Chris
- Herbert Gaynor
- Heron Jane
- Hetherington Stacey
- Hicks Kimberly
- Higgins Linda
- Hijab Adham
- Hill Elaine
- Hill Judy
- Hill Pipa
- Hill Pippa
- Hillman Paul
- Hillman Paul
- Hilman Serena
- Hilman Serena
- Hindle Margaret
- Hines John
- Hoare Kathryn
- Hocking Christopher
- Hodder June
- Hodge Simon
- Hodges Samantha
- Hodgkinson Sheila
- Hodson Hayley
- Hodson Hayley
- Hogan Holly
- Hogan Vesna
- Hogbin Emma
- Hogbin Emma
- Holbrook Andy
- Holbrook Becky
- Holden Simon
- Holdsworth Amanda
- Hollenhorst Helmut
- Holliday Samantha
- Hollingdale Abigail
- Hollis Keri
- Hollister Robert
- Holloway Caroline
- Holmes Evelyn
- Holwerda Eleanor
- Homer David
- Hood Marion
- Hooper Simon
- Hooton Georgia
- Hore Brendan
- Horne Rhian
- Hornzee Gillian
- Hornzee Gillian
- Horton Sarah
- Horwich Alan
- Hoskin Peter
- Hoskin Peter
- Hoskins Ashley
- Hoskins Chloe
- Hotine Jodie
- Hough Adele
- Hough Chris
- Houghton Fionnuala
- Houle Stefanie
- House Gail
- Howard Joanna
- Howard Lucy
- Howard Lucy
- Howitt Pamela
- Hsien John
- Hubley Lynn
- Huddart Robert
- Huddart Robert
- Hudson Zoe
- Hughes Claire
- Hughes Faye
- Hughes Hayley
- Hughes Joanne
- Hughes Kathryn
- Hughes Owen
- Hughes Robert
- Hughes Simon
- Hughes-Davies Luke
- Hugill Angela
- Hugill Angela
- Humber Caroline
- Humpreys Louise
- Hunt Allison
- Hunter Catherine
- Hunter William
- Hunting Liz
- Hutchinson Camille
- Hyde Katherine
- Hyde Katherine
- Hyde Katherine
- Hynds Sharon
- Ibrahim Azman
- Ingham Jo
- Ingle Charlotte
- Inman Hayley
- Innes Helen
- Iordanidi Elina
- Iqbal Fawaad
- Irwin P
- Isaew Andrea
- Iskender Amanda
- Islam Zaheer
- Issa Rami
- Ivie Stephanie
- Jackman Dee
- Jackson Cathy
- Jackson Kim
- Jackson Sister Ann
- Jain Suneil
- Jakeman Christine
- James Naomi
- James Nicholas
- Jamieson Ceri
- Jampana Raj
- Janke Susan
- Jannapureddy Revanth
- Jarvis Claire
- Jastrzebska Patrycja
- Javle P
- Jayachandran Resmi
- Jayachandran Resmi
- Jeffcutt Nicole
- Jeffrey David
- Jelski Joseph
- Jenkins Peter
- Jenkins Suzanne
- Jenner Abigail
- Jennings Marian
- Jepson Debbie
- Jevons Cody
- Jewers Karen
- Jewers Karen
- Jeyasanger Ganesan
- Joe Howard
- John Babbin
- Johns Louise
- Johnson Arlissa
- Johnson Craig
- Johnson Joanne
- Johnson Lyndsey
- Johnson Nigel
- Johnson-Rollings Ashley
- Johnston Laurel
- Johnston Ruth
- Johnstone Dawn
- Johnstone Maria
- Joncas MarieClaude
- Jones (Birch) Janine
- Jones Andrea
- Jones Ania
- Jones Carys
- Jones Cathryn
- Jones Clare
- Jones Dawn
- Jones Gareth
- Jones Ifan
- Jones Jules
- Jones Julia
- Jones Kathryn
- Jones Katie
- Jones Lesley
- Jones Lewis
- Jones Richard
- Jones Rob
- Jones Stephanie
- Jones Stephanie
- Jones-Skipper Kay
- Jonnada Sai
- Jope Carmel
- Jose Sanal
- Joseph Joji
- Joseph Paul K
- Joshi Manisha
- Joshi Manisha
- Joslin Vicky
- Jovic Gordana
- Kaa Bach Birgit
- Kader Nicole
- Kalejaiye Odunayo
- Kaliski Alexandre
- Kalyvas Maria
- Kamran Asim
- Kanaga-Sundaram Subramanian
- Kancherla Kiran
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- Pickles Thomas A
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- Roca Mila
- Rodda Sree
- Rodda Sree
- Rodda Sree
- Rodrigues George B
- Rodwell Sue
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- Russell Emily
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- RĂžnnengart Eva
- Saad Fred
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- Sargent Sister Tracey
- Sathya Jinka R
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- Sayers Ian
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- Shantz Brenda S
- Sharif Shahid
- Sharma Atul
- Sharma Rajesh
- Sharman Emma
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- Stacey Wendy
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- Stuart Robert
- Subramaniam Ramachandran
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- Sydes Matthew R.
- Sylvestre Alma
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- Tapping Sister Hayley
- Tapping Sister Hayley
- Tarver Kathryn L.
- Tasker Lorraine
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- Taussky Daniel
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- Teahan Seamus
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- Thoi Anne-Maree
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- Thomas Carys
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- Thomas Rachel
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- Thomas Sister Viv
- Thomasson Georgia
- Thominson Bronwen
- Thompson Catherine
- Thompson Catherine
- Thompson Chloe-Anne
- Thompson Emma
- Thompson Jane
- Thoms John
- Thomson Alastair H
- Thomson Sister Jane
- Thornton Lorraine
- Thorogood Lucy
- Tickle Vivienne
- Tickle Vivienne
- Tiessen Kyoko
- Tighe (nee Bussey) Rachel
- Tighe Helen
- Tighe Mary
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- Toussi H
- Townley Barbara
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- Towse Jo
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- Tran Anna
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- Tree Alison C.
- Treeby Jo
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- Tseng Eric Chia Lin
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- Zafar Waheed
- Zaidi Sadaf
- Zarkar Anjali
- Zarkar Anjali
- Zarkar Anjali M.
- Zaza Khaled O
- Zelley Sarah
- Zeltser Fred
- Zhang Hanbo
- Zhang Tina Wanting
- Zietz Maria
- Zilkha Helene
- Zinck Connie
- Zinyemba Vivian
- Zurakovsky Hilary
- Zwarych Darlene
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/06/2024
- Field of study
Background
Previous evidence indicates that adjuvant, short-course androgen deprivation therapy (ADT) improves metastasis-free survival when given with primary radiotherapy for intermediate-risk and high-risk localised prostate cancer. However, the value of ADT with postoperative radiotherapy after radical prostatectomy is unclear.
Methods
RADICALS-HD was an international randomised controlled trial to test the efficacy of ADT used in combination with postoperative radiotherapy for prostate cancer. Key eligibility criteria were indication for radiotherapy after radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to radiotherapy alone (no ADT) or radiotherapy with 6 months of ADT (short-course ADT), using monthly subcutaneous gonadotropin-releasing hormone analogue injections, daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as distant metastasis arising from prostate cancer or death from any cause. Standard survival analysis methods were used, accounting for randomisation stratification factors. The trial had 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 80% to 86% (hazard ratio [HR] 0·67). Analyses followed the intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and ClinicalTrials.gov, NCT00541047.
Findings
Between Nov 22, 2007, and June 29, 2015, 1480 patients (median age 66 years [IQR 61â69]) were randomly assigned to receive no ADT (n=737) or short-course ADT (n=743) in addition to postoperative radiotherapy at 121 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 9·0 years (IQR 7·1â10·1), metastasis-free survival events were reported for 268 participants (142 in the no ADT group and 126 in the short-course ADT group; HR 0·886 [95% CI 0·688â1·140], p=0·35). 10-year metastasis-free survival was 79·2% (95% CI 75·4â82·5) in the no ADT group and 80·4% (76·6â83·6) in the short-course ADT group. Toxicity of grade 3 or higher was reported for 121 (17%) of 737 participants in the no ADT group and 100 (14%) of 743 in the short-course ADT group (p=0·15), with no treatment-related deaths.
Interpretation
Metastatic disease is uncommon following postoperative bed radiotherapy after radical prostatectomy. Adding 6 months of ADT to this radiotherapy did not improve metastasis-free survival compared with no ADT. These findings do not support the use of short-course ADT with postoperative radiotherapy in this patient population
Duration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial
- Author
- Abab Julie
- Abbas Ali
- Abbassi Sara
- Abd Alazeez Mohamed
- Abdulwahid Danya
- Abdulwahid Danya
- Abed Jessy
- Adab Fawzi
- Adams Marion
- Adamson Vanessa
- Addison Anglise
- Adeyoju Adebanji
- Adinkra Victoria
- Adnaan Jamila
- Afzal Naveed
- Agdiran Didem
- Aggarwal Ajay
- Ahamadali Sheefa
- Ahmad Belal
- Ahmed Ilyas
- Ahmed Imtiaz
- Ahmed Shahida
- Aiku Abimbola
- Ainsworth Sarah
- Ainsworth Sarah
- Aitken Katherine
- Ajzensztejn Daniel
- Akhtar Naeem
- Al-Chamali Hiba
- Al-hasso Abdulla
- Al-hasso Abdulla
- Al-Samarraie Amir
- Albrecht Virginia
- Alcock Christopher
- Alder Leanne
- Alderton Kate
- Aldous Mary
- Ali Jennyfa
- Ali Maryam
- Ali Zulfiqer
- Ali Zulfiqer
- Allan Elaine
- Allan Elaine
- Allen Julie
- Allen Kirsten
- Allen Rachael
- Allen Susan
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- Allison Michele
- Alonzi Roberto
- AlRashdan Abdulla
- Alzouebi Mymoona
- Amanie John Oliver
- Ammeter Barb
- Amoaten Thomas
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- Anderson Beverley
- Anderson Chris
- Anderson Jim
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- Sinclair Glenda
- Sinclair Julie-Ann
- Sinfield Melanie
- Singh Harpreet
- Singizi Bryan
- Singson Angelina
- Siu Bernard
- Sivananthan Gokulan
- Sivananthan Gokulan
- Sivoglo Virgil
- Sizer Bruce
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- Skene Anna
- Skewes Johanna
- Skwarski Michael
- Slack Jonathan
- Slessor Janet
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- Sloan Andrew
- Smale Daisy May
- Smallwood Sarah
- Smedley (nee McCabe) Janine
- Smedley (nee McCabe) Janine
- Smedley (nee McCabe) Janine
- Smith Beccy
- Smith Carlie
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- Smith Dan
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- Smith Lucy
- Smith Lucy
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- Smith Susan
- Smith Suzanne
- So Alan I
- Sohanpal Sundip
- Sohanpal Sundip
- Somasiri Ashane
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- Southgate Elizabeth
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- Sparrow Geoffrey
- Spearman Mary
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- Sreenivasan Thiagarajan
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- Srihari Narayanan
- Srinivasan Rajaguru
- Srinivasan Rajaguru
- Srinivasan Vaiku
- Stacey Wendy
- Stafferton Ruth
- Staffurth John
- Staines Nikki
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- Stancliffe May
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- Stapleton Stephanie
- Starling Ellen
- Steele Anita
- Steffensen Kirsten
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- Stevens Nicole
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- Stevenson Robert
- Steventon Emily
- Stewart David
- Stewart Simon
- Stewart Simon
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- Stockdale Andrew
- Stockdale Andrew
- Stockley Emma
- Stockport Jane
- Stoddart Jonathan
- Stone Helena
- Stone Matthew
- Stone Sarah
- Storer Julie
- Storrs Sarah
- Stott Mark
- Stott Matthew
- Stower Michael
- Stranex Stephen
- Stretch Alison
- Strider Paula
- Stringer (pr. Davis) Sally
- Strong-Sheldrake Sophia
- Stuart Robert
- Subramaniam Ramachandran
- Sullivan Frank
- Sumner Lesley
- Sundar Santhanam
- Sundar Santhanam
- Sundaram Subramanian Kanaga
- Sunny Manju
- Sutherland Donna
- Swann Michelle
- Sydes Matthew
- Sydes Matthew R
- Sylvestre Alma
- Symon Lesley
- Syndikus Isabel
- Szolin-Jones Jacob
- Szumacher Ewa
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- Tahir Saad
- Tait Ellen
- Tan Matthew
- Tappenden Nancy
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- Tapping Sister Hayley
- Tasker Lorraine
- Tate Janine
- Taussky Daniel
- Tay Jessica
- Taylor Becky
- Taylor Beverley
- Taylor Carol
- Taylor Helen
- Taylor Henry
- Taylor Jacob
- Taylor Jacob
- Taylor Jennifer
- Taylor Jill
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- Taylor Kate
- Taylor Katy
- Taylor Katy
- Taylor Lisa
- Taylor Sister Melanie
- Teahan Seamus
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- Tedd Gemma
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- Teh Chiaw Woon
- Teh Jonathan
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- Templeton Maureen
- tenHaaf Darlene
- Tennant Virginia
- Teo Mark
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- Thallury Sheeba
- Tharahan Nanthini
- Thevarajah Vaishaali
- Thibeault Andreanne
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- Thind Manreet
- Thoi Anne-Maree
- Thoi Anne-Maree
- Thoi Anne-Maree
- Thomas Carys
- Thomas Carys
- Thomas Dianne
- Thomas Heather
- Thomas Helen
- Thomas Isobel
- Thomas Jacqueline
- Thomas Rachel
- Thomas Robert
- Thomas Sister Viv
- Thomasson Georgia
- Thominson Bronwen
- Thompson Catherine
- Thompson Catherine
- Thompson Chloe-Anne
- Thompson Emma
- Thompson Jane
- Thoms John
- Thomson Alastair H
- Thomson Sister Jane
- Thornton Lorraine
- Thorogood Lucy
- Tickle Vivienne
- Tickle Vivienne
- Tiessen Kyoko
- Tighe (nee Bussey) Rachel
- Tighe Helen
- Tighe Mary
- Tikoo Archana
- Timmings Katie
- Tindall Annie
- Tippins Anna
- Tipples Karen
- Todd Anne
- Todd Joanna
- Tolan Shaun
- Toledo Jesusa
- Tomlinson Annabel
- Tomlinson Eve
- Toms Julie
- Topalovich Aleksandra
- Topps Alice
- Torin Lehmann Anna
- Torres Cynthia
- Totten Grace
- Toussi H
- Townley Barbara
- Townley Luke
- Townsend-Thorn Debra
- Towse Jo
- Toy Elizabeth
- Trakalo Kathy
- Tran Anna
- Tran Anna
- Tranter Fiona
- Tranter Helen
- Tranter Helen
- Treasure Ann
- Tree Alison
- Tree Alison
- Treeby Jo
- Treherne Katy
- Tremlett Jean
- Trewsmith Neil
- Tribe Lisa
- Trigg-Hogarth Kate
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- Trudel Diane
- Tsakirdis Thedoros
- Tsalic Medy
- Tsang David
- Tsang Lilian
- Tsawayo Tan
- Tse Karen
- Tseng Eric Chia Lin
- Tsuji Debbie
- Tuazon Juel
- Tuck Jonathan
- Tufail Aisha
- Turley Claudia
- Turley Claudia
- Turner Christy
- Turner Nikki
- Turner Sarah
- Turriff Lisa
- Tweedle James
- Tyldesley Scott
- Tyler Jayne
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- Uherek Maja
- Upson Susan
- Urquhart Zoe
- Uscinska Barbara
- Usmani Nawaid
- Vallieres Isabelle
- Vamplew Luke
- Van As Nicholas
- Van der Voet Hans
- Van Someren Chloe
- Van-Koutrik Lynne
- Vandal Mohammad Tanvir
- Vandborg Maria
- Vandecandalaere Elaine
- Varley Gail
- Varro Robert
- Varughese Mohini
- Varughese Mohini
- Vasanthan Subramanian
- Vaughn Jamie
- Vavassis Peter
- Velec Erin
- Vengalil Salil
- Venkatesan Varagur M
- Venkitaraman Ramachandran
- Venkitaraman Ramachandran
- Vermette Tracy
- Vesprini Danny
- Vickery Kathryn
- Vigneault Eric
- Vijayakumar Vijitha
- Vilarino-Varela Maria
- Vincent Francois
- Vincent LindaSuzanne
- Vinod Cellins
- Virgo Azarel
- Vowell Emma
- Vu Thi
- Wade Lynne
- Wade Rob
- Wadsworth Oliver
- Wakefield Shauna
- Wakelen Paula
- Waldron Eleanor
- Walker Beth
- Walker Caroline
- Walker Georgina
- Walker Georgina
- Walker Heather
- Walker Jayashree
- Walker Julia
- Walker Karen
- Walker Lori
- Walker Suzanne
- Wall Elaine
- Wallace Jan
- Wallace Kris
- Wallbutton Rebecca
- Walmsley Catherine
- Walsh Donna
- Walton Jenny
- Walton Sharon
- Ward Angela
- Ward Colin
- Warde Padraig
- Waring Lynsey
- Waring Lynsey
- Wassall Rebecca
- Watkinson Catrin
- Watson Melanie R
- Watson Michaella
- Watson-Jones Phillip
- Watts Angela
- Watts Erica
- Weaver Andrew
- Weaver Emma
- Webb Andrew
- Webb Claire
- Webb Kerrie
- Webb Paula
- Websdale Cheryl
- Webster Christine
- Wei Joyce
- Weir JoAnn
- Wellman Sandie
- Wells Paula
- Wells Paula
- Wells Paula
- Wells Tom
- Welsh Liam
- Welsh Linda
- Westley Rosalyne
- Weston Alison
- Weston Philip
- Westrop Anna
- Westrop Anna
- Westrop Anna
- Wheatley Duncan
- Wheeler Lucie
- Wheelwright Roger
- Whelan Kate
- Whillis David
- Whinn Samantha
- Whitcher Alison
- White Ann
- White Holly
- White Joanna
- Whitehouse James
- Whitehouse James
- Whiteway Chrystal
- Whittle Stacy
- Whotton Nikita
- Wiggins Sarah
- Wightman John
- Wignall Suzy
- Wild Karen
- Wilke Derek
- Wilkie Karen
- Wilkins Marie
- Wilkinson Nicola
- Williams (NĂ©e Allen) Sister Tania
- Williams Amanda
- Williams Bethan
- Williams Candra
- Williams Jo
- Williams Joanne
- Williams Rachel
- Williams Rachel
- Williams-Yesson Barbara
- Williamson Elizabeth
- Williamson Nicola
- Willing Stephanie
- Wilson David
- Wilson Jim
- Wilson Jo
- Wilson Mark
- Wilson Paula
- Wilson Paula
- Wilson Russ
- Winn Carol
- Winter Sister Helen
- Wise Marcus
- Wise Marcus
- Wise Marcus
- Wiss Elliott
- Wollaston Julie
- Woloshyn Rose
- Wong Jason W T
- Wood Allison
- Wood Catherine
- Wood Cathryn
- Wood Marian
- Wood Pauline
- Wood Pauline
- Wood Sister Kim
- Wood Sister Kim
- Wood Sister Kim
- Woodhouse Iain
- Woods Catherine
- Woods Jane
- Woods Martin
- Woodward Cathryn
- Woodward Elizabeth
- Woolf David
- Woolf David
- Workman Bridget
- Worlding Jane
- Worlding Jane
- Worsley Lucy
- Worthington Hannah
- Wright Ann
- Wright Natalie
- Wright Seonaid
- Wrigley Martha
- Wronski Sue
- Wu Helen
- Wu Min
- Wyatt Clare
- Wylie James
- Wylie James
- Wylie James
- Wynn Hazel
- Wynn Hazel
- Yanchuk Janet
- Yarrow Sue
- Yassa Michael
- yates Victoria
- Yee Don
- Yeo Tanya
- Yoon Frederick
- Youd Sister Jill
- Young Anita
- Young Bobbie
- Young Douglas
- Young Sally
- Youngs Nora
- Yu Jason
- Yunace Lorrie
- Yusof Hilawati
- Zafar Waheed
- Zaidi Sadaf
- Zarkar Anjali
- Zarkar Anjali
- Zaza Khaled O
- Zelley Sarah
- Zeltser Fred
- Zhang Hanbo
- Zhang Tina Wanting
- Zietz Maria
- Zilkha Helene
- Zinck Connie
- Zinyemba Vivian
- Zurakovsky Hilary
- Zwarych Darlene
- Publication venue
- Elsevier
- Publication date
- 07/06/2024
- Field of study
Background
Previous evidence supports androgen deprivation therapy (ADT) with primary radiotherapy as initial treatment for intermediate-risk and high-risk localised prostate cancer. However, the use and optimal duration of ADT with postoperative radiotherapy after radical prostatectomy remains uncertain.
Methods
RADICALS-HD was a randomised controlled trial of ADT duration within the RADICALS protocol. Here, we report on the comparison of short-course versus long-course ADT. Key eligibility criteria were indication for radiotherapy after previous radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to add 6 months of ADT (short-course ADT) or 24 months of ADT (long-course ADT) to radiotherapy, using subcutaneous gonadotrophin-releasing hormone analogue (monthly in the short-course ADT group and 3-monthly in the long-course ADT group), daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as metastasis arising from prostate cancer or death from any cause. The comparison had more than 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 75% to 81% (hazard ratio [HR] 0·72). Standard time-to-event analyses were used. Analyses followed intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and
ClinicalTrials.gov
,
NCT00541047
.
Findings
Between Jan 30, 2008, and July 7, 2015, 1523 patients (median age 65 years, IQR 60â69) were randomly assigned to receive short-course ADT (n=761) or long-course ADT (n=762) in addition to postoperative radiotherapy at 138 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 8·9 years (7·0â10·0), 313 metastasis-free survival events were reported overall (174 in the short-course ADT group and 139 in the long-course ADT group; HR 0·773 [95% CI 0·612â0·975]; p=0·029). 10-year metastasis-free survival was 71·9% (95% CI 67·6â75·7) in the short-course ADT group and 78·1% (74·2â81·5) in the long-course ADT group. Toxicity of grade 3 or higher was reported for 105 (14%) of 753 participants in the short-course ADT group and 142 (19%) of 757 participants in the long-course ADT group (p=0·025), with no treatment-related deaths.
Interpretation
Compared with adding 6 months of ADT, adding 24 months of ADT improved metastasis-free survival in people receiving postoperative radiotherapy. For individuals who can accept the additional duration of adverse effects, long-course ADT should be offered with postoperative radiotherapy.
Funding
Cancer Research UK, UK Research and Innovation (formerly Medical Research Council), and Canadian Cancer Society
Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial.
- Author
- AarĂže Jens
- Abbass Hakam
- Abella-Ovalle Luis
- Adam Zul
- Agyemang Michael
- Ahlehof Ole
- Ahlehoff Ole
- Ahmad Yousif
- Al-Lamee Rasha
- Alberdi LucĂa
- Aleti Shilpa
- Ali Danish
- Allen Kezia
- Alvares Wilson
- Alzuhairi Karam
- Amed Nadifa
- Anantharam Brijesh
- Andersen Grethe
- Andersen Henning Rud
- Anderson Michelle
- Andiapen Mervyn
- Andrews Michelle
- Ankersen Jens Peter
- Ansell Valerie
- Arango Amalia
- Armstrong Elissa
- Astarci Josenir
- Atkinson Emma
- Austin Rosalynn
- Avanzas Pablo
- Aziz Ahmed
- Azkhalil Mohammed
- Bales Emily
- Banerjee Prithwish
- Barclay Justin
- Barker Deborah
- Barker Joann
- Barmby David
- Bates Rachel
- Baucutt Karen
- Been Martin
- Beirnes Charmaine
- Bell Sheila
- Bennett Amy
- Bennett Lorraine
- Bernardo-Alba Pablo
- Berry Alan
- Berry Colin
- Besana Rissa
- Bhatre Gurbir
- Bhatti Rishma
- Bidle Amanda
- Bijsterveld Petra
- Bose Tuhina
- Boyle Georgina
- Brady Rebecca
- Braybrook Christine
- Breeze Jonathan
- Brennan Oliver
- Brett Sarah
- Brogan Richard
- Brown Janette
- Bucciarelli-Ducci Chiara
- Buchanan Louise
- Buelga-DĂaz Covadonga
- Bueno Hector
- Bulluck Heerajnarain
- Burd Amanda
- Burnett Gillian
- Burtonwood Natalie
- Burunsuzoglu Senem
- Butler Robert
- Butler Robert
- Byrne Jean
- BĂžtker Hans Erik
- Capel Robert
- Cappelen Helle
- Carruthers Gayle
- Carstensen Steen
- Castro Rafael
- Champney Felicity
- Chant Nicholas
- Charles Thabitha
- Chester Emma
- Chong Jun
- Christensen Erika Frischknecht
- Christiansen Evald HĂžj
- Christiansen Martin Kirk
- Christmas Natasha
- Chu Rebecca
- Chung Alan
- Cimas Teodorna
- Clapp Brian
- Clare Thomas
- Clarke Millie
- Clayton Tim
- Clifford Piers
- Cockayne Laura
- Colicchia Martina
- Collier Lucy
- Cooper Theresa
- Copas Andrew
- Copestick Jane
- Corps Ellie
- Corrigan Julie
- Cottam Victoria
- Cotton James
- Coward Paul
- Cox Emily
- Crause Jacolene
- Cruden Nick
- Cunliffe Denise
- Cunnington Michael
- Cuxton Josephine
- Dana Ali
- Dana Ali
- Darby Damaris
- Davies John
- Davies Justin
- Davies Nina
- de Cima Sara
- de la Hera Galarza Jesus Maria
- de la Roz Manuel
- De Mance Gianluigi
- De Sousa Phillipa
- Deen Zakhira
- del Valle Raquel
- Delaney Jane
- Denman Joanne
- Dias Priyanthi
- Dillon Angela
- Dimond Kirsty
- Din J.
- Dockerty Francesca
- Dodd Matthew
- Douglas James
- Douthwaite Rebecca
- Drew Martin
- DĂaz-GonzĂĄlez Eloy
- East Clare
- Eaton Michelle
- Ellert Julia
- Elliott Rebecca
- Ellis Howard
- Elshiekh Dr Mohamed
- Elston Ruth
- Emery Lisa
- Engstrom Thomas
- Erntgaard Dennis
- Evans Richard
- Fahrai Gregor
- Farag Mohamed
- Fath-Orboubadi DR Fazin
- Fati Pene
- Fayed Hossam
- Fente Ana I.
- Fernandez Olga
- FernĂĄndez Elena
- FernĂĄndez-Carral Marcos FernĂĄndez-Carral
- FernĂĄndez-Gonzalo David
- FernĂĄndez-Mallo Francisco J.
- Finch Amanda
- Fleming Catherine
- Fofie Joyce
- Foundun Aboo
- Francis Rohin
- Francis Rohin
- Frank Emma
- Freeman Philip
- Freestone Beth
- Fuentes MarĂa D.
- Gale Joanne
- Gale Joanne
- Gallagher Ian
- GalvĂĄn-NĂșñez Pablo
- Gamma Reto
- Garcia-Ruiz José Manuel
- GarcĂa-Alonso MarĂa
- GarcĂa-Castro Alfonso
- Gaughran Lisa
- Germon Rachel
- Gibson Kirsty
- Giebner Matthias
- Gill Abby
- Gill Simrat
- Giuffrida Gaia
- Given Rachel
- Glen James
- Goitia-MartĂn Javier
- Gomes Sara
- Gorog Diana
- Gorog Diana A
- Gowing Anne
- Gracey Jay
- Grech Ever
- Greenwood John
- Greenwood John P
- Gregory Sally
- Gregson Lisa
- Griffiths Huw
- Grosser Konrad
- Gue Ying
- Guinea RocĂo
- Gunn Julian
- Guyatt Samantha
- Hall Charlotte
- Hall Ian
- Hall Lorna
- Hamid Mahmood
- Hansen Henrik Steen
- Hansen Knud NÞrregÄrd
- Hansen Poul Anders
- Hansen Troels Martin Hansen
- Harfield Scott
- Harkins Ruth
- Harland Charlotte
- Hartley Amy
- Hausenloy Derek J
- Haworth Peter
- Hayes Michelle
- Hedegaard Kim Witting
- Hedrera Segundo A.
- Helqvist Steffen
- Henderson Rob
- Hendry Cara
- Heppell Richard
- Hermosa Francisco J.
- HernĂĄndez Ernesto
- Hetherington Daniel
- Hetherington Simon
- Hildick-Smith David
- Hindle Julia
- Hjort Jakob
- Hoare Amy
- Hobson Alex
- Hodgson Adrian
- Hodierne Jeremy
- Hogrefe Kai
- Holloway Rachael
- Holmvang Lene
- Hoole Stephen
- Hopper Oliver
- Horler Stephanie
- Horner Victoria
- Horwood Carol
- Houghton Richard F
- Housley Kay
- Howe Serena
- Hudson Karen
- Hussein Jodie
- Hyndman Samantha
- Ibanez Borja
- Iglesias-Llaca Fernando
- Ilsley Mary
- Ingoldby Fiona
- Iqbal , Javid
- Iversen Allan
- Jack Pearse
- Jackson-Lawrence Karen
- Jakobsen Lars
- Jamal Zahra
- Jamieson-Leadbitter Caroline
- Jennison Alan
- Jensen Lisette Okkels
- Jensen Svend Eggert
- Johnstone Donna
- Jones Leslie
- Jones Sophie
- Joshi Francis
- Joyce Joan
- Junker Anders
- JĂžrgensen Erik
- Kaeng Lee
- Kaltoft Anne
- Kanji Rahim
- Kaur Ramandeep
- Kaur-Babooa Priya
- Kaus Henning
- Keate Kirstie
- KelbĂŠk Henning
- Kelly Julie
- Kelsall Nicci
- Kempel John
- Kennard Sarah
- Khan Arif
- Kharbanda Rajesh
- Kharbanda Rajesh K
- Khawaja Muhammed Zeeshan
- Knight Rosemary
- Knighton Abigail
- Kobson Barbara
- Kodoth Vivek
- Kolakaluri Laurel
- Koothoor Raiji
- Korsgaard Mette Tidemand
- Kotecha Tushar
- Krishnamoorthy Suresh
- Krishnamurthy Arvindra
- Kristensen Steen Dalby
- Laca Sonia I.
- Lakeman Nicki
- Langrish Jeremy
- Lasica Ratko
- Lassen Jens Flensted
- Laurence Julia
- Lazar Nicoleta
- Leathers Chris
- Lee Dr Kaeng
- Lee Kelvin
- Lee Sandra
- Lenzi Valentina
- Leonard Gerry
- Lippert Freddy K
- Llorente-Ălvarez Susana
- Lloyd Steph
- Loder Chris
- Longbottom Colin
- Longman Kristel
- Lozano Iñigo
- Lucking Andrew
- Ludman Andrew
- LĂžnborg Jacob T
- Maart Clint
- Mackenzie Ailie
- Mackie Sarah
- Madsen Morten
- Maeng Michael
- Malik Iqbal
- Marber Michael
- Mark Bettina LĂžjmand
- Markham-Jones Helene
- Martin Katherine
- Martinez-GonzĂĄlez Eugenio
- Martins Joe
- MartĂnez-Bastida GinĂ©s
- MartĂnez-FernĂĄndez CĂ©sar M.
- MartĂnez-PĂ©rez PolĂĄcido J.
- MartĂnez-Valle Marta
- Massey Ian
- Mathur Anthony
- Matic Dragan
- Mcarthy Rachel
- McCormick Louise
- McFarlane-Henry Eleanor
- McGregor Andrew
- McLeod Jane
- McSkeane Anna
- Meade Tom
- Meadows Deborah
- Medina-CameĂĄn Ana B.
- Mehmedbegovic Zlatko
- Merrick Angela
- Metherell Stella
- Middle Janet
- Milasinovic Dejan
- Milgate Sarah
- Mohiddin Saidi
- Mojela Idah
- Moon Angela
- Moore Donna
- Moore Roger
- More Ranjit
- More Ranjit
- Moreby Berni
- Moreira Silvia
- Morgan Maureen
- Morris Steve
- MorĂs CĂ©sar
- Mota Paula
- Mudd Alexandra
- Munir Shahzad
- Muriel-Velasco Ana
- Musa Anntoniette
- Musselwhite Janine
- MĂžller Ulla Kristine
- Nair Sunil
- Naves MarĂa C.
- Neal Debbie
- Nelthorpe Faye
- Neubauer Stephen
- Newman Hannah
- Nicholas Jennifer M
- Nicholson Anne
- Nicholson Susan
- Nonide Marta
- Norfolk Derek
- O'Connor John
- O'Donnell Joshua
- O'Kane Peter
- O'Neill James
- Oakes Trevor
- Ocampo Madelaine
- Odedra Toral
- Oliveira Joana
- Oliver Victoria
- Oommen Anu
- Orr Sarah
- Paddy Loveth
- PadrĂłn Remigio
- Panicker Abeesh Sadasiva
- Parsons Georgina
- Pascual Isaac
- Pascual Susana
- Patale Sheetal
- Pavlidis Antonis
- Pedersen Danny Mejsner
- Pedersen Frants
- Pedersen Karin MĂžller
- Pedersen Knud Erik
- Pedley Lauren
- Pejic Marijana
- PelĂĄez MarĂa C.
- Pemberton Chris
- Pengelley Clare
- Penney Lucy
- Pepper Stacey
- Perara Divaka
- Perkins Alexander
- Phillips Hannah
- Phuyal Urmila
- Pine Amy
- Pitcher Louise
- Pitt Mike
- Polokova Karin
- Polwarth Gary
- Pomar-Amillo Ăngeles
- Pozo-LĂłpez MĂłnica
- Prendergast Bernard
- prentice Scott
- Preston Stephen
- Prodanovic Maja
- Prossora Mary
- Pulikal George
- Quintana Rosa B.
- Radford Elizabeth
- Radosavljevic-Radovanovic Mina
- Radovanovic Nebojsa
- Rai Amrit
- Raju Prashanth
- Rakhit Roby
- Rakhit Roby D
- Ramlall Manish
- Ramos Angelo
- Ratcliffe Amanda
- Raungaard Bent
- Ravkilde Jan
- Redington Andrew
- Redman Emily
- Redwood Simon
- Redwood Simon
- Reed Helen
- Reeve Christy
- Relph Chris
- Richardson James
- Riches Joanne
- Riddervold Ingunn Skogstad
- Riedel Ella
- Roberts Josh
- Robertson Steven
- Rodil-DĂaz Juan A.
- RondĂĄn Juan
- Ross David
- Roy Liby
- Roza CĂ©sar L.
- Rozado José
- Ryan Tony
- Ryding Alisdair
- Ryding Alisdair D
- Saclot Louie
- Samaniego Beatriz
- Sanchez-Vidal Ruth
- Sandhu Kully
- Sarti Charlotte
- SaunamÀki Kari
- Saunders Heidi
- Savic Lidija
- Schmidt Michael R
- Schumacher Natasha
- Scott Kerry
- Sebastian Deepa
- Sebastian Deepti
- Segovia Eduardo
- Sevillano Annaliza
- Shaw Caroline
- Shelton Rhidian
- Shepherd Lucy
- Sherwood Martin
- Sidgwick Sian
- Simpson Holly
- Skipper Nicola
- Skov Charlotte Schmidt
- Smallwood Andrew
- Smee Joanna
- Smit Angelique
- Smith Bethany
- Smith Clare
- Smith Ian
- Smith Jan
- Smith Megan
- Smith Trevor
- Snow Tom
- Solieri Ashley
- Somers Kathryn
- Spence Sharon
- Spickett Helen
- Spinthakis Nicholas
- Stables Rod
- Staines Jocasta
- Stankovic Goran
- Stimson Leah
- Storey Robert F.
- Strike Philip
- Subotic Ida
- Suttling Anne
- SuĂĄrez Alfonso
- SuĂĄrez-Coto Raquel
- SuĂĄrez-Noriega Raquel
- SĂžrensen Henrik Toft
- SĂžrensen Rikke
- Tapp Luke
- Tawiah Cecilia
- Taylor Rebecca
- Terkelsen Christian Juhl
- Thambi Sunil
- Theodorou Nana
- Thim Troels
- Thomas Isobel
- Thompson Rebecca
- Thornborough Lauren
- Thornton Emma
- Thuesen Leif
- Thygesen Kristian
- Tilsted Hans Henrik
- Tipping Aoife
- Tomlinson Lucy
- Tomlinson Sharon
- Topic Dragan
- Tresguerres Jose M.
- Turner Charlotte
- Turner Jenny
- Turney Sharon
- Upton Robert
- Uscumlic Ana
- Van Dyck Laura
- Varma Madhusudhan
- Varma Madhusudhan
- Veerapen Jessry
- Vega-Fernåndez José L.
- Vegas-Valle Jose M.
- Veien Karsten
- Venugopal Vinod
- Vertue Mark
- Victor Saji
- Villadsen Anton Boel
- Villanueva MarĂa J.
- Villar-FernĂĄndez Lara
- Vinagrero MarĂa S.
- Viribay Fernando M.
- Vlad Ionela
- von Weitzel-Mudersbach Paul
- Vukcevic Vladan
- VĂĄzquez-SuĂĄrez MarĂa
- Waddington Natalia
- Wain Jill
- Waitrak Paulina
- Waldron Molly
- Wallace Lauren
- Walshe Siobhan
- Walvin Tom
- Warner Karen
- Watkins Richard
- Watkinson Oliver
- Weatherlley Louise
- Webb Ian
- Webb Ian
- Wells Nicki
- Westwood Mark
- Wheeldon Nigel
- Whitehead Helena
- Whiteside Charlene
- Wilkinson Conor
- Wilson Karen
- Wittrock Daniel
- Wolyrum Mathias
- Woods Sarah
- Wragg Christopher
- Yellon Derek M
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
BACKGROUND: Remote ischaemic conditioning with transient ischaemia and reperfusion applied to the arm has been shown to reduce myocardial infarct size in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). We investigated whether remote ischaemic conditioning could reduce the incidence of cardiac death and hospitalisation for heart failure at 12 months. METHODS: We did an international investigator-initiated, prospective, single-blind, randomised controlled trial (CONDI-2/ERIC-PPCI) at 33 centres across the UK, Denmark, Spain, and Serbia. Patients (age >18 years) with suspected STEMI and who were eligible for PPCI were randomly allocated (1:1, stratified by centre with a permuted block method) to receive standard treatment (including a sham simulated remote ischaemic conditioning intervention at UK sites only) or remote ischaemic conditioning treatment (intermittent ischaemia and reperfusion applied to the arm through four cycles of 5-min inflation and 5-min deflation of an automated cuff device) before PPCI. Investigators responsible for data collection and outcome assessment were masked to treatment allocation. The primary combined endpoint was cardiac death or hospitalisation for heart failure at 12 months in the intention-to-treat population. This trial is registered with ClinicalTrials.gov (NCT02342522) and is completed. FINDINGS: Between Nov 6, 2013, and March 31, 2018, 5401 patients were randomly allocated to either the control group (n=2701) or the remote ischaemic conditioning group (n=2700). After exclusion of patients upon hospital arrival or loss to follow-up, 2569 patients in the control group and 2546 in the intervention group were included in the intention-to-treat analysis. At 12 months post-PPCI, the Kaplan-Meier-estimated frequencies of cardiac death or hospitalisation for heart failure (the primary endpoint) were 220 (8·6%) patients in the control group and 239 (9·4%) in the remote ischaemic conditioning group (hazard ratio 1·10 [95% CI 0·91-1·32], p=0·32 for intervention versus control). No important unexpected adverse events or side effects of remote ischaemic conditioning were observed. INTERPRETATION: Remote ischaemic conditioning does not improve clinical outcomes (cardiac death or hospitalisation for heart failure) at 12 months in patients with STEMI undergoing PPCI. FUNDING: British Heart Foundation, University College London Hospitals/University College London Biomedical Research Centre, Danish Innovation Foundation, Novo Nordisk Foundation, TrygFonden
Bioactive Nanoparticle through Postmodification of Colloidal Silica
- Author
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
Noninfectious Gene Transfer and Expression Systems for Cancer Gene Therapy
- Author
- Acsadi
- Acsadi
- Alexander
- Alimonti
- Allen
- Anderson
- Aoki
- Asher
- Baker
- Bakker
- Barba
- Baskar
- Batra
- Bell
- Bevenisty
- Biamonti
- Biscoff
- Blankenstein
- Boon
- Borrelli
- Boyes
- Boyes
- Brenner
- Brichard
- Brisson
- Brizel
- Brown
- Cai
- Cardoso
- Celis
- Chem
- Chen
- Chen
- Chen
- Chen
- Chen
- Chen
- Chen
- Chen
- Cheng
- Claudio
- Colombo
- Conrad
- Conry
- Cooper
- Cooper
- Cornetta
- Cornetta
- Cotton
- Coulie
- Cox
- Csonka
- Culver
- Dachs
- Davis
- Davis
- DeCaprio
- Delort
- Deuschle
- Donahue
- Dranoff
- Dreano
- Duan
- Dubensky
- Ebersole
- Estin
- Esumi
- Ewen
- Fasbender
- Fearon
- Felgner
- Felgner
- Felsenfeld
- Ferkol
- Ferkol
- Fink
- Fishman
- Freeman
- Friedmann
- Fujiwara
- Furth
- Furth
- Fynan
- Gabathuler
- Gabizon
- Gabizon
- Gabizon
- Ganly
- Gansbacher
- Gansbacher
- Gao
- Gao
- Gao
- Garrido
- Gedde-Dahl
- Gedeon
- Glasser
- Golumbek
- Goren
- Goren
- Gossen
- Gossen
- Graham
- Gray
- Grossi
- Grossi
- Gunter
- Haase
- Halbert
- Hanahan
- Hanahan
- Harms
- Harrington
- Hay
- Heinzel
- Heise
- Heise
- Henning
- Hickman
- Hill
- Hock
- Houbiers
- Huang
- Huang
- Huber
- Huber
- Hurwitz
- Ikeno
- Israel
- Jaenisch
- Jaffee
- Jahroudi
- Jefferies
- Jerome
- Jiang
- Jones
- Julien
- Jung
- Kantor
- Kantor
- Kawakami
- Kawakami
- Kay
- Kay
- Kelleher
- Khuri
- Klinman
- Kowalczyk
- Kreig
- Krieg
- Krieg
- Krieg
- Krimpenfort
- Krummel
- Krysan
- Kwon
- Lanuti
- LaSalle
- Leach
- Lee
- Lesoon-Wood
- Levitsky
- Ley
- Li
- Li
- Lin
- Linzer
- Longman
- Maeurer
- Malik
- Manning
- Manthorpe
- Marples
- Maxwell
- Mayhew
- Middleton
- Milanesi
- Miller
- Miller
- Miller
- Mirzayans
- Mitani
- Monck
- Moolten
- Mortimer
- Moss
- Mroz
- Muiznieks
- Mukhopadhyay
- Mullen
- Mullen
- Mulligan
- Muraro
- Murtha
- Nabel
- Nabel
- Nabel
- Nicolau
- No
- Ornitz
- Osaki
- Papahadjopoulos
- Pardoll
- Passman
- Peace
- Perales
- Perales
- Perales
- Peschon
- Pikaart
- Plautz
- Porgador
- Porgador
- Qin
- Quentin
- Raz
- Restifo
- Rivera
- Rixe
- Rosenthal
- Rothmann
- Rubin
- Rubin
- Russell
- Saravolac
- Sasaoka
- Schoenenberger
- Sebestyen
- Seeger
- Shani
- Shibata
- Shibata
- Sikes
- Skipper
- Smythe
- Stacey
- Stewart
- Stopeck
- Stratford-Perricaudet
- Sun
- Sverdrup
- Takeshita
- Tam
- Tanaka
- Teng
- Tepper
- Tepper
- Thierry
- Townsend
- Tran
- Trojan
- Trojan
- Tronik
- Tseng
- Tsui
- Ulmer
- van der Bruggen
- Vile
- Vile
- Vos
- Wade-Martins
- Wagner
- Wagner
- Wang
- Wang
- Wang
- Wang
- Wang
- Watanabe
- Webb
- Weichselbaum
- Wells
- Westphal
- Wheeler
- Whitmore
- Wilke
- Willard
- Wills
- Wilson
- Wilson
- Wolff
- Wu
- Wu
- Wu
- Wu
- Xu
- Xu
- Yang
- Yang
- Yates
- Yuan
- Zabner
- Zhang
- Zhang
- Zhang
- Zhu
- Ziady
- Ziady
- Ziady
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2002
- Field of study
Mendelian forms of Parkinson's disease
- Author
- Abbas
- Abou-Sleiman
- Aharon-Peretz
- Ahn
- Albanese
- Annesi
- Berg
- Berg
- Biskup
- Bonifati
- Bonifati
- Bosgraaf
- Bras
- Burn
- Canet-Aviles
- Chartier-Harlin
- Chiba-Falek
- Cuervo
- Dachsel
- De Marco
- DeStefano
- Di Fonzo
- Di Fonzo
- Di Fonzo
- Duda
- Duvoisin
- Duvoisin
- Ephraty
- Farrer
- Farrer
- Farrer
- Fuchs
- Fuchs
- Funayama
- Funayama
- Gasser
- Gelmetti
- Gilks
- Gispert
- Gloeckner
- Goedert
- Golbe
- Golbe
- Goldberg
- Goldwurm
- Goris
- Greggio
- Gu
- Hasegawa
- Hasegawa
- Hatano
- Hattori
- Healy
- Hedrich
- Henn
- Hering
- Hicks
- Hilker
- Hofer
- Ibanez
- Ichinose
- Inzelberg
- Ishikawa
- Jones
- Kachergus
- Karamohamed
- Kay
- Khan
- Khan
- Ki
- Kitada
- Klein
- Klein
- KrĂŒger
- Kuroda
- Lautier
- Leenders
- Leroy
- Lesage
- Lincoln
- Lo Bianco
- Lohmann
- Lu
- Lucking
- Lucking
- LĂŒcking
- LĂŒcking
- Maraganore
- Maraganore
- Markopoulou
- Marongiu
- Martinez
- Maruyama
- Mata
- Mata
- Matsumine
- McNaught
- Miller
- Mizuta
- Mjönes
- Mori
- Mueller
- Nichols
- Oliveira
- Ozelius
- Paisan-Ruiz
- Paisan-Ruiz
- Pals
- Pankratz
- Pankratz
- Papapetropoulos
- Periquet
- Polymeropoulos
- Polymeropoulos
- Portman
- Pramstaller
- Pramstaller
- Prestel
- Prestel
- Ramirez
- Rawal
- Ross
- Ross
- Satoh
- Sharma
- Singleton
- Skipper
- Smith
- Spillantini
- Spira
- Strauss
- Takahashi
- Tan
- Tassin
- Tassin
- Thobois
- Thomas Gasser
- Ujike
- Valente
- Valente
- van De Warrenburg
- van Duijn
- Wang
- West
- West
- Winkler
- Wszolek
- Yamamura
- Yang
- Zabetian
- Zarranz
- Ziegler
- Zimprich
- Zimprich
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Effect of transcatheter aortic valve implantation vs surgical aortic valve replacement on all-cause mortality in patients with aortic stenosis
- Author
- Abrams Keith R.
- Abu-Omar Yasir
- Adrego Rita
- Aggarwal Rajesh
- Akhtar Mohammed
- Al-Attar Nawwar
- Al-Hussaini Abtehale
- Alam Mushfeq
- Alexander Donna
- Allen Christopher
- Altman Doug
- Anderson Jon
- Anderson Richard
- Andiapen Mervyn
- Andrew Gillian
- Andrews Michelle
- Appasamy Sara
- Atkinson Bev
- Awad Wael I.
- Ayman Goher
- Baghai Max
- Bahlay Bohdana
- Baig Kamran
- Banks Karen
- Banning Adrian P.
- Barber Vicki
- Barker Deborah
- Barker Thomas
- Barman Cathy
- Barton Janet
- Batra Priyanka
- Baumbach Andreas
- Bawamia Bilal
- Bell Megan
- Bell Sheila
- Bhattacharyya Sanjeev
- Bigg Julie
- Birdi Inderpaul
- Blackman Daniel
- Bland Martin
- Boon Nicholas
- Bose Amal
- Bounford Katrina
- Bowen Sam
- Bowles Ruth
- Brecker Stephen
- Briffa Norman
- Brown Sue
- Buch Mamta
- Butler Mark
- Byrne Jonathan
- Calver Alison
- Campton Marion
- Chandrasekaran Venkatachalam
- Charles Thabitha
- Chase Alexander
- Chaudhry Mubarak
- Chelliah Raj
- Chetty Govind
- Chin Derek
- Chiocchia Virginia
- Chowdhary Saqib
- Chukwuemeka Andrew
- Clarkson Nichola
- Cleland John G. F.
- Clifton Lei
- Cobbe Stuart M.
- Cockburn James
- Conroy Simon P.
- Cooper Graham
- Cotton James
- Cox Ian D.
- Crean Peter
- Crossman David C.
- Crowe Joanne
- Cruden Nick
- Cunningham Nicola
- Cunnington Michael
- Currie Jacqueline
- Curzen Nick
- Dalby Miles
- Dalrymple-Hay Malcolm
- Daniel Tim
- Das Raj
- Davies Lesley
- Davies Simon W.
- Davies William
- de Belder Adam
- de Belder Mark A.
- Dean John
- Deglurkar Indu
- Densem Cameron G.
- Deshpande Ranjit
- Dickerson Deborah
- Dobbs Karen
- Dobson Laura
- Dorman Stephen H.
- Doshi Sagar N.
- Duncan Alison
- Dutton Susan
- Dyer Helen
- Edwards Julie
- Edwards Richard J.
- Encarnacion Delfin
- Engonidou Lazarina
- Evans Betsy
- Fagan Claire
- Fairbairn Timothy
- Fancourt Graham
- Farooq Vaseem
- Fatoba Samuel
- Feeney Sarah
- Flapan Andrew
- Flather Marcus D.
- Fonseca Tiago
- Ford Ian
- Forlani Stefano
- Forrest Mark
- Frame Angela
- Fraser Douglas G. W.
- Gallego Laura
- Gardener Lynn
- Gardner Di
- Gibson Catherine
- Gomes Ari
- Goodwin Andrew
- Gough Sam
- Grant Stuart
- Gray Alastair M.
- Grech Ever
- Gregory Natalie
- Griffiths Jane
- Griffiths Rebecca
- Groves Peter H.
- Gunning Mark G.
- Hall Ian
- Hamshere Steve
- Hanzel Lona
- Harrison James
- Harrison Ursula
- Hasan Ragheb
- Henderson Robert
- Hewitt Aimi
- Hickey Mark
- Hildick-Smith David
- Hiles Stephen
- Hodges Elizabeth
- Holder Jacqueline
- Hounsley Kay
- Hyndman Samantha
- Jackson Matthew
- Jahangiri Marjan
- Javangula Kalyana
- Jeganathan Reuben
- Johnston Nicola
- Jones Stephen
- Kabir Tito
- Kadir Isaac
- Kaul Pankaj
- Kemp Ian
- Kennon Simon
- Kharbanda Raj
- Khogali Saib S.
- Khoo Jeffrey
- Khurana Ayush
- King Rachel
- Knighton Abigail
- Kober Lars
- Kovac Jan
- Kozlowski Victoria
- Krasopoulos George
- Kuduvalli Manoj
- Kumar Pankaj
- Kuyt Katherine
- Levy Richard
- Lloyd Clinton
- Lloyd Stephanie
- Lockie Sharon
- Logtens Elaine
- Loubani Mahmoud
- Luckraz Heyman
- Ludman Peter F.
- Lynch Jane
- MacCarthy Philip
- Mack Stephanie
- Mackie Sarah
- MacNab Anita
- Mahoney Luke
- Malik Iqbal
- Malkin Christopher J.
- Mansouri Anita
- Mariscalco Giovanni
- Marsh Anna-Marie
- Mascaro Jorge
- Massey Ian
- Matthews Elaine
- Matuszewski Maciej
- McAdam John
- McClean Rebecca
- McDowell Lindsey
- McEntegart Margaret B.
- McLeod Karen
- McMurray John
- McPherson Gladys
- McQuade Lorraine
- Mehta Dheeraj
- Metherell Stella
- Middleton Sam
- Mikhail Ghada
- Mills Joseph D.
- Moat Neil E.
- Modi Amit
- Monaghan Mark J.
- Muir Douglas F.
- Mullen Michael J.
- Muthuswamy Akhila
- Nadir Adnan
- Naik Surendra
- Navaneethakrishnan Alagumeenakshi
- Naylor Heather
- Neville Mel
- Newton Jim
- Nicholas Zoe
- Nihoyannopoulos Petros
- Nilsson Annette
- O'Sullivan Michael
- O'Toole Laurence
- Ocampo Madelaine
- Ohri Sunil K.
- Oldroyd Keith G.
- Oommen Anu
- Ossei-Gerning Nick
- Owens Colum G.
- Owens W. Andrew
- Palmer Jim
- Palovaara Teijo
- Panoulas Vas
- Parker Jessica
- Pearce Keith
- Pessotto Renzo
- Pickett Elaine
- Pintacasi Johannes
- Pirone Francesco
- Prendergast Bernard
- Prendergast Claire
- Proctor Kathryn
- Quarto Cesare
- Radmore Judith
- Rahman Haley Shelley
- Raja Shahzad G.
- Rajakaruna Cha
- Rajathurai Thirumaran
- Rakhit Dhrubo
- Ramesh Bandigowdanapalya C.
- Rana Bushra
- Ranasinghe Aaron
- Randall Marc
- Rawlins John
- Ray Simon
- Redwood Simon R.
- Reed Helen
- Ridley Paul D.
- Rif Belinda
- Roberts David
- Roberts Elved
- Roberts Jo
- Roberts Neil
- Robinson Heather
- Rogers Paula
- Rombach Ines
- Ronayne Christina
- Rubie Sonia
- Rusk Rosemary
- Sarma Jaydeep
- Saunders Dawn
- Sayeed Rana
- Schlosshan Dominik
- Sevillano Annaliza
- Shah Benoy
- Sharma Raj
- Shaw Robert
- Sherwood Martin
- Shirkey Beverly
- Singh Surjeet
- Sionas Michail
- Skipper Nicola
- Smallwood Andy
- Smith Bernie
- Smith David
- Somers Kathryn
- Sookhoo Vennessa
- Speke Laura
- Spence Mark S.
- Spyt Tomasz
- Steeds Richard
- Stout Martin
- Sudarshan Catherine
- Suresh Venkat
- Szabolcs Miskolczi
- Szafranek Adam
- Tang Augustine
- Tapp Luke
- Taylor Brian
- Thambyrajah Jeetendra
- Thomas Gladdys
- Thomas Patricia
- Thompson Elizabeth
- Thomson Cath
- Tobin Angela
- Toff William D.
- Townend Jonathan N.
- Townsend Mandie
- Treasure Tom
- Trivedi Uday
- Tsang Geoff
- Tsui Steven
- Uren Neal G.
- Vahabi Sharareh
- Varcoe Richard
- Vasudevan Vasanthi
- Villarreal Elena
- Wain Jill
- Wallis Alisa
- Wang ShuFang
- Warsama Suad
- Waterworth Paul
- Webb Alexis
- Wendler Olaf
- Wheeler Richard
- Whittaker Andrew
- Wilkinson Ian
- Wilkinson Laura
- Williams Lynne
- Williams Paul
- Wilmshurst Natasha
- Wilson Karen
- Winder Will
- Woan Wil
- Wong Lisa
- Yadav Rashmi
- Yeh James
- Youhana Aprim
- Young Andrea
- Young Christopher P.
- Zacharkiw Linda
- Zaman Azfar
- Zamvar Vipin
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 17/05/2022
- Field of study
Importance: Transcatheter aortic valve implantation (TAVI) is a less invasive alternative to surgical aortic valve replacement and is the treatment of choice for patients at high operative risk. The role of TAVI in patients at lower risk is unclear.
Objective: To determine whether TAVI is noninferior to surgery in patients at moderately increased operative risk.
Design, Setting, and Participants: In this randomized clinical trial conducted at 34 UK centers, 913 patients aged 70 years or older with severe, symptomatic aortic stenosis and moderately increased operative risk due to age or comorbidity were enrolled between April 2014 and April 2018 and followed up through April 2019.
Interventions: TAVI using any valve with a CE mark (indicating conformity of the valve with all legal and safety requirements for sale throughout the European Economic Area) and any access route (nâ=â458) or surgical aortic valve replacement (surgery; nâ=â455).
Main Outcomes and Measures: The primary outcome was all-cause mortality at 1 year. The primary hypothesis was that TAVI was noninferior to surgery, with a noninferiority margin of 5% for the upper limit of the 1-sided 97.5% CI for the absolute between-group difference in mortality. There were 36 secondary outcomes (30 reported herein), including duration of hospital stay, major bleeding events, vascular complications, conduction disturbance requiring pacemaker implantation, and aortic regurgitation.
Results: Among 913 patients randomized (median age, 81 years [IQR, 78 to 84 years]; 424 [46%] were female; median Society of Thoracic Surgeons mortality risk score, 2.6% [IQR, 2.0% to 3.4%]), 912 (99.9%) completed follow-up and were included in the noninferiority analysis. At 1 year, there were 21 deaths (4.6%) in the TAVI group and 30 deaths (6.6%) in the surgery group, with an adjusted absolute risk difference of â2.0% (1-sided 97.5% CI, ââ to 1.2%; Pâ<â.001 for noninferiority). Of 30 prespecified secondary outcomes reported herein, 24 showed no significant difference at 1 year. TAVI was associated with significantly shorter postprocedural hospitalization (median of 3 days [IQR, 2 to 5 days] vs 8 days [IQR, 6 to 13 days] in the surgery group). At 1 year, there were significantly fewer major bleeding events after TAVI compared with surgery (7.2% vs 20.2%, respectively; adjusted hazard ratio [HR], 0.33 [95% CI, 0.24 to 0.45]) but significantly more vascular complications (10.3% vs 2.4%; adjusted HR, 4.42 [95% CI, 2.54 to 7.71]), conduction disturbances requiring pacemaker implantation (14.2% vs 7.3%; adjusted HR, 2.05 [95% CI, 1.43 to 2.94]), and mild (38.3% vs 11.7%) or moderate (2.3% vs 0.6%) aortic regurgitation (adjusted odds ratio for mild, moderate, or severe [no instance of severe reported] aortic regurgitation combined vs none, 4.89 [95% CI, 3.08 to 7.75]).
Conclusions and Relevance: Among patients aged 70 years or older with severe, symptomatic aortic stenosis and moderately increased operative risk, TAVI was noninferior to surgery with respect to all-cause mortality at 1 year.
Trial Registration: isrctn.com Identifier: ISRCTN57819173
Empagliflozin in Patients with Chronic Kidney Disease
- Author
- Aamir Navivala
- Abdulwahab Arbi
- Abegail Hernandez Pena
- Abraham Hanburry
- Adedolapo Adeleke
- Adeera Levin
- Adil Hazara
- Adline Ghazi
- Agnes Masengu
- Ahmad Tuffaha
- Ahmed Awad
- Ahmed Ghanem
- Ai Fukasawa
- Aik Kheng Lee
- Aiko Terakawa
- Aiko Tomita
- Aiko Yamada
- Ailsa Geddes
- Airi Sato
- Akane Katanosaka
- Akane Yamamoto
- Akihiro Fujimoto
- Akihiro Katayama
- Akihito Tanaka
- Akiko Fujita
- Akiko Hashimoto
- Akiko Ishiguro
- Akiko Omata
- Akimasa Asai
- Akinwande Akinfolarin
- Akio Kanazawa
- Akiyo Nishiyama
- Akiyo Tanabe
- Alastair Rankin
- Alastair Woodman
- Albert Hing
- Albert Power
- Alberto Rosati
- Aldo P Maggioni
- Aldo Peixoto
- Aleksandra Murawska
- Alessandro D'Amelio
- Alex Aguilera
- Alex Baxter
- Alex Howson
- Alexa Wonnacott
- Alexander Hadley
- Alexander Hodakowski
- Alexander Paliege
- Alexis Africano
- Alexis Stevenson
- Alfio Giuffrida
- Alfred K Cheung
- Alia Hasan
- Alia Zubaidah Bahtar
- Alice Aitken
- Alice Guerini
- Aliseiya Garza
- Alison Cowley
- Alison Jenkins
- Alison Timadjer
- Allen Young
- Allison Leslie
- Amalia Caamano
- Amanda Aliu
- Amanda Axler
- Amanda Davis
- Amanda Scott
- Amanda Tyler
- Amar Ali
- Amber Avery
- Amber Hurst
- Amelia Te
- Ami Inamori
- Amin Oomatia
- Amir Kazory
- Amret Hawfield
- Amritanshu Pandey
- Amy Hudson
- Amy Hunter
- Amy Mottl
- Ana Moncada
- Anand Srivastava
- Anastassiya Reisler
- Anca Gherman
- Andre Valleteau
- Andrea Lorimer
- Andrea Schwab
- Andrea Webster
- Andrea Wilson
- Andreas Schneider
- Andrew Breach
- Andrew Connor
- Andrew Frankel
- Andrew Gordon
- Andrew Lewington
- Andrew Shepherd
- Andrew Steele
- Andy Burke
- Andy Measor
- Angela Bergner
- Angela Chamberlain
- Angela Field
- Angela Moon
- Angeline Mbuyisa
- Angharad Williams
- Anil George
- Anita Hepditch
- Anita Kamarzarian
- Anja Knoppe
- Anju Oommen
- Anke Torp
- Ankit Mehta
- Ann Bennett
- Ann Cooper
- Ann Vasseur
- Anna Brewer
- Anna Liew
- Anna Postal
- Anna Romo
- Anna Sampson
- Annalisa Aloisi
- Anne Froment
- Anne Grace
- Anne Schreiber
- Anne-Marie Beneat
- Annegret Fleischer
- Annette Kraemer-Guth
- Annie Saillant
- Annika KĂŒpper
- Anoushka Bhatt
- Anthony Lambert
- Anthony Torres
- Anthoula Apostolidi
- Antonia Schuster
- Antonio Cardone
- Aoife O'Sullivan
- Aparna Padiyar
- Arash Rashidi
- Archie Maskill
- Arelis Madera
- Arif Khwaja
- Arihiro Kiyosue
- Asako Takesada
- Ashlee Morris
- Ashleigh Wheeler
- Ashley Lawson
- Ashwathy Varughese
- Ashwini Gore
- Asma Sabarai
- Astrid Maselli
- Atsuko Nakatsuka
- Atsuyuki Tokuyama
- Auguste Kutschat
- Autumn Wood
- Aya Kawase
- Aya Tanaka
- Aya Yamanaka
- Ayako Imai
- Ayana Tatsuzawa
- Aydin Er
- Ayesha Ali
- Ayesha Irtiza-Ali
- Aziee Sudin
- Bader Al-Zeer
- Baigent Colin
- Bak Leong Goh
- Balwinder Gill
- Ban Chai Peng
- Baochun Guo
- Barbara Bartolomei Mecatti
- Barbara Tucky
- Barbara Winter-Goodwin
- Barbara Zander
- Barry Johns
- Beate Schumacher
- Bellovich Keith
- Ben Bagwell
- Ben Caplin
- Bernd Hohenstein
- Bernd Kruger
- Bernd Schroppel
- Bernd Stratmann
- Bernhard Banas
- Bernhard Kraemer
- Bernhard Winkelmann
- Bethelihem Gebeyehu
- Bhavya Kothapalli
- Bhrigu Sood
- Bhupinder Grewal
- Bianca Weber
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- Seiji Ueda
- Sendogan Aker
- Sergio Rovner
- Serine Alfaress
- Severin Schricker
- Shahbaz Ahmed
- Shahin Mozaffari
- Shameem Beigh
- Shamila Wanninayake
- Shan Darbeau
- Shana Camp
- Shaopeng Yao
- Sharang Ghavampour
- Shariff Sanguila
- Sharirose Abat
- Shayani Raguwaran
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- Shenglang Zhu
- Sherald Barnes
- Sherry Brown
- Sherry Gasko
- Shi Zhao
- Shiho Iwagaitsu
- Shin Tsunekawa
- Shingo Iwasaki
- Shinichi Araki
- Shinichi Nishi
- Shinji Kitamura
- Shinji Kume
- Shinjiro Kodama
- Shintaro Nunokawa
- Shintaro Yano
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- Shiva Ugni
- Shivinder Jolly
- Shizuka Higashi
- Shogo Banno
- Shogo Kimura
- Shoichi Maruyama
- Shoji Saito
- Shoko Hayashi
- Shoko Otomo
- Shona Murray
- Shota Hashimoto
- Shraddha Shah
- Shuai Tang
- Shuang Xia
- Shuhan Zhou
- Shunichiro Asahara
- Shunsuke Goto
- Shweta Bansal
- Sian Griffin
- Sibylle J Hauske
- Silke Markau
- Simona Barberi
- Simona Bianco
- Simone Boedecker
- Simone Hagge
- Simone Streitenberger
- Simone Vettoretti
- Sina Rolfsmeier
- Sion Roy
- Siti Munirah Jaafar
- Siti Nabilah Mohamad Zaini
- Smeeta Sinha
- Smita Gunda
- Sodai Kubota
- Sofia Dayi
- Sonja Grotjahn
- Sonoka Yamamoto
- Soo Kun Lim
- Soon Yi Sor
- Sorcha Mulligan
- Sri Yarlagadda
- Sridhar Ramanaidu
- Srinivasan Beddhu
- Stacey-Ann Villaruel
- Stacie Hitchcock
- Stacy Gillham
- Staplin Natalie
- Stefan Degenhardt
- Stefan Haack
- Stefan Hantel
- Stefanie Jones
- Stefanie Kuhn
- Stephan Matthias
- Stephanie Bolton
- Stephanie Estcourt
- Stephanie Evans
- Stephanie Martinez
- Stephanie Rosenberg
- Stephanie Watson
- Stephanie Whittaker
- Stephany Topping
- Stephen Aronoff
- Steubl Dominik
- Steven Nagelberg
- Stevens Will
- Stewart Moffat
- Subash Somalanka
- Subha Clarke
- Subrata Debnath
- Sucharit Joshi
- Sue Ann Lee
- Sue Hewins
- SueAnn Squyres
- Sui Phin Kon
- Sunil Bhandari
- Sunita Bavanandan
- Suresh Ramadoss
- Suria Junus
- Susan Haskett
- Susan Hurley
- Susan McLaughlin
- Susannah Pajak
- Susanne Bodine
- Susanne Brenner
- Susumu Nakatani
- Suzannah Dorey
- Sybille Merscher
- Tabbatha Duck
- Tabinda Dugal
- Tadahiro Tomita
- Taeko Uchida
- Tai Meng Chen
- Takahiro Ishikawa
- Takahiro Kato
- Takahiro Matsunaga
- Takahiro Yamano
- Takako Kuramae
- Takako Ozawa
- Takanori Hyo
- Takashi Funayama
- Takashi Kadowaki
- Takashi Kobayashi
- Takashi Udagawa
- Takatoshi Otani
- Takayuki Katsuno
- Takehiko Wada
- Takehiro Sugiyama
- Takeshi Kurose
- Takeshi Miyatsuka
- Takeshi Ogihara
- Takuji Ishimoto
- Takuma Kojo
- Takuya Haraguchi
- Takuya Yokoyama
- Tamaki Sasaki
- Tamara Isakova
- Tammi Glider
- Tammy Ross
- Tanaji Dasgupta
- Taneera Ghate
- Taniya Nimbkar
- Tanvi Talsania
- Tara Johnson
- Tasuku Nagasawa
- Tatsuhito Himeno
- Tatyana Chavagnon
- Tejas Patel
- Teresa Kozlowski
- Teresa McKinley
- Terri Chant
- Tetsuya Hosooka
- Tetsuya Shigehara
- Thahir Abdul-Samad
- The EMPA-KIDNEY Collaborative Group: Colin Baigent
- Theresa McCarthy
- Thiemo Pfab
- Thisun Saram
- Thomas Arnold
- Thomas Jones
- Thomas Phillips
- Thomas Pickett
- Thomas Sitter
- Thomas Walters
- Thomas Weinreich
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- Timothy Ellam
- Tina Harding
- Tina Ramsey
- Ting Meng
- Tingting Kan
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- Toluleyi Sobande
- Tomoe Sato
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- Tomohito Gohda
- Tomohito Izumi
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- Tomoki Kosugi
- Tomoko Hisatake
- Tomoko Morisaki
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- Tomoko Takai
- Tomonori Hasegawa
- Tomoya Mita
- Torsten Schramm
- Toru Ikeda
- Toshiki Kano
- Toshimasa Yamauchi
- Toshiya Yamamoto
- Toshiyuki Komiya
- Toyoyoshi Uchida
- Tracey Cummins
- Tracy Fuller
- Tracy Spinola
- Trevor Greene
- Tricia Young
- Tristan Daniels
- Tsukasa Iwakura
- Tuttle Katherine R
- Tze Jian Ng
- Ulla Ludwig
- Ulrike Giebeln-Hudnell
- Ulrike Schmidt
- Urs Benck
- Ursula Hohenstatt
- Usah Lilavivat
- Vahid Mahabadi
- Vanessa Rivers
- Verlaine Stewart-Ray
- Veronica Poma
- Veronica Yousif
- Vesta Lai
- Vicki Adell
- Vicki Brindle
- Vicki Dodds
- Vicki Donley
- Vickie Jones
- Victoria Carnall
- Victoria Gonce
- Vimal Derebail
- Vinay Varad
- Vittorio Ortalda
- Vivian Yiu
- Vladimir Cejka
- Volker Schettler
- Volker Vielhauer
- Wael Eid
- Wagdy Basily
- Wakako Isari
- Wallendszus Karl
- Waltraud Kmietschak
- Wan Ahmad Faizal Alaidin Razali
- Wan Hazlina Wan Mohamad
- Wanner Christoph
- Waqar Ayub
- Waseem Karsan
- Wasim Deeb
- Wasim Hanif
- Wataru Ogawa
- Wei Wang
- Wei Wei
- Weijing Bian
- Weiping Hou
- Weixin Kong
- Wen Jiun Liu
- Wen Liu
- Wendy Arriaga
- Wiebke Kaluza-Schilling
- Will Stevens
- William Durham
- William G Herrington
- William G Herrington
- William Hodge
- William Petchey
- Wolf-Adam Seeger
- Wolfgang Seeger
- Wuhanbilige Hundei
- Xavier Rossello
- Xia Song
- Xiangcheng Xiao
- Xiaojing Jiao
- Xiaojue Li
- Xiaoliang Wang
- Xinzhou Zhang
- Xiumei Hu
- Xuejiao Liu
- Xueying Wang
- Yan Li
- Yanmei Xu
- Yanping Wang
- YanRu Qiao
- Yanwu Yu
- Yanyun Xie
- Yao Weng
- Yao Yao
- Yasemin Kavak
- Yasuhiko Furukawa
- Yasuhiko Ito
- Yasuhiko Kanaguchi
- Yasuhiro Suzuki
- Yasushi Iwaita
- Ye Mun Low
- Yee Yan Lee
- Yew Fong Liew
- Yi Loon Tye
- Yik Hong Wong
- Yik Shen Lim
- Ying Hu
- Ying Jiang
- Ying Kuan
- Ying Lu
- Yinghua Chen
- Yohei Ejima
- Yoko Inukai
- Yolanda Miller
- Yong Chieh Chan
- Yonghong Bu
- Yoshiaki Morishita
- Yoshie Shibata
- Yoshifumi Tamura
- Yoshihiko Yamasaki
- Yoshihisa Wada
- Yoshikazu Tamori
- Yoshiki Suzuki
- Yoshimitsu Yamasaki
- Yoshinari Yasuda
- Yoshinori Osaki
- Yoshiro Kato
- Yoshiyuki Hamamoto
- Yosuke Hirakawa
- Yosuke Nakagawa
- Youcef Mostefai
- Young Lee-Barkey
- Yu An
- Yu Chen
- Yu Chen Ong
- Yu Yamanouchi
- Yuana Mohd Yusoff
- Yuichiro Munakata
- Yuji Oe
- Yuka Sato
- Yuka Ueda
- Yukari Miura
- Yuki Fujita
- Yuki Fukao
- Yuki Omori
- Yukihiro Shimizu
- Yukihiro Yamaji
- Yukiko Nakayama
- Yukiko Toyonaga
- Yukiko Wakita
- Yuko Katsuda
- Yuko Makita
- Yuko Okada
- Yuko Orimo
- Yumi Osawa
- Yushi Hirota
- Yusuke Suzuki
- Yutaka Kamimura
- Yuya Nishida
- Yvette Webley
- Yvonne Ehrl
- Yvonne Jackson
- Zabrina Lozon
- Zaid Azhari
- Zaiha Harun
- Zainab Sheriff
- Zanaida Cooper
- Zay Htet
- Zhang Duan Tham
- Zhi-Hong Liu
- Zhirui Zhao
- Zhu Doreen
- Zhuo Tang
- Zohreh Forghani
- Zuber Patel
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2023
- Field of study
Background The effects of empagliflozin in patients with chronic kidney disease who are at risk for disease progression are not well understood. The EMPA-KIDNEY trial was designed to assess the effects of treatment with empagliflozin in a broad range of such patients. Methods We enrolled patients with chronic kidney disease who had an estimated glomerular filtration rate (eGFR) of at least 20 but less than 45 ml per minute per 1.73 m(2) of body-surface area, or who had an eGFR of at least 45 but less than 90 ml per minute per 1.73 m(2) with a urinary albumin-to-creatinine ratio (with albumin measured in milligrams and creatinine measured in grams) of at least 200. Patients were randomly assigned to receive empagliflozin (10 mg once daily) or matching placebo. The primary outcome was a composite of progression of kidney disease (defined as end-stage kidney disease, a sustained decrease in eGFR to < 10 ml per minute per 1.73 m(2), a sustained decrease in eGFR of & GE;40% from baseline, or death from renal causes) or death from cardiovascular causes. Results A total of 6609 patients underwent randomization. During a median of 2.0 years of follow-up, progression of kidney disease or death from cardiovascular causes occurred in 432 of 3304 patients (13.1%) in the empagliflozin group and in 558 of 3305 patients (16.9%) in the placebo group (hazard ratio, 0.72; 95% confidence interval [CI], 0.64 to 0.82; P < 0.001). Results were consistent among patients with or without diabetes and across subgroups defined according to eGFR ranges. The rate of hospitalization from any cause was lower in the empagliflozin group than in the placebo group (hazard ratio, 0.86; 95% CI, 0.78 to 0.95; P=0.003), but there were no significant between-group differences with respect to the composite outcome of hospitalization for heart failure or death from cardiovascular causes (which occurred in 4.0% in the empagliflozin group and 4.6% in the placebo group) or death from any cause (in 4.5% and 5.1%, respectively). The rates of serious adverse events were similar in the two groups. Conclusions Among a wide range of patients with chronic kidney disease who were at risk for disease progression, empagliflozin therapy led to a lower risk of progression of kidney disease or death from cardiovascular causes than placebo
Risk of COVID-19 after natural infection or vaccinationResearch in context
- Author
- A. Lina Rosengren
- Abram Burgher
- Adam B. Brosz
- Adam Rosen
- Adam Schwartz
- Adriana Sordo Duran
- Adrienna Marquez
- Adrienne E. Shapiro
- Aeiress Duhart
- Afsoon Roberts
- Albert Liu
- Alejandro Hoberman
- Alejandro QuintĂn Barrat HernĂĄndez
- Alex Greninger
- Alexander Clark
- Alfredo Gilberto Guerreros Benavides
- Alice McGarry
- Alicia Arrazcaeta
- Alisha Lutat
- Alison Bondell
- Alison Pellecchia
- Allie Oplinger
- Allison Green
- Allison O'Brien
- Alpa Patel
- Alyssa-Kay Peay
- Amanda Horn
- Amanda Lilienthal
- Amanda Occhino
- Amanda Philyaw
- Amaran Moodley
- Amber Grant
- Amber Stanford
- Amesika Nyaku
- Amie Shannon
- Amina Z. Haggag
- Amit Paliwal
- Amy Caldwell
- Amy Chamberlain
- Amy Dye
- Amy Falk
- Amy Kelley
- Amy Medina
- Amy Potts
- Amy Salzl
- Amy Sherman
- Amy Starr
- Amy Thompson
- Andrea Berry
- Andrea Clement
- Andrea Wendrow
- Andrea Zimmer
- Andres Bran
- Andres Camacho-Gonzalez
- Andrew Lauria
- Andrew McConnell
- Andrew McWilliams
- Anelgine C. Yoon
- Angela Lee
- Angela R. Branche
- Angelica Kottkamp
- Angella Webb
- Ann M. Milliken
- Ann R. Falsey
- Anna S. Lok
- Anna Wald
- Anne Marit de Groot
- Anne-Marie Rick
- Annette R. Bennett
- Annie Ciambruschini
- Annie Luetkemeyer
- Anthony Kim
- Anum Abbas
- Anyela Lara
- April Pixler
- Ariana C. Stanton
- Arthur L. Zemanek
- Asha Inniss
- Ashley Kennedy
- Ashley Perez
- Ashley Warden
- Asif Noor
- Atoya Adams
- Aurelio Cruz-Valdez
- Austin Chan
- Austin Swanson
- Ayanna Walters
- Ayoade Avworo
- Bailey Jordan
- Barbara Corral
- Barbara Rizzardi
- Barbara Rizzardi
- Barbara S. Taylor
- Barry S. Zingman
- Barton G. Williams
- Beatriz Grinsztejn
- Becky Martinez
- Ben Ladner
- Benjamin Eckhardt
- Benjamin J. Luft
- Bernard Grunstra
- Beth Safirstein
- Bethanie Wilkinson
- Beverly E. Sha
- Beverly Ewing
- Bindu Balani
- Blanca Gomez
- Bo Shopsin
- Boerries Brandenburg
- Brandie Taylor
- Brandon J. Essink
- Brandy Ball
- Breanz Watkins
- Brenda Dorcely
- Brendan Levy
- Brett Gray
- Brett Leav
- Brian D.W. Chow
- Brit Sovic
- Brittany Feijoo
- Brittany Stewart
- Bruce C. Gebhardt
- Bruce G. Rankin
- Bruce McClenathan
- Bruno Valenti
- Bryan Gordon
- C. Mary Healy
- Caitlin J. Guiney
- Caitlin Moran
- Candace Smith
- Candice Montros
- Carina A. Rodriguez
- Carl Fichtenbaum
- Carl P. Griffin
- Carlos A. Fierro
- Carlos del Rio
- Carlos Lopez
- Carlos Malvestutto
- Carmel B. Dyer
- Carmen A. Paez
- Carmen Amador
- Carmen D. Zorrilla
- Carmen Medina
- Carol Ann Linebarger
- Carol Kauffman
- Carol L. Mitchell
- Carolene Stephenson
- Caroline Greene
- Carolyn Scatamacchia
- Carolyn Tran
- Carrie Johnston
- Carrie Sopher
- Catherine A. Bunce
- Catherine Mary Healy
- Catherine Q. Gular
- Cathy Laflan
- Cecilia McKeown-Bragas
- Celia Gonzalez
- Celia Maxwell
- Charles Harper
- Charles M. Fogarty
- Charlotte-Paige Rolle
- Charnell Cromer
- Chelsea Miles
- Chelsie Nutsch
- Chelsie Nutsch
- Chen S. Tan
- Chenchen Yu
- Cheryl Nuss
- Cheryl Young
- Chimeremma Nnadi
- Chinar Desai
- Christian Tomaszewski
- Christina A. Rostad
- Christina Bacher
- Christina Kennelly
- Christine Akamine
- Christine B. Turley
- Christine Hull
- Christine Wilson
- Christopher Carpenter
- Christopher Dedon
- Christopher Galloway
- Christopher Matich
- Christy Schmeck
- Christy Sweet
- Clarence B. Creech II
- Clarisse Baudelaire
- Claudia De La Matta Rodriguez
- Claudia Espinosa
- Claudio Nuñez Lagos
- Clint C. Guillory
- Clint Wilson
- Codi M. Anthony
- Colleen F. Kelley
- Colleen Jacobsen
- Connie Moya
- Cora Sonnier
- Corey G. Anderson
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- Cynthia Bueno
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- Dalia Tovar
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- Daniel Hoft
- Daniel Kaul
- Daniel S. Graciaa
- Daniel T. Lawler
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- Danielle Raley
- Danny Sugimoto
- Danyel Johnson
- Darlene Bartilucci
- David B. Musante
- David Beckmann
- David Browder
- David Dellaero
- David Fitz-Patrick
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- David Pitrak
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- David Rosenberg
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- Dawn Robison
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- Deborah A. Theodore
- Deborah Murray
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- Denise Casey
- Denise Roadman
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- Derek M. Smith
- Destiny S. Heinzig-Cartwright
- Diana Badillo
- Diana F. Florescu
- Diana Vegas
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- Dima Dandachi
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- Donald Quinn
- Donna Percy
- Doris Franco-Vitteri
- Douglas S. Denham
- E. Javier Pretell Alva
- Edgar Garcia
- Edith Swann
- Eduardo Gabriel Våzquez Saldaña
- Edward C. Jones-LĂłpez
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- Edward Ellerbeck
- Edward M. Tavel Jr.
- Elham Ghadishah
- Elie Gharib
- Elisa Swieboda
- Elissa Malkin
- Elizabeth Barranco-Santana
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- Ernesto Delgado
- Esther L. Harmon
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- Evelyn Hall
- Evelyn Lomasney
- Evelyn Quevedo
- Fan Yang
- Farah Irani
- Farhan Siddiqui
- Fernanda Morales
- Fernando L. Merino
- Filip Dubovsky
- Flora Castellino
- Florence Momplaisir
- Florida Aristy
- Frances Downing
- Frank James
- Frank S. Eder
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- Fred E. Newton
- Frederick Raiser III
- Fredric Santiago
- Gail Broder
- Gary Albert
- Gary Headden
- Gary Horwith
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- Gary Simon
- Gayle D. Hennekes
- Genevieve Beninati
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- George H. Bauer Jr.
- George H. Freeman
- Georgette Ebuh
- Georgettea Geuss
- Gerald Kelty
- GermĂĄn Ăñez
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- Gina Rivero
- Glenda E. Gray
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- Howard Schwartz
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- Hyman Scott
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- Lily Aleman
- Lina M. Forero
- Linda M. Schipani
- Linda Murray
- Linda R. Belhorn
- Lindsey R. Baden
- Lisa A. Jackson
- Lisa Chrisley
- Lisa Cohen
- Lisa Holloway
- Lisa J. Sanders
- Lisa Johnson
- Lisa M. Dunkle
- Lisa S. Usdan
- Lisa Stangl
- Lisa Stevens Rameaka
- Logan Ledbetter
- Lois Katz
- Lora J. McGill
- Lori Nesbitt
- Lucy Ng-Price
- Luis H. GonzĂĄlez
- Luis I. De La Cruz
- Luke Friesen
- Luz Zapata
- Lyly Dang
- Lyndsea Folsom
- Lynn Eckert
- Lynne A. Haughey
- M. Juliana McElrath
- M. Mahdee Sobhanie
- Magdalena E. Sobieszczyk
- Maggie Bowers
- Maggie Lewis
- Mai Pham
- Malina Regalado
- Mamodikoe Makhene
- Mandy Vowell
- Manisha Horton
- Mara Kryvicky
- Marc Siegel
- Marcel Curlin
- Marcia Bernard
- Marcia O'Leary
- Marcus J. Zervos
- Marcy Kulic
- Margaret Cheng
- Margaret E. McCort
- Margaret Kautz
- Margaret Powers-Fletcher
- Margaret Rhee
- Margaret Wells
- Marguerite Neill
- Maria G. Becerra
- Maria Hernandez Moran
- Maria I. Bermudez
- Maria Johnson
- Maria L. Alcaide
- Maria M. Regalado
- Maria Mileno
- Marian E. Shaw
- Marianela Carvajal
- Maricruz E. OrtegĂłn
- Marina Lee
- Mario Castro
- Mark A. Turner
- Mark E. Kutner
- Mark Eickhoff
- Mark Hutchens
- Mark Leibowitz
- Mark Lerman
- Mark M. McKenzie
- Mark S. Adams
- Marshall A. Cross
- Marshall Nash
- Martha Carmen Medina
- Martha Cecilia GĂłmora Madrid
- Martha Nason
- Martha Sanchez
- MartĂn BĂ€cker
- Marvin Castellon
- Mary A. Marovich
- Mary Beth Manning
- Mary C. Walsh
- Mary Easley
- Mary Hussain
- Mary Smith
- Mary Vogler
- Maryam Jahromi
- Maryrose Laguio-Vila
- Marysol Villegas
- MarĂa E. Santolaya
- MarĂa I. Rivera
- MarĂa JosĂ© Reyes Fentanes
- Masaru Oshita
- Mashrur Islam Majumder
- Matthew B. Laurens
- Matthew D. Sims
- Matthew G. Davis
- Matthew Hepburn
- Matthew Hong
- Matthew Hong
- Matthew Miles
- Matthew W. Doust
- Maureen Cooney
- May-Yin Suen
- Mayur Ramesh
- Meagan Miller
- Meagan Thomas
- Megan Berman
- Meghan Teherani
- Mehdi Mirsaeidi
- Melanie Jay
- Melinda Katz
- Melissa Carr
- Melissa Gottschlich
- Melody Ronk
- Melody Werne
- Meredith McNairy
- Merlin Robb
- Mesha M. Chadwick
- Michael B. Butcher
- Michael C. Keefer
- Michael Cancilla
- Michael Cancilla
- Michael Chung
- Michael Delgado
- Michael Desjardins
- Michael E. Dever
- Michael Fay
- Michael J. Cotugno
- Michael J. Koren
- Michael J. McCartney
- Michael J. Smith
- Michael Jacobs
- Michael L. Levin
- Michael Lewis
- Michael P. Dube
- Michael R. Adams
- Michael Sciaudone
- Michael Waters
- Michele Baka
- Michele D. Reynolds
- Michele P. Andrasik
- Michele Vertucci
- Michelle DallaPiazza
- Michelle Dickey
- Michelle Haynes
- Michelle King
- Michelle L. Burgett
- Michelle Maxwell
- Michelle Saemann
- Mike Delgado
- Milagritos Tapia
- Mildred Stull
- Millie Manalo
- Milton Haber
- Mimi Van Der Leden
- Mira Baron
- Mitul Shah
- Mohamed S. Al-Ibrahim
- Mohammed Allaw
- Mohammed Antwi
- Monica B. Carrascal
- Monica Mauri
- Monica McArthur
- Monica Murray
- Monica Ruiz
- Morgan Hussey
- Morgan McLaughlin
- Mouna G. Chebib
- Murray A. Kimmel
- Nadine Rouphael
- Nafisa Saleem
- Najat Khan
- Nan Zhai
- Naomi Devine
- Natalia Leistner
- Natalie Ramirez
- Natasa Jenson
- Natasha Montoya
- Natasha Rybak
- Natasha Wilson
- Nathan Alderson
- Nathan Segall
- Neil P. Sheth
- Nelia Sanchez-Crespo
- Nelson Michael
- Nga Le
- Nicholas A. Viens
- Nicole Harrell
- Nicole L. Nollen
- Niles Eaton
- Nina Ahmad
- Njira Lucia Lugogo
- Nolan Mackey
- Norberto Fas
- Noris Peraita
- Norma Vega
- Nzeera Ketter
- Obiageli Sogbetun
- Odette Olivieri
- Oyebisi Olanrewaju
- Padma N. Mangu
- Pamela Kane
- Paola Lichtenberger
- Parke Hedges
- Parul Desai
- Patricia L. Winokur
- Patrick A. Oliver
- Patrick Flume
- Patrick Newingham
- Patty Howenstine
- Patty Price-Abbott
- Patty Reed
- Paul A. Goepfert
- Paul Bondy
- Paul Coplan
- Paul Cramer
- Paul E. Wylie
- Paul G. Matherne
- Paul H. Wakefield
- Paul J. Nugent
- Paul Kilgore
- Paul Nee
- Paul Pickrell
- Paul S. Bradley
- Paulina Miller
- Paulina Rebolledo
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- Peta-Gay Jackson-Booth
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- Purvi Parikh
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- Rafael Lupercio
- Rafael Mendoza
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- Rajesh K. Davit
- Rambod Rouhbakhsh
- Ramin Herati
- Ramy J. Toma
- Raphael J. Landovitz
- Raymond Cornelison
- Rebecca Boas
- Rebecca J. Kurnat
- Rebecca P. Madan
- Rebecca Pitotti
- Rebecca Zash
- Rebone M. Maboa
- Renea Henderson
- Reuben Martinez
- Reza Parungao
- Rhodna Fouts
- Rica Santiago
- Richard Calderone
- Richard Gorman
- Richard L. Gibson
- Richard M. Glover II
- Richard M. Novak
- Richard Powell
- Richard Rupp
- Richard Starlin
- Rickey D. Manning
- Riemke Brakema
- Ripley R. Hollister
- Robert Brownlee
- Robert J. Buynak
- Robert J. Ulrich
- Robert Jeanfreau
- Robert L. Atmar
- Robert M. Grossberg
- Robert Riesenberg
- Robert S. Call
- Robert Samuels
- Robert Schmidt
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- Robert W. Coombs
- Robert W. Frenck Jr.
- Roberto A. Viau Colindres
- Roberto C. Arduino
- Robin Hilder
- Robin Mason
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- Rodney E. Sturgeon
- Roger J. Bedimo
- Rola G. Rucker
- Ronald Ackerman
- Ronald Lubelchek
- Roni Gray
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- Rosamond Hong
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- Rozeli Shelly
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- Ruth S. Pinilla
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- Ryan Little
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- S. Hasan Naqvi
- Saadia Khizer
- Sabina Raja
- Sade Tukuru
- Sally Eppenbach
- Samantha Williams
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- Sandra Janeth Ortega DomĂnguez
- Sandra Kelman
- Sandra Shelton
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- Sarah Dzigiel
- Sarah E. Rutstein
- Sarah Galloway
- Sarah Gordon
- Sarah M. Ingalsbe-Geno
- Sarah Omodele
- Satoshi Kamidani
- Sauda Muhammad
- Scott Borgetti
- Scott Kahney
- Scott N. Syndergaard
- Sebastian Garcia Escallon
- Secia DĂaz-Miralrio
- Sergio E. Recuenco
- Sha-Wanda Richmond
- Shamika Huskey
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- Shanda Gower
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- Shannon Walker
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- Sharon E. Frey
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- Sharon Nachman
- Sharzhaad Molina Guizar
- Shashi Kapadia
- Shauna H. Gunaratne
- Sheetal Kandiah
- Shelby Olds
- Shelby Pickle
- Sherif Naguib
- Sherrie Baker
- Sherry Lamberth
- Sheryl L. Henderson
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- Shishir K. Khetan
- Shivanjali Shankaran
- Shobha Swaminathan
- Sigridh Muñoz-Gómez
- Siham Mahgoub
- Sikhongi Phungwayo
- Silvano Omar MartĂnez PĂ©rez
- Simbarashe G. Takuva
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- Sonal Munsiff
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- Sonja Neumeister
- Spyros A. Kalams
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- Stacy Ford
- Stacy Slechta
- Stanford Plavin
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- Stefanie Tyson
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- Stephan Hong
- Stephanie Andree
- Stephanie Rolsma
- Stephanie Skipper
- Stephanie Sterling
- Stephen A. Spector
- Stephen Daniels
- Stephen Morris
- Stephen R. Walsh
- Stephen R. Walsh
- Steve Clemons
- Steven E. Carsons
- Steven Palmer
- Steven Shinn
- Steven Shoptaw
- Steven Sperber
- Stuart H. Cohen
- Surisday Mederos
- Susan Jeanfreau
- Susan Kline
- Susan L. Koletar
- Susan Parker
- Susanne Doblecki-Lewis
- Suzanna Studdard
- Suzanne Fiorillo
- Suzanne Gharib
- Suzanne Swan
- Sybil G. Hosek
- Szheckera Fearon
- Tamara Richards
- Tambra Dora
- Tameika Scott
- Tami Wahlin
- Tammi L. Shlotzhauer
- Tana Bourgeois
- Tanya Hutchins
- Taryn Petty
- Tatiana Beresnev
- Tavane Harrison
- Taylor Nelson
- Teletha Gipson
- Teresa A. Batteiger
- Teresa Becker
- Teresa Deese
- Teresa S. Sligh
- Teri Thompson-Seim
- Terri Moye
- Terry D. Klein
- Terry L. Poling
- Terry Piedra
- Theresa Hegmann
- Thomas B. Campbell
- Thomas C. Klein
- Thomas C.S. Martin
- Thomas Mellman
- Thomas Patterson
- Thomas Weiss
- Tiffany Esinhart
- Tiffany Nemecek
- Tiffany Schwasinger-Schmidt
- Tilly Varughese
- Timothy J. Hatlen
- Timothy P. Vachris
- Timothy Shope
- Timothy W. Schacker
- Timothy Wilkin
- Tina Tong
- Tina Wang
- Toby Briskin
- Todd Simmons
- Tom Fiel
- Toni Robinson
- Toni White
- Tracy Okonya
- Tracy R. Klein
- Trina L. Reynolds
- Troy Holdeman
- Tyler D. Bold
- Uriel R. Felsen
- Valentine M. Ebuh
- Valeria D. Cantos
- Valerie K. Arnold
- Vanessa Abad
- Vanessa Raabe
- Veronica G. Fragoso
- Veronica Garcia-Fragoso
- Veronica Procasky
- Veronica Viar
- Vicki E. Miller
- Vickie Leathers
- Victoria Andriulis
- Victoria Engler
- Victoria Mosteller
- Victoria R. Anderson
- Vida Veronica Ruiz Herrera
- Vincent Huynh
- Vincent Mirkil
- Vivek Rajasekhar
- Viviana Gonzalez
- Vladimir Berthaud
- Walter Patton
- Wanda Ramon
- Waseem Chughtai
- Wayne L. Harper
- Wayne Woo
- Wendell Lewis
- Wendell Lewis III
- Wendy A. Keitel
- Wesley Campbell
- Wesley Van Ever
- Westly Keating
- Whitney West
- Will Hernandez
- William B. Davis
- William B. Smith
- William H. Jones
- William Jennings
- William Kirby
- William P. Silver
- William R. Hartman
- William S. Davis Jr.
- William Schnitz
- William Seger
- Winniberg Stephany Alvarez LeĂłn
- Winston Cavert
- Xiaomi Tong
- Yaa D. Oppong
- Yi H. Wu
- Ying Huang
- Yogesh K. Paliwal
- Youyi Fong
- Yunda Huang
- Yunda Huang
- Yvonne Davis
- Zachary Bittner
- Zainab Rizvi
- Zindy YazmĂn ZĂĄrate Hinojosa
- Zudi-Mwak Takizala
- Publication venue
- Elsevier
- Publication date
- 01/10/2023
- Field of study
Summary: Background: While vaccines have established utility against COVID-19, phase 3 efficacy studies have generally not comprehensively evaluated protection provided by previous infection or hybrid immunity (previous infection plus vaccination). Individual patient data from US government-supported harmonized vaccine trials provide an unprecedented sample population to address this issue. We characterized the protective efficacy of previous SARS-CoV-2 infection and hybrid immunity against COVID-19 early in the pandemic over three-to six-month follow-up and compared with vaccine-associated protection. Methods: In this post-hoc cross-protocol analysis of the Moderna, AstraZeneca, Janssen, and Novavax COVID-19 vaccine clinical trials, we allocated participants into four groups based on previous-infection status at enrolment and treatment: no previous infection/placebo; previous infection/placebo; no previous infection/vaccine; and previous infection/vaccine. The main outcome was RT-PCR-confirmed COVID-19 >7â15 days (per original protocols) after final study injection. We calculated crude and adjusted efficacy measures. Findings: Previous infection/placebo participants had a 92% decreased risk of future COVID-19 compared to no previous infection/placebo participants (overall hazard ratio [HR] ratio: 0.08; 95% CI: 0.05â0.13). Among single-dose Janssen participants, hybrid immunity conferred greater protection than vaccine alone (HR: 0.03; 95% CI: 0.01â0.10). Too few infections were observed to draw statistical inferences comparing hybrid immunity to vaccine alone for other trials. Vaccination, previous infection, and hybrid immunity all provided near-complete protection against severe disease. Interpretation: Previous infection, any hybrid immunity, and two-dose vaccination all provided substantial protection against symptomatic and severe COVID-19 through the early Delta period. Thus, as a surrogate for natural infection, vaccination remains the safest approach to protection. Funding: National Institutes of Health