The Don de langue and the archival pledge: Dado's Les Oiseaux d’Irène and Némirovsky's Suite française

© Edinburgh University Press. Accepted manuscript version deposited in accordance with SHERPA RoMEO guidelines. The definitive version is available at http://www.euppublishing.com/doi/abs/10.3366/nfs.2012.0031.This article considers the underlying archival poetics of the collaboration between the artist Dado (Miodrag Djuric) and the author Claude Louis-Combet. In particular I consider the collaborative work Les Oiseaux d'Irène (2007), in which a specific archival encounter is documented: Dado appeals to the imaginary figure of Irène Némirovsky while simultaneously engaging with the unique history of the manuscript of Némirovsky's Suite française. Dado's illustrations of Némirovsky's manuscript folios point to a deep ethical engagement with the archive which recalls the function of the manuscript as pledge and legacy in Némirovsky's biography. The archival function is related, via Derrida's account of the archive, to the late phase of Dado's work in which the creation of an internet archive, L'Anti-musée virtuel, is accompanied by the creation of a second Dado archive, at IMEC

Néomorts et faux vivants: communautés dépeuplées chez Beckett et Agamben

Post print version deposited in accordance with SHERPA RoMEO guidelines. The definitive version is available at http://www.rodopi.nl/senj.asp?BookId=BECKETT+17.This article reworks and recontextualises the problematic of the unspeakable in Beckett’s Le Dépeupleur by reference to the recent work of Giorgio Agamben, and in particular the analysis of the figure of the Muselmann in Ce qui reste d’Auschwitz. As well as producing textual parallels with the ‘vaincu’ in Le Dépeupleur, the association of the Muselmann with unspeakability, exclusion and exception in Agamben’s work allows new light to be shed on the elusive project of Beckett’s text. In both cases, representation is avowedly impossible: while the narrative structure of Le Dépeupleur turns on a series of internal ‘errors’, Agamben’s theory in Ce qui reste d’Auschwitz is based on the impossible testimony of the Muselmann, a figure who by definition cannot bear witness

The inadequate archive: ethical remaking in Silvia Kolbowski’s After Hiroshima mon amour

© The Author(s) 2013. Accepted version deposited in accordance with SHERPA RoMEO guidelines. The definitive version is available at http://frc.sagepub.com/content/24/4/417.abstract.This article considers Silvia Kolbowski’s video installation After Hiroshima mon amour as an instance of ethical remaking. In remaking Duras and Resnais’s Hiroshima mon amour (1959) in the shadow of the Iraq war, Kolbowski taps into an existing repetition dynamic: Kolbowski foregrounds the impossibility of an end to the conflict in Iraq by reference to a film concerned with the memorial persistence of Hiroshima. Kolbowski’s practice further recalls the concern with remaking in Derrida’s account of archive fever. In Derrida, to archive is both to record and to erase: repetition compulsion is bound up with the death drive. Kolbowski contests Derrida’s conception of the archive by reshaping the memory and amnesia of Hiroshima mon amour through two interrelated strategies: first, an iterative process focusing on a film which is itself concerned with repetition; and, second, by problematising the classification and archiving of her own work

MEETING OF THE COMMISSION ON THE SOCIAL DETERMINANTS OF HEALTH

Objectives a. Consultation with Canadian Government b. Consultation on indigenous health c. Expert comments on interim statemen

Clusters of Galaxies and the Diffuse Gamma Ray Background

We discuss the diffuse emission of gamma rays and neutrinos from galaxy clusters in the viable models for structure formation in the universe. We use a self-consistent picture for cluster formation and evolution starting from a primordial density perturbation spectrum, and a realistic modelling for the distribution of the intergalactic medium which is abundantly present within galaxy clusters. We find that an evolving population of clusters can produce a fraction $\sim 0.5 \div 2$ of the diffuse gamma-ray background (DGRB) observed by EGRET. This result is robust and is weakly dependent on the cosmological scenario and on the degree of evolution of the inter galactic medium (IGM) in distant clusters, because the bulk of the sources contributing to the DGRB is located at redshifts z \simlt 0.2. We also found a correlation between the non-thermal, gamma-ray and the thermal X-ray emissions from these structures. Using this result, we derived a list of gamma-ray clusters observable with the next generation $\gamma$-ray detectors. Finally, we briefly discuss the possible relevance of galaxy clusters for neutrino astronomy and for very high energy particle astronomy.Comment: 37 pages, 9 Figures, Latex (using elsart,epsfig), to appear in Astroparticle Physics. Send comments to S.Colafrancesco: [email protected]

Earthquakes: from chemical alteration to mechanical rupture

In the standard rebound theory of earthquakes, elastic deformation energy is progressively stored in the crust until a threshold is reached at which it is suddenly released in an earthquake. We review three important paradoxes, the strain paradox, the stress paradox and the heat flow paradox, that are difficult to account for in this picture, either individually or when taken together. Resolutions of these paradoxes usually call for additional assumptions on the nature of the rupture process (such as novel modes of deformations and ruptures) prior to and/or during an earthquake, on the nature of the fault and on the effect of trapped fluids within the crust at seismogenic depths. We review the evidence for the essential importance of water and its interaction with the modes of deformations. Water is usually seen to have mainly the mechanical effect of decreasing the normal lithostatic stress in the fault core on one hand and to weaken rock materials via hydrolytic weakening and stress corrosion on the other hand. We also review the evidences that water plays a major role in the alteration of minerals subjected to finite strains into other structures in out-of-equilibrium conditions. This suggests novel exciting routes to understand what is an earthquake, that requires to develop a truly multidisciplinary approach involving mineral chemistry, geology, rupture mechanics and statistical physics.Comment: 44 pages, 1 figures, submitted to Physics Report

Association of Dietary Factors with Presence and Severity of Tinnitus in a Middle-Aged UK Population

Objective The impact of dietary factors on tinnitus has received limited research attention, despite being a considerable concern among people with tinnitus and clinicians. The objective was to examine the link between dietary factors and presence and severity of tinnitus. Design This study used the UK Biobank resource, a large cross-sectional study of adults aged 40–69. 171,722 eligible participants were asked questions specific to tinnitus (defined as noises such as ringing or buzzing in the head or ears). Dietary factors included portions of fruit and vegetables per day, weekly fish consumption (oily and non-oily), bread type, cups of caffeinated coffee per day, and avoidance of dairy, eggs, wheat and sugar. We controlled for lifestyle, noise exposure, hearing, personality and comorbidity factors. Results Persistent tinnitus, defined as present at least a lot of the time, was elevated with increased: (i) fruit/vegetable intake (OR = 1.01 per portion/day), (ii) bread (wholemeal/wholegrain, OR = 1.07; other bread, 1.20) and (iii) dairy avoidance (OR = 1.27). Persistent tinnitus was reduced with: (i) fish consumption (non-oily, OR = 0.91; oily, 0.95), (ii) egg avoidance (OR = 0.87) and (iii) caffeinated coffee consumption (OR = 0.99 per cup/day). Reports of “bothersome” tinnitus (moderate-severe handicap) increased with wholemeal/wholegrain bread intake (OR = 0.86). Reports of less frequent transient tinnitus increased with dairy avoidance (OR = 1.18) and decreased with caffeinated coffee (OR = 0.98 per cup/day) and brown bread (OR = 0.94). Conclusions This is the first population study to report the association between dietary factors and tinnitus. Although individually dietary associations are mostly modest, particular changes in diet, such as switching between foodstuffs, may result in stronger associations. These findings offer insights into possible dietary associations with tinnitus, and this may be useful when discussing management options in combination with other lifestyle changes and therapies

Towards an understanding of the information and support needs of surgical adolescent idiopathic scoliosis patients: a qualitative analysis

<p>Abstract</p> <p>Background</p> <p>Informed decision making for adolescents and families considering surgery for scoliosis requires essential information, including expected outcomes with or without treatment and the associated risks and benefits of treatment. Ideally families should also receive support in response to their individual concerns. The aim of this study was to identify health-specific needs for online information and support for patients with adolescent idiopathic scoliosis who have had or anticipate having spinal surgery.</p> <p>Methods</p> <p>Focus group methodology was chosen as the primary method of data collection to encourage shared understandings, as well as permit expression of specific, individual views. Participants were considered eligible to participate if they had either experienced or were anticipating surgery for adolescent idiopathic scoliosis within 12 months, were between the ages of 10 and 18 years of age, and were English-speaking.</p> <p>Results</p> <p>Two focus groups consisting of 8 adolescents (1 male, 7 female) and subsequent individual interviews with 3 adolescents (1 male, 2 female) yielded a range of participant concerns, in order of prominence: (1) recovery at home; (2) recovery in hospital; (3) post-surgical appearance; (4) emotional impact of surgery and coping; (5) intrusion of surgery and recovery of daily activities; (6) impact of surgery on school, peer relationships and other social interactions; (7) decision-making about surgery; (8) being in the operating room and; (9) future worries.</p> <p>Conclusion</p> <p>In conclusion, adolescents welcomed the possibility of an accessible, youth-focused website with comprehensive and accurate information that would include the opportunity for health professional-moderated, online peer support.</p

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN