Technology Support for Smart Computational Grid (SCG) in Future Wireless Systems

The communication grid is an emerging infrastructure that will fundamentally change the way we think – and use – computing. Communication grid is used by analogy with the electric power grid, as an infrastructure that provides pervasive access to electricity. Like the computer and a small number of other advances had a dramatic impact on human capabilities and utilization of the scarce frequency resource, it is believed that allowing all components of our information technology infrastructure – computational capabilities, databases, sensors, and people – to be shared flexibly as true collaborative tools, the Smart Computational Grid (SCG) will have a similar transforming effect, allowing new classes of applications to emerge. Improvement in spectrum usage achieved by CR technology and associated collaborative computations on white spaces. Every spectrum hole includes several channels. Implementing collaborative algorithms over the channels help track changing environment parameters and managed to achieve smooth handoffs, which is maximized to offer services ranging from low-data-rate non-rea-time applications to high-speed real-time multimedia applications. With virtualization, the heterogeneous wireless access networks complement each other to deliver maximal signal strength, wider coverage, efficient data rate, low latency and reduced loss rate. Keywords: computation, detection, grid, sensing, virtualization DOI: 10.7176/CEIS/10-7-04 Publication date: November 30th 201

Determination of work index of graphite from Samanburkono (Nigeria) using modified bond's method

This report covers the work index determination of Saman-Burkono graphite. The test sample was obtained from Saman-Burkono in Ningi Local Government Area of Bauchi state, while reference material (coal) was sourced from Okaba coal mine, Ankpa Local Government Area of Kogi State. A known weight of graphite sample and coal were crushed, pulverized and ground using the laboratory milling machine. The two samples were grinded with two cells of diameter 3.5cm and 222g weight. The analysis of the feed size fort the two samples was found graphically to be 180μm and 175μm, and ball mill discharge was 130μm and 140μm respectively. The work index of a coal as reference material was 7.65 kWh/ short ton, this was used to calculate the work index of the graphite which was found to be 11.047 kWh/short ton, being the required energy to comminute one ton of graphite.Keywords: Comminution, Graphite, Saman-Burkono, Nigeria, Modified Bonds metho

Avanços recentes em nutrição de larvas de peixes

Os requisitos nutricionais de larvas de peixes são ainda mal compreendidos, o que leva a altas mortalidades e problemas de qualidade no seu cultivo. Este trabalho pretende fazer uma revisão de novas metodologias de investigação, tais como estudos com marcadores, genómica populacional, programação nutricional, génomica e proteómica funcionais, e fornecer ainda alguns exemplos das utilizações presentes e perspectivas futuras em estudos de nutrição de larvas de peixes

The phenotypic spectrum of WWOX -related disorders: 20 additional cases of WOREE syndrome and review of the literature

Purpose: Germline WWOX pathogenic variants have been associated with disorder of sex differentiation (DSD), spinocerebellar ataxia (SCA), and WWOX-related epileptic encephalopathy (WOREE syndrome). We review clinical and molecular data on WWOX-related disorders, further describing WOREE syndrome and phenotype/genotype correlations. Methods: We report clinical and molecular findings in 20 additional patients from 18 unrelated families with WOREE syndrome and biallelic pathogenic variants in the WWOX gene. Different molecular screening approaches were used (quantitative polymerase chain reaction/multiplex ligation-dependent probe amplification [qPCR/MLPA], array comparative genomic hybridization [array-CGH], Sanger sequencing, epilepsy gene panel, exome sequencing). Results: Two copy-number variations (CNVs) or two single-nucleotide variations (SNVs) were found respectively in four and nine families, with compound heterozygosity for one SNV and one CNV in five families. Eight novel missense pathogenic variants have been described. By aggregating our patients with all cases reported in the literature, 37 patients from 27 families with WOREE syndrome are known. This review suggests WOREE syndrome is a very severe epileptic encephalopathy characterized by absence of language development and acquisition of walking, early-onset drug-resistant seizures, ophthalmological involvement, and a high likelihood of premature death. The most severe clinical presentation seems to be associated with null genotypes. Conclusion: Germline pathogenic variants in WWOX are clearly associated with a severe early-onset epileptic encephalopathy. We report here the largest cohort of individuals with WOREE syndrome

Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020

We show the distribution of SARS-CoV-2 genetic clades over time and between countries and outline potential genomic surveillance objectives. We applied three available genomic nomenclature systems for SARS-CoV-2 to all sequence data from the WHO European Region available during the COVID-19 pandemic until 10 July 2020. We highlight the importance of real-time sequencing and data dissemination in a pandemic situation. We provide a comparison of the nomenclatures and lay a foundation for future European genomic surveillance of SARS-CoV-2.Peer reviewe

Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

Background: Understanding the health consequences associated with exposure to risk factors is necessary to inform public health policy and practice. To systematically quantify the contributions of risk factor exposures to specific health outcomes, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 aims to provide comprehensive estimates of exposure levels, relative health risks, and attributable burden of disease for 88 risk factors in 204 countries and territories and 811 subnational locations, from 1990 to 2021. Methods: The GBD 2021 risk factor analysis used data from 54 561 total distinct sources to produce epidemiological estimates for 88 risk factors and their associated health outcomes for a total of 631 risk–outcome pairs. Pairs were included on the basis of data-driven determination of a risk–outcome association. Age-sex-location-year-specific estimates were generated at global, regional, and national levels. Our approach followed the comparative risk assessment framework predicated on a causal web of hierarchically organised, potentially combinative, modifiable risks. Relative risks (RRs) of a given outcome occurring as a function of risk factor exposure were estimated separately for each risk–outcome pair, and summary exposure values (SEVs), representing risk-weighted exposure prevalence, and theoretical minimum risk exposure levels (TMRELs) were estimated for each risk factor. These estimates were used to calculate the population attributable fraction (PAF; ie, the proportional change in health risk that would occur if exposure to a risk factor were reduced to the TMREL). The product of PAFs and disease burden associated with a given outcome, measured in disability-adjusted life-years (DALYs), yielded measures of attributable burden (ie, the proportion of total disease burden attributable to a particular risk factor or combination of risk factors). Adjustments for mediation were applied to account for relationships involving risk factors that act indirectly on outcomes via intermediate risks. Attributable burden estimates were stratified by Socio-demographic Index (SDI) quintile and presented as counts, age-standardised rates, and rankings. To complement estimates of RR and attributable burden, newly developed burden of proof risk function (BPRF) methods were applied to yield supplementary, conservative interpretations of risk–outcome associations based on the consistency of underlying evidence, accounting for unexplained heterogeneity between input data from different studies. Estimates reported represent the mean value across 500 draws from the estimate's distribution, with 95% uncertainty intervals (UIs) calculated as the 2·5th and 97·5th percentile values across the draws. Findings: Among the specific risk factors analysed for this study, particulate matter air pollution was the leading contributor to the global disease burden in 2021, contributing 8·0% (95% UI 6·7–9·4) of total DALYs, followed by high systolic blood pressure (SBP; 7·8% [6·4–9·2]), smoking (5·7% [4·7–6·8]), low birthweight and short gestation (5·6% [4·8–6·3]), and high fasting plasma glucose (FPG; 5·4% [4·8–6·0]). For younger demographics (ie, those aged 0–4 years and 5–14 years), risks such as low birthweight and short gestation and unsafe water, sanitation, and handwashing (WaSH) were among the leading risk factors, while for older age groups, metabolic risks such as high SBP, high body-mass index (BMI), high FPG, and high LDL cholesterol had a greater impact. From 2000 to 2021, there was an observable shift in global health challenges, marked by a decline in the number of all-age DALYs broadly attributable to behavioural risks (decrease of 20·7% [13·9–27·7]) and environmental and occupational risks (decrease of 22·0% [15·5–28·8]), coupled with a 49·4% (42·3–56·9) increase in DALYs attributable to metabolic risks, all reflecting ageing populations and changing lifestyles on a global scale. Age-standardised global DALY rates attributable to high BMI and high FPG rose considerably (15·7% [9·9–21·7] for high BMI and 7·9% [3·3–12·9] for high FPG) over this period, with exposure to these risks increasing annually at rates of 1·8% (1·6–1·9) for high BMI and 1·3% (1·1–1·5) for high FPG. By contrast, the global risk-attributable burden and exposure to many other risk factors declined, notably for risks such as child growth failure and unsafe water source, with age-standardised attributable DALYs decreasing by 71·5% (64·4–78·8) for child growth failure and 66·3% (60·2–72·0) for unsafe water source. We separated risk factors into three groups according to trajectory over time: those with a decreasing attributable burden, due largely to declining risk exposure (eg, diet high in trans-fat and household air pollution) but also to proportionally smaller child and youth populations (eg, child and maternal malnutrition); those for which the burden increased moderately in spite of declining risk exposure, due largely to population ageing (eg, smoking); and those for which the burden increased considerably due to both increasing risk exposure and population ageing (eg, ambient particulate matter air pollution, high BMI, high FPG, and high SBP). Interpretation: Substantial progress has been made in reducing the global disease burden attributable to a range of risk factors, particularly those related to maternal and child health, WaSH, and household air pollution. Maintaining efforts to minimise the impact of these risk factors, especially in low SDI locations, is necessary to sustain progress. Successes in moderating the smoking-related burden by reducing risk exposure highlight the need to advance policies that reduce exposure to other leading risk factors such as ambient particulate matter air pollution and high SBP. Troubling increases in high FPG, high BMI, and other risk factors related to obesity and metabolic syndrome indicate an urgent need to identify and implement interventions. Funding: Bill & Melinda Gates Foundation

Densification and properties of superhard B6O materials with cobalt additions

The search for suitable additives for boron suboxide (B 6O) materials which could improve densification, reduce sintering temperature and tailor the microstructure has been productive. B 6O materials doped with 0-5vol% cobalt addition were sintered at temperatures up to 1850°C and pressure of 50MPa for 20min. Relationships between the formed phases, microstructures and mechanical properties of the sintered materials were investigated as a function of sintering conditions and added cobalt content. The hardness of the sintered B 6O materials increases with sintering temperature, while the fracture toughness increases with increasing cobalt content and reduces with increasing sintering temperature

Improvement on the fabrication of SiC materials: Processing, reinforcing phase, fabricating route—A review

Abstracts: The ceaseless exploration for the improvement of ceramic materials has created a lot of techniques, all aimed at producing ceramic materials that can withstand environmental conditions and other factors. Most of thecommon techniques have their advantages and drawbacks. Some of the techniques involve the addition of a reinforcing phase to monolithic ceramic, the application of diverse sintering routes for the fabrication of ceramic products, and the preparatory methods for producing powder materials which cannot be jettisoned. These processes have been evaluated to influence the final ceramic products. Undoped/monolithic/single-phase ceramic has had some limitations in its processing, densification, and mechanical properties limiting its wide application in all circumstances. Hence, the incorporation of reinforcing phase, which can sometimes be called the secondary phase in the ceramic matrix, has significantly evolved into one of the possible means to nullify these challenges posed by undoped ceramics. This review consciously highlights and pinpoints all routes that have been taken to improve the properties of undoped SiC via the introduction of reinforcing phase, processing techniques, sintering techniques, etc. Finally, the possible prospects for future directions, advancement, and opportunities in the production of ceramic materials are concluded