Usable Interface Design for Everyone

En el diseño de "interfaces para todo el mundo" para los sistemas interactivos, es importante tener en cuenta factores como el costo, el mercado de destino, el estado del medio ambiente,etc. Los interfaces de usuario son fundamentales para el proceso de desarrollo de cualquier aplicación, y su diseño debe estar contemplado desde el principio. De las distintas partes de un sistema (hardware y software), es la interfaz el sistema que permite al usuario el acceso a los recursos informáticos. Los siete principios del "Diseño Universal" o "Diseño para Todos" se centran en un diseño utilizable universal, pero al mismo tiempo reconocer la influencia de factores internos y externos. Los cambios estructurales en los servicios sociales y de salud podrían proporcionar un aumento en el bienestar de los ciudadanos de un país a través del uso de la programación de auto-cuidado y la gestión proactiva / prevención de la enfermedad. Plataformas automatizadas en el hogar pueden actuar como un instrumento que permitan a los usuarios evitar, compensar, mitigar o neutralizar las deficiencias y las dependencias causada por el envejecimiento.When designing “interfaces for everyone” for interactive systems, it is important to consider factors such as cost, the intended market, the state of the environment, etc. User interfaces are fundamental for the developmental process in any application, and its design must be contemplated from the start. Of the distinct parts of a system (hardware and software), it is the interface that permits the user access to computer resources. The seven principles of “Universal Design” or “Design for Everyone” focus on a universal usable design, but at the same time acknowledge the influences of internal and external factors. Structural changes in social and health services could provide an increase in the well-being of a country’s citizens through the use of self-care programming and proactive management/prevention of disease. Automated home platforms can act as an accessibility instrument which permits users to avoid, compensate, mitigate, or neutralize the deficiencies and dependencies caused by living alon

CORTEZA PREFRONTAL HUMANA: ÁREAS 10m, 11o Y 46d CITOARQUITECTURA E IMPLICACIONES FUNCIONALES

RESUMENEn este artículo se presenta información referente a la organización citoarquitectónica de la región prefrontal de la corteza cerebral humana; en particular, de las tres superficies que la conforman: "Medial", "orbital" y "lateral". Para obtener esta información se recogieron muestras post-mortem del Instituto de Medicina Legal y Ciencias Forenses, regional Bogotá de cinco sujetos humanos, específicamente de las áreas 10 medial, 11 orbital y 46 lateral.Estos tejidos fueron tratados mediante procedimientos de inmunohistoquímica, para el anticuerpo monoclonal NeuN, el cual marca la población completa de neuronas corticales. De este material se realizaron registros fotográficos sistemáticos, en los cuales se practicaron mediciones tanto del espesor cortical, como del espesor relativo de cada una de sus láminas. Estos datos se sometieron a análisis de varianza de una vía, para determinar el grado de similitud o diferencia entre las distintas áreas.Los resultados muestran patrones de organización laminar, que se diferencian en distinto grado, de las descripciones realizadas mediante tinciones celulares básicas, como la tinción de Nisssl. En general se encuentra una mayor homogeneidad entre las cortezas procedentes de las superficies orbital y medial, mientras que la superficie lateral presenta características diferenciales respecto de las dos anteriores. El análisis de estos patrones, se consideró a la luz del concepto de acuerdo con el cual, la organización citoarquitectónica permite predecir los patrones de conectividad y estos a su vez permiten realizar inferencias sobre la función.Palabras Claves: Corteza Prefrontal, citoarquitectura, NeuN. ABSTRACT In the present paper the cytoachitecture of the human prefrontal cortex is presented, particularly sectors from areas 10-medial, 11-orbital and 46-lateral. Brain tissue samples were obtained from post- morten material of five human subjects from the Instituto de Medicina Legal y Ciencias Forenses, regional Bogotá. Tissue was processed by means of immuno-hystochemical procedures, with the monoclonal anti-body NeuN, which stains the total population of cortical neurons. Systematic photographic registers were performed, as well as measurements of cortical depth and the relative thickness of each layer. This data were analyzed with one way ANOVA, in order to evaluate the degree of similitude or difference among the areas considered.The results show a pattern of laminar organization, which differs in variable degrees, from that obtained with basic cellular staining, such as Nissl. As a general trend it was found more homogeneity between cortices from orbital and medial surfaces, while the lateral surface showed different characteristics when compared with the other cortical sectors considered. The analysis of these patterns were discuss considering that the cytoachitectonic organization may predicts the connectivity allowing to draw inferences regarding function.Key Words: Prefrontal Cortex, Cytoarchitecture, NeuN, Human

CORTEZA PREFRONTAL HUMANA: ÁREAS 10m, 11o Y 46d CITOARQUITECTURA E IMPLICACIONES FUNCIONALES

RESUMENEn este artículo se presenta información referente a la organización citoarquitectónica de la región prefrontal de la corteza cerebral humana; en particular, de las tres superficies que la conforman: "Medial", "orbital" y "lateral". Para obtener esta información se recogieron muestras post-mortem del Instituto de Medicina Legal y Ciencias Forenses, regional Bogotá de cinco sujetos humanos, específicamente de las áreas 10 medial, 11 orbital y 46 lateral.Estos tejidos fueron tratados mediante procedimientos de inmunohistoquímica, para el anticuerpo monoclonal NeuN, el cual marca la población completa de neuronas corticales. De este material se realizaron registros fotográficos sistemáticos, en los cuales se practicaron mediciones tanto del espesor cortical, como del espesor relativo de cada una de sus láminas. Estos datos se sometieron a análisis de varianza de una vía, para determinar el grado de similitud o diferencia entre las distintas áreas.Los resultados muestran patrones de organización laminar, que se diferencian en distinto grado, de las descripciones realizadas mediante tinciones celulares básicas, como la tinción de Nisssl. En general se encuentra una mayor homogeneidad entre las cortezas procedentes de las superficies orbital y medial, mientras que la superficie lateral presenta características diferenciales respecto de las dos anteriores. El análisis de estos patrones, se consideró a la luz del concepto de acuerdo con el cual, la organización citoarquitectónica permite predecir los patrones de conectividad y estos a su vez permiten realizar inferencias sobre la función.Palabras Claves: Corteza Prefrontal, citoarquitectura, NeuN. ABSTRACT In the present paper the cytoachitecture of the human prefrontal cortex is presented, particularly sectors from areas 10-medial, 11-orbital and 46-lateral. Brain tissue samples were obtained from post- morten material of five human subjects from the Instituto de Medicina Legal y Ciencias Forenses, regional Bogotá. Tissue was processed by means of immuno-hystochemical procedures, with the monoclonal anti-body NeuN, which stains the total population of cortical neurons. Systematic photographic registers were performed, as well as measurements of cortical depth and the relative thickness of each layer. This data were analyzed with one way ANOVA, in order to evaluate the degree of similitude or difference among the areas considered.The results show a pattern of laminar organization, which differs in variable degrees, from that obtained with basic cellular staining, such as Nissl. As a general trend it was found more homogeneity between cortices from orbital and medial surfaces, while the lateral surface showed different characteristics when compared with the other cortical sectors considered. The analysis of these patterns were discuss considering that the cytoachitectonic organization may predicts the connectivity allowing to draw inferences regarding function.Key Words: Prefrontal Cortex, Cytoarchitecture, NeuN, Human

Developability Assessment of Physicochemical Properties and Stability Profiles of HIV-1 BG505 SOSIP.664 and BG505 SOSIP.v4.1-GT1.1 gp140 Envelope Glycoprotein Trimers as Candidate Vaccine Antigens

This work is licensed under a Creative Commons Attribution 4.0 International License.The induction of broadly neutralizing antibodies (bNAbs) is a major goal in the development of an effective vaccine against HIV-1. A soluble, trimeric, germline (gI) bNAb-targeting variant of the HIV-1 envelope glycoprotein (termed BG505 SOSIP.v4.1-GT1.1 gp140, abbreviated to GT1.1) has recently been developed. Here, we have compared this new immunogen with the parental trimer from which it was derived, BG505 SOSIP.664 gp140. We used a comprehensive suite of biochemical and biophysical methods to determine physicochemical similarities and differences between the 2 trimers, and thereby assessed whether additional formulation development efforts were needed for the GT1.1 vaccine candidate. The overall higher order structure and oligomeric states of the 2 vaccine antigens were quite similar, as were their thermal, chemical, and colloidal stability profiles, as evaluated during accelerated stability studies. Overall, we conclude that the primary sequence changes made to create the gl bNAb-targeting GT1.1 trimer did not detrimentally affect its physicochemical properties or stability profiles from a pharmaceutical perspective. This developability assessment of the BG505 GT1.1 vaccine antigen supports using the formulation and storage conditions previously identified for the parental SOSIP.664 trimer and enables the development of GT1.1 for phase I clinical studies.Bill and Melinda Gates Foundation Collaboration for AIDS Vaccine Development (OPP1147661)Bill and Melinda Gates Foundation Collaboration for AIDS Vaccine Development (OPP1153692)NIH HIVRAD grant P01 AI 110657Aids Fonds grant 201601

Benchmark Workshop on selected stocks in the Western Waters in 2021 (WKWEST).

The goal of a benchmark is consensus agreement on an assessment methodology that is to be used in future update assessments. This assessment methodology can be an analytical assessment, but can also be non-analytical, for instance based on trends in an assessment or in a selected set of (survey) indicators, with or without forecasts. The result will be the 'best available' method that ICES advice will be based on. WKWEST 2021 dealt with the following stocks: Sardine (Sardina pilchardus) in Subarea 7 (southern Celtic Seas, and the English Channel); Pollack (Pollachius pollachius) in subareas 6-7 (Celtic Seas and the English Channel); Red gurnard (Chelidonichthys cuculus) in subareas 3–8 (Northeast Atlantic); Plaice (Pleuronectes platessa) in divisions 7.h–k (Celtic Sea South, southwest of Ireland); Sole (Solea solea) in divisions 8.c and 9.a (Cantabrian Sea and Atlantic Iberian waters)

El sujeto contemporáneo : una perspectiva analítico-filosófica

RESUMEN: El sujeto contemporáneo: una perspectiva analítico-filosófica, es el producto del Seminario Internacional que lleva su mismo nombre, realizado en la ciudad de Medellín durante los días 24 a 26 de mayo de 2007 en la Universidad de Antioquia, bajo el auspicio del Departamento de Psicoanálisis y el Grupo de Investigación Psicoanálisis, sujeto y sociedad. Los invitados, los doctores Gabriel Lombardi, Juan Guillermo Uribe, Juan Fernando Pérez, Juan Manuel Uribe, John Fredy Lenis y Luis Antonio Ramírez, psicoanalistas y filósofos, encararon con decisión y rigurosidad un par de conceptos centrales en el desarrollo de Occidente y que, necesariamente discutibles, son motivo de debate teorético en el espacio de la contemporaneidad pensante

Changes in Life History Traits of Small Pelagic Fish in the Western Mediterranean Sea

21 pages, 8 figures, 3 tables, supplementary material https://www.frontiersin.org/articles/10.3389/fmars.2021.570354/full#supplementary-material.-- Data Availability Statement: The datasets presented in this article are not readily available because the dataset is available by request to the Spanish Institute of Oceanography. Requests to access the datasets should be directed to [email protected] pelagic fish (SPF) in the western Mediterranean Sea are key elements of the marine food web and are important in terms of biomass and fisheries catches. Significant declines in biomass, landings, and changes in the age/size structure of sardine Sardina pilchardus and anchovy Engraulis encrasicolus have been observed in recent decades, particularly in the northern area of the western Mediterranean Sea. To understand the different patterns observed in SPF populations, we analyzed key life history traits [total length at age, length at maturity, gonadosomatic index (GSI), and body condition (Kn)] of sardine and anchovy collected between 2003 and 2017, from different fishing harbors distributed along a latitudinal gradient from northern to southern Spain. We used Generalized Linear Models (GLM) to estimate the length at maturity and Generalized Additive Models (GAMs) to test the relationship with environmental variables (seawater temperature, water currents, and net primary productivity). The life history traits of both species presented seasonal, interannual and latitudinal differences with a clear decline in length at age, length at first maturity, and body condition, for both species in the northern part of the study area. In the southern part, on the contrary, life history traits did not present a clear temporal trend. The environmental conditions partially explained the long-term changes in life history traits, but the selected variables differed between areas, highlighting the importance of regional oceanographic conditions to understand the dynamics of small pelagic fish. The truncated length-at-age pattern for both species with the disappearance of the larger individuals of the population could have contributed to the poor condition of small pelagic fish populations in the northern part of the western Mediterranean Sea in recent years. In the south area, recent declines in body condition for sardine and anchovy were observed and could be a possible first sign for future population declines. This study highlights the importance of understanding the trade-off between the energy invested in reproduction, maintenance and growth at seasonal and interannual level to advance our knowledge on how environmental and human pressures influence population dynamics of small pelagic fish at local and regional scalesThis study was carried out within the Spanish Research project PELWEB (CTM2017-88939-R) funded by Spanish Ministry of Science, Innovation and Universities and the European Research Contract SPELMED (SC NR 02-TENDER EASME/EMFF/2016/032XXX) funded by EC EASME. Fisheries data collection has been co-funded by the EU through the European Maritime and Fisheries Fund (EMFF) within the National Program of collection, management and use of data in the fisheries sector and support for scientific advice regarding the Common Fisheries Policy (Regulation, EU 2017/1004)With funding from the Spanish government through the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2019-000928-S)Peer reviewe

Absceso cerebral por Cladophialophora bantiana en un paciente con trasplante renal: reporte de un caso

Cerebral feohifomycosis are severe infections caused by dematiaceous fungi. Cladophialophora bantiana is one of the most commonly isolated species; it has central nervous system tropism and it often manifests as a brain abscess in immunocompetent patients. In immunocompromised patients, it can lead to brain abscesses and disseminated infections.Despite the availability of broad-spectrum antifungal drugs, it is a must to perform surgical management, in addition to drug therapy. However, mortality is high. The diagnostic approach must be invasive to establish a timely diagnosis and direct treatment based on culture and susceptibility tests.We report a case of brain abscess caused by C. bantiana in an immunosuppressed patient who was treated with surgical resection and voriconazole with an adequate response to therapy and without neurological sequels.Las feohifomicosis cerebrales son infecciones graves causadas por mohos dematiáceos, entre los cuales Cladophialophora bantiana es una de las especies más comúnmente aislada. Esta tiene tropismo por el sistema nervioso central y frecuentemente produce abscesos cerebrales en pacientes inmunocompetentes; además, en los inmunocomprometidos también puede ocasionar infección diseminada.Pese a la disponibilidad de medicamentos antifúngicos de amplio espectro, a menudo se requiere también la intervención quirúrgica; de todas maneras, la mortalidad es elevada.El diagnóstico debe hacerse interviniendo para tomar la muestra y hacer el cultivo y las pruebas de sensibilidad.Se presenta aquí el caso de un paciente con trasplante renal que presentó un absceso cerebral por C. bantiana, el cual se extrajo mediante resección quirúrgica. El paciente recibió tratamiento con voriconazol, con adecuada respuesta, mejoría y sin secuelas neurológicas

The state of the Martian climate

60°N was +2.0°C, relative to the 1981–2010 average value (Fig. 5.1). This marks a new high for the record. The average annual surface air temperature (SAT) anomaly for 2016 for land stations north of starting in 1900, and is a significant increase over the previous highest value of +1.2°C, which was observed in 2007, 2011, and 2015. Average global annual temperatures also showed record values in 2015 and 2016. Currently, the Arctic is warming at more than twice the rate of lower latitudes