104 research outputs found
Effect of Maternal Nutrition on Fetal Adipocyte Development
The objective of this experiment was to determine the effects of maternal nutrition on the expression of genes in fetal tissues. Genes of interest were selected because each has been demonstrated previously to influence body composition. Twenty‐two Angus‐cross bred heifers (BW = 1161 ± 19 lbs) randomly were assigned to three dietary treatments. Maternal dietary treatments were formulated and intake was controlled to provide 150% (HIGH), 100% (INT), and 80% (LOW) of maintenance energy requirements for growing pregnant Angus heifers (NRC, 2000). Heifers were on dietary treatment from d 85 to d 180 of gestation, at which point fetuses were removed via cesarean section and muscle, subcutaneous fat, and liver samples were collected. At trial initiation dam BW was similar between treatment groups. Dam BW differed (P = 0.002) at the end of the treatment period as a result of dietary treatment. Final BW was lowest for the LOW dams, intermediate for INT dams, and highest for HIGH dams. Both ribfat thickness and ribeye area were increased in the HIGH treatment group compared with LOW and INT dams (P \u3c 0.05). Thus, dam growth was influenced by diet during treatment period. Dietary treatment did not influence fetal weight, crown rump length, liver weight, or right hind leg weight of the fetus. Relative gene expression for preadipocyte factor‐1 was more highly expressed (P \u3c 0.05) in HIGH heifers as compared with INT and LOW heifers. These preliminary results suggest that fetal growth characteristics are not affected by manipulation of maternal nutrition during mid‐gestation in beef cows. However, gene expression differences could potentially lead to differences in composition of growth, and warrants further investigation
A Naturally Narrow Positive Parity Theta^+
We present a consistent color-flavor-spin-orbital wave function for a
positive parity Theta^+ that naturally explains the observed narrowness of the
state. The wave function is totally symmetric in its flavor-spin part and
totally antisymmetric in its color-orbital part. If flavor-spin interactions
dominate, this wave function renders the positive parity Theta^+ lighter than
its negative parity counterpart. We consider decays of the Theta^+ and compute
the overlap of this state with the kinematically allowed final states. Our
results are numerically small. We note that dynamical correlations between
quarks are not necessary to obtain narrow pentaquark widths.Comment: 10 pages, 1 figure, Revtex4, two-column format, version to be
published in Phys. Rev. D, includes numerical estimates of decay width
Some (further) Comments on the Theta(1540) Pentaquark
Additional broader I=0 states in the KN channel near (1540) are
expected in many models, making the absence of any signature in the
K-deuteron scattering data even more puzzling.
In an ideal "three-body" picture the is viewed as two compact
ud(1)ud(2) color diquarks and an quark. A "QCD-type"
inequality involving , the mass of the L=1 excitation and that of a new I=0 tetraquark vector meson then follows.
The inequality suggests a very light new vector meson, and is violated.
We note that "associated production" of the pentaquark with another
quadriquark or anti-pentaquark may be favored. This along with some estimates
of the actual production cross sections suggest that the can be found
in BaBar or Belle e-e colliders.Comment: 6 page
Z^* Resonances: Phenomenology and Models
We explore the phenomenology of, and models for, the Z^* resonances, the
lowest of which is now well established, and called the Theta. We provide an
overview of three models which have been proposed to explain its existence
and/or its small width, and point out other relevant predictions, and potential
problems, for each. The relation to what is known about KN scattering,
including possible resonance signals in other channels, is also discussed.Comment: 29 pages, uses RevTeX4; expanded version (published form
QCD Sum Rules and Applications to Nuclear Physics
Applications of QCD sum-rule methods to the physics of nuclei are reviewed,
with an emphasis on calculations of baryon self-energies in infinite nuclear
matter. The sum-rule approach relates spectral properties of hadrons
propagating in the finite-density medium, such as optical potentials for
quasinucleons, to matrix elements of QCD composite operators (condensates). The
vacuum formalism for QCD sum rules is generalized to finite density, and the
strategy and implementation of the approach is discussed. Predictions for
baryon self-energies are compared to those suggested by relativistic nuclear
physics phenomenology. Sum rules for vector mesons in dense nuclear matter are
also considered.Comment: 92 pages, ReVTeX, 9 figures can be obtained upon request (to Xuemin
Jin
The Role of Color Neutrality in Nuclear Physics--Modifications of Nucleonic Wave Functions
The influence of the nuclear medium upon the internal structure of a
composite nucleon is examined. The interaction with the medium is assumed to
depend on the relative distances between the quarks in the nucleon consistent
with the notion of color neutrality, and to be proportional to the nucleon
density. In the resulting description the nucleon in matter is a superposition
of the ground state (free nucleon) and radial excitations. The effects of the
nuclear medium on the electromagnetic and weak nucleon form factors, and the
nucleon structure function are computed using a light-front constituent quark
model. Further experimental consequences are examined by considering the
electromagnetic nuclear response functions. The effects of color neutrality
supply small but significant corrections to predictions of observables.Comment: 37 pages, postscript figures available on request to
[email protected]
The genome of the stable fly, Stomoxys calcitrans, reveals potential mechanisms underlying reproduction, host interactions, and novel targets for pest control.
The stable fly, Stomoxys calcitrans, is a major blood-feeding pest of livestock that has near worldwide distribution, causing an annual cost of over $2 billion for control and product loss in the USA alone. Control of these flies has been limited to increased sanitary management practices and insecticide application for suppressing larval stages. Few genetic and molecular resources are available to help in developing novel methods for controlling stable flies.
This study examines stable fly biology by utilizing a combination of high-quality genome sequencing and RNA-Seq analyses targeting multiple developmental stages and tissues. In conjunction, 1600 genes were manually curated to characterize genetic features related to stable fly reproduction, vector host interactions, host-microbe dynamics, and putative targets for control. Most notable was characterization of genes associated with reproduction and identification of expanded gene families with functional associations to vision, chemosensation, immunity, and metabolic detoxification pathways.
The combined sequencing, assembly, and curation of the male stable fly genome followed by RNA-Seq and downstream analyses provide insights necessary to understand the biology of this important pest. These resources and new data will provide the groundwork for expanding the tools available to control stable fly infestations. The close relationship of Stomoxys to other blood-feeding (horn flies and Glossina) and non-blood-feeding flies (house flies, medflies, Drosophila) will facilitate understanding of the evolutionary processes associated with development of blood feeding among the Cyclorrhapha
Experimental and Theoretical Challenges in the Search for the Quark Gluon Plasma: The STAR Collaboration's Critical Assessment of the Evidence from RHIC Collisions
We review the most important experimental results from the first three years
of nucleus-nucleus collision studies at RHIC, with emphasis on results from the
STAR experiment, and we assess their interpretation and comparison to theory.
The theory-experiment comparison suggests that central Au+Au collisions at RHIC
produce dense, rapidly thermalizing matter characterized by: (1) initial energy
densities above the critical values predicted by lattice QCD for establishment
of a Quark-Gluon Plasma (QGP); (2) nearly ideal fluid flow, marked by
constituent interactions of very short mean free path, established most
probably at a stage preceding hadron formation; and (3) opacity to jets. Many
of the observations are consistent with models incorporating QGP formation in
the early collision stages, and have not found ready explanation in a hadronic
framework. However, the measurements themselves do not yet establish
unequivocal evidence for a transition to this new form of matter. The
theoretical treatment of the collision evolution, despite impressive successes,
invokes a suite of distinct models, degrees of freedom and assumptions of as
yet unknown quantitative consequence. We pose a set of important open
questions, and suggest additional measurements, at least some of which should
be addressed in order to establish a compelling basis to conclude definitively
that thermalized, deconfined quark-gluon matter has been produced at RHIC.Comment: 101 pages, 37 figures; revised version to Nucl. Phys.
Distinct clinical symptom patterns in patients hospitalised with COVID-19 in an analysis of 59,011 patients in the ISARIC-4C study
COVID-19 is clinically characterised by fever, cough, and dyspnoea. Symptoms affecting other organ systems have been reported. However, it is the clinical associations of different patterns of symptoms which influence diagnostic and therapeutic decision-making. In this study, we applied clustering techniques to a large prospective cohort of hospitalised patients with COVID-19 to identify clinically meaningful sub-phenotypes. We obtained structured clinical data on 59,011 patients in the UK (the ISARIC Coronavirus Clinical Characterisation Consortium, 4C) and used a principled, unsupervised clustering approach to partition the first 25,477 cases according to symptoms reported at recruitment. We validated our findings in a second group of 33,534 cases recruited to ISARIC-4C, and in 4,445 cases recruited to a separate study of community cases. Unsupervised clustering identified distinct sub-phenotypes. First, a core symptom set of fever, cough, and dyspnoea, which co-occurred with additional symptoms in three further patterns: fatigue and confusion, diarrhoea and vomiting, or productive cough. Presentations with a single reported symptom of dyspnoea or confusion were also identified, alongside a sub-phenotype of patients reporting few or no symptoms. Patients presenting with gastrointestinal symptoms were more commonly female, had a longer duration of symptoms before presentation, and had lower 30-day mortality. Patients presenting with confusion, with or without core symptoms, were older and had a higher unadjusted mortality. Symptom sub-phenotypes were highly consistent in replication analysis within the ISARIC-4C study. Similar patterns were externally verified in patients from a study of self-reported symptoms of mild disease. The large scale of the ISARIC-4C study enabled robust, granular discovery and replication. Clinical interpretation is necessary to determine which of these observations have practical utility. We propose that four sub-phenotypes are usefully distinct from the core symptom group: gastro-intestinal disease, productive cough, confusion, and pauci-symptomatic presentations. Importantly, each is associated with an in-hospital mortality which differs from that of patients with core symptoms
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