Mudança científica: modelos filosóficos e pesquisa histórica

The authors call for a more thorough testing of the empirical claims of recent theories of scientific change. To facilitate this the empirical claims of Kuhn, Feyerabend, Lakatos and Laudan are listed in nontechnical language, both by author and by topic. A bibliography of case studies is included.Os autores deste ensaio entendem que é preciso testar de forma mais completa as afirmações empíricas das recentes teorias da mudança científica. Tendo em vista facilitar tal empreendimento, apresentam-se em linguagem não-técnica as afirmações empíricas de Kuhn, Feyerabend, Lakatos e Laudan, que estão organizadas por autor e por assunto. Ao final, inclui-se uma bibliografia de estudos de caso

Spatially resolved stellar, dust and gas properties of the post-interacting Whirlpool Galaxy system

Using infrared imaging from the Herschel Space Observatory, observed as part of the VNGS, we investigate the spatially resolved dust properties of the interacting Whirlpool galaxy system (NGC 5194 and NGC 5195), on physical scales of 1 kpc. Spectral energy distribution modelling of the new infrared images in combination with archival optical, near- through mid-infrared images confirms that both galaxies underwent a burst of star formation ~370-480 Myr ago and provides spatially resolved maps of the stellar and dust mass surface densities. The resulting average dust-to-stellar mass ratios are comparable to other spiral and spheroidal galaxies studied with Herschel, with NGC 5194 at log M(dust)/M(star)= -2.5+/-0.2 and NGC 5195 at log M(dust)/M(star)= -3.5+/-0.3. The dust-to-stellar mass ratio is constant across NGC 5194 suggesting the stellar and dust components are coupled. In contrast, the mass ratio increases with radius in NGC 5195 with decreasing stellar mass density. Archival mass surface density maps of the neutral and molecular hydrogen gas are also folded into our analysis. The gas-to-dust mass ratio, 94+/-17, is relatively constant across NGC 5194. Somewhat surprisingly, we find the dust in NGC 5195 is heated by a strong interstellar radiation field, over 20 times that of the ISRF in the Milky Way, resulting in relatively high characteristic dust temperatures (~30 K). This post-starburst galaxy contains a substantial amount of low-density molecular gas and displays a gas-to-dust ratio (73+/-35) similar to spiral galaxies. It is unclear why the dust in NGC 5195 is heated to such high temperatures as there is no star formation in the galaxy and its active galactic nucleus is 5-10 times less luminous than the one in NGC 5194, which exhibits only a modest enhancement in the amplitude of its ISRF.Comment: 26 pages, 24 figures, Accepted for publication in Ap

Nova-like Cataclysmic Variables in the Infrared

Novalike cataclysmic variables have persistently high mass transfer rates and prominent steady state accretion disks. We present an analysis of infrared observations of twelve novalikes obtained from the Two Micron All Sky Survey, the Spitzer Space Telescope, and the Wide-field Infrared Survey Explorer All Sky Survey. The presence of an infrared excess at >3-5 microns over the expectation of a theoretical steady state accretion disk is ubiquitous in our sample. The strength of the infrared excess is not correlated with orbital period, but shows a statistically significant correlation (but shallow trend) with system inclination that might be partially (but not completely) linked to the increasing view of the cooler outer accretion disk and disk rim at higher inclinations. We discuss the possible origin of the infrared excess in terms of emission from bremsstrahlung or circumbinary dust, with either mechanism facilitated by the mass outflows (e.g., disk wind/corona, accretion stream overflow, and so on) present in novalikes. Our comparison of the relative advantages and disadvantages of either mechanism for explaining the observations suggests that the situation is rather ambiguous, largely circumstantial, and in need of stricter observational constraints.Peer reviewe

Differential expression of VEGF-Axxx isoforms is critical for development of pulmonary fibrosis

RATIONALE Fibrosis after lung injury is related to poor outcome, and idiopathic pulmonary fibrosis (IPF) can be regarded as an exemplar. Vascular endothelial growth factor (VEGF)-A has been implicated in this context, but there are conflicting reports as to whether it is a contributory or protective factor. Differential splicing of the VEGF-A gene produces multiple functional isoforms including VEGF-Aa and VEGF-Ab, a member of the inhibitory family. To date there is no clear information on the role of VEGF-A in IPF. OBJECTIVES To establish VEGF-A isoform expression and functional effects in IPF. METHODS We used tissue sections, plasma, and lung fibroblasts from patients with IPF and control subjects. In a bleomycin-induced lung fibrosis model we used wild-type MMTV mice and a triple transgenic mouse SPC-rtTATetoCreLoxP-VEGF-Ato conditionally induce VEGF-A isoform deletion specifically in the alveolar type II (ATII) cells of adult mice. MEASUREMENTS AND MAIN RESULTS IPF and normal lung fibroblasts differentially expressed and responded to VEGF-Aa and VEGF-Ab in terms of proliferation and matrix expression. Increased VEGF-Ab was detected in plasma of progressing patients with IPF. In a mouse model of pulmonary fibrosis, ATII-specific deficiency of VEGF-A or constitutive overexpression of VEGF-Ab inhibited the development of pulmonary fibrosis, as did treatment with intraperitoneal delivery of VEGF-Ab to wild-type mice. CONCLUSIONS These results indicate that changes in the bioavailability of VEGF-A sourced from ATII cells, namely the ratio of VEGF-Aa to VEGF-Ab, are critical in development of pulmonary fibrosis and may be a paradigm for the regulation of tissue repair

SWIRE: The SIRTF Wide‐Area Infrared Extragalactic Survey

The SIRTF Wide-Area Infrared Extragalactic Survey (SWIRE), the largest SIRTF Legacy program, is a wide-area imaging survey to trace the evolution of dusty, star-forming galaxies, evolved stellar populations, and active galactic nuclei (AGNs) as a function of environment, from redshifts to the current z ∼ 3 epoch. SWIRE will survey seven high-latitude fields, totaling 60–65 deg2 in all seven SIRTF bands: Infrared Array Camera (IRAC) 3.6, 4.5, 5.6, and 8 mm and Multiband Imaging Photometer for SIRTF (MIPS) 24, 70, and 160 mm. Extensive modeling suggests that the Legacy Extragalactic Catalog may contain in excess of 2 million IR-selected galaxies, dominated by (1) ∼150,000 luminous infrared galaxies (LIRGs; LFIR 1 1011 L,) detected by MIPS (and significantly more detected by IRAC), ∼7000 of these with ; (2) 1 million IRAC- z 1 2 detected early-type galaxies (∼ with and ∼10,000 with ); and (3) ∼20,000 classical AGNs 5 2 # 10 z 1 1 z 1 2 detected with MIPS, plus significantly more dust-obscured quasi-stellar objects/AGNs among the LIRGs. SWIRE will provide an unprecedented view of the evolution of galaxies, structure, and AGNs. The key scientific goals of SWIRE are (1) to determine the evolution of actively star forming and passively evolving galaxies in order to understand the history of galaxy formation in the context of cosmic structure formation; (2) to determine the evolution of the spatial distribution and clustering of evolved galaxies, starbursts, and AGNs in the key redshift range over which much of cosmic evolution has occurred; and (3) to 0.5 ! z ! 3 determine the evolutionary relationship between “normal galaxies” and AGNs and the contribution of AGN accretion energy versus stellar nucleosynthesis to the cosmic backgrounds. The large area of SWIRE is important to establish statistically significant population samples over enough volume cells that we can resolve the star formation history as a function of epoch and environment, i.e., in the context of structure formation. The large volume is also optimized for finding rare objects. The SWIRE fields are likely to become the next generation of large “cosmic windows” into the extragalactic sky. They have been uniquely selected to minimize Galactic cirrus emission over large scales. The Galaxy Evolution Explorer will observe them as part of its deep 100 deg2 survey, as will Herschel. SWIRE includes ∼9 deg2 of the unique large-area XMM Large Scale Structure hard X-ray imaging survey and is partly covered by the UKIDSS deep J and K survey. An extensive optical/near-IR imaging program is underway from the ground. The SWIRE data are nonproprietary; catalogs and images will be released twice yearly, beginning about 11 months after SIRTF launch. Details of the data products and release schedule are presented

Validation and characterisation of a novel peptide that binds monomeric and aggregated beta-amyloid and inhibits the formation of neurotoxic oligomers

Although the formation of β-amyloid (Aβ) deposits in the brain is a hallmark of Alzheimer disease (AD), the soluble oligomers rather than the mature amyloid fibrils most likely contribute to Aβ toxicity and neurodegeneration. Thus, the discovery of agents targeting soluble Aβ oligomers is highly desirable for early diagnosis prior to the manifestation of a clinical AD phenotype and also more effective therapies. We have previously reported that a novel 15-amino acid peptide (15-mer), isolated via phage display screening, targeted Aβ and attenuated its neurotoxicity (Taddei, K., Laws, S. M., Verdile, G., Munns, S., D'Costa, K., Harvey, A. R., Martins, I. J., Hill, F., Levy, E., Shaw, J. E., and Martins, R. N. (2010) Neurobiol. Aging 31, 203–214). The aim of the current study was to generate and biochemically characterize analogues of this peptide with improved stability and therapeutic potential. We demonstrated that a stable analogue of the 15-amino acid peptide (15M S.A.) retained the activity and potency of the parent peptide and demonstrated improved proteolytic resistance in vitro (stable to t = 300 min, c.f. t = 30 min for the parent peptide). This candidate reduced the formation of soluble Aβ42 oligomers, with the concurrent generation of non-toxic, insoluble aggregates measuring up to 25–30 nm diameter as determined by atomic force microscopy. The 15M S.A. candidate directly interacted with oligomeric Aβ42, as shown by coimmunoprecipitation and surface plasmon resonance/Biacore analysis, with an affinity in the low micromolar range. Furthermore, this peptide bound fibrillar Aβ42 and also stained plaques ex vivo in brain tissue from AD model mice. Given its multifaceted ability to target monomeric and aggregated Aβ42 species, this candidate holds promise for novel preclinical AD imaging and therapeutic strategies

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

Using the daylight savings clock change to show ambient light conditions significantly influence active travel

This article reports a novel procedure used to investigate whether ambient light conditions affect the number of people who choose to walk or cycle. Pedestrian and cyclist count data were analysed using the biannual daylight-saving clock changes to compare daylight and after-dark conditions whilst keeping seasonal and time-of-day factors constant. Changes in frequencies during a 1-h case period before and after a clock change, when light conditions varied significantly between daylight and darkness, were compared against control periods when the light condition did not change. Odds ratios indicated the numbers of pedestrians and cyclists during the case period were significantly higher during daylight conditions than after-dark, resulting in a 62% increase in pedestrians and a 38% increase in cyclists. These results show the importance of light conditions on the numbers of pedestrian and cyclists, and highlight the potential of road lighting as a policy measure to encourage active travel after-dark

Biofilm Development on Caenorhabditis elegans by Yersinia Is Facilitated by Quorum Sensing-Dependent Repression of Type III Secretion

Yersinia pseudotuberculosis forms biofilms on Caenorhabditis elegans which block nematode feeding. This genetically amenable host-pathogen model has important implications for biofilm development on living, motile surfaces. Here we show that Y. pseudotuberculosis biofilm development on C. elegans is governed by N-acylhomoserine lactone (AHL)-mediated quorum sensing (QS) since (i) AHLs are produced in nematode associated biofilms and (ii) Y. pseudotuberculosis strains expressing an AHL-degrading enzyme or in which the AHL synthase (ypsI and ytbI) or response regulator (ypsR and ytbR) genes have been mutated, are attenuated. Although biofilm formation is also attenuated in Y. pseudotuberculosis strains carrying mutations in the QS-controlled motility regulator genes, flhDC and fliA, and the flagellin export gene, flhA, flagella are not required since fliC mutants form normal biofilms. However, in contrast to the parent and fliC mutant, Yop virulon proteins are up-regulated in flhDC, fliA and flhA mutants in a temperature and calcium independent manner. Similar observations were found for the Y. pseudotuberculosis QS mutants, indicating that the Yop virulon is repressed by QS via the master motility regulator, flhDC. By curing the pYV virulence plasmid from the ypsI/ytbI mutant, by growing YpIII under conditions permissive for type III needle formation but not Yop secretion and by mutating the type III secretion apparatus gene, yscJ, we show that biofilm formation can be restored in flhDC and ypsI/ytbI mutants. These data demonstrate that type III secretion blocks biofilm formation and is reciprocally regulated with motility via QS