Acemannan Gels and Aerogels

The procedures to obtain two types of acemannan (AC) physical gels and their respective aerogels are reported. The gelation was induced by the diffusion of an alkali or a non-solvent, then supercritical CO2 drying technology was used to remove the solvent out and generate the AC aerogels. Fourier-transform infrared spectroscopic analysis indicated that alkali diffusion produced extensive AC deacetylation. Conversely, the non-solvent treatment did not affect the chemical structure of AC. Both types of gels showed syneresis and the drying process induced further volume reduction. Both aerogels were mesoporous nanostructured materials with pore sizes up to 6.4 nm and specific surface areas over 370 m2/g. The AC physical gels and aerogels enable numerous possibilities of applications, joining the unique features of these materials with the functional and bioactive properties of the AC

Uso de videos en el estudio y comprensión de la Teoría de Sistemas y el Pensamiento de Sistemas: Propuesta de una guía para la búsqueda y selección

[ES] Como parte de las actividades de innovación educativa que realizan los docentes, se tiene la necesidad de contar con materiales didácticos para el desarrollo de las clases, pero no siempre se dispone del tiempo y recursos necesarios para crearlos. Sin embargo, en Internet existen muchos materiales educativos que pueden ayudar tanto a profesores como a estudiantes en las actividades de enseñanza, aprendizaje o investigación. Muchos de estos recursos son de dominio público o han sido publicados con alguna licencia de propiedad intelectual, mismos que pueden ser aprovechados para entender mejor los temas teóricos que representan complejidad por su nivel de abstracción, como puede ser la Teoría General de Sistemas. El objetivo de este trabajo es generar y proponer una guía para la búsqueda y selección de recursos educativos abiertos en modalidad de video, que facilite la actividad de indagación de temas a los estudiantes de ingeniería industrial en asignaturas que tratan la Teoría de Sistemas y el Pensamiento de Sistemas, para que logren el propósito de aprendizaje de contenidos temáticos de una manera rápida y dinámica. El presente artículo describe un trabajo colaborativo realizado entre estudiantes y maestros de la Licenciatura en Ingeniería Industrial que da cuenta de la importancia que tiene el video como recurso de apoyo a las actividades de autoaprendizaje, además de mostrar la utilidad y beneficio del uso de videos en los últimos años.Este proyecto ha sido apoyado por el Consejo Nacional de Ciencia y Tecnología bajo el proyecto A1-S-20925 del “Fondo Sectorial de Investigación para la Educación.Niccolas Morales, H.; Garnica González, J.; Sánchez Ortíz, C.; San Martín Sampayo, I.; Reséndiz López, G.; Toto Arellano, N.; Monzalvo Hernández, Á. (2021). Uso de videos en el estudio y comprensión de la Teoría de Sistemas y el Pensamiento de Sistemas: Propuesta de una guía para la búsqueda y selección. En Proceedings INNODOCT/20. International Conference on Innovation, Documentation and Education. Editorial Universitat Politècnica de València. 741-750. https://doi.org/10.4995/INN2020.2020.11921OCS74175

Sistema axiológico de los alumnos del Programa Contaduría Pública de la Universidad Católica Luis Amigó – Medellín – Colombia

The objective of this work is to diagnose the axiological system of the students of the Public Accounting Program of the School of Administrative, Economic and Accounting Sciences of the Catholic University Luis Amigó - Medellín - Colombia. The study was carried out with a sample of one hundred and twenty-nine students from the Public Accounting Program. The students established that the main values are respect, honesty and responsibility; while the values of little importance are independence, capacity for reflection and work

Circulating microRNA expression profile in B-cell acute lymphoblastic leukemia

BACKGROUND: Acute lymphoblastic leukemia (ALL) is a highly diverse disease characterized by cytogenetic and molecularabnormalities, including altered microRNA (miRNA) expression signatures. AIM: We perform and validate a plasma miRNA expression profiling to identify potential miRNA involved in leukemogenesis METHODS: MiRNA expression profiling assay was realized in 39 B-ALL and 7 normal control plasma samples using TaqMan Low Density Array (TLDA) plates on Applied Biosystems 7900 HT Fast Real-Time PCR System. MiRNA validation was done for six miRNA differentially expressed by quantitative real-time PCR. RESULTS: Seventy-seven circulating miRNA differentially expressed: hsa-miR-511, -222, and -34a were overexpressed, whereas hsa-miR-199a-3p, -223, -221, and -26a were underexpressed (p values < 0.005 for both sets). According to operating characteristic curve analysis, hsa-miR-511 was the most valuable biomarker for distinguishing B-ALL from normal controls,with an area under curve value of 1 and 100% for sensitivity, and specificity respectively. CONCLUSIONS: Measuring circulating levels of specific miRNA implicated in regulation of cell differentiation and/or cell proliferation such as hsa-miRNA-511, offers high sensitivity and specificity in B-ALL detection and may be potentially useful for detection of disease progression, as indicator of therapeutic response, and in the assessment of biological and/or therapeutic targets for patients with B-ALL

Impact of SCHOLAR-1 Criteria on Chimeric Antigen Receptor T Cell Therapy Efficacy in Aggressive B Lymphoma: A Real-World GELTAMO/GETH Study

In the pre-chimeric antigen receptor T cell (CAR-T) therapy era, the SCHOLAR-1 study identified a group of patients with refractory aggressive B cell lymphoma (ABCL) with particularly poor prognoses. We recently published our real -world data from Spain, focused on this SCHOLAR-1 refractory group, and compared patients who underwent CAR-T therapy with the previous standard of care. In this study, we found that the efficacy of CAR-T therapy in refractory patients, in terms of progression-free survival (PFS) and overall survival (OS), was superior to that of the treatments available in the pre-CAR-T era. The main objective of these new analyses was to analyze treatment efficacy in terms of response rates and survival for patients with ABCL with or without the SCHOLAR-1 criteria. In addition, we ana-lyzed the prognostic impact of each SCHOLAR-1 criterion independently. Our study aimed to assess the prognostic impact of SCHOLAR-1 criteria on ABCL patients treated with CAR-T therapy in Spain. This multicenter, retrospective, observational study. We included all adult patients treated with commercially available CAR-T cell products and diag-nosed with ABCL different from primary mediastinal large B cell lymphoma between February 2019 and July 2022. Patients meeting any SCHOLAR-1 criteria (progressive disease as the best response to any line of therapy, stable dis-ease as the best response to >4 cycles of first-line therapy or >2 cycles of later-line therapy, or relapse at <12 months after autologous stem cell transplantation [auto-SCT]) in the line of treatment before CAR-T therapy (SCHOLAR-1 group) were compared with those not meeting any of these criteria (non-SCHOLAR-1 group). To analyze the prognos-tic impact of individual SCHOLAR-1 criteria, all the patients who met any of the SCHOLAR-1 criteria at any time were included to assess whether these criteria have the same prognostic impact in the CAR-T era. In addition, patients were grouped according to whether they were refractory to the first line of treatment, refractory to the last line of treatment, or relapsed early after auto-SCT. The PFS and OS were calculated from the time of appearance of the SCHOLAR-1 refractoriness criteria. Of 329 patients treated with CAR-T (169 with axi-cel and 160 with tisa-cel), 52 were in the non-SCHOLAR-1 group and 277 were in the SCHOLAR-1 group. We found significantly better outcomes in the non-SCHOLAR-1 patients compared with the SCHOLAR-1 patients (median PFS of 12.2 and 3.3 months, respectively; P = .009). In addition, axi-cel showed better results in terms of efficacy than tisa-cel for both the non SCHOLAR-1 group (hazard ratio [HR] for PFS, 2.7 [95% confidence interval (CI), 1.1 to 6.7; P = .028]; HR for OS, 7.1 [95% CI, 1.5 to 34.6; P = .015]) and SCHOLAR-1 group (HR for PFS, 1.8 [95% CI, 1.3 to 2.5; P < .001]; HR for OS, 1.8 [95% CI, 1.2 to 2.6; P = .002]), but also significantly more toxicity. Finally, separately analyzing the prognostic impact of each SCHOLAR-1 criterion revealed that refractoriness to the last line of treatment was the variable with the most significant impact on survival. In conclusion, SCHOLAR-1 refractoriness criteria notably influence the efficacy of CAR-T therapy. In our experience, axi-cel showed better efficacy than tisa-cel for both SCHOLAR-1 and non-SCHOLAR-1 patients. Refractoriness to the last line of treatment was the variable with the most significant impact on survival in the CAR-T therapy era.(c) 2023 The American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc

Best Treatment Option for Patients With Refractory Aggressive B-Cell Lymphoma in the CAR-T Cell Era: Real-World Evidence From GELTAMO/GETH Spanish Groups

Real-world evidence comparing the efficacy of chimeric antigen receptor (CAR) T-cell therapy against that of the previous standard of care (SOC) for refractory large B-cell lymphoma (LBCL) is scarce. We retrospectively collected data from patients with LBCL according to SCHOLAR-1 criteria treated with commercial CAR T-cell therapy in Spain (204 patients included and 192 treated, 101 with axicabtagene ciloleucel [axi-cel], and 91 with tisagenlecleucel [tisa-cel]) and compared the results with a historical refractory population of patients (n = 81) obtained from the GELTAMO-IPI study. We observed superior efficacy for CAR-T therapy (for both axi-cel and tisa-cel) over pSOC, with longer progression-free survival (PFS) (median of 5.6 vs. 4-6 months, p <= 0.001) and overall survival (OS) (median of 15 vs. 8 months, p < 0.001), independently of other prognostic factors (HR: 0.59 (95% CI: 0.44-0.80); p < 0.001] for PFS, and 0.45 [(95% CI: 0.31-0.64)] for OS). Within the CAR-T cohort, axi-cel showed longer PFS (median of 7.3 versus 2.8 months, respectively, p = 0.027) and OS (58% versus 42% at 12 months, respectively, p = 0.048) than tisa-cel. These differences were maintained in the multivariable analysis. On the other hand, axi-cel was independently associated with a higher risk of severe cytokine release syndrome and neurotoxicity. Our results suggest that the efficacy of CAR-T cell therapy is superior to pSOC in the real-world setting. Furthermore, axi-cel could be superior in efficacy to tisa-cel, although more toxic, in this group of refractory patients according to SCHOLAR-1 criteria

The Seventeenth Data Release of the Sloan Digital Sky Surveys: Complete Release of MaNGA, MaStar and APOGEE-2 Data

This paper documents the seventeenth data release (DR17) from the Sloan Digital Sky Surveys; the fifth and final release from the fourth phase (SDSS-IV). DR17 contains the complete release of the Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey, which reached its goal of surveying over 10,000 nearby galaxies. The complete release of the MaNGA Stellar Library (MaStar) accompanies this data, providing observations of almost 30,000 stars through the MaNGA instrument during bright time. DR17 also contains the complete release of the Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2) survey which publicly releases infra-red spectra of over 650,000 stars. The main sample from the Extended Baryon Oscillation Spectroscopic Survey (eBOSS), as well as the sub-survey Time Domain Spectroscopic Survey (TDSS) data were fully released in DR16. New single-fiber optical spectroscopy released in DR17 is from the SPectroscipic IDentification of ERosita Survey (SPIDERS) sub-survey and the eBOSS-RM program. Along with the primary data sets, DR17 includes 25 new or updated Value Added Catalogs (VACs). This paper concludes the release of SDSS-IV survey data. SDSS continues into its fifth phase with observations already underway for the Milky Way Mapper (MWM), Local Volume Mapper (LVM) and Black Hole Mapper (BHM) surveys

Low cost instrumentation for spin-coating deposition of thin films in an undergraduate aboratory

Se describe la implementación de un sistema de bajo costo spin-coating para depositar películas delgadas de materiales disueltos en un solvente volátil. El sistema puede ser fácilmente construido con el conocimiento interdisciplinario de la mecánica, mecánica de fluidos y la electrónica a nivel de pregrado. El sistema permite la deposición de capas delgadas de hasta 5cm2 de área y es construido de un motor comercial de DVD y un circuito electrónico diseñado para controlar la velocidad de giro y tiempo de giro de hasta 10.000rpm y 60seg, respectivamente. En nuestro diseño, ambas variables se pueden ajustar manualmente a través de un arreglo de micro interruptores y un varistor. Para ilustrar el uso de nuestro sistema de spin-coating, fueron preparadas películas de MDMO-PPV conjugando polímeros a partir de soluciones en clorobenceno y tetrahidrofurano y sus propiedades de absorción óptica y propiedades fotoluminiscencia son analizadas y discutidas.We describe the implementation of an inexpensive spin-coating system to deposit thin films of materials dissolved in a volatile solvent. The system can be easily built with interdisciplinary knowledge of mechanics, fluid mechanics and electronics at undergraduate level. The system allows the deposition of thin films of up to 5cm2 in area and is constructed from a commercial DVD player drive motor and an electronic circuit designed to control the spinning speed and spinning time up to 10,000rpm and 60seg, respectively. In our design, both variables can be adjusted manually through an array of micro push button switches and a varistor. To illustrate the use of our spin-coating system, were prepared films of MDMO-PPV conjugated polymer from solutions in chlorobenzene and tetrahydrofuran and their optical absorption and photoluminescence properties are analyzed and discussed

Business plan for the creation of a treated water bottling company in the city of Riohacha, Department of Guajira.

Éste proyecto que tiene por nombre “Wüin Ka´i”1 el cual, es la entrega del servicio de agua desalinizada completamente consumible al público mediante su comercialización a través de diferentes presentaciones, en lugares estratégicos del municipio de Riohacha que corresponden a las 10 comunas donde concentran la mayor afluencia de público urbano así, como su sector turístico siendo éste el primer punto de partida, dada su alta demanda insatisfecha de la población local como del público visitante nacional e internacional. Para este propósito, se ha desarrollado un plan de negocios detallado, donde se expone los diferentes estadíos a realizar para llevar a cabo un proyecto de esta altura bajo la perspectiva económica, social y altamente responsable con el medio ambiente. En base a los anteriores criterios, se ha definido participar en la industria de agua embotellada, que hoy en día es liderada por la marca Cristal con un 49% de participación en el mercado.This project has the name "Wüin Ka'i" which is the delivery of desalinated water service fully consumable to the public through its marketing through different presentations, in strategic locations in the municipality of Riohacha, which correspond to the 10 municipalities where they concentrate the greater affluence of urban public thus, as its tourist sector being this the first starting point, given its high unsatisfied demand of the local population as of the national and international visiting public. For this purpose, a detailed business plan has been made, showing the different nuances to be met in order to carry out a project of this scale, economic, social and highly responsible with the environment. Based on the above criteria, it has been decided to participate in the bottled water industry, which today is led by the Cristal brand with a 49% share in the market. Even so it is observed that there is an opportunity in this industry and in this city, mainly due to the unmet demand and the large influx of national and international tourists that visit the municipality, in addition to the continuous search for a healthy life, which makes the product goes hand in hand with this idea. Another point in favor is the projected increase in water consumption, prioritizing it in relation to other beverages, according to figures projected by the National Department of Statistics DANE.Magister en Administración de Empresa

Propiedades y características de una aleación de colada de aluminio

Se diseñó una serie de experimentos para estudiar la variación de las propiedades mecánicas en una aleación Al-Si-Cu, tipo A319, en base a variaciones en composición química, cinética de solidificación y tratamiento térmico