10 research outputs found
Modified supine versus prone percutaneous nephrolithotomy: Surgical outcomes from a tertiary teaching hospital
Purpose: The traditional prone positioning of percutaneous nephrolithotomy (PCNL) is associated with various anesthetic and logistic
difficulties. We aimed to compare the surgical outcomes of PCNLs performed using our modified supine position with those
performed in the standard prone position.
Materials and Methods: A prospective group of 236 renal units (224 patients) undergoing PCNL were included in this 2 site study:
160 were performed in the modified supine position were compared with 76 undergoing PCNL in the prone position. The outcomes
of radiation dose, radiation time, stone free rate, body mass index (BMI), stone size, operative time, length of stay (LOS), in
hospital and complications were compared. Chi-square and t-tests were used.
Results: There were no significant differences in mean radiation time, radiation dose or stone size between the modified supine
and prone groups. The supine group had a higher mean BMI (31 kg/m2
vs. 28 kg/m2
, p=0.03), shorter mean surgical time (93 minutes
vs. 123 minutes, p<0.001), shorter mean LOS (2 days vs. 3 days, p=0.005) and higher stone free rate (70% vs. 50%, p=0.005).
There were no differences in septic or bleeding complications but the prone group had a higher rate of overall complications.
Conclusions: Modified supine PCNL has significantly lower operative time, shorter LOS and higher stone-free rate compared with
prone in our series, while remaining a safe procedure
The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology
10.1038/s41467-021-25175-5Nature Communications121504