17 research outputs found

    Oscillations of neutrinos and mesons in quantum field theory

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    This report deals with the quantum field theory of particle oscillations in vacuum. We first review the various controversies regarding quantum-mechanical derivations of the oscillation formula, as well as the different field-theoretical approaches proposed to settle them. We then clear up the contradictions between the existing field-theoretical treatments by a thorough study of the external wave packet model. In particular, we show that the latter includes stationary models as a subcase. In addition, we explicitly compute decoherence terms, which destroy interferences, in order to prove that the coherence length can be increased without bound by more accurate energy measurements. We show that decoherence originates not only in the width and in the separation of wave packets, but also in their spreading through space-time. In this review, we neither assume the relativistic limit nor the stability of oscillating particles, so that the oscillation formula derived with field-theoretical methods can be applied not only to neutrinos but also to neutral K and B mesons. Finally, we discuss oscillations of correlated particles in the same framework.Comment: v2, 124 pages, 10 figures (7 more); updated review of the literature; complete derivation of the oscillation probability at short and large distance; more details on the influence of the spreading of the amplitude on decoherence; submitted to Physics Report

    Novel Role for Glutathione S-Transferase π: REGULATOR OF PROTEIN S-GLUTATHIONYLATION FOLLOWING OXIDATIVE AND NITROSATIVE STRESS*

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    Glutathione S-transferase Pi (GSTπ) is a marker protein in many cancers and high levels are linked to drug resistance, even when the selecting drug is not a substrate. S-Glutathionylation of proteins is critical to cellular stress response, but characteristics of the forward reaction are not known. Our results show that GSTπ potentiates S-glutathionylation reactions following oxidative and nitrosative stress in vitro and in vivo. Mutational analysis indicated that the catalytic activity of GST is required. GSTπ is itself redox-regulated. S-Glutathionylation on Cys47 and Cys101 autoregulates GSTπ, breaks ligand binding interactions with c-Jun NH2-terminal kinase (JNK), and causes GSTπ multimer formation, all critical to stress response. Catalysis of S-glutathionylation at low pK cysteines in proteins is a novel property for GSTπ and may be a cause for its abundance in tumors and cells resistant to a range of mechanistically unrelated anticancer drugs
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