Design and development of a high precision, high payload telescope dual drive system

A high precision, dual drive system has been designed and developed for the Wide Field Upgrade to the Hobby-Eberly Telescope* at McDonald Observatory in support of the Hobby-Eberly Telescope Dark Energy Experiment‡. Analysis,design and controls details will be of interest to designers of large scale, high precision robotic motion devices. The drive system positions the 19,000 kg star tracker to a precision of less than 5 microns along its 4-meter travel. While positioning requirements remain essentially equal to the existing HET, tracker mass increases by a factor greater than 5. The 10.5-meter long tracker is driven at each end by planetary roller screws, each having two distinct drive sources dictated by the desired operation: one slowly rotates the screw when tracking celestial objects and the second rotates the nut for rapid displacements. Key results of the roller screw rotordynamics analysis are presented. A description of the complex bearing arrangement providing required degrees of freedom as well as the impact of a detailed Failure Modes and Effects Analysis addressing necessary safety systems is also presented. Finite element analysis results demonstrate how mechanical springs increase the telescope's natural frequency response by 22 percent. The critical analysis and resulting design is provided.Center for Electromechanic

A cross-sectional survey of 5-year-old children with non-syndromic unilateral cleft lip and palate:the Cleft Care UK study. Part 1: background and methodology

OBJECTIVES: We describe the methodology for a major study investigating the impact of reconfigured cleft care in the United Kingdom (UK) 15 years after an initial survey, detailed in the Clinical Standards Advisory Group (CSAG) report in 1998, had informed government recommendations on centralization. SETTING AND SAMPLE POPULATION: This is a UK multicentre cross-sectional study of 5-year-olds born with non-syndromic unilateral cleft lip and palate. Children born between 1 April 2005 and 31 March 2007 were seen in cleft centre audit clinics. MATERIALS AND METHODS: Consent was obtained for the collection of routine clinical measures (speech recordings, hearing, photographs, models, oral health, psychosocial factors) and anthropometric measures (height, weight, head circumference). The methodology for each clinical measure followed those of the earlier survey as closely as possible. RESULTS: We identified 359 eligible children and recruited 268 (74.7%) to the study. Eleven separate records for each child were collected at the audit clinics. In total, 2666 (90.4%) were collected from a potential 2948 records. The response rates for the self-reported questionnaires, completed at home, were 52.6% for the Health and Lifestyle Questionnaire and 52.2% for the Satisfaction with Service Questionnaire. CONCLUSIONS: Response rates and measures were similar to those achieved in the previous survey. There are practical, administrative and methodological challenges in repeating cross-sectional surveys 15 years apart and producing comparable data

Atoms interacting with intense, high-frequency laser pulses: Effect of the magnetic-field component on atomic stabilization

Published versio

The intellectual disability-associated CAMK2G p.Arg292Pro mutation acts as a pathogenic gain-of-function

The abundantly expressed calcium/calmodulin-dependent protein kinase II (CAMK2), alpha (CAMK2A), and beta (CAMK2B) isoforms are essential for learning and memory formation. Recently, a de novo candidate mutation (p.Arg292Pro) in the gamma isoform of CAMK2 (CAMK2G) was identified in a patient with severe intellectual disability (ID), but the mechanism(s) by which this mutation causes ID is unknown. Here, we identified a second, unrelated individual, with a de novo CAMK2G p.Arg292Pro mutation, and used in vivo and in vitro assays to assess the impact of this mutation on CAMK2G and neuronal function. We found that knockdown of CAMK2G results in inappropriate precocious neuronal maturation. We further found that the CAMK2G p.Arg292Pro mutation acts as a highly pathogenic gain-of-function mutation, leading to increased phosphotransferase activity and impaired neuronal maturation as well as impaired targeting of the nuclear CAMK2G isoform. Silencing the catalytic site of the CAMK2G p.Arg292Pro protein reversed the pathogenic effect of the p.Arg292Pro mutation on neuronal maturation, without rescuing its nuclear targeting. Taken together, our results reveal an indispensable function of CAMK2G in neurodevelopment and indicate that the CAMK2G p.Arg292Pro protein acts as a pathogenic gain-of-function mutation, through constitutive activity toward cytosolic targets, rather than impaired targeting to the nucleus

Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics

Essential metals, such as iron and copper, play a critical role in a plethora of cellular processes including cell growth and proliferation. However, concomitantly, excess of these metal ions in the body can have deleterious effects due to their ability to generate cytotoxic reactive oxygen species (ROS). Thus, the human body has evolved a very well-orchestrated metabolic system that keeps tight control on the levels of these metal ions. Considering their very high proliferation rate, cancer cells require a high abundance of these metals compared to their normal counterparts. Interestingly, new anti-cancer agents that take advantage of the sensitivity of cancer cells to metal sequestration and their susceptibility to ROS have been developed. These ligands can avidly bind metal ions to form redox active metal complexes, which lead to generation of cytotoxic ROS. Furthermore, these agents also act as potent metastasis suppressors due to their ability to up-regulate the metastasis suppressor gene, N-myc downstream regulated gene 1. This review discusses the importance of iron and copper in the metabolism and progression of cancer, how they can be exploited to target tumors and the clinical translation of novel anti-cancer chemotherapeutics

A common biological basis of obesity and nicotine addiction

J. Kaprio ja J. Tuomilehto työryhmien jäseniä (yht. 281).Peer reviewe

Suspension Trade Studies for Hybrid Electric Combat Vehicles

The University of Texas at Austin Center for Electromechanics (UT-CEM) has been developing advanced suspension technology for high-speed off-road applications since 1993. During the course of the program, advanced simulation techniques, verified by hardware demonstrations, were developed and refined. Recently, UT-CEM conducted a detailed simulation-based comparison of passive, semi-active, and full-active suspension systems for an 18,000 kg (20 ton) 8 x 8 vehicle. Performance metrics were developed to compare crew comfort, crew effectiveness, on-board equipment effectiveness, and power/energy consumption. This paper presents the methodology and rationale for metrics used in the study, simulation results, and data from this trade study. Results indicate significant advantages offered by well-designed active systems compared to both passive and semi-active, in all metrics.Center for Electromechanic

The effects of a thermal discharge on the macroinvertebrate community of a large British river: implications for climate change.

Anthropogenic changes to the temperature regimes of rivers, whether through thermal pollution, removal of shade, or climate change, could affect community stability and cause phenological changes in aquatic species. This study examines the impact of a thermal discharge from a power station on the diversity and composition of the aquatic macroinvertebrate community in the River Severn, UK. Daily temperatures up to 2 km downstream of the thermal discharge averaged 4.5°C above ambient. Abundance and taxon richness metrics were reduced at a site approximately 0.5 km downstream of the power station outfall, but were largely unaffected at a second site about 2 km downstream. The majority of the macroinvertebrate taxa observed were recorded at both control and heated sites, suggesting species were below their thermal tolerance threshold or had developed adaptations to survive increased temperatures. However, indicator species analysis suggests certain taxa were associated with particular sites; abundances of Musculium lacustre, Simulium reptans, and Orthocladiinae were greater at the unheated control site, whereas more pollution-tolerant species such Asellus aquaticus and Erpobdella octoculata were more common in the thermally impacted reaches. Overall, the results provide an indication of potential species and community response to future warming under climate change scenarios