Detector Description and Performance for the First Coincidence Observations between LIGO and GEO

For 17 days in August and September 2002, the LIGO and GEO interferometer gravitational wave detectors were operated in coincidence to produce their first data for scientific analysis. Although the detectors were still far from their design sensitivity levels, the data can be used to place better upper limits on the flux of gravitational waves incident on the earth than previous direct measurements. This paper describes the instruments and the data in some detail, as a companion to analysis papers based on the first data.Comment: 41 pages, 9 figures 17 Sept 03: author list amended, minor editorial change

Dense Stellar Populations: Initial Conditions

This chapter is based on four lectures given at the Cambridge N-body school "Cambody". The material covered includes the IMF, the 6D structure of dense clusters, residual gas expulsion and the initial binary population. It is aimed at those needing to initialise stellar populations for a variety of purposes (N-body experiments, stellar population synthesis).Comment: 85 pages. To appear in The Cambridge N-body Lectures, Sverre Aarseth, Christopher Tout, Rosemary Mardling (eds), Lecture Notes in Physics Series, Springer Verla

Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics

Essential metals, such as iron and copper, play a critical role in a plethora of cellular processes including cell growth and proliferation. However, concomitantly, excess of these metal ions in the body can have deleterious effects due to their ability to generate cytotoxic reactive oxygen species (ROS). Thus, the human body has evolved a very well-orchestrated metabolic system that keeps tight control on the levels of these metal ions. Considering their very high proliferation rate, cancer cells require a high abundance of these metals compared to their normal counterparts. Interestingly, new anti-cancer agents that take advantage of the sensitivity of cancer cells to metal sequestration and their susceptibility to ROS have been developed. These ligands can avidly bind metal ions to form redox active metal complexes, which lead to generation of cytotoxic ROS. Furthermore, these agents also act as potent metastasis suppressors due to their ability to up-regulate the metastasis suppressor gene, N-myc downstream regulated gene 1. This review discusses the importance of iron and copper in the metabolism and progression of cancer, how they can be exploited to target tumors and the clinical translation of novel anti-cancer chemotherapeutics

Physical and chemical properties of the products of in situ vitrification engineering tests 5, 6, and 7

In situ vitrification (ISV) is an in situ thermal treatment process that is being investigated by the Idaho National Engineering Laboratory (INEL) for application to buried waste sites. ISV is a thermal treatment process that converts contaminated soil into a chemically inert and stable glass and crystalline product. The INEL is evaluating whether the treatment process is a viable one for remediating a buried mixed transuranic waste site at the INEL Subsurface Disposal Area (SDA). The SDA is a Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) site. As part of the INEL investigation, a series of tests have been performed that address issues associated with vitrification of buried waste. Two pilot ISV tests and four tests at laboratory scale, formerly called engineering scale, were performed in 1990 to support the INEL investigation. The chemical composition and leaching of the produce glass is described

Product evaluation of in situ vitrification engineering, Test 4

This report is one of several that evaluates the In Situ Vitrification (ISV) Engineering-Scale Test 4 (ES-4). This document describes the chemical and physical composition, microstructure, and leaching characteristics of ES-4 product samples; these data provide insight into the expected performance of a vitrified product in an ISV buried waste application similar to that studied in ES-4

Clinical research in dementia: A perspective on implementing innovation

The increasing global prevalence of dementia demands concrete actions that are aimed strategically at optimizing processes that drive clinical innovation. The first step in this direction requires outlining hurdles in the transition from research to practice. The different parties needed to support translational processes have communication mismatches; methodological gaps hamper evidence-based decision-making; and data are insufficient to provide reliable estimates of long-term health benefits and costs in decisional models. Pilot projects are tackling some of these gaps, but appropriate methods often still need to be devised or adapted to the dementia field. A consistent implementation perspective along the whole translational continuum, explicitly defined and shared among the relevant stakeholders, should overcome the "research-versus-adoption" dichotomy, and tackle the implementation cliff early on. Concrete next steps may consist of providing tools that support the effective participation of heterogeneous stakeholders and agreeing on a definition of clinical significance that facilitates the selection of proper outcome measures