Mass matrix Ansatz and lepton flavor violation in the THDM-III

Predictive Higgs-fermion couplings can be obtained when a specific texture for the fermion mass matrices is included in the general two-Higgs doublet model. We derive the form of these couplings in the charged lepton sector using a Hermitian mass matrix Ansatz with four-texture zeros. The presence of unconstrained phases in the vertices phi-li-lj modifies the pattern of flavor-violating Higgs interactions. Bounds on the model parameters are obtained from present limits on rare lepton flavor violating processes, which could be extended further by the search for the decay tau -> mu mu mu and mu-e conversion at future experiments. The signal from Higgs boson decays phi -> tau mu could be searched at the large hadron collider (LHC), while e-mu transitions could produce a detectable signal at a future e mu-collider, through the reaction e mu -> h0 -> tau tau.Comment: 17 pages, 9 figure

Lepton Flavour Violating Heavy Higgs Decays Within the nuMSSM and Their Detection at the LHC

Within the $\nu$MSSM, a Minimal Supersymmetric neutrino See-saw Model, Lepton Flavour Violating Higgs couplings are strongly enhanced at large $\tan\beta$ (\gsim30), which can lead to BR$(H^0/A^0 \to \tau\mu) \simeq O(10^{-4})$, for M_{H^0/A^0}\gsim 160 GeV. Enhancements on the production of Higgs bosons, through the gluon fusion mechanism, $gg\to H^0/A^0$, and the associated production channel $gg,q\bar q\to b\bar bH^0/A^0$, whose rates grow with $\tan\beta$, as well as the mass degeneracy that occurs between the $H^0$ and $A^0$ states in this regime, also contribute to further the possibilities to detect a heavy Higgs signal into $\tau\mu$ pairs. We show that the separation of $\tau\mu$ Higgs events from the background at the upcoming CERN Large Hadron Collider could be done for Higgs masses up to about 600 GeV for 300 fb$^{-1}$ of luminosity, for large $\tan\beta$ values. However, even with as little as 10 fb$^{-1}$ one can probe $H^0/A^0$ masses up to 400 GeV or so, if $\tan\beta=60$. Altogether, these processes then provide a new Higgs discovery mode as well as an independent test of flavour physics.Comment: 13 pages, 5 figure

AltitudeOmics: The Integrative Physiology of Human Acclimatization to Hypobaric Hypoxia and Its Retention upon Reascent.

An understanding of human responses to hypoxia is important for the health of millions of people worldwide who visit, live, or work in the hypoxic environment encountered at high altitudes. In spite of dozens of studies over the last 100 years, the basic mechanisms controlling acclimatization to hypoxia remain largely unknown. The AltitudeOmics project aimed to bridge this gap. Our goals were 1) to describe a phenotype for successful acclimatization and assess its retention and 2) use these findings as a foundation for companion mechanistic studies. Our approach was to characterize acclimatization by measuring changes in arterial oxygenation and hemoglobin concentration [Hb], acute mountain sickness (AMS), cognitive function, and exercise performance in 21 subjects as they acclimatized to 5260 m over 16 days. We then focused on the retention of acclimatization by having subjects reascend to 5260 m after either 7 (n = 14) or 21 (n = 7) days at 1525 m. At 16 days at 5260 m we observed: 1) increases in arterial oxygenation and [Hb] (compared to acute hypoxia: PaO2 rose 9±4 mmHg to 45±4 while PaCO2 dropped a further 6±3 mmHg to 21±3, and [Hb] rose 1.8±0.7 g/dL to 16±2 g/dL; 2) no AMS; 3) improved cognitive function; and 4) improved exercise performance by 8±8% (all changes p<0.01). Upon reascent, we observed retention of arterial oxygenation but not [Hb], protection from AMS, retention of exercise performance, less retention of cognitive function; and noted that some of these effects lasted for 21 days. Taken together, these findings reveal new information about retention of acclimatization, and can be used as a physiological foundation to explore the molecular mechanisms of acclimatization and its retention

The Higgs Working Group: Summary Report

Report of the Higgs working group for the Workshop "Physics at TeVColliders", Les Houches, France 8-18 June 1999. It contains 6 separatesections: 1. Measuring Higgs boson couplings at the LHC. 2. Higgs boson production at hadron colliders at NLO. 3. Signatures of Heavy Charged Higgs Bosons at the LHC. 4. Light stop effects and Higgs boson searches at the LHC. 5. Double Higgs production at TeV Colliders in the MSSM. 6. Programs and Tools for Higgs Bosons

Neutral Higgs bosons in the MNMSSM with explicit CP violation

Within the framework of the minimal non-minimal supersymmetric standard model (MNMSSM) with tadpole terms, CP violation effects in the Higgs sector are investigated at the one-loop level, where the radiative corrections from the loops of the quark and squarks of the third generation are taken into account. Assuming that the squark masses are not degenerate, the radiative corrections due to the stop and sbottom quarks give rise to CP phases, which trigger the CP violation explicitly in the Higgs sector of the MNMSSM. The masses, the branching ratios for dominant decay channels, and the total decay widths of the five neutral Higgs bosons in the MNMSSM are calculated in the presence of the explicit CP violation. The dependence of these quantities on the CP phases is quite recognizable, for given parameter values.Comment: 25 pages, 8 figure

Measuring the Higgs Sector

If we find a light Higgs boson at the LHC, there should be many observable channels which we can exploit to measure the relevant parameters in the Higgs sector. We use the SFitter framework to map these measurements on the parameter space of a general weak-scale effective theory with a light Higgs state of mass 120 GeV. Our analysis benefits from the parameter determination tools and the error treatment used in new--physics searches, to study individual parameters and their error bars as well as parameter correlations.Comment: 45 pages, Journal version with comments from refere

Associated Production of Higgs Bosons with Scalar Quarks at Future Hadron and e+e−e^+e^- Colliders

We analyze the production of neutral Higgs particles in association with the supersymmetric scalar partners of the third generation quarks at future high--energy hadron colliders [upgraded Tevatron, LHC] and $e^+e^-$ linear machines [including the $\gamma \gamma$ option]. In the Minimal Supersymmetric extension of the Standard Model, the cross section for the associated production of the lightest neutral $h$ boson with the lightest top squark pairs can be rather substantial at high energies. This process would open a window for the measurement of the $h \tilde{t} \tilde{t}$ coupling, the potentially largest coupling in the supersymmetric theory.Comment: 34 pages, LaTex, 11 PS figures using axodraw.sty. More detailed discussion on the rho-parameter constraints. Numerical results and conclusions unchanged. To appear in Nucl. Phys.

Search for the standard model Higgs boson decaying into two photons in pp collisions at sqrt(s)=7 TeV

A search for a Higgs boson decaying into two photons is described. The analysis is performed using a dataset recorded by the CMS experiment at the LHC from pp collisions at a centre-of-mass energy of 7 TeV, which corresponds to an integrated luminosity of 4.8 inverse femtobarns. Limits are set on the cross section of the standard model Higgs boson decaying to two photons. The expected exclusion limit at 95% confidence level is between 1.4 and 2.4 times the standard model cross section in the mass range between 110 and 150 GeV. The analysis of the data excludes, at 95% confidence level, the standard model Higgs boson decaying into two photons in the mass range 128 to 132 GeV. The largest excess of events above the expected standard model background is observed for a Higgs boson mass hypothesis of 124 GeV with a local significance of 3.1 sigma. The global significance of observing an excess with a local significance greater than 3.1 sigma anywhere in the search range 110-150 GeV is estimated to be 1.8 sigma. More data are required to ascertain the origin of this excess.Comment: Submitted to Physics Letters

An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup

BACKGROUND. Chronic obstructive pulmonary disease (COPD) is a heterogeneous smoking-related disease characterized by airway obstruction and inflammation. This inflammation may persist even after smoking cessation and responds variably to corticosteroids. Personalizing treatment to biologically similar "molecular phenotypes" may improve therapeutic efficacy in COPD. IL-17A is involved in neutrophilic inflammation and corticosteroid resistance, and thus may be particularly important in a COPD molecular phenotype. METHODS. We generated a gene expression signature of IL-17A response in bronchial airway epithelial brushings from smokers with and without COPD (n = 238), and validated it using data from 2 randomized trials of IL-17 blockade in psoriasis. This IL-17 signature was related to clinical and pathologic characteristics in 2 additional human studies of COPD: (a) SPIROMICS (n = 47), which included former and current smokers with COPD, and (b) GLUCOLD (n = 79), in which COPD participants were randomized to placebo or corticosteroids. RESULTS. The IL-17 signature was associated with an inflammatory profile characteristic of an IL-17 response, including increased airway neutrophils and macrophages. In SPIROMICS the signature was associated with increased airway obstruction and functional small airways disease on quantitative chest CT. In GLUCOLD the signature was associated with decreased response to corticosteroids, irrespective of airway eosinophilic or type 2 inflammation. CONCLUSION. These data suggest that a gene signature of IL-17 airway epithelial response distinguishes a biologically, radiographically, and clinically distinct COPD subgroup that may benefit from personalized therapy

Collider aspects of flavour physics at high Q

This review presents flavour related issues in the production and decays of heavy states at LHC, both from the experimental side and from the theoretical side. We review top quark physics and discuss flavour aspects of several extensions of the Standard Model, such as supersymmetry, little Higgs model or models with extra dimensions. This includes discovery aspects as well as measurement of several properties of these heavy states. We also present public available computational tools related to this topic.Comment: Report of Working Group 1 of the CERN Workshop ``Flavour in the era of the LHC'', Geneva, Switzerland, November 2005 -- March 200