332 research outputs found
Phonon-induced quadrupolar ordering of the magnetic superconductor TmNiBC
We present synchrotron x-ray diffraction studies revealing that the lattice
of thulium borocarbide is distorted below T_Q = 13.5 K at zero field. T_Q
increases and the amplitude of the displacements is drastically enhanced, by a
factor of 10 at 60 kOe, when a magnetic field is applied along [100]. The
distortion occurs at the same wave vector as the antiferromagnetic ordering
induced by the a-axis field. A model is presented that accounts for the
properties of the quadrupolar phase and explains the peculiar behavior of the
antiferromagnetic ordering previously observed in this compound.Comment: submitted to PR
Equilibrium basal-plane magnetization of superconductive YNi(2)B(2)C - the influence of non-local electrodynamics
For a single crystal of YNi(2)B(2)C superconductor, the equilibrium
magnetization M in the square basal plane has been studied experimentally as a
function of temperature and magnetic field. While the magnetization M(H)
deviates from conventional London predictions, a recent extension of London
theory (to include effects of non-local electrodynamics) describes the
experiments accurately. The resulting superconductive parameters are well
behaved. These results are compared with corresponding findings for the case
with M perpendicular to the basal plane.Comment: 7 pages, 5 Postscript Figures, 2 table
Optical IFU Observations of the Brightest Cluster Galaxy NGC 4696: The Case for a Minor Merger and Shock-excited Filaments
We present deep optical integral-field spectroscopic observations of the
nearby (z ~ 0.01) brightest cluster galaxy NGC 4696 in the core of the
Centaurus Cluster, made with the Wide Field Spectrograph (WiFeS) on the ANU
2.3m telescope at Siding Spring Observatory. We investigate the morphology,
kinematics, and excitation of the emission-line filaments and discuss these in
the context of a model of a minor merger. We suggest that the emission-line
filaments in this object have their origin in the accretion of a gas-rich
galaxy and that they are excited by v ~100-200 km/s shocks driven into the cool
filament gas by the ram pressure of the transonic passage of the merging system
through the hot halo gas of NGC 4696.Comment: 19 pages, 15 figures, accepted for publication in The Astrophysical
Journa
Far-Ultraviolet Radiation from Elliptical Galaxies
Far-ultraviolet radiation is a ubiquitous, if unanticipated, phenomenon in
elliptical galaxies and early-type spiral bulges. It is the most variable
photometric feature associated with old stellar populations. Recent
observational and theoretical evidence shows that it is produced mainly by
low-mass, small-envelope, helium-burning stars in extreme horizontal branch and
subsequent phases of evolution. These are probably descendents of the dominant,
metal rich population of the galaxies. Their lifetime UV outputs are remarkably
sensitive to their physical properties and hence to the age and the helium and
metal abundances of their parents. UV spectra are therefore exceptionally
promising diagnostics of old stellar populations, although their calibration
requires a much improved understanding of giant branch mass loss, helium
enrichment, and atmospheric diffusion.Comment: 46 pages; includes LaTeX text file, 9 PS figures, 1 JPG figure, 2
style files. Full resolution figures and PS version available at
http://www.astro.virginia.edu/~rwo/araa99/. Article to appear in Annual
Reviews of Astronomy & Astrophysics, 199
Foreground removal from CMB temperature maps using an MLP neural network
One of the main obstacles in extracting the Cosmic Microwave Background (CMB)
signal from observations in the mm-submm range is the foreground contamination
by emission from galactic components: mainly synchrotron, free-free and thermal
dust emission. Due to the statistical nature of the intrinsic CMB signal it is
essential to minimize the systematic errors in the CMB temperature
determinations. Following the available knowledge of the spectral behavior of
the galactic foregrounds simple, power law-like spectra have been assumed. The
feasibility of using a simple neural network for extracting the CMB temperature
signal from the combined CMB and foreground signals has been investigated. As a
specific example, we have analysed simulated data, like that expected from the
ESA Planck Surveyor mission. A simple multilayer perceptron neural network with
2 hidden layers can provide temperature estimates, over more than 80 percent of
the sky, that are to a high degree uncorrelated with the foreground signals. A
single network will be able to cover the dynamic range of the Planck noise
level over the entire sky.Comment: Accepted for publication in Astrophysics and Space Scienc
Whole-genome amplified DNA from stored dried blood spots is reliable in high resolution melting curve and sequencing analysis
<p>Abstract</p> <p>Background</p> <p>The use of dried blood spots (DBS) samples in genomic workup has been limited by the relative low amounts of genomic DNA (gDNA) they contain. It remains to be proven that whole genome amplified DNA (wgaDNA) from stored DBS samples, constitutes a reliable alternative to gDNA.</p> <p>We wanted to compare melting curves and sequencing results from wgaDNA derived from DBS samples with gDNA derived from whole blood.</p> <p>Methods</p> <p>gDNA was extracted from whole blood obtained from 10 patients with lone atrial fibrillation (mean age 22.3 years). From their newborn DBS samples, stored at -24°C, genomic DNA was extracted and whole-genome amplified in triplicates. Using high resolution melting curve analysis and direct sequencing in both wgaDNA and gDNA samples, all coding regions and adjacent intron regions of the genes <it>SCN5A </it>and <it>KCNA5 </it>were investigated.</p> <p>Results</p> <p>Altered melting curves was present in 85 of wgaDNA samples and 81 of gDNA samples. Sequence analysis identified a total of 31 variants in the 10 wgaDNA samples. The same 31 variants were found in the exact same pattern of samples in the gDNA group. There was no false positive or negative sequence variation in the wgaDNA group.</p> <p>Conclusions</p> <p>The use of DNA amplified in triplicates from DBS samples is reliable and can be used both for high resolution curve melting analysis as well as direct sequence analysis. DBS samples therefore can serve as an alternative to whole blood in sequence analysis.</p
Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci.
Genetic and environmental components as well as their interaction contribute to the risk of schizophrenia, making it highly relevant to include environmental factors in genetic studies of schizophrenia. This study comprises genome-wide association (GWA) and follow-up analyses of all individuals born in Denmark since 1981 and diagnosed with schizophrenia as well as controls from the same birth cohort. Furthermore, we present the first genome-wide interaction survey of single nucleotide polymorphisms (SNPs) and maternal cytomegalovirus (CMV) infection. The GWA analysis included 888 cases and 882 controls, and the follow-up investigation of the top GWA results was performed in independent Danish (1396 cases and 1803 controls) and German-Dutch (1169 cases, 3714 controls) samples. The SNPs most strongly associated in the single-marker analysis of the combined Danish samples were rs4757144 in ARNTL (P=3.78 × 10(-6)) and rs8057927 in CDH13 (P=1.39 × 10(-5)). Both genes have previously been linked to schizophrenia or other psychiatric disorders. The strongest associated SNP in the combined analysis, including Danish and German-Dutch samples, was rs12922317 in RUNDC2A (P=9.04 × 10(-7)). A region-based analysis summarizing independent signals in segments of 100 kb identified a new region-based genome-wide significant locus overlapping the gene ZEB1 (P=7.0 × 10(-7)). This signal was replicated in the follow-up analysis (P=2.3 × 10(-2)). Significant interaction with maternal CMV infection was found for rs7902091 (P(SNP × CMV)=7.3 × 10(-7)) in CTNNA3, a gene not previously implicated in schizophrenia, stressing the importance of including environmental factors in genetic studies
Planck intermediate results. III. The relation between galaxy cluster mass and Sunyaev-Zeldovich signal
We examine the relation between the galaxy cluster mass M and
Sunyaev-Zeldovich (SZ) effect signal D_A^2 Y for a sample of 19 objects for
which weak lensing (WL) mass measurements obtained from Subaru Telescope data
are available in the literature. Hydrostatic X-ray masses are derived from
XMM-Newton archive data and the SZ effect signal is measured from Planck
all-sky survey data. We find an M_WL-D_A^2 Y relation that is consistent in
slope and normalisation with previous determinations using weak lensing masses;
however, there is a normalisation offset with respect to previous measures
based on hydrostatic X-ray mass-proxy relations. We verify that our SZ effect
measurements are in excellent agreement with previous determinations from
Planck data. For the present sample, the hydrostatic X-ray masses at R_500 are
on average ~ 20 per cent larger than the corresponding weak lensing masses, at
odds with expectations. We show that the mass discrepancy is driven by a
difference in mass concentration as measured by the two methods, and, for the
present sample, the mass discrepancy and difference in mass concentration is
especially large for disturbed systems. The mass discrepancy is also linked to
the offset in centres used by the X-ray and weak lensing analyses, which again
is most important in disturbed systems. We outline several approaches that are
needed to help achieve convergence in cluster mass measurement with X-ray and
weak lensing observations.Comment: 19 pages, 9 figures, matches accepted versio
Maternal Use of Antibiotics, Hospitalisation for Infection during Pregnancy, and Risk of Childhood Epilepsy: A Population-Based Cohort Study
BACKGROUND: Maternal infection during pregnancy may be a risk factor for epilepsy in offspring. Use of antibiotics is a valid marker of infection. METHODOLOGY/PRINCIPAL FINDINGS: To examine the relationship between maternal infection during pregnancy and risk of childhood epilepsy we conducted a historical cohort study of singletons born in northern Denmark from 1998 through 2008 who survived ≥29 days. We used population-based medical databases to ascertain maternal use of antibiotics or hospital contacts with infection during pregnancy, as well as first-time hospital contacts with a diagnosis of epilepsy among offspring. We compared incidence rates (IR) of epilepsy among children of mothers with and without infection during pregnancy. We examined the outcome according to trimester of exposure, type of antibiotic, and total number of prescriptions, using Poisson regression to estimate incidence rate ratios (IRRs) while adjusting for covariates. Among 191,383 children in the cohort, 948 (0.5%) were hospitalised or had an outpatient visit for epilepsy during follow-up, yielding an IR of 91 per 100 000 person-years (PY). The five-year cumulative incidence of epilepsy was 4.5 per 1000 children. Among children exposed prenatally to maternal infection, the IR was 117 per 100,000 PY, with an adjusted IRR of 1.40 (95% confidence interval (CI): 1.22-1.61), compared with unexposed children. The association was unaffected by trimester of exposure, antibiotic type, or prescription count. CONCLUSIONS/SIGNIFICANCE: Prenatal exposure to maternal infection is associated with an increased risk of epilepsy in childhood. The similarity of estimates across types of antibiotics suggests that processes common to all infections underlie this outcome, rather than specific pathogens or drugs
Planck Intermediate Results II: Comparison of Sunyaev-Zeldovich measurements from Planck and from the Arcminute Microkelvin Imager for 11 galaxy clusters
A comparison is presented of Sunyaev-Zeldovich measurements for 11 galaxy
clusters as obtained by Planck and by the ground-based interferometer, the
Arcminute Microkelvin Imager. Assuming a universal spherically-symmetric
Generalised Navarro, Frenk & White (GNFW) model for the cluster gas pressure
profile, we jointly constrain the integrated Compton-Y parameter (Y_500) and
the scale radius (theta_500) of each cluster. Our resulting constraints in the
Y_500-theta_500 2D parameter space derived from the two instruments overlap
significantly for eight of the clusters, although, overall, there is a tendency
for AMI to find the Sunyaev-Zeldovich signal to be smaller in angular size and
fainter than Planck. Significant discrepancies exist for the three remaining
clusters in the sample, namely A1413, A1914, and the newly-discovered Planck
cluster PLCKESZ G139.59+24.18. The robustness of the analysis of both the
Planck and AMI data is demonstrated through the use of detailed simulations,
which also discount confusion from residual point (radio) sources and from
diffuse astrophysical foregrounds as possible explanations for the
discrepancies found. For a subset of our cluster sample, we have investigated
the dependence of our results on the assumed pressure profile by repeating the
analysis adopting the best-fitting GNFW profile shape which best matches X-ray
observations. Adopting the best-fitting profile shape from the X-ray data does
not, in general, resolve the discrepancies found in this subset of five
clusters. Though based on a small sample, our results suggest that the adopted
GNFW model may not be sufficiently flexible to describe clusters universally.Comment: update to metadata author list onl
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