Late-Glacial and Holocene Geology of the Middle St. John River Valley

Guidebook to the geology of Northeastern Maine and neighboring New Brunswick: The 72nd annual meeting of the New England Intercollegiate Geological Conference, Presque Isle, Maine, October 10-13, 1980: Trip C-

Ice flow and deglaciation: Northwestern Maine

Maine Geological Survey, Open-File Report 86-18. Guidebook for 49th Annual Friends of the Pleistocene field triphttps://digitalmaine.com/mgs_publications/1176/thumbnail.jp

Contributions to the Quaternary Geology of Northern Maine and Adjacent Canada

Contributions to the Quaternary Geology of Northern Maine and Adjacent Canada Bulletin 37 - Maine Geological Survey, Department of Conservation, Augusta, Maine 04333 (1988). Contents: Introduction / A GEOMORPHIC METHOD FOR RECONSTRUCTING PALEO ICE SHEETS, Part I: GLACIAL GEOLOGY. - T. Hughes and J. Fastook / A GEOMORPHIC METHOD FOR RECONSTRUCTING PALEO ICE SHEETS, Part II: GLACIOLOGY. - J. Fastook and T. Hughes / TILL STRATIGRAPHY AT THE BALD MOUNTAIN MINE SITE, NORTHERN MAINE - W. R. Holland and F. F. Bragdon / GLACIAL DISPERSAL FROM THE PRIESTLY LAKE AND DEBOULLIE PLUTONS, NORTHERN MAINE - E. F. Halter / GLACIATION OF NORTHWESTERN MAINE - T. V. Lowell and J. S. Kite / AN UNUSUAL GLACIAL STRATIGRAPHY EXPOSED IN THE AROOSTOOK RIVER VALLEY, NORTHERN MAINE - H. W. Borns, Jr. and M. P. Borns / DEGLACIATION OF NORTHWESTERN MAINE - T. V. Lowell and J. S. Kite / DEGLACIATION AND STRATIGRAPHY OF THE LOWER ST. LAWRENCE VALLEY AND APPALACHIAN MOUNTAINS OF SOUTHEASTERN QUEBEC - P. LaSalle / QUATERNARY GEOLOGY OF MADAWASKA COUNTY, WESTERN NEW BRUNSWICK: A BRIEF OVERVIEW - V. N. Rampton / ICE MOVEMENTS IN MADAWASKA AND VICTORIA COUNTIES, NORTHWESTERN NEW BRUNSWICK - M. Rappol / POSTGLACIAL HISTORY OF THE UPPER ST. JOHN DRAINAGE BASIN - J. S. Kite and R. Stuckenrath / THE ARCHAEOLOGY OF THE UPPER ST. JOHN RIVER: OVERVIEW AND INTERPRETATION - G. P. Nicholashttps://digitalcommons.usm.maine.edu/me_collection/1188/thumbnail.jp

Oral Abstracts 7: RA ClinicalO37. Long-Term Outcomes of Early RA Patients Initiated with Adalimumab Plus Methotrexate Compared with Methotrexate Alone Following a Targeted Treatment Approach

Background: This analysis assessed, on a group level, whether there is a long-term advantage for early RA patients treated with adalimumab (ADA) + MTX vs those initially treated with placebo (PBO) + MTX who either responded to therapy or added ADA following inadequate response (IR). Methods: OPTIMA was a 78- week, randomized, controlled trial of ADA + MTX vs PBO + MTX in MTX-naïve early (<1 year) RA patients. Therapy was adjusted at week 26: ADA + MTX-responders (R) who achieved DAS28 (CRP) <3.2 at weeks 22 and 26 (Period 1, P1) were re-randomized to withdraw or continue ADA and PBO + MTX-R continued randomized therapy for 52 weeks (P2); IR-patients received open-label (OL) ADA + MTX during P2. This post hoc analysis evaluated the proportion of patients at week 78 with DAS28 (CRP) <3.2, HAQ-DI <0.5, and/or ΔmTSS ≤0.5 by initial treatment. To account for patients who withdrew ADA during P2, an equivalent proportion of R was imputed from ADA + MTX-R patients. Results: At week 26, significantly more patients had low disease activity, normal function, and/or no radiographic progression with ADA + MTX vs PBO + MTX (Table 1). Differences in clinical and functional outcomes disappeared following additional treatment, when PBO + MTX-IR (n = 348/460) switched to OL ADA + MTX. Addition of OL ADA slowed radiographic progression, but more patients who received ADA + MTX from baseline had no radiographic progression at week 78 than patients who received initial PBO + MTX. Conclusions: Early RA patients treated with PBO + MTX achieved comparable long-term clinical and functional outcomes on a group level as those who began ADA + MTX, but only when therapy was optimized by the addition of ADA in PBO + MTX-IR. Still, ADA + MTX therapy conferred a radiographic benefit although the difference did not appear to translate to an additional functional benefit. Disclosures: P.E., AbbVie, Merck, Pfizer, UCB, Roche, BMS—Provided Expert Advice, Undertaken Trials, AbbVie—AbbVie sponsored the study, contributed to its design, and participated in the collection, analysis, and interpretation of the data, and in the writing, reviewing, and approval of the final version. R.F., AbbVie, Pfizer, Merck, Roche, UCB, Celgene, Amgen, AstraZeneca, BMS, Janssen, Lilly, Novartis—Research Grants, Consultation Fees. S.F., AbbVie—Employee, Stocks. A.K., AbbVie, Amgen, AstraZeneca, BMS, Celgene, Centocor-Janssen, Pfizer, Roche, UCB—Research Grants, Consultation Fees. H.K., AbbVie—Employee, Stocks. S.R., AbbVie—Employee, Stocks. J.S., AbbVie, Amgen, AstraZeneca, BMS, Celgene, Centocor-Janssen, GlaxoSmithKline, Lilly, Pfizer (Wyeth), MSD (Schering-Plough), Novo-Nordisk, Roche, Sandoz, UCB—Research Grants, Consultation Fees. R.V., AbbVie, BMS, GlaxoSmithKline, Human Genome Sciences, Merck, Pfizer, Roche, UCB Pharma—Consultation Fees, Research Support. Table 1.Week 78 clinical, functional, and radiographic outcomes in patients who received continued ADA + MTX vs those who continued PBO + MTX or added open-label ADA following an inadequate response ADA + MTX, n/N (%)a PBO + MTX, n/N (%)b Outcome Week 26 Week 52 Week 78 Week 26 Week 52 Week 78 DAS28 (CRP) <3.2 246/466 (53) 304/465 (65) 303/465 (65) 139/460 (30)*** 284/460 (62) 300/460 (65) HAQ-DI <0.5 211/466 (45) 220/466 (47) 224/466 (48) 150/460 (33)*** 203/460 (44) 208/460 (45) ΔmTSS ≤0.5 402/462 (87) 379/445 (86) 382/443 (86) 330/459 (72)*** 318/440 (72)*** 318/440 (72)*** DAS28 (CRP) <3.2 + ΔmTSS ≤0.5 216/462 (47) 260/443 (59) 266/443 (60) 112/459 (24)*** 196/440 (45) 211/440 (48)*** DAS28 (CRP) <3.2 + HAQ-DI <0.5 + ΔmTSS ≤0.5 146/462 (32) 168/443 (38) 174/443 (39) 82/459 (18)*** 120/440 (27)*** 135/440 (31)** aIncludes patients from the ADA Continuation (n = 105) and OL ADA Carry On (n = 259) arms, as well as the proportional equivalent number of responders from the ADA Withdrawal arm (n = 102). bIncludes patients from the MTX Continuation (n = 112) and Rescue ADA (n = 348) arms. Last observation carried forward: DAS28 (CRP) and HAQ-DI; Multiple imputations: ΔmTSS. ***P < 0.001 and **iP < 0.01, respectively, for differences between initial treatments from chi-squar

The 16th Data Release of the Sloan Digital Sky Surveys: First Release from the APOGEE-2 Southern Survey and Full Release of eBOSS Spectra

This paper documents the 16th data release (DR16) from the Sloan Digital Sky Surveys (SDSS), the fourth and penultimate from the fourth phase (SDSS-IV). This is the first release of data from the Southern Hemisphere survey of the Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2); new data from APOGEE-2 North are also included. DR16 is also notable as the final data release for the main cosmological program of the Extended Baryon Oscillation Spectroscopic Survey (eBOSS), and all raw and reduced spectra from that project are released here. DR16 also includes all the data from the Time Domain Spectroscopic Survey and new data from the SPectroscopic IDentification of ERosita Survey programs, both of which were co-observed on eBOSS plates. DR16 has no new data from the Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey (or the MaNGA Stellar Library "MaStar"). We also preview future SDSS-V operations (due to start in 2020), and summarize plans for the final SDSS-IV data release (DR17)

The 16th Data Release of the Sloan Digital Sky Surveys : First Release from the APOGEE-2 Southern Survey and Full Release of eBOSS Spectra

This paper documents the 16th data release (DR16) from the Sloan Digital Sky Surveys (SDSS), the fourth and penultimate from the fourth phase (SDSS-IV). This is the first release of data from the Southern Hemisphere survey of the Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2); new data from APOGEE-2 North are also included. DR16 is also notable as the final data release for the main cosmological program of the Extended Baryon Oscillation Spectroscopic Survey (eBOSS), and all raw and reduced spectra from that project are released here. DR16 also includes all the data from the Time Domain Spectroscopic Survey and new data from the SPectroscopic IDentification of ERosita Survey programs, both of which were co-observed on eBOSS plates. DR16 has no new data from the Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey (or the MaNGA Stellar Library "MaStar"). We also preview future SDSS-V operations (due to start in 2020), and summarize plans for the final SDSS-IV data release (DR17).Peer reviewe

Cold-Air Trap Temperature Records Support Simple High-Density Air-Flow Mechanisms at an Appalachian Limestone Cave Entrance Sinkhole

Many Appalachian caves act as cold-air traps, widely open systems chilled by high-density cold air during chilly weather that evolve into density-stratified, nearly closed systems in warm weather. Like algific talus slopes, rock cities, and other cold-air traps in the region, these caves appear to function in accordance with a simple natural refrigeration model popularized by Balch (1900), in which circulation is dominated by static, thermally stratified conditions intermittently disrupted by sinking cold air. Crowder Cave, in Monroe County, West Virginia, hosts two separate cold-air traps in chambers contiguous to an entrance pit, a ~12,000 m3 sinkhole lined with 6 to 18 m high limestone cliffs. The sinkhole and both cave chambers appear poorly connected to surface or subsurface streams. Davies (1958) reported historical accounts of seasonal ice in the small room as late as July, but our ongoing hourly temperature monitoring indicates ice regularly has disappeared by late April in five of the last six years. The entrance pit functions as a relatively open cold-air trap system with a mean annual temperature of ~7°C, well below mean annual surface temperatures of ~10°C recorded at nearby weather stations. In summer, both cave chambers are virtually closed systems with very gradual increases (\u3c0.1 to 0.2 C°/day) in temperature; neither experienced a temperature reading greater than 9.2°C during our monitoring. In stark contrast, both chambers commonly experience brief winter episodes of rapidly plunging (4 to 8 C°/day) temperatures, reaching as low as -13 to -15° C. Icicles, columns, frozen lenses, and other ice accumulations have been observed in the small ~350 m3 chamber at the northeast end of the cave, where mean temperature has been ~2.7° C. Ice stalagmites and various other ice forms have been seen on the floor of the large ~12,000 m3 chamber on the south end of the pit, where the mean temperature has been ~3.5° C. Entrance pit temperatures respond very quickly when atmospheric conditions are appreciably colder than pre-existing air in Crowder Cave; temperatures in the two adjacent chambers seldom lag more than 1-3 hours behind. Despite similar timing, the amplitude of temperature response in the large chamber is considerably less than the small chamber, presumably because of a 35-fold difference in chamber volume. The amplitude of temperature change decreases and mean temperature increases with distance from the mouth of the large chamber. More characteristic of typical cave conditions, temperatures near the end of a narrow 85 m long side passage varied little (9.8° to 10.6° C) during the last 4.5 years. Crowder Cave data show the interplay between density-driven cold air flow, karst topography, and cave geometry lead to wide variability in winter conditions that may give rise to very different bat hibernacula conditions in a single cave. The ecological significance of cold air traps associated with sinkholes may be profound, both as climate change indicators and for a potential role they may play in the course of the ongoing white-nose syndrome (Pseudogymnoascus destructans) epidemic. Conference Topic: Investigation, Monitoring, and Remediation in Kars

Postglacial evolution of drainage in the middle and upper St. John River basin, Maine and New Brunswick

in Tucker, Robert D., and Marvinney, Robert G. (editors), Studies in Maine geology: Volume 6 - Quaternary geology: Maine Geological Survey, p. 135-142.https://digitalmaine.com/mgs_publications/1082/thumbnail.jp

Postglacial evolution of drainage in the middle and upper St. John River basin, Maine and New Brunswick

in Tucker, Robert D., and Marvinney, Robert G. (editors), Studies in Maine geology: Volume 6 - Quaternary geology: Maine Geological Survey, p. 135-142.https://digitalmaine.com/mgs_publications/1082/thumbnail.jp