'Pour le bien du roy et de son royaume' : Burgundian propaganda under John the Fearless, Duke of Burgundy, 1405-1419

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Lecture rapture: The place and case for lectures in the new normal

Following the pivot to online teaching as a result of COVID-19, a longstanding debate as to whether higher education should abandon traditional face-to-face lectures has reignited. In this paper, we set out our reflection on this issue based on the evidence available. We conclude that traditional on-campus lectures, and the recordings of those lectures have a place in higher education and the suggestion that they should be abandoned is as unhelpful as the suggestion that they should be the default mode of teaching. When lectures are deliberately chosen as the most appropriate method of teaching and when the same pedagogical care and attention is given as to other modes of delivery, they provide an effective, pragmatic solution, particularly for large classes

The cost of asking ‘say that again?’: a social capital theory view into how lecture recording supports widening participation

FUNDING This work was funded by Quality Assurance Agency Scotland as part of the Collaborative Cluster: Widening Participation with Lecture Recording: https://www.enhancementthemes.ac. uk/completed-enhancement-themes/evidence-for-enhancement/ student-engagement-and-demographics/widening-participation- with-lecture-recording. ACKNOWLEDGMENTS We acknowledge the support of the Widening Participation teams at the University’s of Glasgow, Edinburgh and Aberdeen, and the student participants in this project. We also acknowledge the support of the QAA Widening Participation with Lecture Recording Collaborate Cluster.Peer reviewedPublisher PD

Test-Retest Reliability of the Repetitive Step Test in Community Dwelling Older Adults

Each year one in every three adults over the age of 65 experience a fall resulting in serious injury and in some instances death. In this population, falling injuries are the leading cause of death and are associated with the greatest number of nonfatal injuries and trauma hospital admissions. Since balance and muscle performance decreases as one ages, it is vitally important to assess these factors as part of a comprehensive strategy to monitor and predict fall risk. Previous data analysis of the Repetitive Step Test (RST) has shown that there is a significant performance difference between non-fallers and recurrent fallers in particular stepping conditions, and that significant inter-limb differences exist in non-fallers.https://ecommons.udayton.edu/dpt_symposium/1033/thumbnail.jp

R2Play development: Fostering user-driven technology that supports return-to-play decision-making following pediatric concussion

ObjectiveTo design a multi-domain return-to-play assessment system (R2Play) for youth athletes with concussion.MethodsThe R2Play system was developed using an overarching user-centered approach, the Design Thinking Framework, and research activities included: 1) structured brainstorming within our research team, 2) interviews with clinician and youth sports coaches, 3) building a testable prototype, and 4) interface testing through cognitive walkthroughs with clinician partners.ResultsClinician and coach participants provided feedback on the R2Play concept, which was integrated into the design process and provided future directions for research. Examples of feedback-driven design choices included reducing assessment time, increasing ecological validity by adding in background noise, and developing youth-friendly graphical results screens. Following refinement based on stakeholder feedback, the R2Play system was outlined in detail and a testable prototype was developed. It is made up of two parts: a clinician tablet, and a series of tablet “buttons” that display numbers and letters. Youth athletes run between the buttons to connect a “trail” in ascending alphanumeric order, 1-A-2-B, etc. Their performance across a series of levels of increasing difficulty is logged on the clinician tablet. Initial testing with five clinicians showed the system's interface to have excellent usability with a score of 81% (SD = 8.02) on the System Usability Scale.ConclusionThrough this research, a prototype of the R2Play system was innovated and evaluated by clinician and coach stakeholders. Initial usability was excellent and directions for future iterations were highlighted. Outcomes suggest the potential benefits of using technologies to assist in complex clinical assessment, as well as utilizing a user-centered approach to design

Ohio Wesleyan Bacillus Collection Student Research

This semester students in BIOL 328 Bacterial Physiology lab worked in teams on a laboratory project that they devised, developed, and conducted. Each group met weekly with Dr. Tuhela-Reuning and Maddy Russell during the first third of the semester to develop a research project that involved the Bacillus culture collection at OWU. The Bacillus collection contains over 3000 isolates of Bacillus obtained from wild songbirds in Ohio, Arizona, and Washington, and many of these isolates degrade feathers. Student projects involved quantification of bird feather degradation by several Bacillus isolates, scanning electron microscopy (SEM) of biofilms and feather, possible correlation of biofilm production with speed of feather degradation, ability of Bacillus isolates to produce antibiotics effective against Gram positive and negative bacteria, and the ability to transform Bacillus isolates with pigment-producing plasmids. Students experienced the actual research process by troubleshooting problems, coordinating their lab work schedules, analyzing complex results, and working as a team. The final results of the projects will be presented by each team in oral and written formats

Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors.

The Cre-loxP system is invaluable for spatial and temporal control of gene knockout, knockin, and reporter expression in the mouse nervous system. However, we report varying probabilities of unexpected germline recombination in distinct Cre driver lines designed for nervous system-specific recombination. Selective maternal or paternal germline recombination is showcased with sample Cre lines. Collated data reveal germline recombination in over half of 64 commonly used Cre driver lines, in most cases with a parental sex bias related to Cre expression in sperm or oocytes. Slight differences among Cre driver lines utilizing common transcriptional control elements affect germline recombination rates. Specific target loci demonstrated differential recombination; thus, reporters are not reliable proxies for another locus of interest. Similar principles apply to other recombinase systems and other genetically targeted organisms. We hereby draw attention to the prevalence of germline recombination and provide guidelines to inform future research for the neuroscience and broader molecular genetics communities

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

DACC Resting State Functional Connectivity as a Predictor of Pain Symptoms Following Motor Vehicle Crash: A Preliminary Investigation

There is significant heterogeneity in pain outcomes following motor vehicle crashes (MVCs), such that a sizeable portion of individuals develop symptoms of chronic pain months after injury while others recover. Despite variable outcomes, the pathogenesis of chronic pain is currently unclear. Previous neuroimaging work implicates the dorsal anterior cingulate cortex (dACC) in adaptive control of pain, while prior resting state functional magnetic resonance imaging studies find increased functional connectivity (FC) between the dACC and regions involved in pain processing in those with chronic pain. Hyper-connectivity of the dACC to regions that mediate pain response may therefore relate to pain severity. The present study completed rsfMRI scans on N=22 survivors of MVCs collected within two weeks of the incident to test whole-brain dACC-FC as a predictor of pain severity six months later. At two weeks, pain symptoms were predicted by positive connectivity between the dACC and the premotor cortex. Controlling for pain symptoms at two weeks, pain symptoms at six months were predicted by negative connectivity between the dACC and the precuneus. Previous research implicates the precuneus in the individual subjective awareness of pain. Given a relatively small sample size, approximately half of which did not experience chronic pain at six months, findings warrant replication. Nevertheless, this study provides preliminary evidence of enhanced dACC connectivity with motor regions and decreased connectivity with pain processing regions as immediate and prospective predictors of pain following MVC. Perspective: This article presents evidence of distinct neural vulnerabilities that predict chronic pain in motor vehicle crash survivors based on whole-brain connectivity with the dorsal anterior cingulate cortex