Influenza A Virus Inhibits Type I IFN Signaling via NF-κB-Dependent Induction of SOCS-3 Expression

The type I interferon (IFN) system is a first line of defense against viral infections. Viruses have developed various mechanisms to counteract this response. So far, the interferon antagonistic activity of influenza A viruses was mainly observed on the level of IFNβ gene induction via action of the viral non-structural protein 1 (NS1). Here we present data indicating that influenza A viruses not only suppress IFNβ gene induction but also inhibit type I IFN signaling through a mechanism involving induction of the suppressor of cytokine signaling-3 (SOCS-3) protein. Our study was based on the observation that in cells that were infected with influenza A virus and subsequently stimulated with IFNα/β, phosphorylation of the signal transducer and activator of transcription protein 1 (STAT1) was strongly reduced. This impaired STAT1 activation was not due to the action of viral proteins but rather appeared to be induced by accumulation of viral 5′ triphosphate RNA in the cell. SOCS proteins are potent endogenous inhibitors of Janus kinase (JAK)/STAT signaling. Closer examination revealed that SOCS-3 but not SOCS-1 mRNA levels increase in an RNA- and nuclear factor kappa B (NF-κB)-dependent but type I IFN-independent manner early in the viral replication cycle. This direct viral induction of SOCS-3 mRNA and protein expression appears to be relevant for suppression of the antiviral response since in SOCS-3 deficient cells a sustained phosphorylation of STAT1 correlated with elevated expression of type I IFN-dependent genes. As a consequence, progeny virus titers were reduced in SOCS-3 deficient cells or in cells were SOCS-3 expression was knocked-down by siRNA. These data provide the first evidence that influenza A viruses suppress type I IFN signaling on the level of JAK/STAT activation. The inhibitory effect is at least in part due to the induction of SOCS-3 gene expression, which results in an impaired antiviral response

Production of He-4 and (4) in Pb-Pb collisions at root(NN)-N-S=2.76 TeV at the LHC

Results on the production of He-4 and (4) nuclei in Pb-Pb collisions at root(NN)-N-S = 2.76 TeV in the rapidity range vertical bar y vertical bar <1, using the ALICE detector, are presented in this paper. The rapidity densities corresponding to 0-10% central events are found to be dN/dy4(He) = (0.8 +/- 0.4 (stat) +/- 0.3 (syst)) x 10(-6) and dN/dy4 = (1.1 +/- 0.4 (stat) +/- 0.2 (syst)) x 10(-6), respectively. This is in agreement with the statistical thermal model expectation assuming the same chemical freeze-out temperature (T-chem = 156 MeV) as for light hadrons. The measured ratio of (4)/He-4 is 1.4 +/- 0.8 (stat) +/- 0.5 (syst). (C) 2018 Published by Elsevier B.V.Peer reviewe

Distributed Discovery of User Handles with Privacy

Decentralized Online Social Networks (DOSN) seek to increase their users’ privacy by removing centralized data storage and control. Their lack of usability and competitive features has severely hindered their success. Even a privacy preserving user discovery, which seems paramount for a social networking service, so far has not been implemented. Aiming at a hybrid architecture of decentralized servers, as it is suggested by the currently most successful DOSN Diaspora amongst others, we suggest a distributed discovery of users. Our discovery mechanism protects privacy of users and does not create vulnerabilities to mass collections of profiles or SPAM. The scheme adapts known techniques like DHT, indirection, and proof of knowledge, to meet the service specific requirements. A general implementation for a popular XMPP server furthermore gives proof of our concept and represents a first step towards constructing a reliable distributed social networking service with user discovery on decentralized servers, without leaking any information about its users

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Technical Specification IEC TS 62989:2018 : Primary Optics for Concentrator Photovoltaic Systems

The first edition of the Technical Specification (TS) on Primary Optics for Concentrator Photovoltaic (CPV) Systems, IEC TS 62989:2018, has been published by the International Electrotechnical Commission (IEC), on March 8th, 2018. TS 62989 covers aspects related to the primary optics including: product identification, optical characteristics, mechanical characteristics, materials, (design) geometry, and visual appearance. This paper focuses on the key aspects of the norm, including optical performance, in order to promote the awareness and use of the standard. We describe the three methods intended to measure the key optical characteristics of the primary elements, i.e. focal spot size and optical efficiency, by using the encircled energy. The three methods are using different light sources, optical components and receiver sensors, but yielded very similar results in a round robin test. This justifies the continued use of all three methods. The use of a website (opticstests.pbworks.com) for documentation of discussions and references was novel to the standard development. The website proved to be useful for the introduction of new members of the group. The website helped to keep track of changes to the document as well as the required actions of the project team

An end of service life assessment of PMMA lenses from veteran concentrator photovoltaic systems

The optical performance of poly(methyl methacrylate) lenses from veteran concentrator photovoltaic modules was examined after the end of their service life. Lenses from the Martin-Marietta and Intersol module designs were examined from the “Solar Village” site near Riyadh, Saudi Arabia, as well as the Phoenix Sky Harbor airport, followed by the Arizona Public Service Solar Test and Research (APS-STaR) center in Tempe, Arizona. The various lens specimens were deployed for 20, 27, and 22 years, respectively. Optical characterizations included lens efficiency (Solar Simulator instrument), material transmittance and haze (of coupons cut from veteran lenses, then measured again after their faceted back surface was polished, and then measured again after the incident front surface was polished), and direct transmittance (as a function of detector's acceptance angle, using the Very Low Angular Beam Spread (“VLABS”) instrument). Lens efficiency measurements compared the central region to the entire lens, also using hot and cold mirror measurements to diagnose differences in performance. A series of subsequent characterizations was performed because a decrease in performance of greater than 10% was observed for some of the veteran lenses. The optimal focal distance of the lenses was quantified using the Solar Simulator, and then correlated to lens curvature using a recently developed measurement technique. Surface roughness was examined using atomic force microscopy and scanning electron microscopy. Facet geometry (tip and valley radius) was quantified on cross-sectioned specimens. Molecular weight was compared between the incident and faceted surfaces of the lenses