223 research outputs found
Decoherence of matter waves by thermal emission of radiation
Emergent quantum technologies have led to increasing interest in decoherence
- the processes that limit the appearance of quantum effects and turn them into
classical phenomena. One important cause of decoherence is the interaction of a
quantum system with its environment, which 'entangles' the two and distributes
the quantum coherence over so many degrees of freedom as to render it
unobservable. Decoherence theory has been complemented by experiments using
matter waves coupled to external photons or molecules, and by investigations
using coherent photon states, trapped ions and electron interferometers. Large
molecules are particularly suitable for the investigation of the
quantum-classical transition because they can store much energy in numerous
internal degrees of freedom; the internal energy can be converted into thermal
radiation and thus induce decoherence. Here we report matter wave
interferometer experiments in which C70 molecules lose their quantum behaviour
by thermal emission of radiation. We find good quantitative agreement between
our experimental observations and microscopic decoherence theory. Decoherence
by emission of thermal radiation is a general mechanism that should be relevant
to all macroscopic bodies.Comment: 5 pages, 4 figure
Probing Mechanical and Chemical Instabilities in Neutron-Rich Matter
The isospin-dependence of mechanical and chemical instabilities is
investigated within a thermal and nuclear transport model using a Skyrme-type
phenomenological equation of state for neutron-rich matter. Respective roles of
the nuclear mean field and the 2-body stochastic scattering on the evolution of
density and isospin fluctuations in either mechanically or chemically unstable
regions of neutron-rich matter are investigated. It is found that the mean
field dominates overwhelmingly the fast growth of both fluctuations, while the
2-body scattering influences significantly the later growth of the isospin
fluctuation only. The magnitude of both fluctuations decreases with the
increasing isospin asymmetry because of the larger reduction of the attractive
isoscalar mean field by the stronger repuslive neutron symmetry potential in
the more neutron-rich matter. Moreover, it is shown that the isospin
fractionation happens later, but grows faster in the more neutron-rich matter.
Implications of these results to current experiments exploring properties of
neutron-rich matter are discussed.Comment: 18 pages & 15 figures, Nuclear Physics A (2001) in pres
The Spitzer Extragalactic Representative Volume Survey (SERVS): The Environments of High-z SDSS Quasi-Stellar-Objects
This paper presents a study of the environments of SDSS Quasi-Stellar-Objects
(QSOs) in the Spitzer Extragalactic Representative Volume Survey (SERVS). We
concentrate on the high-redshift QSOs as these have not been studied in large
numbers with data of this depth before. We use the IRAC 3.6-4.5{\mu}m colour of
objects and ancillary r-band data to filter out as much foreground
contamination as possible. This technique allows us to find a significant (>
4-{\sigma}) over-density of galaxies around QSOs in a redshift bin centred on z
~ 2.0 and a (> 2-{\sigma}) over-density of galaxies around QSOs in a redshift
bin centred on z ~ 3.3. We compare our findings to the predictions of a
semi-analytic galaxy formation model, based on the {\Lambda}CDM millennium
simulation, and find for both redshift bins that the model predictions match
well the source-density we have measured from the SERVS data.Comment: 13 pages, 12 figures, Accepted by Ap
The Atacama Cosmology Telescope: Dynamical Masses and Scaling Relations for a Sample of Massive Sunyaev-Zel'dovich Effect Selected Galaxy Clusters
We present the first dynamical mass estimates and scaling relations for a
sample of Sunyaev-Zel'dovich effect (SZE) selected galaxy clusters. The sample
consists of 16 massive clusters detected with the Atacama Cosmology Telescope
(ACT) over a 455 sq. deg. area of the southern sky. Deep multi-object
spectroscopic observations were taken to secure intermediate-resolution
(R~700-800) spectra and redshifts for ~60 member galaxies on average per
cluster. The dynamical masses M_200c of the clusters have been calculated using
simulation-based scaling relations between velocity dispersion and mass. The
sample has a median redshift z=0.50 and a median mass M_200c~12e14 Msun/h70
with a lower limit M_200c~6e14 Msun/h70, consistent with the expectations for
the ACT southern sky survey. These masses are compared to the ACT SZE
properties of the sample, specifically, the match-filtered central SZE
amplitude y, the central Compton parameter y0, and the integrated Compton
signal Y_200c, which we use to derive SZE-Mass scaling relations. All SZE
estimators correlate with dynamical mass with low intrinsic scatter (<~20%), in
agreement with numerical simulations. We explore the effects of various
systematic effects on these scaling relations, including the correlation
between observables and the influence of dynamically disturbed clusters. Using
the 3-dimensional information available, we divide the sample into relaxed and
disturbed clusters and find that ~50% of the clusters are disturbed. There are
hints that disturbed systems might bias the scaling relations but given the
current sample sizes these differences are not significant; further studies
including more clusters are required to assess the impact of these clusters on
the scaling relations.Comment: 15 pages, 4 figures. Accepted for publication in The Astrophysical
Journal; matches published version. Full Table 8 with complete spectroscopic
member sample available in machine-readable form in the journal site and upon
request to C. Sif\'o
Removal of nicotine from indoor air using titania-modified polypropylene fibers: nicotine decomposition by titania-modified polypropylene fibers
Timed sequential chemotherapy with concomitant Granulocyte Colony-Stimulating Factor for high-risk acute myelogenous leukemia: a single arm clinical trial
BACKGROUND: The timed-sequential chemotherapy regimen consisting of etoposide, mitoxantrone and cytarabine (EMA) is an effective therapy for relapsed or refractory acute myelogenous leukemia (AML). We postulated that granulocyte colony-stimulating factor (G-CSF) might enhance the cytotoxicity of EMA by increasing the proportion of leukemic blasts in S-phase. We added G-CSF to EMA (EMA-G) for therapy of advanced high-risk AML patients. METHODS: High-risk AML was defined as refractory, relapsed or secondary to either an antecedent hematologic disorder or exposure to cytotoxic agents. The patients were treated with one course of EMA-G consisting of mitoxantrone and cytarabine on days 1â3, and etoposide and cytarabine on days 8â10. G-CSF was started on day 4 and continued until absolute neutrophil count recovered. RESULTS: Thirty patients were enrolled. The median age was 51 years (range, 25â75). Seventeen (61%) patients had unfavorable cytogenetic karyotypes. Twenty (69%) patients had secondary AML. Ten (34%) had relapsed disease. Four (14%) had refractory AML. Three (10%) patients died from febrile neutropenia and sepsis. Major non-hematologic toxicity included hyperbilirubimenia, renal insufficiency, mucositis, diarrhea, nausea and vomiting, skin rash. A complete remission was achieved in 13 (46%) patients. Median overall survival was 9 months (range, 0.5â66). Median relapse-free survival (RFS) for those who had a CR was 3 months (range, 0.5â63) with RFS censored at the time of allogeneic bone marrow transplantation or peripheral stem cell transplantation for 6 of the patients. CONCLUSIONS: EMA-G is a safe and efficacious option for induction chemotherapy in advanced, high-risk AML patients. The activity of EMA may be increased if applied in patients with less advanced disease
A chemical survey of exoplanets with ARIEL
Thousands of exoplanets have now been discovered with a huge range of masses, sizes and orbits: from rocky Earth-like planets to large gas giants grazing the surface of their host star. However, the essential nature of these exoplanets remains largely mysterious: there is no known, discernible pattern linking the presence, size, or orbital parameters of a planet to the nature of its parent star. We have little idea whether the chemistry of a planet is linked to its formation environment, or whether the type of host star drives the physics and chemistry of the planetâs birth, and evolution. ARIEL was conceived to observe a large number (~1000) of transiting planets for statistical understanding, including gas giants, Neptunes, super-Earths and Earth-size planets around a range of host star types using transit spectroscopy in the 1.25â7.8 ÎŒm spectral range and multiple narrow-band photometry in the optical. ARIEL will focus on warm and hot planets to take advantage of their well-mixed atmospheres which should show minimal condensation and sequestration of high-Z materials compared to their colder Solar System siblings. Said warm and hot atmospheres are expected to be more representative of the planetary bulk composition. Observations of these warm/hot exoplanets, and in particular of their elemental composition (especially C, O, N, S, Si), will allow the understanding of the early stages of planetary and atmospheric formation during the nebular phase and the following few million years. ARIEL will thus provide a representative picture of the chemical nature of the exoplanets and relate this directly to the type and chemical environment of the host star. ARIEL is designed as a dedicated survey mission for combined-light spectroscopy, capable of observing a large and well-defined planet sample within its 4-year mission lifetime. Transit, eclipse and phase-curve spectroscopy methods, whereby the signal from the star and planet are differentiated using knowledge of the planetary ephemerides, allow us to measure atmospheric signals from the planet at levels of 10â100 part per million (ppm) relative to the star and, given the bright nature of targets, also allows more sophisticated techniques, such as eclipse mapping, to give a deeper insight into the nature of the atmosphere. These types of observations require a stable payload and satellite platform with broad, instantaneous wavelength coverage to detect many molecular species, probe the thermal structure, identify clouds and monitor the stellar activity. The wavelength range proposed covers all the expected major atmospheric gases from e.g. H2O, CO2, CH4 NH3, HCN, H2S through to the more exotic metallic compounds, such as TiO, VO, and condensed species. Simulations of ARIEL performance in conducting exoplanet surveys have been performed â using conservative estimates of mission performance and a full model of all significant noise sources in the measurement â using a list of potential ARIEL targets that incorporates the latest available exoplanet statistics. The conclusion at the end of the Phase A study, is that ARIEL â in line with the stated mission objectives â will be able to observe about 1000 exoplanets depending on the details of the adopted survey strategy, thus confirming the feasibility of the main science objectives.Peer reviewedFinal Published versio
Shortest-Path Network Analysis Is a Useful Approach toward Identifying Genetic Determinants of Longevity
Background
Identification of genes that modulate longevity is a major focus of aging-related research and an area of intense public interest. In addition to facilitating an improved understanding of the basic mechanisms of aging, such genes represent potential targets for therapeutic intervention in multiple age-associated diseases, including cancer, heart disease, diabetes, and neurodegenerative disorders. To date, however, targeted efforts at identifying longevity-associated genes have been limited by a lack of predictive power, and useful algorithms for candidate gene-identification have also been lacking. Methodology/Principal Findings
We have utilized a shortest-path network analysis to identify novel genes that modulate longevity in Saccharomyces cerevisiae. Based on a set of previously reported genes associated with increased life span, we applied a shortest-path network algorithm to a pre-existing proteinâprotein interaction dataset in order to construct a shortest-path longevity network. To validate this network, the replicative aging potential of 88 single-gene deletion strains corresponding to predicted components of the shortest-path longevity network was determined. Here we report that the single-gene deletion strains identified by our shortest-path longevity analysis are significantly enriched for mutations conferring either increased or decreased replicative life span, relative to a randomly selected set of 564 single-gene deletion strains or to the current data set available for the entire haploid deletion collection. Further, we report the identification of previously unknown longevity genes, several of which function in a conserved longevity pathway believed to mediate life span extension in response to dietary restriction. Conclusions/Significance
This work demonstrates that shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity and represents the first application of network analysis of aging to be extensively validated in a biological system. The novel longevity genes identified in this study are likely to yield further insight into the molecular mechanisms of aging and age-associated disease
The stellar wind cycles and planetary radio emission of the Tau Boo system
Tau Boo is an intriguing planet-host star that is believed to undergo
magnetic cycles similar to the Sun, but with a duration that is about one order
of magnitude smaller than that of the solar cycle. With the use of
observationally derived surface magnetic field maps, we simulate the magnetic
stellar wind of Tau Boo by means of three-dimensional MHD numerical
simulations. As the properties of the stellar wind depend on the particular
characteristics of the stellar magnetic field, we show that the wind varies
during the observed epochs of the cycle. Although the mass loss-rates we find
(~2.7e-12 Msun/yr) vary less than 3 per cent during the observed epochs of the
cycle, our derived angular momentum loss-rates vary from 1.1 to 2.2e32erg. The
spin-down times associated to magnetic braking range between 39 and 78Gyr. We
also compute the emission measure from the (quiescent) closed corona and show
that it remains approximately constant through these epochs at a value of
~10^{50.6} cm^{-3}. This suggests that a magnetic cycle of Tau Boo may not be
detected by X-ray observations. We further investigate the interaction between
the stellar wind and the planet by estimating radio emission from the
hot-Jupiter that orbits at 0.0462 au from Tau Boo. By adopting reasonable
hypotheses, we show that, for a planet with a magnetic field similar to Jupiter
(~14G at the pole), the radio flux is estimated to be about 0.5-1 mJy,
occurring at a frequency of 34MHz. If the planet is less magnetised (field
strengths roughly <4G), detection of radio emission from the ground is
unfeasible due to the Earth's ionospheric cutoff. According to our estimates,
if the planet is more magnetised than that and provided the emission beam
crosses the observer line-of-sight, detection of radio emission from Tau Boo b
is only possible by ground-based instruments with a noise level of < 1 mJy,
operating at low frequencies.Comment: 15 pages, 10 figures, MNRAS accepte
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