19 research outputs found

    Verbraucherrechte im öffentlichen Personenverkehr: Eine verkehrsträgerübergreifende Analyse

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    Das Personenbeförderungsrecht ist in verschiedenen Gesetzen geregelt, wobei das BGB nur subsidiär greift. Für die drei untersuchten Verkehrsträger gibt es im deutschen Recht eigene Regelungen, obwohl sie letztlich dieselbe Leistung - eine Beförderung - erbringen. Ist dieser recht hohe Aufwand erforderlich? Zur Beantwortung dieser Frage werden die wesentlichen Vertragspunkte verkehrsträgerübergreifend untersucht

    Photography-based taxonomy is inadequate, unnecessary, and potentially harmful for biological sciences

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    The question whether taxonomic descriptions naming new animal species without type specimen(s) deposited in collections should be accepted for publication by scientific journals and allowed by the Code has already been discussed in Zootaxa (Dubois & Nemésio 2007; Donegan 2008, 2009; Nemésio 2009a–b; Dubois 2009; Gentile & Snell 2009; Minelli 2009; Cianferoni & Bartolozzi 2016; Amorim et al. 2016). This question was again raised in a letter supported by 35 signatories published in the journal Nature (Pape et al. 2016) on 15 September 2016. On 25 September 2016, the following rebuttal (strictly limited to 300 words as per the editorial rules of Nature) was submitted to Nature, which on 18 October 2016 refused to publish it. As we think this problem is a very important one for zoological taxonomy, this text is published here exactly as submitted to Nature, followed by the list of the 493 taxonomists and collection-based researchers who signed it in the short time span from 20 September to 6 October 2016

    Lophyrus spinosus C. Duméril & A. Duméril, 1851, a case of mistaken identity

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    Lophyrus spinosus Duméril & Duméril, 1851 has been considered synonymous with Bronchocela marmorata Gray, 1845 since its original description. The name-bearing type of Lophyrus spinosus is the specimen collected by Hombron and Jacquinot (MNHN 6896) by original designation and the holotype by monotypy of Bronchocela marmorata is the specimen deposited under NHMUK 1946.8.11.16. Accordingly, these two scientific names do not share name-bearing types. Prior to the original descriptions of Lophyrus spinosus and Bronchocela marmorata Hombron & Jacquinot (1843) published a plate depicting Lophyrus spinosus, but only naming the species in French. The nomenclatural implications of this publication are discussed. Our comparison of the holotypes reveals that these two species are not identical. Therefore we resurrect Lophyrus spinosus from its synonymy with Bronchocela marmorata and show that the specimen collected by Hombron and Jacquinot actually belongs to the genus Hypsilurus. Duméril and Duméril (1851) were the first to make the name Lophyrus (= Hypsilurus) spinosus available and the authorship has to be assigned to them. Based on evidence from original travel reports and biogeography we propose that the collection locality of Lophyrus spinosus, i.e. Hypsilurus spinosus Duméril & Duméril (1851), should be corrected to Triton Bay, Kaimana, West Papua, Indonesia

    Lophyrus spinosus C. Duméril & A. Duméril, 1851, a case of mistaken identity

    No full text
    Lophyrus spinosus Duméril & Duméril, 1851 has been considered synonymous with Bronchocela marmorata Gray, 1845 since its original description. The name-bearing type of Lophyrus spinosus is the specimen collected by Hombron and Jacquinot (MNHN 6896) by original designation and the holotype by monotypy of Bronchocela marmorata is the specimen deposited under NHMUK 1946.8.11.16. Accordingly, these two scientific names do not share name-bearing types. Prior to the original descriptions of Lophyrus spinosus and Bronchocela marmorata Hombron & Jacquinot (1843) published a plate depicting Lophyrus spinosus, but only naming the species in French. The nomenclatural implications of this publication are discussed. Our comparison of the holotypes reveals that these two species are not identical. Therefore we resurrect Lophyrus spinosus from its synonymy with Bronchocela marmorata and show that the specimen collected by Hombron and Jacquinot actually belongs to the genus Hypsilurus. Duméril and Duméril (1851) were the first to make the name Lophyrus (= Hypsilurus) spinosus available and the authorship has to be assigned to them. Based on evidence from original travel reports and biogeography we propose that the collection locality of Lophyrus spinosus, i.e. Hypsilurus spinosus Duméril & Duméril (1851), should be corrected to Triton Bay, Kaimana, West Papua, Indonesia

    Computational electrophysiology:The molecular dynamics of ion channel permeation and selectivity in atomistic detail

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    ABSTRACT Presently, most simulations of ion channel function rely upon nonatomistic Brownian dynamics calculations, indirect interpretation of energy maps, or application of external electric fields. We present a computational method to directly simulate ion flux through membrane channels based on biologically realistic electrochemical gradients. In close analogy to single-channel electrophysiology, physiologically and experimentally relevant timescales are achieved. We apply our method to the bacterial channel PorB from pathogenic Neisseria meningitidis, which, during Neisserial infection, inserts into the mitochondrial membrane of target cells and elicits apoptosis by dissipating the membrane potential. We show that our method accurately predicts ion conductance and selectivity and elucidates ion conduction mechanisms in great detail. Handles for overcoming channel-related antibiotic resistance are identified

    The Bruchpilot cytomatrix determines the size of the readily releasable pool of synaptic vesicles

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    Synaptic vesicles (SVs) fuse at a specialized membrane domain called the active zone (AZ), covered by a conserved cytomatrix. How exactly cytomatrix components intersect with SV release remains insufficiently understood. We showed previously that loss of the Drosophila melanogaster ELKS family protein Bruchpilot (BRP) eliminates the cytomatrix (T bar) and declusters Ca(2+) channels. In this paper, we explored additional functions of the cytomatrix, starting with the biochemical identification of two BRP isoforms. Both isoforms alternated in a circular array and were important for proper T-bar formation. Basal transmission was decreased in isoform-specific mutants, which we attributed to a reduction in the size of the readily releasable pool (RRP) of SVs. We also found a corresponding reduction in the number of SVs docked close to the remaining cytomatrix. We propose that the macromolecular architecture created by the alternating pattern of the BRP isoforms determines the number of Ca(2+) channel-coupled SV release slots available per AZ and thereby sets the size of the RRP
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