Principles and practice in reporting structural equation analyses

Principles for reporting analyses using structural equation modeling are reviewed, with the goal of supplying readers with complete and accurate information. It is recommended that every report give a detailed justification of the model used, along with plausible alternatives and an account of identifiability. Nonnormality and missing data problems should also be addressed. A complete set of parameters and their standard errors is desirable, and it will often be convenient to supply the correlation matrix and discrepancies, as well as goodness-of-fit indices, so that readers can exercise independent critical judgment. A survey of fairly representative studies compares recent practice with the principles of reporting recommended here

The role of Schizosaccharomyces pombe SUMO ligases in genome stability

SUMOylation is a post-translational modification that affects a large number of proteins, many of which are nuclear. While the role of SUMOylation is beginning to be elucidated, it is clear that understanding the mechanisms that regulate the process is likely to be important. Control of the levels of SUMOylation is brought about through a balance of conjugating and deconjugating activities, i.e. of SUMO (small ubiquitin-related modifier) conjugators and ligases versus SUMO proteases. Although conjugation of SUMO to proteins can occur in the absence of a SUMO ligase, it is apparent that SUMO ligases facilitate the SUMOylation of specific subsets of proteins. Two SUMO ligases in Schizosaccharomyces pombe, Pli1 and Nse2, have been identified, both of which have roles in genome stability. We report here on a comparison between the properties of the two proteins and discuss potential roles for the proteins

Study of heterogeneous nucleation of eutectic Si in high-purity Al-Si alloys with Sr addition

The official published version can be accessed from the link below - Copyright @ 2010 The Minerals, Metals & Materials Society and ASM InternationalAl-5 wt pct Si master-alloys with controlled Sr and/or P addition/s were produced using super purity Al 99.99 wt pct and Si 99.999 wt pct materials in an arc melter. The master-alloy was melt-spun resulting in the production of thin ribbons. The Al matrix of the ribbons contained entrained Al-Si eutectic droplets that were subsequently investigated. Differential scanning calorimetry, thermodynamic calculations, and transmission electron microscopy techniques were employed to examine the effect of the Sr and P additions on eutectic undercoolings and nucleation phenomenon. Results indicate that, unlike P, Sr does not promote nucleation. Increasing Sr additions depressed the eutectic nucleation temperature. This may be a result of the formation of a Sr phase that could consume or detrimentally affect potent AlP nucleation sites.This work is financially supported by the Higher Education Commission of Pakistan and managerially supported from the OAD

The Acoustic Peak in the Lyman Alpha Forest

We present the first simulation of the signature of baryonic acoustic oscillations (BAO) in Lyman alpha forest data containing 180,000 mock quasar sight-lines. We use eight large dark-matter only simulations onto which we paint the Lyman alpha field using the fluctuating Gunn-Peterson approximation. We argue that this approach should be sufficient for the mean signature on the scales of interest. Our results indicate that Lyman alpha flux provides a good tracer of the underlying dark matter field on large scales and that redshift space distortions are well described by a simple linear theory prescription. We compare Fourier and configuration space approaches to describing the signal and argue that configuration space statistics provide useful data compression. We also investigate the effect of a fluctuating photo-ionizing background using a simplified model and find that such fluctuations do add smooth power on large scales. The acoustic peak position is, however, unaffected for small amplitude fluctuations (<10%). Larger amplitude fluctuations make the recovery of the BAO signal more difficult and may degrade the achievable significance of the measurement.Comment: 10 pages, 8 figures; v2: minor revision matching version accepted by JCAP (new references, better figures, clarifications

On the Correlations between Galaxy Properties and Supermassive Black Hole Mass

We use a large sample of upper limits and accurate estimates of supermassive black holes masses coupled with libraries of host galaxy velocity dispersions, rotational velocities and photometric parameters extracted from Sloan Digital Sky Survey i-band images to establish correlations between the SMBH and host galaxy parameters. We test whether the mass of the black hole, MBH, is fundamentally driven by either local or global galaxy properties. We explore correlations between MBH and stellar velocity dispersion sigma, bulge luminosity, bulge mass Sersic index, bulge mean effective surface brightness, luminosity of the galaxy, galaxy stellar mass, maximum circular velocity Vc, galaxy dynamical and effective masses. We verify the tightness of the MBH-sigma relation and find that correlations with other galaxy parameters do not yield tighter trends. We do not find differences in the MBH-sigma relation of barred and unbarred galaxies. The MBH-sigma relation of pseudo-bulges is also coarser and has a different slope than that involving classical bulges. The MBH-bulge mass is not as tight as the MBH-sigma relation, despite the bulge mass proving to be a better proxy of MBH than bulge luminosity. We find a rather poor correlation between MBH and Sersic index suggesting that MBH is not related to the bulge light concentration. The correlations between MBH and galaxy luminosity or mass are not a marked improvement over the MBH sigma relation. If Vc is a proxy for the dark matter halo mass, the large scatter of the MBH-Vc relation then suggests that MBH is more coupled to the baryonic rather than the dark matter. We have tested the need for a third parameter in the MBH scaling relations, through various linear correlations with bulge and galaxy parameters, only to confirm that the fundamental plane of the SMBH is mainly driven by sigma, with a small tilt due to the effective radius. (Abridged)Comment: 32 pages, 18 figures, 6 tables, accepted for publication in MNRA

The Simplest Dark-Matter Model, CDMS II Results, and Higgs Detection at LHC

The direct-search experiment for dark matter performed by the CDMS II Collaboration has observed two candidate events. Although these events cannot be interpreted as significant evidence for the presence of weakly interacting massive particle (WIMP) dark matter (DM), the total CDMS II data have led to an improved upper-limit on the WIMP-nucleon spin-independent cross-section. We study some implications of these results for the simplest WIMP DM model, the SM+D, which extends the standard model (SM) by the addition of a real SM-singlet scalar field dubbed darkon to play the role of the DM. We find that, although the CDMS II data rule out a sizable portion of parameter space of the model, a large part of the parameter space is still allowed. We obtain strong correlations among the darkon mass, darkon-nucleon cross-section, mass of the Higgs boson, and branching ratio of its invisible decay. We point out that measurements of the Higgs invisible branching-ratio at the LHC can lift some possible ambiguities in determining the darkon mass from direct DM searches.Comment: 10 pages, 5 figures; results updated with WMAP7 input, references added, conclusions unchanged, to match published versio

Late stage C―H activation of a privileged scaffold; synthesis of a library of benzodiazepines

A library of over twenty 5-(2-arylphenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-ones has been formed by a microwave-mediated late-stage palladium-catalysed arylation of 1,4-benzodiazepines using diaryliodonium salts. This can also be applied to nordazepam (7-chloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one), the active metabolite of diazepam, and subsequent N-alkylation and/or H/D exchange allows further diversification towards elaborated pharmaceuticals and their 3,3'-deuterated analogues

MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia.

A novel potassium channel gene has been cloned, characterized, and associated with cardiac arrhythmia. The gene encodes MinK-related peptide 1 (MiRP1), a small integral membrane subunit that assembles with HERG, a pore-forming protein, to alter its function. Unlike channels formed only with HERG, mixed complexes resemble native cardiac IKr channels in their gating, unitary conductance, regulation by potassium, and distinctive biphasic inhibition by the class III antiarrhythmic E-4031. Three missense mutations associated with long QT syndrome and ventricular fibrillation are identified in the gene for MiRP1. Mutants form channels that open slowly and close rapidly, thereby diminishing potassium currents. One variant, associated with clarithromycin-induced arrhythmia, increases channel blockade by the antibiotic. A mechanism for acquired arrhythmia is revealed: genetically based reduction in potassium currents that remains clinically silent until combined with additional stressors

Chronic Idiopathic Myelofibrosis Presenting as Cauda Equina Compression due to Extramedullary Hematopoiesis: A Case Report

Extramedullary hematopoiesis (EMH) is occasionally reported in idiopathic myelofibrosis and is generally found in the liver, spleen, and lymph nodes several years after diagnosis. Myelofibrosis presenting as spinal cord compression, resulting from EMH tissue is very rare. A 39-yr-old man presented with back pain, subjective weakness and numbness in both legs. Sagittal magnetic resonance imaging showed multiple anterior epidural mass extending from L4 to S1 with compression of cauda equina and nerve root. The patient underwent gross total removal of the mass via L4, 5, and S1 laminectomy. Histological analysis showed islands of myelopoietic cells surrounded by fatty tissue, consistent with EMH, and bone marrow biopsy performed after surgery revealed hypercellular marrow and megakaryocytic hyperplasia and focal fibrosis. The final diagnosis was chronic idiopathic myelofibrosis leading to EMH in the lumbar spinal canal. Since there were no abnormal hematological findings except mild myelofibrosis, additional treatment such as radiothepary was not administered postoperatively for fear of radiotoxicity. On 6 month follow-up examination, the patient remained clinically stable without recurrence. This is the first case of chronic idiopathic myelofibrosis due to EMH tissue in the lumbar spinal canal in Korea