1,039 research outputs found
Sequence Specificity of BAL 31 Nuclease for ssDNA Revealed by Synthetic Oligomer Substrates Containing Homopolymeric Guanine Tracts
- Author
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2008
- Field of study
Background: The extracellular nuclease from Alteromonas espejiana, BAL 31 catalyzes the degradation of single-stranded and linear duplex DNA to 59-mononucleotides, cleaves negatively supercoiled DNA to the linear duplex form, and cleaves duplex DNA in response to the presence of apurinic sites. Principal Findings: In this work we demonstrate that BAL 31 activity is affected by the presence of guanine in singlestranded DNA oligomers. Specifically, nuclease activity is shown to be affected by guanine’s presence in minimal homopolymeric tracts in the middle of short oligomer substrates and also by its presence at the 39 end of ten and twenty base oligomers. GNC rich regions in dsDNA are known to cause a decrease in the enzyme’s nuclease activity which has been attributed to the increased thermal stability of these regions, thus making it more difficult to unwind the strands required for enzyme access. Our results indicate that an additional phenomenon could be wholly or partly responsible for the loss of activity in these GNC rich regions. Thus the presence of a guanine tract per se impairs the enzyme’s functionality, possibly due to the tract’s bulky nature and preventing efficient progression through the active site. Conclusions: This study has revealed that the general purpose BAL 31 nuclease commonly used in molecular genetics exhibits a hithertofore non-characterized degree of substrate specificity with respect to single-stranded DNA (ssDNA
Analytic philosophy for biomedical research: the imperative of applying yesterday's timeless messages to today's impasses
- Author
- A Armiento
- A Gare
- A Hilfinger
- A Karmon
- A Lin
- A Ross-Gillespie
- A Sekikawa
- A Zuniga
- AA Thompson
- AC Oates
- AD Asatryan
- AI Tauber
- AL Byrd
- AM Hosios
- AM Jaeger
- AP Monaco
- B Berger
- B Rehermann
- BP Abbott
- BW O’Malley
- C Glymour
- C Kadelka
- C Willyard
- CA Tulk
- CN Bagot
- Collaboration Open Science
- CT Walsh
- D Reker
- D Wallach
- DC Clary
- DJ Depew
- DJ Nicholson
- DP Norris
- DY Gouvêa
- E Bizzi
- E Del Soldato
- E Piskounova
- E Toprak
- Editors
- EJ Louis
- F Davidoff
- F Leigh
- F Rohwer
- FE Abbot
- GJ Romanes
- GJ Toomer
- GM Bodner
- GM Brodeur
- H Braak
- H Ledford
- H Varmus
- HB Frieboes
- HJ Anders
- HL Van Epps
- HM Lopez
- HS Chung
- I Brigandt
- IL Markov
- IM Lonie
- J Couzin-Frankel
- J Dong
- J Elf
- J Greene
- J Gunawardena
- J Gunawardena
- J Lister
- J Manchak
- J Odenbaugh
- J Raspopovic
- J Su
- JA Barnett
- JC Cardwell
- JE Allen
- JF Fisher
- JH Woodger
- JI Seeman
- JJ McNeil
- JM Barry
- JM Tanner
- JN Weiss
- JP Capp
- JP Robinson
- JRA
- JS Steffan
- JT Leek
- K Arney
- K Lewis
- K Neupane
- K Servick
- K Shrinivas
- KT Smith
- L Tadrist
- LA DiMeglio
- LA Hug
- M Baym
- M Buchanan
- M Delling
- M Friedman
- M Greaves
- M Kramer
- M Levin
- M Nei
- M Niepel
- M Pigliucci
- M Schaapveld
- M Thamer
- MA McCormick
- MB Everaert
- MC Marchetti
- MD Hauser
- ME Feder
- N Chomsky
- N Chomsky
- N Yang
- N Yucel
- NQ Balaban
- OR Jones
- P Bauer
- P Griffiths
- P Lieshout
- P McNamara
- P Robustelli
- Plato
- PN Singer
- Q Justman
- Q Zhong
- R Chatterjee
- R Chen
- R Gregory
- R Kolter
- R Losick
- R MacCoun
- R Scholl
- RC Berwick
- RC Lewontin
- RJ Britten
- RL Wasserstein
- RM Nesse
- RV Christie
- RZ Moger-Reischer
- S Bartley
- S Cukierman
- S Gordon
- S Kannan
- S Kryazhimskiy
- S Ling
- S Smit
- S Uphoff
- S Wong
- SA Hoption Cann
- SH Orzack
- SJ Biller
- SJ Diede
- SM Connell
- SM Fleming
- SM Mozaffari
- TA Carey
- TE Kottke
- TG Nakashige
- V Lazar
- W Shou
- W Szybalski
- WD Casebeer
- X Wei
- XS Xie
- Y Hatwalne
- YE Nikiforov
- Publication venue
- Publication date
- 01/01/2020
- Field of study
The mantra that "the best way to predict the future is to invent it" (attributed to the computer scientist Alan Kay) exemplifies some of the expectations from the technical and innovative sides of biomedical research at present. However, for technical advancements to make real impacts both on patient health and genuine scientific understanding, quite a number of lingering challenges facing the entire spectrum from protein biology all the way to randomized controlled trials should start to be overcome. The proposal in this chapter is that philosophy is essential in this process. By reviewing select examples from the history of science and philosophy, disciplines which were indistinguishable until the mid-nineteenth century, I argue that progress toward the many impasses in biomedicine can be achieved by emphasizing theoretical work (in the true sense of the word 'theory') as a vital foundation for experimental biology. Furthermore, a philosophical biology program that could provide a framework for theoretical investigations is outlined
Reactive oxygen species and small-conductance calcium-dependent potassium channels are key mediators of inflammation-induced hypotension and shock
- Author
- A Cauwels
- A Cauwels
- A Cauwels
- A Cauwels
- A Cauwels
- A Cauwels
- A Ellis
- A Gillissen
- A Lopez
- A Makino
- Anje Cauwels
- B Hauser
- Ben Janssen
- BT Larsen
- C Thiemermann
- D Fernandes
- DA Wink
- DE Taylor
- DJ Keating
- DW Landry
- EG Shesely
- Elke Rogge
- GJ Crane
- GM Rubanyi
- H Cai
- HB Nguyen
- HC Hartzell
- HH Schmidt
- I Grgic
- JC Toledo Jr
- K Prasad
- L Connelly
- M Feletou
- M Jiang
- N Ardanaz
- Peter Brouckaert
- S Heumuller
- S Kimura
- T Suvorava
- VE Laubach
- XD Tang
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2010
- Field of study
Septic shock is associated with life-threatening vasodilation and hypotension. To cause vasodilation, vascular endothelium may release nitric oxide (NO), prostacyclin (PGI2), and the elusive endothelium-derived hyperpolarizing factor (EDHF). Although NO is critical in controlling vascular tone, inhibiting NO in septic shock does not improve outcome, on the contrary, precipitating the search for alternative therapeutic targets. Using a hyperacute tumor necrosis factor (TNF)-induced shock model in mice, we found that shock can develop independently of the known vasodilators NO, cGMP, PGI2, or epoxyeicosatrienoic acids. However, the antioxidant tempol efficiently prevented hypotension, bradycardia, hypothermia, and mortality, indicating the decisive involvement of reactive oxygen species (ROS) in these phenomena. Also, in classical TNF or lipopolysaccharide-induced shock models, tempol protected significantly. Experiments with (cell-permeable) superoxide dismutase or catalase, N-acetylcysteine and apocynin suggest that the ROS-dependent shock depends on intracellular \documentclass[12pt]{minimal}
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\begin{document}∙OH\end{document} radicals. Potassium channels activated by ATP (KATP) or calcium (KCa) are important mediators of vascular relaxation. While NO and PGI2-induced vasodilation involves KATP and large-conductance BKCa channels, small-conductance SKCa channels mediate vasodilation induced by EDHF. Interestingly, also SKCa inhibition completely prevented the ROS-dependent shock. Our data thus indicate that intracellular \documentclass[12pt]{minimal}
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\begin{document}∙OH\end{document} and SKCa channels represent interesting new therapeutic targets for inflammatory shock. Moreover, they may also explain why antioxidants other than tempol fail to provide survival benefit during shock
Search for Kaluza-Klein Graviton Emission in ppˉ Collisions at s=1.8 TeV using the Missing Energy Signature
- Author
- Acosta D
- Affolder T
- Akimoto H
- Albrow MG
- Ambrose D
- Amidei D
- Anikeev K
- Antos J
- Apollinari G
- Arisawa T
- Artikov A
- Asakawa T
- Ashmanskas W
- Azfar F
- Azzi-Bacchetta P
- Bacchetta N
- Bachacou H
- Badgett W
- Bailey S
- Barbaro-Galtieri A
- Barnes VE
- Barnett BA
- Baroiant S
- Barone M
- Bauer G
- Bedeschi F
- Behari S
- Belforte S
- Bell WH
- Bellettini G
- Bellinger J
- Benjamin D
- Bensinger J
- Beretvas A
- Berryhill J
- Bhatti A
- Binkley M
- Bisello D
- Bishai M
- Blair RE
- Blocker C
- Bloom K
- Blumenfeld B
- Blusk SR
- Bocci A
- Bodek A
- Bolla G
- Bolshov A
- Bonushkin Y
- Bortoletto D
- Boudreau J
- Brandl A
- Bromberg C
- Brozovic M
- Brubaker E
- Bruner N
- Budagov J
- Budd HS
- Burkett K
- Busetto G
- Byrum KL
- Cabrera S
- Calafiura P
- Campbell M
- Carithers W
- Carlsmith D
- Carlson J
- Caskey W
- Castro A
- Cauz D
- Cecco SD
- Cerri A
- Cerrito L
- Chan AW
- Chang PS
- Chang PT
- Chapman J
- Chen C
- Chen YC
- Cheng MT
- Chertok M
- Chiarelli G
- Chirikov-Zorin I
- Chlachidze G
- Chlebana F
- Christofek L
- Chu ML
- Chung JY
- Chung WH
- Chung YS
- Ciobanu CI
- Clark AG
- Coca M
- Connolly A
- Convery M
- Conway J
- Cordelli M
- Cranshaw J
- Culbertson R
- D'Auria S
- D'Onofrio M
- da Costa JG
- Dagenhart D
- de Barbaro P
- de Troconiz JF
- de Troconiz JF
- DeJongh F
- Dell'Agnello S
- Dell'Orso M
- Demers S
- Demortier L
- Deninno M
- Denis RS
- Derwent PF
- Devlin T
- Dionisi C
- Dittmann JR
- Dominguez A
- Donati S
- Dorigo T
- Eddy N
- Einsweiler K
- Engels E
- Erbacher R
- Errede D
- Errede S
- Eusebi R
- Fan Q
- Farrington S
- Feild RG
- Fernandez JP
- Ferretti C
- Field RD
- Fiori I
- Flaugher B
- Flores-Castillo LR
- Foster GW
- Franklin M
- Freeman J
- Friedman J
- Fukui Y
- Furic I
- Galeotti S
- Gallas A
- Gallinaro M
- Gao T
- Garcia-Sciveres M
- Garfinkel AF
- Gatti P
- Gay C
- Gerdes DW
- Gerstein E
- Giagu S
- Giannetti P
- Giolo K
- Giordani M
- Giromini P
- Glagolev V
- Glenzinski D
- Gold M
- Goldschmidt N
- Goldstein J
- Gomez G
- Goncharov M
- Gorelov I
- Goshaw AT
- Gotra Y
- Goulianos K
- Green C
- Greene MG
- Gresele A
- Grim G
- Grosso-Pilcher C
- Guenther M
- Guillian G
- Haas RM
- Haber C
- Hahn SR
- Halkiadakis E
- Hall C
- Handa T
- Handler R
- Happacher F
- Hara K
- Hardman AD
- Harris RM
- Hartmann F
- Hatakeyama K
- Hauser J
- Heinrich J
- Heiss A
- Hennecke M
- Herndon M
- Hill C
- Hocker A
- Hoffman KD
- Hollebeek R
- Holloway L
- Hou S
- Huffman BT
- Hughes R
- Huston J
- Huth J
- Ikeda H
- Incandela J
- Introzzi G
- Iori M
- Issever C
- Ivanov A
- Iwai J
- Iwata Y
- Iyutin B
- James E
- Jones M
- Joshi U
- Kambara H
- Kamon T
- Kaneko T
- Kang J
- Karr K
- Kartal S
- Kasha H
- Kato Y
- Keaffaber TA
- Kelley K
- Kelly M
- Kennedy RD
- Kephart R
- Khazins D
- Kikuchi T
- Kilminster B
- Kim BJ
- Kim DH
- Kim HS
- Kim MJ
- Kim SB
- Kim SH
- Kim TH
- Kim YK
- Kirby M
- Kirk M
- Kirsch L
- Klimenko S
- Koehn P
- Kondo K
- Konigsberg J
- Korn A
- Korytov A
- Kostritskiy AV
- Kotcher J
- Kotelnikov K
- Kothari B
- Kotwal AV
- Kovacs E
- Kovacs E
- Kozelov AV
- Kozlovsky EA
- Krane J
- Krishnaswamy MR
- Krivkova P
- Kroll J
- Kroll J
- Kruse M
- Kruse M
- Krutelyov V
- Krutelyov V
- Krzywdzinski S
- Kubantsev M
- Kuhlmann SE
- Kuhlmann SE
- Kuleshov S
- Kulik Y
- Kunori S
- Kupco A
- Kurino K
- Kurino K
- Kuwabara T
- Kuwabara T
- Kuznetsov VE
- Kuznetsova N
- Kuznetsova N
- Laasanen AT
- Laasanen AT
- Lai N
- Lai N
- Lami S
- Lami S
- Lammel S
- Lammel S
- Lamoureux JI
- Lancaster J
- Lancaster J
- Lancaster M
- Lancaster M
- Lander R
- Lander R
- Landsberg G
- Lannon K
- Lannon K
- Lath A
- Lath A
- Latino G
- Latino G
- Le Y
- Le Y
- LeCompte T
- LeCompte T
- Lee AM
- Lee J
- Lee J
- Lee K
- Lee SW
- Lee SW
- Lee WM
- Leflat A
- Lehner F
- Leonardo N
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- Leone S
- Leone S
- Leonidopoulos C
- Lewis JD
- Lewis JD
- Li J
- Li K
- Li K
- Li QZ
- Lima JGR
- Lin CS
- Lin CS
- Lincoln D
- Lindgren M
- Lindgren M
- Linn SL
- Linnemann J
- Lipton R
- Liss TM
- Liss TM
- Litvintsev DO
- Litvintsev DO
- Liu JB
- Liu JB
- Liu T
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- Liu YC
- Liu YC
- Lobban O
- Lockyer NS
- Lockyer NS
- Loginov A
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- Loken J
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- Loreti M
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- Lucchesi D
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- Lueking L
- Lukens P
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- Lundstedt C
- Luo C
- Lusin S
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- Lyons L
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- Lys J
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- Maciel AKA
- Madaras RJ
- Madrak R
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- Maeshima K
- Maeshima K
- Maksimovic P
- Maksimovic P
- Malferrari L
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- Malyshev VL
- Manankov V
- Manca G
- Manca G
- Mangano M
- Mangano M
- Mao HS
- Mariotti M
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- Marshall T
- Martignon G
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- Martin A
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- Martin V
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- Matthews JAJ
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- Mattingly SEK
- Mayer J
- Mayorov AA
- Mazzanti P
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- McCarthy R
- McFarland KS
- McFarland KS
- McIntyre P
- McIntyre P
- McKigney E
- McMahon T
- Melanson HL
- Melnitchouk A
- Menguzzato M
- Menguzzato M
- Menzione A
- Menzione A
- Merkel P
- Merkel P
- Merkin M
- Merritt KW
- Mesropian C
- Mesropian C
- Meyer A
- Meyer A
- Miao C
- Miao T
- Miao T
- Miettinen H
- Mihalcea D
- Miller JS
- Miller JS
- Miller R
- Miller R
- Minato H
- Minato H
- Miscetti S
- Miscetti S
- Mishina M
- Mishina M
- Mitselmakher G
- Mitselmakher G
- Miyazaki Y
- Moggi N
- Moggi N
- Mokhov N
- Mondal NK
- Montgomery HE
- Moore E
- Moore E
- Moore R
- Moore R
- Moore RW
- Morita Y
- Morita Y
- Moulik T
- Moulik T
- Mukherjee A
- Mukherjee A
- Mulhearn M
- Mulhearn M
- Muller T
- Muller T
- Munar A
- Munar A
- Murat P
- Murat P
- Murgia S
- Murgia S
- Musy M
- Mutaf YD
- Nachtman J
- Nachtman J
- Nagaslaev V
- Nagy E
- Nahn S
- Nahn S
- Nakada H
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- Nakano I
- Nakano I
- Nakaya T
- Napora R
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- Narain M
- Narasimham VS
- Naumann NA
- Neal HA
- Neal HKorytov A
- Negret JP
- Nelson C
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- Neu C
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- Neubauer MS
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- Neuberger D
- Neuberger D
- Newman-Holmes C
- Newman-Holmes C
- Ngan CYP
- Ngan CYP
- Nicolaidi P
- Niell F
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- Nigmanov T
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- Niu H
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- Nodulman L
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- Nomerotski A
- Nomerotski A
- Nunnemann T
- O'Neil D
- Oguri V
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- Pagliarone C
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- Palmonari F
- Pan Y
- Paoletti R
- Paoletti R
- Papadimitriou V
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- Pappas SP
- Parashar N
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- Phillips TJ
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- Piacentino G
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- Piedra J
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- Piegaia R
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- Poukhov O
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- Prosper HB
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- Proudfoot J
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- Przybycien MB
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- Rakitine A
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- Ratnikov F
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- Reichold A
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- Tanaka M
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- Tannenbaum B
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- Tecchio M
- Tecchio M
- Teng PK
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- Terashi K
- Terashi K
- Tesarek RJ
- Tesarek RJ
- Tether S
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- Theriot D
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- Tipton P
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- Tkaczyk S
- Tkaczyk S
- Toback D
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- Tollefson K
- Tollefson K
- Tollestrup A
- Tonelli D
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- Tonnesmann M
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- Yang UK
- Yao W
- Yao W
- Yao W
- Yasuda T
- Yatsunenko YA
- Yeh GP
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- Yeh P
- Yi K
- Yi K
- Yoh J
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- Zhou J
- Zsenei A
- Zucchelli Spatra AK
- Zucchelli Sychev D
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2004
- Field of study
We report on a search for direct Kaluza-Klein graviton production in a data
sample of 84 pb−1 of \ppb collisions at s = 1.8 TeV, recorded
by the Collider Detector at Fermilab. We investigate the final state of large
missing transverse energy and one or two high energy jets. We compare the data
with the predictions from a 3+1+n-dimensional Kaluza-Klein scenario in which
gravity becomes strong at the TeV scale. At 95% confidence level (C.L.) for
n=2, 4, and 6 we exclude an effective Planck scale below 1.0, 0.77, and 0.71
TeV, respectively.Comment: Submitted to PRL, 7 pages 4 figures/Revision includes 5 figure
Measurement of the average time-integrated mixing probability of b-flavored hadrons produced at the Tevatron
- Author
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- Wicklund AB
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- Wijngaarden DA
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- Winer BL
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- Wu SL
- Wu X
- Wu X
- Wu X
- Wurthwein F
- Wurthwein F
- Wurthwein F
- Wyatt A
- Wyss J
- Wyss J
- Xu Q
- Yagil A
- Yagil A
- Yamada R
- Yamamoto K
- Yamashita T
- Yang UK
- Yang UK
- Yang UK
- Yao W
- Yao W
- Yao W
- Yeh GP
- Yeh GP
- Yeh P
- Yi K
- Yi K
- Yoh J
- Yoh J
- Yoon P
- Yorita K
- Yosef C
- Yoshida T
- Yoshida T
- Yu I
- Yu I
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- Yu Z
- Yu Z
- Yu Z
- Yun JC
- Yun JC
- Zanello L
- Zanello L
- Zanetti A
- Zanetti A
- Zaw I
- Zetti F
- Zetti F
- Zhou J
- Zsenei A
- Zucchelli Spatra AK
- Zucchelli Sychev D
- Zucchelli SZetti F
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 08/09/2003
- Field of study
We have measured the number of like-sign (LS) and opposite-sign (OS) lepton
pairs arising from double semileptonic decays of b and bˉ-hadrons,
pair-produced at the Fermilab Tevatron collider. The data samples were
collected with the Collider Detector at Fermilab (CDF) during the 1992-1995
collider run by triggering on the existence of μμ and eμ candidates
in an event. The observed ratio of LS to OS dileptons leads to a measurement of
the average time-integrated mixing probability of all produced b-flavored
hadrons which decay weakly, χˉ=0.152±0.007 (stat.) ±0.011
(syst.), that is significantly larger than the world average χˉ=0.118±0.005.Comment: 47 pages, 10 figures, 15 tables Submitted to Phys. Rev.
Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Acosta D
- Acosta JG
- Acosta MV
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- Roland C
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- Romeo F
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- Rosowsky A
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- Soares MS
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- Wissing C
- Wittich P
- Wittmer B
- Woehri HK
- Wolf M
- Wolf R
- Womersley WJ
- Won S
- Wood D
- Wood J
- Wood JS
- Worm SD
- Wright D
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- Wuerthwein F
- Wulz C-E
- Wyslouch B
- Xiao H
- Xie S
- Xu M
- Yagil A
- Yalvac M
- Yang F
- Yang M
- Yang Y
- Yang ZC
- Yazgan E
- Yelton J
- Yetkin T
- Yi K
- Yildirim E
- Yilmaz Y
- Yohay R
- Yoo HD
- Yoo J
- Yoon AS
- York A
- Yu I
- Yu SS
- Yumiceva F
- Yun JC
- Zabel J
- Zabi A
- Zablocki J
- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti M
- Zang J
- Zang SL
- Zarubin A
- Zatserklyaniy A
- Zeinali M
- Zeise M
- Zeuner WD
- Zeyrek M
- Zhang J
- Zhang Z
- Zheng Y
- Zhokin A
- Zhu B
- Zhu RY
- Zhukov V
- Zhukova V
- Ziebarth EB
- Ziegler J
- Zielinski M
- Zito G
- Zoeller MH
- Zotto P
- Zou W
- Zumerle G
- Zuranski A
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2012
- Field of study
The performance of muon reconstruction, identification, and triggering in CMS
has been studied using 40 inverse picobarns of data collected in pp collisions
at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection
criteria covering a wide range of physics analysis needs have been examined.
For all considered selections, the efficiency to reconstruct and identify a
muon with a transverse momentum pT larger than a few GeV is above 95% over the
whole region of pseudorapidity covered by the CMS muon system, abs(eta) < 2.4,
while the probability to misidentify a hadron as a muon is well below 1%. The
efficiency to trigger on single muons with pT above a few GeV is higher than
90% over the full eta range, and typically substantially better. The overall
momentum scale is measured to a precision of 0.2% with muons from Z decays. The
transverse momentum resolution varies from 1% to 6% depending on pseudorapidity
for muons with pT below 100 GeV and, using cosmic rays, it is shown to be
better than 10% in the central region up to pT = 1 TeV. Observed distributions
of all quantities are well reproduced by the Monte Carlo simulation.Comment: Replaced with published version. Added journal reference and DO
X-ray emission from the Sombrero galaxy: discrete sources
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Acosta D
- Acosta JG
- Acosta MV
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adzic P
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Aguilo E
- Ahmad M
- Ahmad WH
- Ahmed I
- Ahuja S
- Akchurin N
- Akgun B
- Akgun U
- Akin IV
- Alagoz E
- Albajar C
- Albayrak EA
- Albergo S
- Albrow M
- Alexander J
- Aliev T
- Allfrey P
- Almeida N
- Alver B
- Alverson G
- Alves GA
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- Yilmaz Y
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- Zeuner WD
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- Ziebarth EB
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- Zotto P
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- Zumerle G
- Zuranski A
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2010
- Field of study
We present a study of discrete X-ray sources in and around the
bulge-dominated, massive Sa galaxy, Sombrero (M104), based on new and archival
Chandra observations with a total exposure of ~200 ks. With a detection limit
of L_X = 1E37 erg/s and a field of view covering a galactocentric radius of ~30
kpc (11.5 arcminute), 383 sources are detected. Cross-correlation with Spitler
et al.'s catalogue of Sombrero globular clusters (GCs) identified from HST/ACS
observations reveals 41 X-rays sources in GCs, presumably low-mass X-ray
binaries (LMXBs). We quantify the differential luminosity functions (LFs) for
both the detected GC and field LMXBs, whose power-low indices (~1.1 for the
GC-LF and ~1.6 for field-LF) are consistent with previous studies for
elliptical galaxies. With precise sky positions of the GCs without a detected
X-ray source, we further quantify, through a fluctuation analysis, the GC LF at
fainter luminosities down to 1E35 erg/s. The derived index rules out a
faint-end slope flatter than 1.1 at a 2 sigma significance, contrary to recent
findings in several elliptical galaxies and the bulge of M31. On the other
hand, the 2-6 keV unresolved emission places a tight constraint on the field
LF, implying a flattened index of ~1.0 below 1E37 erg/s. We also detect 101
sources in the halo of Sombrero. The presence of these sources cannot be
interpreted as galactic LMXBs whose spatial distribution empirically follows
the starlight. Their number is also higher than the expected number of cosmic
AGNs (52+/-11 [1 sigma]) whose surface density is constrained by deep X-ray
surveys. We suggest that either the cosmic X-ray background is unusually high
in the direction of Sombrero, or a distinct population of X-ray sources is
present in the halo of Sombrero.Comment: 11 figures, 5 tables, ApJ in pres
Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV
- Author
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- Abbiendi G
- Abbrescia M
- Abdullin S
- Acosta D
- Acosta JG
- Acosta MV
- Adair A
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- Adam W
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- Adiguzel A
- Adler V
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- Aguilar-Benitez M
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- Ahmad WH
- Ahuja S
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- Akgun B
- Akgun U
- Akin IV
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- Albayrak EA
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- Andreev Y
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- Yilmaz Y
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- Yumiceva F
- Yun JC
- Zabel J
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- Zakaria M
- Zalewski P
- Zanetti M
- Zang J
- Zang SL
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- Zeinali M
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- Zeyrek M
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- Zoeller MH
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- Zumerle G
- Zuranski A
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2012
- Field of study
The performance of muon reconstruction, identification, and triggering in CMS
has been studied using 40 inverse picobarns of data collected in pp collisions
at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection
criteria covering a wide range of physics analysis needs have been examined.
For all considered selections, the efficiency to reconstruct and identify a
muon with a transverse momentum pT larger than a few GeV is above 95% over the
whole region of pseudorapidity covered by the CMS muon system, abs(eta) < 2.4,
while the probability to misidentify a hadron as a muon is well below 1%. The
efficiency to trigger on single muons with pT above a few GeV is higher than
90% over the full eta range, and typically substantially better. The overall
momentum scale is measured to a precision of 0.2% with muons from Z decays. The
transverse momentum resolution varies from 1% to 6% depending on pseudorapidity
for muons with pT below 100 GeV and, using cosmic rays, it is shown to be
better than 10% in the central region up to pT = 1 TeV. Observed distributions
of all quantities are well reproduced by the Monte Carlo simulation.Comment: Replaced with published version. Added journal reference and DO
Azimuthal anisotropy of charged particles at high transverse momenta in PbPb collisions at sqrt(s[NN]) = 2.76 TeV
- Author
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- Abbiendi G
- Abbrescia M
- Abdullin S
- Abdulsalam A
- Acosta D
- Acosta JG
- Acosta MV
- Adair A
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- Adiguzel A
- Adler V
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- Afanasiev S
- Agostino L
- Agram JL
- Aguilar-Benitez M
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- Chang YW
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- Chao Y
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- Chatterjee A
- Chauhan S
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- Choudhury S
- Christiansen T
- Chuang SH
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- Cipriano PMR
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- Ciulli V
- Civinini C
- Claes DR
- Clare R
- Clarida W
- Clement E
- Clerbaux B
- Cline D
- CMS Collaboration
- Coarasa Perez JA
- Cockerill DJA
- Codispoti G
- Colafranceschi S
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- Cole JE
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- Colling D
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- Yi K
- Yildirim E
- Yilmaz Y
- Yohay R
- Yoo HD
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- Yumiceva F
- Yun JC
- Zabel J
- Zabi A
- Zablocki J
- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti M
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- Zatserklyaniy A
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- Zumerle G
- Zuranski A
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
The azimuthal anisotropy of charged particles in PbPb collisions at
nucleon-nucleon center-of-mass energy of 2.76 TeV is measured with the CMS
detector at the LHC over an extended transverse momentum (pt) range up to
approximately 60 GeV. The data cover both the low-pt region associated with
hydrodynamic flow phenomena and the high-pt region where the anisotropies may
reflect the path-length dependence of parton energy loss in the created medium.
The anisotropy parameter (v2) of the particles is extracted by correlating
charged tracks with respect to the event-plane reconstructed by using the
energy deposited in forward-angle calorimeters. For the six bins of collision
centrality studied, spanning the range of 0-60% most-central events, the
observed v2 values are found to first increase with pt, reaching a maximum
around pt = 3 GeV, and then to gradually decrease to almost zero, with the
decline persisting up to at least pt = 40 GeV over the full centrality range
measured.Comment: Replaced with published version. Added journal reference and DO
Performance of the CMS Cathode Strip Chambers with Cosmic Rays
- Author
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- Churin I
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- Xaplanteris L.
- Xella S.
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- Yagil A
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- Zabolotny W
- Zachariadou A
- Zalewski P
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- Zanetti M
- Zang SL
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- Zeidler C
- Zeinali M
- Zeise M
- Zelepoukine S
- Zeuner WD
- Zeyrek M
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- Zhukova V
- Ziebarth EB
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- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2009
- Field of study
The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device
in the CMS endcaps. Their performance has been evaluated using data taken
during a cosmic ray run in fall 2008. Measured noise levels are low, with the
number of noisy channels well below 1%. Coordinate resolution was measured for
all types of chambers, and fall in the range 47 microns to 243 microns. The
efficiencies for local charged track triggers, for hit and for segments
reconstruction were measured, and are above 99%. The timing resolution per
layer is approximately 5 ns
- …