A randomized, double-blind, active-controlled, double-dummy, parallel-group study to determine the safety and efficacy of oxycodone/naloxone prolonged-release tablets in patients with moderate/severe, chronic cancer pain

Objective: An examination of whether oxycodone/naloxone prolonged-release tablets (OXN PR) can improve constipation and maintain analgesia, compared with oxycodone prolonged-release tablets (OxyPR) in patients with moderate/severe cancer pain

Elliptic flow of charged particles in Pb-Pb collisions at 2.76 TeV

We report the first measurement of charged particle elliptic flow in Pb-Pb collisions at 2.76 TeV with the ALICE detector at the CERN Large Hadron Collider. The measurement is performed in the central pseudorapidity region (|$\eta$|<0.8) and transverse momentum range 0.2< $p_{\rm T}$< 5.0 GeV/$c$. The elliptic flow signal v$_2$, measured using the 4-particle correlation method, averaged over transverse momentum and pseudorapidity is 0.087 $\pm$ 0.002 (stat) $\pm$ 0.004 (syst) in the 40-50% centrality class. The differential elliptic flow v$_2(p_{\rm T})$ reaches a maximum of 0.2 near $p_{\rm T}$ = 3 GeV/$c$. Compared to RHIC Au-Au collisions at 200 GeV, the elliptic flow increases by about 30%. Some hydrodynamic model predictions which include viscous corrections are in agreement with the observed increase.Comment: 10 pages, 4 captioned figures, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/389

The ALICE Transition Radiation Detector: Construction, operation, and performance

The Transition Radiation Detector (TRD) was designed and built to enhance the capabilities of the ALICE detector at the Large Hadron Collider (LHC). While aimed at providing electron identification and triggering, the TRD also contributes significantly to the track reconstruction and calibration in the central barrel of ALICE. In this paper the design, construction, operation, and performance of this detector are discussed. A pion rejection factor of up to 410 is achieved at a momentum of 1 GeV/c in p-Pb collisions and the resolution at high transverse momentum improves by about 40% when including the TRD information in track reconstruction. The triggering capability is demonstrated both for jet, light nuclei, and electron selection. (c) 2017 CERN for the benefit of the Authors. Published by Elsevier B.V

Higher harmonic anisotropic flow measurements of charged particles in Pb-Pb collisions at 2.76 TeV

We report on the first measurement of the triangular $v_3$, quadrangular $v_4$, and pentagonal $v_5$ charged particle flow in Pb-Pb collisions at 2.76 TeV measured with the ALICE detector at the CERN Large Hadron Collider. We show that the triangular flow can be described in terms of the initial spatial anisotropy and its fluctuations, which provides strong constraints on its origin. In the most central events, where the elliptic flow $v_2$ and $v_3$ have similar magnitude, a double peaked structure in the two-particle azimuthal correlations is observed, which is often interpreted as a Mach cone response to fast partons. We show that this structure can be naturally explained from the measured anisotropic flow Fourier coefficients.Comment: 10 pages, 4 figures, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/387

Domain size as a parameter for studying the potential alkali-silica reactivity of chert-bearing aggregates

The presence of chert or flint in aggregates used for concrete manufacture has long been a source of concern in the context of alkali-silica reactivity. The global in-service performance of chert and flint-bearing aggregates, however, varies from innocuous to deleterious. This could be due to variations in the degree of crystallinity of the silica, which influences potential reactivity. Chert occurs in significant Irish sources of aggregate used for concrete, yet no cases of deleterious expansion have been reported in the Republic of Ireland to date. Many of these sources fail to conclusively demonstrate innocuous behaviour in the laboratory expansion tests despite satisfactory in-service behaviour. A previous X-ray diffraction study, employing quartz crystallinity index, had indicated a significant difference between Irish Carboniferous cherts and English Cretaceous flints. This paper reports a further study of crystallinity, correlated with mortar bar expansion tests, but employing both quartz crystallinity index and domain size in the characterisation of crystallinity. The influence of chert content was also studied. Twenty-three Irish aggregate sources were sampled, and petrographic analysis revealed that 17 of these contained chert. Three flint-bearing aggregates, from sources in England that had demonstrated alkali-silica reactivity, were also sampled. Chert and flint were extracted from the aggregate samples by a petrographer experienced in the field of concrete technology. Twenty-six distinct samples were successfully extracted from 13 of the Irish and the three English sources. X-ray diffraction testing confirmed the previous findings (using the quartz crystallinity indices) that the Irish cherts are,more crystalline than the English flints. Domain size determination, however, showed that the difference in crystallinity of the national sets was less than that anticipated. The influence of chert content is advanced as a hypothesis to explain the apparent reactivity of Irish cherts in screening tests. The potential value of combining domain size and chert content determination in helping to classify aggregate reactivity is advanced for cases where in-service behaviour is in significant conflict with findings from standard laboratory tests.Other funderIrish Cement Ltd"Full acknowledgement to source and publisher must be given. Please link to website: http://www.icevirtuallibrary.com/ ". Publiher version - http://www.icevirtuallibrary.com/content/article/10.1680/macr.2004.56.4.201. DG 29/07/10 au,ke.kpw25/8/1