1,372 research outputs found
SAP HANA distributed in-memory database system: Transaction, session, and metadata management
One of the core principles of the SAP HANA database system is the comprehensive support of distributed query facility. Supporting scale-out scenarios was one of the major design principles of the system from the very beginning. Within this paper, we first give an overview of the overall functionality with respect to data allocation, metadata caching and query routing. We then dive into some level of detail for specific topics and explain features and methods not common in traditional disk-based database systems. In summary, the paper provides a comprehensive overview of distributed query processing in SAP HANA database to achieve scalability to handle large databases and heterogeneous types of workloads
THOC5, a member of the mRNA export complex, contributes to processing of a subset of wingless/integrated (Wnt) target mRNAs and integrity of the gut epithelial barrier
THO (Suppressors of the transcriptional defects of hpr1 delta by
overexpression) complex 5 (THOC5), an mRNA export protein, is involved in the
expression of only 1% of all genes. Using an interferon inducible knockout
mouse system, we have previously shown that THOC5 is an essential element in
the maintenance of hematopoietic stem cells and cytokine-mediated
hematopoiesis in adult mice. Here we interrogate THOC5 function in cell
differentiation beyond the hematopoietic system and study pathological changes
caused by THOC5 deficiency. To examine whether THOC5 plays a role in general
differentiation processes, we generated tamoxifen inducible THOC5 knockout
mice. We show here that the depletion of THOC5 impaired not only hematopoietic
differentiation, but also differentiation and self renewal of the gut
epithelium. Depletion of the THOC5 gene did not cause pathological alterations
in liver or kidney.We further show that THOC5 is indispensable for processing
of mRNAs induced by Wnt (wingless/integrated) signaling which play key roles
in epithelial cell differentiation/proliferation. A subset of Wnt target
mRNAs, SRY-box containing gene 9 (Sox9), and achaete-scute complex homolog 2
(Ascl2), but not Fibronectin 1 (Fn1), were down-regulated in THOC5 knockout
intestinal cells. The down-regulated Wnt target mRNAs were able to bind to
THOC5. Furthermore, pathological alterations in the gastrointestinal tract
induced translocation of intestinal bacteria and caused sepsis in mice. The
bacteria translocation may cause Toll-like receptor activation. We identified
one of the Toll-like receptor inducible genes, prostaglandin-endoperoxidase
synthase 2 (Ptgs2 or COX2) transcript as THOC5 target mRNA. THOC5 is
indispensable for processing of only a subset of mRNAs, but plays a key role
in processing of mRNAs inducible by Wnt signals. Furthermore, THOC5 is
dispensable for general mRNA export in terminally differentiated organs,
indicating that multiple mRNA export pathways exist. These data imply that
THOC5 may be a useful tool for studying intestinal stem cells, for modifying
the differentiation processes and for cancer therapy
Heat Treated NiPâSiC Composite Coatings: Elaboration and Tribocorrosion Behaviour in NaCl Solution
Tribocorrosion behaviour of heat-treated NiP and NiPâSiC composite coatings was investigated in a 0.6 M NaCl solution. The tribocorrosion tests were performed in a linear sliding tribometer with an electrochemical cell interface. It was analyzed the influence of SiC particles dispersion in the NiP matrix on current density developed, on coefficient of friction and on wear volume loss. The results showed that NiPâSiC composite coatings had a lower wear volume loss compared to NiP coatings. However, the incorporation of SiC particles into the metallic matrix affects the current density developed by the system during the tribocorrosion test. It was verified that not only the volume of co-deposited particles (SiC vol.%) but also the number of SiC particles per coating area unit (and consequently the SiC particles size) have made influence on the tribocorrosion behaviour of NiPâSiC composite coatings
Canonicalizing Knowledge Base Literals
Ontology-based knowledge bases (KBs) like DBpedia are very valuable resources, but their usefulness and usability is limited by various quality issues. One such issue is the use of string literals instead of semantically typed entities. In this paper we study the automated canonicalization of such literals, i.e., replacing the literal with an existing entity from the KB or with a new entity that is typed using classes from the KB. We propose a framework that combines both reasoning and machine learning in order to predict the relevant entities and types, and we evaluate this framework against state-of-the-art baselines for both semantic typing and entity matching
Sex differences in zonulin in affective disorders and associations with current mood symptoms
Zonulin measurement was funded by Institut Allergosan (Graz, Austria).Introduction: The bidirectional connection between the brain and the gut within psychiatric entities has gained increasing scientific attention over the last years. As a regulator of intestinal permeability, zonulin acts as a key player on the interface of this interplay. Like several psychiatric disorders, intestinal permeability was associated with inflammation in previous findings. Methods: In this study we explored differences in zonulin serum levels in currently depressed (n = 55) versus currently euthymic (n = 37) individuals with an affective disorder. Further, we explored sex differences and possible influences on zonulin and affective symptoms like medication, age, body mass index, and smoking status. Results: Serum zonulin was significantly higher in females than in men independent from affective status (z = -2.412, p = .016). More specifically, females in the euthymic subgroup had higher zonulin levels than euthymic men (z = -2.114, p = .035). There was no difference in zonulin serum levels in individuals taking or not taking a specific psychopharmacotherapy. We found no correlation between zonulin serum levels and depression severity. Discussion: Increased serum zonulin levels as a proxy for increased intestinal permeability in women may indicate a state of elevated susceptibility for depression-inducing stimuli.Publisher PDFPeer reviewe
Differential branching fraction and angular analysis of the decay B0âKâ0ÎŒ+ÎŒâ
The angular distribution and differential branching fraction of the decay B 0â K â0 ÎŒ + ÎŒ â are studied using a data sample, collected by the LHCb experiment in pp collisions at sâ=7 TeV, corresponding to an integrated luminosity of 1.0 fbâ1. Several angular observables are measured in bins of the dimuon invariant mass squared, q 2. A first measurement of the zero-crossing point of the forward-backward asymmetry of the dimuon system is also presented. The zero-crossing point is measured to be q20=4.9±0.9GeV2/c4 , where the uncertainty is the sum of statistical and systematic uncertainties. The results are consistent with the Standard Model predictions
Measurements of the branching fractions of B+âppK+ decays
The branching fractions of the decay B+ â ppÌK+ for different intermediate states are measured using data, corresponding to an integrated luminosity of 1.0 fb-1, collected by the LHCb experiment. The total branching fraction, its charmless component MppÌ < 2.85 GeV/c2 and the branching fractions via the resonant ccÌ states η c(1S) and Ï(2S) relative to the decay via a J/Ï intermediate state are [Equation not available: see fulltext.] Upper limits on the B + branching fractions into the η c(2S) meson and into the charmonium-like states X(3872) and X(3915) are also obtained
Searches for B0(s)âJ/ÏppË and B+âJ/ÏppËÏ+ decays
The results of searches for B0(s)âJ/Ï ppÂŻ and B + â J/Ï p pÂŻ Ï+ decays are reported. The analysis is based on a data sample, corresponding to an integrated luminosity of 1.0 fbâ1 of pp collisions, collected with the LHCb detector. An excess with 2.8 Ï significance is seen for the decay B0sâJ/Ï ppÂŻ and an upper limit on the branching fraction is set at the 90 % confidence level: B(B0sâJ/Ï ppÂŻ) < 4.8 Ă 10â6, which is the first such limit. No significant signals are seen for B0 â J/Ï ppÂŻ and B+ â J/Ï ppÂŻ Ï + decays, for which the corresponding limits are set: B(B0âJ/Ï ppÂŻ) < 5.2 Ă 10â7, which significantly improves the existing limit; and B(B+âJ/Ï ppÂŻÏ+) < 5.0 Ă 10â7, which is the first limit on this branching fraction
Observation of associated production of a boson with a meson in the~forward region
A search for associated production of a boson with an open charm meson is
presented using a data sample, corresponding to an integrated luminosity of
of proton--proton collisions at a centre-of-mass energy
of 7\,TeV, collected by the LHCb experiment. %% Seven candidate events for
associated production of a boson with a meson and four candidate
events for a boson with a meson are observed with a combined
significance of 5.1standard deviations. The production cross-sections in the
forward region are measured to be where the first uncertainty is statistical and the
second systematic.Comment: 18 pages, 2 figure
Measurement of the relative rate of prompt Ïc0, Ïc1 and Ïc2 production at âs=7TeV
Prompt production of charmonium Ïc0, Ïc1 and Ïc2 mesons is studied using proton-proton collisions at the LHC at a centre-of-mass energy of âs=7TeV. The Ïc mesons are identified through their decay to J/ÏÎł, with J/ÏâÎŒ+muâ using photons that converted in the detector. A data sample, corresponding to an integrated luminosity of 1.0fbâ1 collected by the LHCb detector, is used to measure the relative prompt production rate of Ïc1 and Ïc2 in the rapidity range 2.0<y<4.5 as a function of the J/Ï transverse momentum from 3 to 20 GeV/c. First evidence for Ïc0 meson production at a hadron collider is also presented
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