423 research outputs found
Constraining scalar fields with stellar kinematics and collisional dark matter
The existence and detection of scalar fields could provide solutions to
long-standing puzzles about the nature of dark matter, the dark compact objects
at the centre of most galaxies, and other phenomena. Yet, self-interacting
scalar fields are very poorly constrained by astronomical observations, leading
to great uncertainties in estimates of the mass and the
self-interacting coupling constant of these fields. To counter this,
we have systematically employed available astronomical observations to develop
new constraints, considerably restricting this parameter space. In particular,
by exploiting precise observations of stellar dynamics at the centre of our
Galaxy and assuming that these dynamics can be explained by a single boson
star, we determine an upper limit for the boson star compactness and impose
significant limits on the values of the properties of possible scalar fields.
Requiring the scalar field particle to follow a collisional dark matter model
further narrows these constraints. Most importantly, we find that if a scalar
dark matter particle does exist, then it cannot account for both the
dark-matter halos and the existence of dark compact objects in galactic nucleiComment: 23 pages, 8 figures; accepted for publication by JCAP after minor
change
Helical distribution of the bacterial chemoreceptor via colocalization with the Sec protein translocation machinery
In Escherichia coli, chemoreceptor clustering at a cell pole seems critical for signal amplification and adaptation. However, little is known about the mechanism of localization itself. Here we examined whether the aspartate chemoreceptor (Tar) is inserted directly into the polar membrane by using its fusion to green fluorescent protein (GFP). After induction of TarâGFP, fluorescent spots first appeared in lateral membrane regions, and later cell poles became predominantly fluorescent. Unexpectedly, TarâGFP showed a helical arrangement in lateral regions, which was more apparent when a TarâGFP derivative with two cysteine residues in the periplasmic domain was cross-linked to form higher oligomers. Moreover, similar distribution was observed even when the cytoplasmic domain of the double cysteine TarâGFP mutant was replaced by that of the kinase EnvZ, which does not localize to a pole. Observation of GFPâSecE and a translocation-defective MalEâGFP mutant, as well as indirect immunofluorescence microscopy on SecG, suggested that the general protein translocation machinery (Sec) itself is arranged into a helical array, with which Tar is transiently associated. The Sec coil appeared distinct from the MreB coil, an actin-like cytoskeleton. These findings will shed new light on the mechanisms underlying spatial organization of membrane proteins in E. coli
Galactic Halos of Fluid Dark Matter
Dwarf spiral galaxies - and in particular the prototypical DDO 154 - are
known to be completely dominated by an unseen component. The putative
neutralinos - so far the favored explanation for the astronomical dark matter -
fail to reproduce the well measured rotation curves of those systems because
these species tend to form a central cusp whose presence is not supported by
observation. We have considered here a self-coupled charged scalar field as an
alternative to neutralinos and investigated whether a Bose condensate of that
field could account for the dark matter inside DDO 154 and more generally
inside dwarf spirals. The size of the condensate turns out to be precisely
determined by the scalar mass m and self-coupling lambda of the field. We find
actually that for m^4 / lambda = 50 - 75 eV^4, the agreement with the
measurements of the circular speed of DDO 154 is impressive whereas it lessens
for larger systems. The cosmological behavior of the field is also found to be
consistent - yet marginally - with the limits set by BBN on the effective
number of neutrino families. We conclude that classical configurations of a
scalar and self-coupled field provide a possible solution to the astronomical
dark matter problem and we suggest further directions of research.Comment: 20 pages, 7 figures; one reference added, version to be published in
PR
Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances
We use a genome-wide association of 1 million parental lifespans of genotyped subjects and data on mortality risk factors to validate previously unreplicated findings near CDKN2B-AS1, ATXN2/BRAP, FURIN/FES, ZW10, PSORS1C3, and 13q21.31, and identify and replicate novel findings near ABO, ZC3HC1, and IGF2R. We also validate previous findings near 5q33.3/EBF1 and FOXO3, whilst finding contradictory evidence at other loci. Gene set and cell-specific analyses show that expression in foetal brain cells and adult dorsolateral prefrontal cortex is enriched for lifespan variation, as are gene pathways involving lipid proteins and homeostasis, vesicle-mediated transport, and synaptic function. Individual genetic variants that increase dementia, cardiovascular disease, and lung cancer - but not other cancers - explain the most variance. Resulting polygenic scores show a mean lifespan difference of around five years of life across the deciles.Peer reviewe
Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms
Type 2 diabetes (T2D) affects Latinos at twice the rate seen in populations of European descent. We recently identified a risk haplotype spanning SLC16A11 that explains âŒ20% of the increased T2D prevalence in Mexico. Here, through genetic fine-mapping, we define a set of tightly linked variants likely to contain the causal allele(s). We show that variants on the T2D-associated haplotype have two distinct effects: (1) decreasing SLC16A11 expression in liver and (2) disrupting a key interaction with basigin, thereby reducing cell-surface localization. Both independent mechanisms reduce SLC16A11 function and suggest SLC16A11 is the causal gene at this locus. To gain insight into how SLC16A11 disruption impacts T2D risk, we demonstrate that SLC16A11 is a proton-coupled monocarboxylate transporter and that genetic perturbation of SLC16A11 induces changes in fatty acid and lipid metabolism that are associated with increased T2D risk. Our findings suggest that increasing SLC16A11 function could be therapeutically beneficial for T2D. Video Abstract [Figure presented] Keywords: type 2 diabetes (T2D); genetics; disease mechanism; SLC16A11; MCT11; solute carrier (SLC); monocarboxylates; fatty acid metabolism; lipid metabolism; precision medicin
The comparative responsiveness of Hospital Universitario Princesa Index and other composite indices for assessing rheumatoid arthritis activity
Objective
To evaluate the responsiveness in terms of correlation of the Hospital Universitario La Princesa Index (HUPI) comparatively to the traditional composite indices used to assess disease activity in rheumatoid arthritis (RA), and to compare the performance of HUPI-based response criteria with that of the EULAR response criteria.
Methods
Secondary data analysis from the following studies: ACT-RAY (clinical trial), PROAR (early RA cohort) and EMECAR (pre-biologic era long term RA cohort). Responsiveness was evaluated by: 1) comparing change from baseline (Delta) of HUPI with Delta in other scores by calculating correlation coefficients; 2) calculating standardised effect sizes. The accuracy of response by HUPI and by EULAR criteria was analyzed using linear regressions in which the dependent variable was change in global assessment by physician (Delta GDA-Phy).
Results
Delta HUPI correlation with change in all other indices ranged from 0.387 to 0.791); HUPI's standardized effect size was larger than those from the other indices in each database used. In ACT-RAY, depending on visit, between 65 and 80% of patients were equally classified by HUPI and EULAR response criteria. However, HUPI criteria were slightly more stringent, with higher percentage of patients classified as non-responder, especially at early visits. HUPI response criteria showed a slightly higher accuracy than EULAR response criteria when using Delta GDA-Phy as gold standard.
Conclusion
HUPI shows good responsiveness in terms of correlation in each studied scenario (clinical trial, early RA cohort, and established RA cohort). Response criteria by HUPI seem more stringent than EULAR''s
Description of Atmospheric Conditions at the Pierre Auger Observatory using the Global Data Assimilation System (GDAS)
Atmospheric conditions at the site of a cosmic ray observatory must be known
for reconstructing observed extensive air showers. The Global Data Assimilation
System (GDAS) is a global atmospheric model predicated on meteorological
measurements and numerical weather predictions. GDAS provides
altitude-dependent profiles of the main state variables of the atmosphere like
temperature, pressure, and humidity. The original data and their application to
the air shower reconstruction of the Pierre Auger Observatory are described. By
comparisons with radiosonde and weather station measurements obtained on-site
in Malarg\"ue and averaged monthly models, the utility of the GDAS data is
shown
Ï production in pâPb collisions at âsNN=8.16 TeV
Ï production in pâPb interactions is studied at the centre-of-mass energy per nucleonânucleon collision âsNN = 8.16 TeV with the ALICE detector at the CERN LHC. The measurement is performed reconstructing bottomonium resonances via their dimuon decay channel, in the centre-of-mass rapidity intervals 2.03 < ycms < 3.53 and â4.46 < ycms < â2.96, down to zero transverse momentum. In this work, results on the Ï(1S) production cross section as a function of rapidity and transverse momentum are presented. The corresponding nuclear modification factor shows a suppression of the Ï(1S) yields with respect to pp collisions, both at forward and backward rapidity. This suppression is stronger in the low transverse momentum region and shows no significant dependence on the centrality of the interactions. Furthermore, the Ï(2S) nuclear modification factor is evaluated, suggesting a suppression similar to that of the Ï(1S). A first measurement of the Ï(3S) has also been performed. Finally, results are compared with previous ALICE measurements in pâPb collisions at âsNN = 5.02 TeV and with theoretical calculations.publishedVersio
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