252 research outputs found
Highly Pathogenic Avian Influenza (HPAI H5Nx, Clade 2.3.4.4.b) in Poultry and Wild Birds in Sweden: Synopsis of the 2020-2021 Season
Simple Summary Highly pathogenic avian influenza is a virus-induced contagious disease that has killed a large number of poultry and wild birds in Europe in the recent decade and is an increasing problem worldwide. In the winter of 2020-2021, Sweden experienced its worst period to date when the disease was diagnosed on 15 commercial poultry farms and over 2.2 million birds died or were euthanised. The disease was also diagnosed in 130 wild birds and nine flocks of hobby, game or zoo birds between 1 October 2020 and 30 September 2021. The aim of this article was to describe the influenza situation in Sweden during this period and to add to the knowledge related to the alarming situation with highly pathogenic influenza in birds. The disease caused animal suffering and death in wild and domestic birds and incurred high costs due to losses and extensive measures to stop spread. The outbreak investigations, where contacts were traced and virus strains were compared, concluded that the virus was brought to poultry farms by wild birds in most cases. More research is needed to obtain knowledge on risk factors, biosecurity, and wild bird presence on poultry farms to prevent future disease outbreaks. Highly pathogenic avian influenza (HPAI, Gs/Gd lineage) was introduced to Europe in 2005 and has since caused numerous outbreaks in birds. The 2020-2021 season was the hitherto most devastating when considering bird numbers and duration in Europe. Surveillance data, virologic results and epidemiologic investigations from the 2020-2021 outbreaks in Sweden were analysed. Subtypes H5N8 and H5N5 were detected on 24 farms with poultry or other captive birds. In wild birds, subtypes H5N8, H5N5, H5N1, H5N4, H5Nx were detected in 130 out of 811 sampled birds. There was a spatiotemporal association between cases in wild birds and poultry. Based on phylogeny and epidemiology, most of the introductions of HPAI to commercial poultry were likely a result of indirect contact with wild birds. A definite route of introduction to poultry could not be established although some biosecurity breaches were observed. No spread between farms was identified but airborne spread between flocks on the same farm was suspected. Our findings exemplify the challenges posed by the continuously changing influenza viruses that seem to adapt to a broader species spectrum. This points to the importance of wild bird surveillance, compliance to biosecurity, and identification of risk factors for introduction on poultry farms
The chances of detecting life on Mars
AbstractMissions to Mars progressively reveal the past and present habitability of the red planet. The current priority for Mars science is the recognition of definitive biosignatures related to past or present life. Success of life detection missions requires choices of the best mission design, location on Mars and particular sample to be analyzed. It is essential therefore to incorporate as much information as possible into the mission planning stages to maximize the precious opportunities provided by robotic operation on Mars. Bayesian statistics allow us to accommodate the many unknowns associated with a mission that has yet to take place. We have used Bayesian statistics to reveal that although in situ missions are less complex the overall probabilities of a successful mission to detect biosignatures on Mars are higher for sample return. If a mission has been designed with safe landing and operation as a priority, recognizing and avoiding those samples that do not contain the target biosignature is the most important characteristic, while for a mission where the best possible samples have been targeted the probability that the sample contains the target biosignature and that it can be correctly detected is the most dominant issue. Usefully, Bayesian statistics can be used to evaluate the chances of detecting past or present life for missions to different landing sites on Mars. A comparative assessment of Eberswelde Crater and Gale Crater indicates a higher probability of success for the latter and the probabilities of success are consistently higher for the sample return mission variant. Bayesian statistics, therefore, can inform future Mars mission planning steps to help maximize the possibility of success
First in-situ analysis of dust devil tracks on Earth and their comparison with tracks on Mars
In this study we report about the first in-situ analysis of terrestrial dust devil tracks (DDTs) observed in the Turpan depression desert in northwestern China. Passages of active dust devils remove a thin layer of fine grained material (< ∼63 μm), cleaning the upper surface of coarse sands (0.5–1 mm). This erosional process changes the photometric properties of the upper surface causing the albedo differences within the track to the surroundings. Measurements imply that a removal of an equivalent layer thickness of ∼2 μm is sufficient to form the dark dust devil tracks. Our terrestrial results are in agreement with the mechanism proposed by Greeley et al. (2005) for the formation of DDTs on Mars
Seasonal melting and the formation of sedimentary rocks on Mars, with predictions for the Gale Crater mound
A model for the formation and distribution of sedimentary rocks on Mars is
proposed. The rate-limiting step is supply of liquid water from seasonal
melting of snow or ice. The model is run for a O(10^2) mbar pure CO2
atmosphere, dusty snow, and solar luminosity reduced by 23%. For these
conditions snow only melts near the equator, and only when obliquity >40
degrees, eccentricity >0.12, and perihelion occurs near equinox. These
requirements for melting are satisfied by 0.01-20% of the probability
distribution of Mars' past spin-orbit parameters. Total melt production is
sufficient to account for aqueous alteration of the sedimentary rocks. The
pattern of seasonal snowmelt is integrated over all spin-orbit parameters and
compared to the observed distribution of sedimentary rocks. The global
distribution of snowmelt has maxima in Valles Marineris, Meridiani Planum and
Gale Crater. These correspond to maxima in the sedimentary-rock distribution.
Higher pressures and especially higher temperatures lead to melting over a
broader range of spin-orbit parameters. The pattern of sedimentary rocks on
Mars is most consistent with a Mars paleoclimate that only rarely produced
enough meltwater to precipitate aqueous cements and indurate sediment. The
results suggest intermittency of snowmelt and long globally-dry intervals,
unfavorable for past life on Mars. This model makes testable predictions for
the Mars Science Laboratory rover at Gale Crater. Gale Crater is predicted to
be a hemispheric maximum for snowmelt on Mars.Comment: Submitted to Icarus. Minor changes from submitted versio
Freshwater salinization syndrome limits management efforts to improve water quality
Freshwater Salinization Syndrome (FSS) refers to groups of biological, physical, and chemical impacts which commonly occur together in response to salinization. FSS can be assessed by the mobilization of chemical mixtures, termed “chemical cocktails”, in watersheds. Currently, we do not know if salinization and mobilization of chemical cocktails along streams can be mitigated or reversed using restoration and conservation strategies. We investigated 1) the formation of chemical cocktails temporally and spatially along streams experiencing different levels of restoration and riparian forest conservation and 2) the potential for attenuation of chemical cocktails and salt ions along flowpaths through conservation and restoration areas. We monitored high-frequency temporal and longitudinal changes in streamwater chemistry in response to different pollution events (i.e., road salt, stormwater runoff, wastewater effluent, and baseflow conditions) and several types of watershed management or conservation efforts in six urban watersheds in the Chesapeake Bay watershed. Principal component analysis (PCA) indicates that chemical cocktails which formed along flowpaths (i.e., permanent reaches of a stream) varied due to pollution events. In response to winter road salt applications, the chemical cocktails were enriched in salts and metals (e.g., Na+, Mn, and Cu). During most baseflow and stormflow conditions, chemical cocktails were less enriched in salt ions and trace metals. Downstream attenuation of salt ions occurred during baseflow and stormflow conditions along flowpaths through regional parks, stream-floodplain restorations, and a national park. Conversely, chemical mixtures of salt ions and metals, which formed in response to multiple road salt applications or prolonged road salt exposure, did not show patterns of rapid attenuation downstream. Multiple linear regression was used to investigate variables that influence changes in chemical cocktails along flowpaths. Attenuation and dilution of salt ions and chemical cocktails along stream flowpaths was significantly related to riparian forest buffer width, types of salt pollution, and distance downstream. Although salt ions and chemical cocktails can be attenuated and diluted in response to conservation and restoration efforts at lower concentration ranges, there can be limitations in attenuation during road salt events, particularly if storm drains bypass riparian buffers
Humoral and cellular responses to repeated COVID-19 exposure in multiple sclerosis patients receiving B-cell depleting therapies: a single-center, one-year, prospective study
Multiple sclerosis patients treated with anti-CD20 therapy (aCD20-MS) are considered especially vulnerable to complications from SARS-CoV-2 infection due to severe B-cell depletion with limited viral antigen-specific immunoglobulin production. Therefore, multiple vaccine doses as part of the primary vaccination series and booster updates have been recommended for this group of immunocompromised individuals. Even though much less studied than antibody-mediated humoral responses, T-cell responses play an important role against CoV-2 infection and are induced efficiently in vaccinated aCD20-MS patients. For individuals with such decoupled adaptive immunity, an understanding of the contribution of T-cell mediated immunity is essential to better assess protection against CoV-2 infection. Here, we present results from a prospective, single-center study for the assessment of humoral and cellular immune responses induced in aCD20-MS patients (203 donors/350 samples) compared to a healthy control group (43/146) after initial exposure to CoV-2 spike antigen and subsequent re-challenges. Low rates of seroconversion and RBD-hACE2 blocking activity were observed in aCD20-MS patients, even after multiple exposures (responders after 1st exposure = 17.5%; 2nd exposure = 29.3%). Regarding cellular immunity, an increase in the number of spike-specific monofunctional IFNγ+-, IL-2+-, and polyfunctional IFNγ+/IL-2+-secreting T-cells after 2nd exposure was found most noticeably in healthy controls. Nevertheless, a persistently higher T-cell response was detected in aCD20-MS patients compared to control individuals before and after re-exposure (mean fold increase in spike-specific IFNγ+-, IL-2+-, and IFNγ+/IL-2+-T cells before re-exposure = 3.9X, 3.6X, 3.5X/P< 0.001; after = 3.2X, 1.4X, 2.2X/P = 0.002, P = 0.05, P = 0.004). Moreover, cellular responses against sublineage BA.2 of the currently circulating omicron variant were maintained, to a similar degree, in both groups (15-30% T-cell response drop compared to ancestral). Overall, these results highlight the potential for a severely impaired humoral response in aCD20-MS patients even after multiple exposures, while still generating a strong T-cell response. Evaluating both humoral and cellular responses in vaccinated or infected MS patients on B-cell depletion therapy is essential to better assess individual correlations of immune protection and has implications for the design of future vaccines and healthcare strategies
Origin and development of theater-headed valleys in the Atacama Desert, northern Chile: Morphological analogs to martian valley networks
HiRISE imaging of impact megabreccia and sub-meter aqueous strata in Holden Crater, Mars
Dust Devil Tracks
Dust devils that leave dark- or light-toned tracks are common on Mars and they can also be found on the Earth’s surface. Dust devil tracks (hereinafter DDTs) are ephemeral surface features with mostly sub-annual lifetimes. Regarding their size, DDT widths can range between ∼1 m and ∼1 km, depending on the diameter of dust devil that created the track, and DDT lengths range from a few tens of meters to several kilometers, limited by the duration and horizontal ground speed of dust devils. DDTs can be classified into three main types based on their morphology and albedo in contrast to their surroundings; all are found on both planets: (a) dark continuous DDTs, (b) dark cycloidal DDTs, and (c) bright DDTs. Dark continuous DDTs are the most common type on Mars. They are characterized by their relatively homogenous and continuous low albedo surface tracks. Based on terrestrial and martian in situ studies, these DDTs most likely form when surficial dust layers are removed to expose larger-grained substrate material (coarse sands of ≥500 μm in diameter). The exposure of larger-grained materials changes the photometric properties of the surface; hence leading to lower albedo tracks because grain size is photometrically inversely proportional to the surface reflectance. However, although not observed so far, compositional differences (i.e., color differences) might also lead to albedo contrasts when dust is removed to expose substrate materials with mineralogical differences. For dark continuous DDTs, albedo drop measurements are around 2.5 % in the wavelength range of 550–850 nm on Mars and around 0.5 % in the wavelength range from 300–1100 nm on Earth. The removal of an equivalent layer thickness around 1 μm is sufficient for the formation of visible dark continuous DDTs on Mars and Earth. The next type of DDTs, dark cycloidal DDTs, are characterized by their low albedo pattern of overlapping scallops. Terrestrial in situ studies imply that they are formed when sand-sized material that is eroded from the outer vortex area of a dust devil is redeposited in annular patterns in the central vortex region. This type of DDT can also be found in on Mars in orbital image data, and although in situ studies are lacking, terrestrial analog studies, laboratory work, and numerical modeling suggest they have the same formation mechanism as those on Earth. Finally, bright DDTs are characterized by their continuous track pattern and high albedo compared to their undisturbed surroundings. They are found on both planets, but to date they have only been analyzed in situ on Earth. Here, the destruction of aggregates of dust, silt and sand by dust devils leads to smooth surfaces in contrast to the undisturbed rough surfaces surrounding the track. The resulting change in photometric properties occurs because the smoother surfaces have a higher reflectance compared to the surrounding rough surface, leading to bright DDTs. On Mars, the destruction of surficial dust-aggregates may also lead to bright DDTs. However, higher reflective surfaces may be produced by other formation mechanisms, such as dust compaction by passing dust devils, as this may also cause changes in photometric properties. On Mars, DDTs in general are found at all elevations and on a global scale, except on the permanent polar caps. DDT maximum areal densities occur during spring and summer in both hemispheres produced by an increase in dust devil activity caused by maximum insolation. Regionally, dust devil densities vary spatially likely controlled by changes in dust cover thicknesses and substrate materials. This variability makes it difficult to infer dust devil activity from DDT frequencies. Furthermore, only a fraction of dust devils leave tracks. However, DDTs can be used as proxies for dust devil lifetimes and wind directions and speeds, and they can also be used to predict lander or rover solar panel clearing events. Overall, the high DDT frequency in many areas on Mars leads to drastic albedo changes that affect large-scale weather patterns
Characteristics of large Martian dust devils using Mars Odyssey Thermal Emission Imaging System visual and infrared images
A search for Martian dust devils has been carried out, using Mars Odyssey Thermal Emission Imaging System (THEMIS) visible-wavelength images. Simultaneous THEMIS thermal infrared wavelength images were then processed and analyzed to investigate the thermal properties of the dust devils observed; 3079 images were checked, concentrating on northern spring, summer, and autumn (LS from 0° to 270°, 20°S to 50°N). Mars Express High Resolution Stereo Camera, Mars Global Surveyor Mars Orbiter Camera, and other THEMIS visible images were used for comparison to potentially rule out any ambiguous geological features. Eight clear examples of dust devils have been found in five separate images, with a comparable number of unconfirmed possible devils. The rarity of dust devils observed is believed to result from a combination of the difficulty in identifying dust devils in medium resolution THEMIS data and the fact that the Mars Odyssey orbit flyover local time is later in the afternoon than would be optimum for dust devil searching. The temporal distribution of dust devil activity appears to be weighted more toward later afternoon, compared to Earth, but this may be a sampling effect due to size variation with time of sol, greater coverage later in the sol, or the small-number statistics. The thermal infrared images indicate that the lofted dust in the column is cooler than the surrounding surface and must be equilibrating with the atmosphere in the dust devil. This energy transfer is estimated to be about 10% of the heat flux energy that is available to drive the systems. The ground shadowed by the dust column also appears colder than the surroundings, because of reduced solar illumination. From the visible-wavelength images, the shadows of the dust columns were used to estimate the column opacity, which in turn gave estimates of the dust loadings, which ranged from 1.9 × 10?5 to 1.5 × 10?4 kg m?3, similar to lander-based observations. No thermal or visible trails are associated with the dust devils, indicating that the surface equilibrates quickly after the devil has passed and that track counting as a dust devil survey technique must underestimate dust devil populations and consequently dust loading calculations, confirming previous work
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