Experience in Water-Cure : a familiar exposition of the principles and results of water treatment, in the cure of acute and chronic diseases, illustrated by numerous cases in the practice of the author : with an explanation of water-cure processes, advice on diet and regimen, and particular directions to women in the treatment of female diseases, water treatment in childbirth, and the diseases of infancy /

Includes index."Entered according to act of Congress, in the year 1849 ..."--T.p. verso."Stereotyped."Mode of access: Internet

Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development

GATA transcription factors, together with Friend of GATA (FOG) cofactors, are required for the differentiation of diverse cell types. Multiple aspects of hematopoiesis are controlled by the interaction of FOG-1 with the GATA-1/2/3 subfamily. Likewise, FOG-2 is coexpressed with the GATA-4/5/6 subfamily at other sites, including the heart and gonads. FOG-2 and GATA-4 are required for cardiac development. Through transgenic rescue of hematopoietic defects of FOG-1(–/–) embryos we define an unsuspected role for FOG-1 in heart development. In particular, rescued FOG-1(–/–) mice die at embryonic day (E) 14.5 with cardiac defects that include double outlet right ventricle and a common atrioventricular valve. Using conditional inactivation of Fog-1 we assign the cell of origin in which FOG-1 function is required. Neural crest cells migrate properly into FOG-1(–/–) hearts and mice with FOG-1 conditionally excised from neural crest derivatives fail to develop cardiac abnormalities. In contrast, conditional inactivation of FOG-1 in endothelial-derived tissues by means of Tie-2-expressed Cre recapitulates the rescue-knockout defects. These findings establish a nonredundant requirement for FOG-1 in the outlet tract and atrioventricular valves of the heart that depend on expression in endothelial-derived tissue and presumably reflect cooperation with the GATA-4/5/6 subfamily

Modeling Individual Animal Histories with Multistate Capture–Recapture Models

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