3 research outputs found
Genomic-Glycosylation Aberrations in Tumor Initiation, Progression and Management
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- Publication venue
- 'American Institute of Mathematical Sciences (AIMS)'
- Publication date
- 01/01/2016
- Field of study
Mapping the human genetic architecture of COVID-19
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- Abdelrazik M
- Abdullah T
- Abe R
- Abe S
- Abecasis GR
- Abel L
- Abernathy C
- Abraheem A
- Abul-Husn NS
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- de Geus EJC
- de Gordoa LO-R
- de Gordoa LO-R
- De Grandi A
- de Jong H
- de Jong MD
- De la Horra C
- De Neef M
- de Pablo R
- de Rojas I
- de Salazar A
- de Silva T
- De Vivo O
- De Vivo O
- de Vries H
- Deacon B
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- Dearden J
- Death Y
- Deboever C
- Debreceni G
- Deelen P
- Deelen P
- Deery J
- Degenhardt F
- Dei S
- Dela Rosa A
- Delaneau O
- Delgado CC
- Delgado J
- Della Monica M
- Dellot P
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- Demetriou C
- Denmade C
- Dennis C
- Dent K
- Dent M
- Depante M
- Dervisevic S
- Desanctis E
- Desgranges F
- deSouza F
- Di Angelantonio E
- di Bartolomeo C
- Di Biagio A
- Di Domenico P
- Di Pietro M
- Di Sarno L
- Di Valentin E
- Digby B
- Digby S
- Dincarslan O
- Ding L
- Ding Y
- Djeugam B
- Do R
- Dobano C
- Dobson E
- Docherty AB
- Doddato G
- Dodds S
- Domingues F
- Donaldson A
- Donaldson D
- Donati A
- Dongelmans D
- Donlon S
- Donnachie J
- Donne B
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- Donnelly L
- Donner K
- Donnison P
- Donnison P
- Donohue C
- Dooks E
- Doonan R
- Dopazo X
- Dore R
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- Douglas K
- Douthwaite S
- Downes C
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- Dreher M
- Drummond A
- Drummond A
- Duberly S
- Dudman S
- Dueker N
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- Duffin D
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- Duffy S
- Duga S
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- Dumas M-E
- Duncan E
- Duncan T
- Dunham I
- Dunmore C
- Dunn C
- Dunning J
- DuRand I
- Durand M
- Durga L
- Durham C
- Durie A
- Durrans LJ
- Durrant G
- Dushianthan A
- Duskova M
- Dutta AK
- Dutta AK
- Dutta AK
- Dyer P
- Dyer T
- Dykes J
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- Eapen B
- Earle SG
- Eastgate-Jackson C
- Easthope A
- Easthope A
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- Easton J
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- Edmond I
- Edwards M
- Efford G
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- Eggermann T
- El Kandoussi K
- Elabd H
- Elbers P
- Elhassan M
- Ellinghaus D
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- Ellis H
- Elsaadany M
- Elston K
- Eltayeb A
- Emiliozzi A
- Emmert D
- Endo A
- Endo M
- English K
- Enomoto T
- Erard V
- Erard V
- Erdmann J
- Eriguchi Y
- Esko T
- Esmaeeli S
- Espana PP
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- Eziefula C
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- Fagan A
- Fairfield CJ
- Falcone M
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- Fallerini C
- Farh K
- Farnell-Ward S
- Farquhar F
- Farre X
- Farre X
- Farzad Z
- Faucon A
- Faucon AB
- Faulkner B
- Faulkner M
- Fava F
- Fave M-J
- Faverio P
- Fawkes A
- Fazaal J
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- Fegan C
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- Ferguson S
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- Fernandez Z
- Fernandez-Cadenas I
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- Fernandez-Cadenas I
- Fernandez-Roman J
- Ferrando C
- Ferreira MAR
- Ferrer R
- Ferrero GB
- Ferri C
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- Ferwerda B
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- Filipe ADS
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- Fiorentino G
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- Fletcher T
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- Flint N
- Foco L
- Fofano A
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- Folkersen L
- Folkes L
- Folseraas T
- Foote D
- Force HCT
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- Forgetta V
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- Foster L
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- Fottrell-Gould D
- Foucras S
- Fourman MH
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- Fowler S
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- Francisci D
- Franke A
- Franke G
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- Friaza V
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- Fujiwara A
- Fuke S
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- Gallagher B
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- Galvan-Femenia I
- Galvan-Femenia I
- Gamble C
- Ganesan A
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- Garcia Sanchez F
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- Gendall E
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- Hirata H
- Hiscox JA
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- Hodgkiss T
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- Holmes A
- Holten AR
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- Hong EL
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- Hormis A
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- Hornsby J
- Horowitz JE
- Horsley E
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- Houlden H
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- Howle R
- Howlett A
- Hruska M
- Hu C
- Huang C
- Huang QQ
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- Huang Y
- Huckins LM
- Hudig L
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- Hussain M
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- Hussain S
- Hussain Y
- Hutton P
- Huynen P
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- Ichikado K
- Ichimura N
- Ihara S
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- Ikemura S
- Ilinsky V
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- Imeson-Wood J
- Imoto S
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- Intxausti M
- Invernizzi P
- Inweregbu K
- Ioannidis A
- Iolascon A
- Ionita-Laza I
- Iou-Olivgeris MP
- Ireland J
- Irvine V
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- Ishiguro T
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- Izquierdo-Sanchez L
- Izumi N
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- Kamdar D
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- Kaneyama Y
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- zu Bentrup FM
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- Zwinderman AHK
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- Publication venue
- Publication date
- 01/01/2021
- Field of study
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3,4,5,6,7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease
Genetic studies of body mass index yield new insights for obesity biology
- Author
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- Abecasis G
- Abecasis GR
- Abecasis GR
- Abecasis Gonçalo R.
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- Österholm AM
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Note: A full list of authors and affiliations appears at the end of the article.
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P 20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.</p