Designing a Community-based Water Harvesting System: Understanding Water Use in Endallah, Tanzania

The World Health Organization (WHO) states it is a human right to have access to sufficient, safe water within one kilometer of the home (WHO, 2015b). However, 1.6 billion people experience economic water shortage and struggle to secure water for personal and domestic use (UN-Water & FAO, 2007). In the village of Endallah, Tanzania, seasonal rainfalls, high rates of evaporation, and inadequate water harvesting infrastructure leave many of the approximately 900 households facing economic water shortage. Around 90% of villagers depend on rainfed subsistence farming; however, annual crop yields are not consistent due to sporadic rainfall. The purpose of this research was to quantify water use, access, and needs in the village of Endallah to inform the design of a sustainable, community-based water harvesting system. In January 2015, a Purdue University Global Development Team traveled to Endallah to survey 25 households on their water collection and use. The results from the 12-question survey were coded, analyzed, and interpreted. The survey showed a significant need to improve water access in Endallah. Based on the survey results, most people in Endallah spend over three hours a day collecting water for domestic use. Water needs in Endallah have not been previously quantified, so the results will be crucial to the development of an accessible, community-based water harvesting system. Ultimately, by decreasing economic water shortage, the people of Endallah will have greater access to water for domestic consumption and can move toward using water to improve livestock health and agricultural productivity

Atmospheric temperature responses to solar irradiance and geomagnetic activity

The relative effects of solar irradiance and geomagnetic activity on the atmospheric temperature anomalies (Ta) are examined from the monthly to interdecadal timescales. Geomagnetic Ap (Ap) signals are found primarily in the stratosphere, while the solar F10.7-cm radio flux (Fs) signals are found in both the stratosphere and troposphere. In the troposphere, 0.1–0.4 K increases in Ta are associated with Fs. Enhanced Fs signals are found when the stratospheric quasi-biennial oscillation (QBO) is westerly. In the extrapolar region of the stratosphere, 0.1–0.6 and 0.1–0.7 K increases in Ta are associated with solar irradiance and with geomagnetic activity, respectively. In this region, Fs signals are strengthened when either the QBO is easterly, or geomagnetic activity is high, while Ap signals are strengthened when either the QBO is westerly, or solar irradiance is high. High solar irradiance and geomagnetic activity tend to enhance each other's signatures either making the signals stronger and symmetric about the equator or extending the signals to broader areas, or both. Positive Ap signals dominate the middle Arctic stratosphere and are two to five times larger than those of Fs. When solar irradiance is low, the signature of Ap in Ta is asymmetric about the equator, with positive signals in the Arctic stratosphere and negative signals at midlatitudes of the NH stratosphere. Weaker stratospheric QBO signals are associated with high Ap and Fs, suggesting possible disturbances on the QBO. The signals of Ap and Fs are distinct from the positive temperature anomalies resulting from volcanic eruptions

Cloxacillin versus vancomycin for presumed late-onset sepsis in the Neonatal Intensive Care Unit and the impact upon outcome of coagulase negative staphylococcal bacteremia: a retrospective cohort study

BACKGROUND: Coagulase negative staphylococcus (CONS) is the main cause of late-onset sepsis in Neonatal Intensive Care Units (NICU). Although CONS rarely causes fulminant sepsis, vancomycin is frequently used as empiric therapy. Indiscriminate use of vancomycin has been linked to the emergence of vancomycin resistant organisms. The objective of this study was to compare duration of CONS sepsis and mortality before and after implementation of a policy of selective vancomycin use and compare use of vancomycin between the 2 time periods. METHODS: A retrospective study was conducted of infants ≥4 days old, experiencing signs of sepsis with a first positive blood culture for CONS, during two 12-month periods. Late-onset sepsis was treated empirically with vancomycin and gentamicin during period 1, and cloxacillin and gentamicin during period 2. The confidence interval method was used to assess non-inferiority of the outcomes between the two study groups. RESULTS: There were 45 episodes of CONS sepsis during period 1 and 37 during period 2. Duration of sepsis was similar between periods (hazard ratio of 1.00, 95%CI: 0.64, 1.57). One death during period 2 was possibly related to CONS sepsis versus none in period 1. Vancomycin was used in 97.8% of episodes in period 1 versus 81.1% of episodes in period 2. CONCLUSION: Although we failed to show non-inferiority of duration of sepsis in the cloxacillin and gentamicin group compared to the vancomycin and gentamicin group, duration of sepsis was clinically similar. Restricting vancomycin for confirmed cases of CONS sepsis resistant to oxacillin appears effective and safe, and significantly reduces vancomycin use in the NICU

Beyond Federalism: Estimating and Explaining the Territorial Structure of Government

This paper suggests that the basic distinction between federal and unitary government has limited as well as served our understanding of government. The notion that variation in the structure of government is a difference of kind rather than degree has straight-jacketed attempts to estimate the authority of intermediate government. One result has been the claim that a country’s footprint, not its population, is decisive for government. Analyzing data for 39 countries since 1950, and comparing our own findings with those of alternative measurements, we find evidence for the causal effect of population. This can be theorized in terms of a trade-off between responsiveness to soft information and per capita economies in public good provision

Mass incarceration and neoliberal penality : a response to Lloyd and Whitehead’s Kicked to the Curb

This paper is written in response to Lloyd and Whitehead’s (2018) Kicked to the Curb: The triangular trade of neoliberal polity, social insecurity, and penal expul-sion. Using the “triangular trade” that underpinned chattel slavery as an analytical metaphor, Lloyd and Whitehead (2018) argue that the growth of mass incarcera-tion is an endogenous feature of neoliberalism. They conclude a distinctive form of penality - neoliberal penality has developed over the past forty years. Lloyd and Whitehead (2018) propose that a tripartite model - neoliberalism, precarity and mass incarceration - as the basis for a model of neoliberal penality. This paper uses an exploration of the arguments raised by Lloyd and Whitehead (2018) to examine the links between neoliberalism and the expansion of the penal state. Whilst rec-ognising the centrality of race to these issues, the paper argues that the model that Lloyd and Whitehead (2018) present offers a partial explanation for mass incarcer-ation. This paper acknowledges that the triangular trade metaphor is a powerful one but will conclude that it has limitations. In particular, the comparison be-tween mass incarceration and chattel slavery is overstated. The economic impact of slavery and its centrality to the modern capitalism (Williams, 2014) cannot be compared to the exploitation that occurs in the current prison system. The paper argues that neoliberalism, precarity and mass incarceration are clearly linked but do not constitute a triangular trade as Lloyd and Whitehead (2018) conclude

Freedom and the “choice to choose oneself” in being and time

What Heidegger means by “freedom” in Being and Time is somewhat mysterious: while the notion crops up repeatedly in the book, there is no dedicated section or study, and the concept is repeatedly connected to a new and opaque idea – that of the “choice to choose oneself.” Yet the specificity of Being and Time’s approach to freedom becomes apparent when the book is compared to other texts of the same period, in particular The Metaphysical Foundations of Logic, The Fundamental Concepts of Metaphysics, The Essence of Grounds, and The Essence of Freedom. Although there are some differences, the definition of freedom that can be found there identifies it with “existence” or “transcendence,” Dasein’s ek-static opening onto the world. Thus “being in the world must also be primordially bound up with or derived from the basic feature of Dasein’s existence, freedom… Dasein’s transcendence and freedom are identical! Freedom provides itself with intrinsic possibility: a being is, as free, necessarily in itself transcending” (GA 26: 238; Heidegger’s italics). Note the apodictic modality of the claim: it is not simply the case that Dasein, as transcending, is free. Anything that has the structure of being in the world must be free: freedom is co-extensive with Dasein. Yet Dasein is often pictured in Being and Time as anything but free: it “ensnares itself” (268), is “lost” (264), “alienated” (178), and needs to be “liberated” (264, 303). Thus comparison between Being and Time and other texts on freedom yields an important paradox: although by definition it transcends toward the world, the Dasein of Division I is deprived of freedom. It must be free, and yet phenomenological analysis shows that it is not free. To understand the specific meaning of freedom in Being and Time, one has to square this circle

A Genome-Wide Association Study of Total Bilirubin and Cholelithiasis Risk in Sickle Cell Anemia

Serum bilirubin levels have been associated with polymorphisms in the UGT1A1 promoter in normal populations and in patients with hemolytic anemias, including sickle cell anemia. When hemolysis occurs circulating heme increases, leading to elevated bilirubin levels and an increased incidence of cholelithiasis. We performed the first genome-wide association study (GWAS) of bilirubin levels and cholelithiasis risk in a discovery cohort of 1,117 sickle cell anemia patients. We found 15 single nucleotide polymorphisms (SNPs) associated with total bilirubin levels at the genome-wide significance level (p value <5×10−8). SNPs in UGT1A1, UGT1A3, UGT1A6, UGT1A8 and UGT1A10, different isoforms within the UGT1A locus, were identified (most significant rs887829, p = 9.08×10−25). All of these associations were validated in 4 independent sets of sickle cell anemia patients. We tested the association of the 15 SNPs with cholelithiasis in the discovery cohort and found a significant association (most significant p value 1.15×10−4). These results confirm that the UGT1A region is the major regulator of bilirubin metabolism in African Americans with sickle cell anemia, similar to what is observed in other ethnicities