Measurement in biological systems from the self-organisation point of view

Measurement in biological systems became a subject of concern as a consequence of numerous reports on limited reproducibility of experimental results. To reveal origins of this inconsistency, we have examined general features of biological systems as dynamical systems far from not only their chemical equilibrium, but, in most cases, also of their Lyapunov stable states. Thus, in biological experiments, we do not observe states, but distinct trajectories followed by the examined organism. If one of the possible sequences is selected, a minute sub-section of the whole problem is obtained, sometimes in a seemingly highly reproducible manner. But the state of the organism is known only if a complete set of possible trajectories is known. And this is often practically impossible. Therefore, we propose a different framework for reporting and analysis of biological experiments, respecting the view of non-linear mathematics. This view should be used to avoid overoptimistic results, which have to be consequently retracted or largely complemented. An increase of specification of experimental procedures is the way for better understanding of the scope of paths, which the biological system may be evolving. And it is hidden in the evolution of experimental protocols.Comment: 13 pages, 5 figure

The Timing of School Transitions and Early Adolescent Problem Behavior

This longitudinal study investigates whether rural adolescents who transition to a new school in sixth grade have higher levels of risky behavior than adolescents who transition in seventh grade. Our findings indicate that later school transitions had little effect on problem behavior between sixth and ninth grades. Cross-sectional analyses found a small number of temporary effects of transition timing on problem behavior: Spending an additional year in elementary school was associated with higher levels of deviant behavior in the Fall of Grade 6 and higher levels of antisocial peer associations in Grade 8. However, transition effects were not consistent across waves and latent growth curve models found no effects of transition timing on the trajectory of problem behavior. We discuss policy implications and compare our findings with other research on transition timing

A Conceptual Framework for Analyzing the Use of Context in Groupware

Abstract. This article presents a conceptual framework for the identification and classification of contextual elements included in groupware applications. Contextual elements store information that helps group members to characterize and to understand the interaction and its associate information. The conceptual framework can be used not only to guide the development of new groupware applications but also to analyze existing groupware. We illustrate the use of the framework in the analysis of three groupware tools.

The effect of porosity of dust particles on polarization and color with special reference to comets

[EN] Cosmic dust particles are mostly responsible for polarization of the light that we observe from astrophysical objects. They also lead to color-extinction, thermal re-emission and other scattering related phenomena. Micrometric dust particles are often made of smaller constituent (nanometric grains). They are characterized by their size (average radius), chemical composition and morphology (including porosity). In the present work, we address the question of the role of the dust particle porosity on light polarization and color, using Discrete Dipole Approximation (DDA) light scattering code. To this purpose, we develop an algorithm to generate dust particles of arbitrary values of porosity. In brief, starting from a compact spherical ensemble of dipoles,randomly the dipoles are removed one by one, such that the remaining dipoles remain connected within their neighbours. We stop the removal process when the desired porosity is obtained. Then we compute and study the optical properties of the porous dust particle. The main objective of this paper is to develop a tool to generate dust particles with an arbitrary value of porosity and to study the effect of porosity on their light scattering properties. As a possible application, we simulate cometary polarization and color values which grossly match with the observed ones for the comet 1P/Halley, leaving scope for future work.R.B. thanks the Assam University, Silchar, for hospitality in the framework of 'Global Initiative for Academic Network' (GIAN) programme from MHRD, April 2016. The authors AKS and RV thank Erasmus Mundus - NAMASTE programme for funds to do this collaborative work. Finally, we are thankful to anonymous referees of this paper, due to whose comments we believe the quality of paper has improved.Sen, AK.; Botet, R.; Vilaplana Cerda, RI.; Choudhury, NR.; Gupta, R. (2017). The effect of porosity of dust particles on polarization and color with special reference to comets. Journal of Quantitative Spectroscopy and Radiative Transfer. 198:164-178. doi:10.1016/j.jqsrt.2017.05.009S16417819

Search for excited leptons in pp collisions at √s=7 TeV

This is the pre-print version of the final published paper that is available from the link belowResults are presented of a search for compositeness in electrons and muons using a data sample of pp collisions at a center-of-mass energy √s=7 TeV collected with the CMS detector at the LHC and corresponding to an integrated luminosity of 5.0 fb−15.0 fb−1. Excited leptons (ℓ⁎) are assumed to be produced via contact interactions in conjunction with a standard model lepton and to decay via ℓ⁎→ℓγ, yielding a final state with two energetic leptons and a photon. The number of events observed in data is consistent with that expected from the standard model. The 95% confidence upper limits for the cross section for the production and decay of excited electrons (muons), with masses ranging from 0.6 to 2 TeV, are 1.48 to 1.24 fb (1.31 to 1.11 fb). Excited leptons with masses below 1.9 TeV are excluded for the case where the contact interaction scale equals the excited lepton mass. The limits on the cross sections are the most stringent ones published to date

Observation of electroweak production of Wγ with two jets in proton-proton collisions at √s = 13 TeV

A first observation is presented for the electroweak production of a W boson, a photon, and two jets in proton-proton collisions. The W boson decays are selected by requiring one identified electron or muon and an imbalance in transverse momentum. The two jets are required to have a high dijet mass and a large separation in pseudorapidity. The measurement is based on data collected with the CMS detector at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 35.9 fb$^{-1}$. The observed (expected) significance for this process is 4.9 (4.6) standard deviations. After combining with previously reported CMS results at 8 TeV, the observed (expected) significance is 5.3 (4.8) standard deviations. The cross section for the electroweak W$_{γjj}$ production in a restricted fiducial region is measured as 20.4 +/- 4.5 fb and the total cross section for W$_{γ}$ production in association with 2 jets in the same fiducial region is 108 +/- 16 fb. All results are in good agreement with recent theoretical predictions. Constraints are placed on anomalous quartic gauge couplings in terms of dimension-8 effective field theory operators

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

The parental care behaviour of Paratilapia polleni (Perciformes, Labroidei), a phylogenetically primitive cichlid from Madagascar, with a discussion of the evolution of maternal care in the family Cichlidae

The parental behaviour of the Madagascan cichlid, Paratilapia polleni , was studied in the laboratory. According to current hypotheses of phylogenetic intrarelationship for the family Cichlidae, Paratilapia is a representative of a phylogenetically primitive cichlid lineage, and as such is of particular interest in comparative evolutionary studies. Given the basal phylogenetic placement of Paratilapia it seems reasonable to expect that, if maternal participation in brood care arose within the extant Cichlidae, then the proposed plesiomorphic system of extensive male care of eggs and embryos may be retained in this taxon. This is not the case, and already by the fertilized-egg interval male and female roles in Paratilapia are strongly differentiated with the female as the primary care giver. In addition to specialized behavioural roles, a unique egg morphology and mobile egg mass is described for Paratilapia . The results of the study are discussed in the context of theories of the evolution of maternal brood care within the Cichlidae.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/42636/1/10641_2004_Article_BF00004768.pd