2,393 research outputs found
Conceptual design study of a coal gasification combined-cycle powerplant for industrial cogeneration
A conceptual design study was conducted to assess technical feasibility, environmental characteristics, and economics of coal gasification. The feasibility of a coal gasification combined cycle cogeneration powerplant was examined in response to energy needs and to national policy aimed at decreasing dependence on oil and natural gas. The powerplant provides the steam heating and baseload electrical requirements while serving as a prototype for industrial cogeneration and a modular building block for utility applications. The following topics are discussed: (1) screening of candidate gasification, sulfur removal and power conversion components; (2) definition of a reference system; (3) quantification of plant emissions and waste streams; (4) estimates of capital and operating costs; and (5) a procurement and construction schedule. It is concluded that the proposed powerplant is technically feasible and environmentally superior
Fluctuation-induced excess conductivity in the compounds CaREBaCu<SUB>3</SUB>O<SUB>7-y</SUB> (RE=La and Sm)
The compounds CaREBaCu3O7-y (RE=La and Sm) are tetragonal at
room temperature with Tc between 60 and 70 K. The single-phase compounds were prepared by
solid-state reaction. The resistivity was measured by a four-probe technique in a continuous flow cryostat with the
temperature being controlled to an accuracy of 10 mK. The resistivity vs temperature showed a break in slope
around 180 K in CaLaBaCu3O7-y and around 220 K in
CaSmBaCu3O7-y . The results were analysed for fluctuation conductivity from
180 K downwards. A plot of dp/dT vs T showed a sharp peak at Tm =69.69 K for La compound
and 66.00 K for the Sm compound. Detailed analysis of the resistivity in the region Ton to 180 K
was carried out using the procedure due to Veira and Vidal. The results are discussed in this paper
Fifty Years of IMF Variation: The Intermediate-Mass Stars
I track the history of star count estimates of the Milky Way field star and
open cluster IMFs, concentrating on the neglected mass range from 1 to 15
M. The prevalent belief in a universal IMF appears to be without
basis for this mass range. Two recent estimates of the field star IMF using
different methods and samples give values of the average logarithmic slope
between -1.7 and -2.1 in the mass range 1.1 to 4 M. Two
older estimates between 2 and 15 M disagree severely; the field IMF
in this range is essentially unknown from star counts. Variations in
among open cluster IMFs in this mass range have not decreased despite numerous
detailed studies, even for studies using homogeneous data and reduction
procedures and including only clusters with a significant mass range. These
cluster variations \textit{might} be due to the combined effects of sampling,
systematic errors, stellar evolution uncertainties, dynamical evolution, and
unresolved binaries. If so, then the cluster data are consistent with a
universal IMF, but are also consistent with sizeable variations. The cluster
data do not allow an estimate of an average IMF or because the average
depends on the choice of weighting procedure and other effects. If the spread
in cluster IMFs is in excess of the effects listed above, real IMF variations
must occur that do not depend much on physical conditions explored so far. The
complexity of the star formation process seen in observations and simulations
suggests that large realization-to-realization differences might be expected,
in which case an individual cluster IMF would be in part the product of
evolutionary contingency in star formation, and the function of interest is the
probability distribution of IMF parameters.Comment: 18 pages, including 4 figures: invited talk presented at the
conference on "IMF@50: The Stellar Initial Mass Function Fifty Years Later"
held at Abbazia di Spineto, Siena, Italy, May 2004; to be published by Kluwer
Academic Publishers, edited by E. Corbelli, F. Palla, and H. Zinnecke
East Midlands Research into Ageing Network (EMRAN) Discussion Paper Series
Academic geriatric medicine in Leicester
.
There has never been a better time to consider joining us. We have recently appointed a
Professor in Geriatric Medicine, alongside Tom Robinson in stroke and Victoria Haunton,
who has just joined as a Senior Lecturer in Geriatric Medicine. We have fantastic
opportunities to support students in their academic pursuits through a well-established
intercalated BSc programme, and routes on through such as ACF posts, and a successful
track-record in delivering higher degrees leading to ACL post. We collaborate strongly
with Health Sciences, including academic primary care. See below for more detail on our
existing academic set-up.
Leicester Academy for the Study of Ageing
We are also collaborating on a grander scale, through a joint academic venture focusing
on ageing, the ‘Leicester Academy for the Study of Ageing’ (LASA), which involves the
local health service providers (acute and community), De Montfort University; University
of Leicester; Leicester City Council; Leicestershire County Council and Leicester Age UK.
Professors Jayne Brown and Simon Conroy jointly Chair LASA and have recently been
joined by two further Chairs, Professors Kay de Vries and Bertha Ochieng. Karen
Harrison Dening has also recently been appointed an Honorary Chair.
LASA aims to improve outcomes for older people and those that care for them that takes
a person-centred, whole system perspective. Our research will take a global perspective,
but will seek to maximise benefits for the people of Leicester, Leicestershire and Rutland,
including building capacity. We are undertaking applied, translational, interdisciplinary
research, focused on older people, which will deliver research outcomes that address
domains from: physical/medical; functional ability, cognitive/psychological; social or
environmental factors. LASA also seeks to support commissioners and providers alike for
advice on how to improve care for older people, whether by research, education or
service delivery. Examples of recent research projects include: ‘Local History Café’
project specifically undertaking an evaluation on loneliness and social isolation; ‘Better
Visits’ project focused on improving visiting for family members of people with dementia
resident in care homes; and a study on health issues for older LGBT people in Leicester.
Clinical Geriatric Medicine in Leicester
We have developed a service which recognises the complexity of managing frail older
people at the interface (acute care, emergency care and links with community services).
There are presently 17 consultant geriatricians supported by existing multidisciplinary
teams, including the largest complement of Advance Nurse Practitioners in the country.
Together we deliver Comprehensive Geriatric Assessment to frail older people with
urgent care needs in acute and community settings.
The acute and emergency frailty units – Leicester Royal Infirmary
This development aims at delivering Comprehensive Geriatric Assessment to frail older
people in the acute setting. Patients are screened for frailty in the Emergency
Department and then undergo a multidisciplinary assessment including a consultant
geriatrician, before being triaged to the most appropriate setting. This might include
admission to in-patient care in the acute or community setting, intermediate care
(residential or home based), or occasionally other specialist care (e.g. cardiorespiratory).
Our new emergency department is the county’s first frail friendly build and includes
fantastic facilities aimed at promoting early recovering and reducing the risk of hospital
associated harms.
There is also a daily liaison service jointly run with the psychogeriatricians (FOPAL); we
have been examining geriatric outreach to oncology and surgery as part of an NIHR
funded study.
We are home to the Acute Frailty Network, and those interested in service developments
at the national scale would be welcome to get involved.
Orthogeriatrics
There are now dedicated hip fracture wards and joint care with anaesthetists,
orthopaedic surgeons and geriatricians. There are also consultants in metabolic bone
disease that run clinics.
Community work
Community work will consist of reviewing patients in clinic who have been triaged to
return to the community setting following an acute assessment described above.
Additionally, primary care colleagues refer to outpatients for sub-acute reviews. You will
work closely with local GPs with support from consultants to deliver post-acute, subacute,
intermediate and rehabilitation care services.
Stroke Medicine
24/7 thrombolysis and TIA services. The latter is considered one of the best in the UK
and along with the high standard of vascular surgery locally means one of the best
performances regarding carotid intervention
Active Membrane Fluctuations Studied by Micropipet Aspiration
We present a detailed analysis of the micropipet experiments recently
reported in J-B. Manneville et al., Phys. Rev. Lett. 82, 4356--4359 (1999),
including a derivation of the expected behaviour of the membrane tension as a
function of the areal strain in the case of an active membrane, i.e.,
containing a nonequilibrium noise source. We give a general expression, which
takes into account the effect of active centers both directly on the membrane,
and on the embedding fluid dynamics, keeping track of the coupling between the
density of active centers and the membrane curvature. The data of the
micropipet experiments are well reproduced by the new expressions. In
particular, we show that a natural choice of the parameters quantifying the
strength of the active noise explains both the large amplitude of the observed
effects and its remarkable insensitivity to the active-center density in the
investigated range. [Submitted to Phys Rev E, 22 March 2001]Comment: 14 pages, 5 encapsulated Postscript figure
Systematic behaviour of the in-plane penetration depth in d-wave cuprates
We report the temperature T and oxygen concentration dependences of the
penetration depth of grain-aligned YBa_2Cu_3O_{7-\delta} with \delta= 0.0, 0.3
and 0.43. The values of the in-plane \lambda_{ab}(0) and out-of-plane
\lambda_{c}(0) penetration depths, the low temperature linear term in
\lambda_{ab}(T), and the ratio \lambda_{c}(0) /\lambda_{ab}(T) were found to
increase with increasing . The systematic changes of the linear term in
\lambda_{ab}(T) with T_c found here and in recent work on HgBa_2Ca_{n-1}
Cu_nO_{2n+2+\delta} (n = 1 and 3) are discussed.Comment: 4 pages, 4 figure
TIEG1/KLF10 Modulates Runx2 Expression and Activity in Osteoblasts
Deletion of TIEG1/KLF10 in mice results in a gender specific osteopenic skeletal phenotype with significant defects in both cortical and trabecular bone, which are observed only in female animals. Calvarial osteoblasts isolated from TIEG1 knockout (KO) mice display reduced expression levels of multiple bone related genes, including Runx2, and exhibit significant delays in their mineralization rates relative to wildtype controls. These data suggest that TIEG1 plays an important role in regulating Runx2 expression in bone and that decreased Runx2 expression in TIEG1 KO mice is in part responsible for the observed osteopenic phenotype. In this manuscript, data is presented demonstrating that over-expression of TIEG1 results in increased expression of Runx2 while repression of TIEG1 results in suppression of Runx2. Transient transfection and chromatin immunoprecipitation assays reveal that TIEG1 directly binds to and activates the Runx2 promoter. The zinc finger containing domain of TIEG1 is necessary for this regulation supporting that activation occurs through direct DNA binding. A role for the ubiquitin/proteasome pathway in fine tuning the regulation of Runx2 expression by TIEG1 is also implicated in this study. Additionally, the regulation of Runx2 expression by cytokines such as TGFβ1 and BMP2 is shown to be inhibited in the absence of TIEG1. Co-immunoprecipitation and co-localization assays indicate that TIEG1 protein associates with Runx2 protein resulting in co-activation of Runx2 transcriptional activity. Lastly, Runx2 adenoviral infection of TIEG1 KO calvarial osteoblasts leads to increased expression of Runx2 and enhancement of their ability to differentiate and mineralize in culture. Taken together, these data implicate an important role for TIEG1 in regulating the expression and activity of Runx2 in osteoblasts and suggest that decreased expression of Runx2 in TIEG1 KO mice contributes to the observed osteopenic bone phenotype
Drosophila TIEG Is a Modulator of Different Signalling Pathways Involved in Wing Patterning and Cell Proliferation
Acquisition of a final shape and size during organ development requires a
regulated program of growth and patterning controlled by a complex genetic
network of signalling molecules that must be coordinated to provide positional
information to each cell within the corresponding organ or tissue. The mechanism
by which all these signals are coordinated to yield a final response is not well
understood. Here, I have characterized the Drosophila ortholog
of the human TGF-β Inducible Early Gene 1 (dTIEG). TIEG are zinc-finger
proteins that belong to the Krüppel-like factor (KLF) family and were
initially identified in human osteoblasts and pancreatic tumor cells for the
ability to enhance TGF-β response. Using the developing wing of
Drosophila as “in vivo” model, the dTIEG
function has been studied in the control of cell proliferation and patterning.
These results show that dTIEG can modulate Dpp signalling. Furthermore, dTIEG
also regulates the activity of JAK/STAT pathway suggesting a conserved role of
TIEG proteins as positive regulators of TGF-β signalling and as mediators of
the crosstalk between signalling pathways acting in a same cellular context
Biosurfactants produced by Bacillus subtilis A1 and Pseudomonas stutzeri NA3 reduce longevity and fecundity of Anopheles stephensi and show high toxicity against young instars
Anopheles stephensi acts as vector of Plasmodium parasites, which are responsible for malaria in tropical and subtropical areas worldwide. Currently, malaria management is a big challenge due to the presence of insecticide-resistant strains as well as to the development of Plasmodium species highly resistant to major antimalarial drugs. Therefore, the present study focused on biosurfactant produced by two bacteria Bacillus subtilis A1 and Pseudomonas stutzeri NA3, evaluating them for insecticidal applications against malaria mosquitoes. The produced biosurfactants were characterized using FT-IR spectroscopy and gas chromatography-mass spectrometry (GC-MS), which confirmed that biosurfactants had a lipopeptidic nature. Both biosurfactants were tested against larvae and pupae of A. stephensi. LC50 values were 3.58 (larva I), 4.92 (II), 5.73 (III), 7.10 (IV), and 7.99 (pupae) and 2.61 (I), 3.68 (II), 4.48 (III), 5.55 (IV), and 6.99 (pupa) for biosurfactants produced by B. subtilis A1 and P. stutzeri NA3, respectively. Treatments with bacterial surfactants led to various physiological changes including longer pupal duration, shorter adult oviposition period, and reduced longevity and fecundity. To the best of our knowledge, there are really limited reports on the mosquitocidal and physiological effects due to biosurfactant produced by bacterial strains. Overall, the toxic activity of these biosurfactant on all young instars of A. stephensi, as well as their major impact on adult longevity and fecundity, allows their further consideration for the development of insecticides in the fight against malaria mosquitoes
Measurement of χ c1 and χ c2 production with s√ = 7 TeV pp collisions at ATLAS
The prompt and non-prompt production cross-sections for the χ c1 and χ c2 charmonium states are measured in pp collisions at s√ = 7 TeV with the ATLAS detector at the LHC using 4.5 fb−1 of integrated luminosity. The χ c states are reconstructed through the radiative decay χ c → J/ψγ (with J/ψ → μ + μ −) where photons are reconstructed from γ → e + e − conversions. The production rate of the χ c2 state relative to the χ c1 state is measured for prompt and non-prompt χ c as a function of J/ψ transverse momentum. The prompt χ c cross-sections are combined with existing measurements of prompt J/ψ production to derive the fraction of prompt J/ψ produced in feed-down from χ c decays. The fractions of χ c1 and χ c2 produced in b-hadron decays are also measured
- …