VERTICAL POWER-FORCE-VELOCITY PROFILING: RELIABILITY COMPARISON OF MULITPLE- AND TWO-POINT METHODS

Power-Force-velocity (P-F-v) profiling is an approach used for performance diagnostics to assess an athlete’s anaerobic performance level. The aim of the study was to determine and compare the test-retest reliability of the 5p-method and the 2p-method for a group of sport students. With respect to the 2p-method this was the first study to determine the reliability using an independent data-set for vertical jumps. Acceptable reliability (ICC \u3e 0.78, CV \u3c 7.6%, no significant differences) was obtained for the variables F0, v0 and Pmax obtained through the 5p-method. Using the 2p-method acceptable reliability was just found for the variables F0 and Pmax. Therefore, the use of the 5p-method is recommended for performance diagnostics and derived individualized training regimes based on these P-F-v profiling results, as well as for research on this topic involving populations similar to sport students

How gesture and speech interact during production and comprehension

This thesis investigates the mechanisms that underlie the interaction of gesture and speech during the production and comprehension of language on a temporal and semantic level. The results from the two gesture-speech production experiments provide unambiguous evidence that gestural content is shaped online by the ways in which speakers package information into planning units in speech rather than being influenced by how events are lexicalised. In terms of gesture-speech synchronisation, a meta-analysis of these experiments showed that lexical items which are semantically related to the gesture's content (i.e., semantic affiliates) compete for synchronisation when these affiliates are separated within a sentence. This competition leads to large proportions of gestures not synchronising with any semantic affiliate. These findings demonstrate that gesture onset can be attracted by lexical items that do not co-occur with the gesture. The thesis then tested how listeners process gestures when synchrony is lost and whether preceding discourse related to a gesture's meaning impacts gesture interpretation and processing. Behavioural and ERP results show that gesture interpretation and processing is discourse dependent. Moreover, the ERP experiment demonstrates that when synchronisation between gesture and semantic affiliate is not present the underlying integration processes are different from synchronous gesture-speech combinations

Information packaging in speech shapes information packaging in gesture : the role of speech planning units in the coordination of speech-gesture production

Linguistic encoding influences the gestural manner and path depiction of motion events. Gestures depict manner and path of motion events differently across languages, either conflating or separating manner and path, depending on whether manner and path are linguistically encoded within one clause (e.g., “rolling down”) or multiple clauses (e.g., “descends as it rolls”) respectively. However, it is unclear whether such gestural differences are affected by how speech packages information into planning units or by the way information is lexicalised (as verb plus particle or as two verbs). In two experiments, we manipulated the linguistic encoding of motion events in either one or two planning units while lexicalisation patterns were kept constant (i.e., verb plus particle). It was found that separating manner (verb) and path (particle) into different planning units also increased gestural manner and path separation. Thus, lexicalisation patterns do not drive gestural depiction of motion events. Rather gestures are shaped online by how speakers package information into planning units in speech production

Early and Differential Diagnosis of Dementia and Mild Cognitive Impairment Design and Cohort Baseline Characteristics of the German Dementia Competence Network

Background: The German Dementia Competence Network (DCN) has established procedures for standardized multicenter acquisition of clinical, biological and imaging data, for centralized data management, and for the evaluation of new treatments. Methods: A longitudinal cohort study was set up for patients with mild cognitive impairment (MCI), patients with mild dementia and control subjects. The aims were to establish the diagnostic, differential diagnostic and prognostic power of a range of clinical, laboratory and imaging methods. Furthermore, 2 clinical trials were conducted with patients suffering from MCI and mild to moderate Alzheimer's Disease (AD). These trials aimed at evaluating the efficacy and safety of the combination of galantamine and memantine versus galantamine alone. Results: Here, we report on the scope and projects of the DCN, the methods that were employed, the composition and flow within the diverse groups of patients and control persons and on the clinical and neuropsychological baseline characteristics of the group of 2,113 subjects who participated in the observational and clinical trials. Conclusion: These data have an impact on the procedures for the early and differential clinical diagnosis of dementias, the current standard treatment of AD as well as on future clinical trials in AD. Copyright (C) 2009 S. Karger AG, Base

Memory Concerns, Memory Performance and Risk of Dementia in Patients with Mild Cognitive Impairment

Background: Concerns about worsening memory ("memory concerns"; MC) and impairment in memory performance are both predictors of Alzheimer's dementia (AD). The relationship of both in dementia prediction at the pre-dementia disease stage, however, is not well explored. Refined understanding of the contribution of both MC and memory performance in dementia prediction is crucial for defining at-risk populations. We examined the risk of incident AD by MC and memory performance in patients with mild cognitive impairment (MCI). Methods: We analyzed data of 417 MCI patients from a longitudinal multicenter observational study. Patients were classified based on presence (n=305) vs. absence (n=112) of MC. Risk of incident AD was estimated with Cox Proportional-Hazards regression models. Results: Risk of incident AD was increased by MC (HR=2.55, 95% CI: 1.33-4.89), lower memory performance (HR=0.63, 95% CI: 0.56-0.71) and ApoE4-genotype (HR=1.89, 95% CI: 1.18-3.02). An interaction effect between MC and memory performance was observed. The predictive power of MC was greatest for patients with very mild memory impairment and decreased with increasing memory impairment. Conclusions: Our data suggest that the power of MC as a predictor of future dementia at the MCI stage varies with the patients' level of cognitive impairment. While MC are predictive at early stage MCI, their predictive value at more advanced stages of MCI is reduced. This suggests that loss of insight related to AD may occur at the late stage of MCI

Memory Concerns, Memory Performance and Risk of Dementia in Patients with Mild Cognitive Impairment

Background: Concerns about worsening memory ("memory concerns"; MC) and impairment in memory performance are both predictors of Alzheimer's dementia (AD). The relationship of both in dementia prediction at the pre-dementia disease stage, however, is not well explored. Refined understanding of the contribution of both MC and memory performance in dementia prediction is crucial for defining at-risk populations. We examined the risk of incident AD by MC and memory performance in patients with mild cognitive impairment (MCI). Methods: We analyzed data of 417 MCI patients from a longitudinal multicenter observational study. Patients were classified based on presence (n=305) vs. absence (n=112) of MC. Risk of incident AD was estimated with Cox Proportional-Hazards regression models. Results: Risk of incident AD was increased by MC (HR=2.55, 95% CI: 1.33-4.89), lower memory performance (HR=0.63, 95% CI: 0.56-0.71) and ApoE4-genotype (HR=1.89, 95% CI: 1.18-3.02). An interaction effect between MC and memory performance was observed. The predictive power of MC was greatest for patients with very mild memory impairment and decreased with increasing memory impairment. Conclusions: Our data suggest that the power of MC as a predictor of future dementia at the MCI stage varies with the patients' level of cognitive impairment. While MC are predictive at early stage MCI, their predictive value at more advanced stages of MCI is reduced. This suggests that loss of insight related to AD may occur at the late stage of MCI

DU Undergraduate Showcase: Research, Scholarship, and Creative Works

DU Undergraduate Showcase: Research, Scholarship, and Creative Work

Photography-based taxonomy is inadequate, unnecessary, and potentially harmful for biological sciences

The question whether taxonomic descriptions naming new animal species without type specimen(s) deposited in collections should be accepted for publication by scientific journals and allowed by the Code has already been discussed in Zootaxa (Dubois & Nemésio 2007; Donegan 2008, 2009; Nemésio 2009a–b; Dubois 2009; Gentile & Snell 2009; Minelli 2009; Cianferoni & Bartolozzi 2016; Amorim et al. 2016). This question was again raised in a letter supported by 35 signatories published in the journal Nature (Pape et al. 2016) on 15 September 2016. On 25 September 2016, the following rebuttal (strictly limited to 300 words as per the editorial rules of Nature) was submitted to Nature, which on 18 October 2016 refused to publish it. As we think this problem is a very important one for zoological taxonomy, this text is published here exactly as submitted to Nature, followed by the list of the 493 taxonomists and collection-based researchers who signed it in the short time span from 20 September to 6 October 2016

Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

A. Palotie on työryhmän Schizophrenia Working Grp Psychiat jäsen.We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, we estimate the genetic correlation between ALS and schizophrenia to be 14.3% (7.05-21.6; P = 1 x 10(-4)) with schizophrenia polygenic risk scores explaining up to 0.12% of the variance in ALS (P = 8.4 x 10(-7)). A modest increase in comorbidity of ALS and schizophrenia is expected given these findings (odds ratio 1.08-1.26) but this would require very large studies to observe epidemiologically. We identify five potential novel ALS-associated loci using conditional false discovery rate analysis. It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies.Peer reviewe