Relació entre el coneixement bàsic sobre alimentació i nutrició i els hàbits alimentaris de l'alumnat d'ESO de l'Institut Damià Campeny. Proposta d'intervenció

Curs 2012-2013La recerca que presento a continuació té l’objectiu fonamental, com el seu propi títol indica, de relacionar els coneixements bàsics sobre alimentació i nutrició i els hàbits alimentaris de l’alumnat d’Educació Secundària Obligatòria (ESO) de l’Institut Damià Campeny de Mataró. Aquesta temàtica m’ha interessat des de la meva infància, ja que jo mateix era un jove amb sobrepès absorbit pels vicis alimentaris de la societat i la família. Vaig haver de sobreposar-me a aquest petit trauma i trobar solucions a una situació que m’era incòmode i perjudicial. Gràcies a l’esport i a una voluntat de millora dels meus hàbits alimentaris vaig poder reconvertir la situació fins a tenir un pes saludable. Des d’aleshores sempre m’ha interessat el tema d’alimentació i nutrició, i m’he anat formant gràcies a la meva recerca personal més que pels recursos que se m’han ofert, molt limitats sobretot des de l’escola i l’institut. Per últim vull agregar que aquesta recerca té un caràcter totalment individualitzat en l’Institut Damià Campeny de Mataró ja que ha estat el centre on jo he realitzat les pràctiques de professor d’Educació Física durant els mesos de febrer i maig de 2013. A més d’analitzar el seu context i planificar una proposta d’intervenció interdisciplinar el més adequada possible, m’agradaria que el treball no s’estanqués en aquest punt i que algú de l’Institut pogués aprofitar-se d’aquesta feina realitzada per intentar aplicar aquesta proposta a mig/llarg termini.Director/a: Gemma Boluda Viñuale

Average Game Physical Demands and the Most Demanding Scenarios of Basketball Competition in Various Age Groups

The purpose of this study was to compare average physical demands and the most demanding 60-s scenarios of basketball match-play between five different age groups. Sixty-four male basketball players from five different age groups were monitored across eight regular-season home games. Physical demands were examined using a local positioning system and included total distance covered, distance >18 km.h(-1), the number of accelerations (>= 2 m.s(-2)) and decelerations (18 km.h(-1) in basketball players was assessed. More specifically, the Under-12 age group achieved the lowest values and showed significant differences with the other four teams in both game analysis techniques (p < .001; effect size = 0.53 - 1.32). In conclusion, average game demands are shown to remarkably underestimate the most demanding scenarios of basketball match-play, and there are multiple significant differences between particular age groups.The authors of this article would like to thank the basketball players who took part in this study and all the FC Barcelona performance department staff members who assisted in player monitoring. The authors also gratefully acknowledge the support of a Spanish government subproject Mixed method approach in performance analysis (in training and competition) in elite and academy sport [PGC2018-098742-B-C33] [Ministerio de Ciencia, Innovacion y Universidades (MCIU), la Agencia Estatal de Investigacion (AEI) y el Fondo Europeo de Desarrollo Regional (FEDER)]), which is part of the New approach of research in physical activity and sport from mixed methods perspective (NARPAS_MM) [SPGC201800X098742CV0] coordinated project

Physical demands in three different basketball competitions played by the same under-18 players

[EN] The goal of this study was to compare the physical demands of the same team in three different basketball com- petitions (EBA league (EBA), U18 regional league (U18L), and a U18 international tournament (U18T)) during the same season. Data from eleven U18 players (age: 16.92 ± 0.67 years) were collected using inertial movement units. As external load variables, Player Load (PL), accelerations (ACC), decelerations (DEC), changes of direction (COD), and jumps (JUMP) were expressed in their total (t) and high intensity (h) values. The analysis of variances (ANOVA) and effect size (ES, Cohen’s d) with their respective 90% confidence intervals were applied to identify differences between the competitions. U18T showed the highest values in PL, tACC, tDEC, hDEC, tCOD, tJUMP, and hJUMP (small to moderate ES). However, the hACC and hCOD values were greater in EBA (small ES) than in U18L and U18T. In conclusion, all three competitions presented different external load demands for the same group of players. This data could help basketball coaches to optimize the training process based on the competition in which their team plays. Furthermore, data could also indicate the most suitable competition for players’ development

Regulation of GABAA and Glutamate Receptor Expression, Synaptic Facilitation and Long-Term Potentiation in the Hippocampus of Prion Mutant Mice

Background: Prionopathies are characterized by spongiform brain degeneration, myoclonia, dementia, and periodic electroencephalographic (EEG) disturbances. The hallmark of prioniopathies is the presence of an abnormal conformational isoform (PrP(sc)) of the natural cellular prion protein (PrP(c)) encoded by the Prnp gene. Although several roles have been attributed to PrP(c), its putative functions in neuronal excitability are unknown. Although early studies of the behavior of Prnp knockout mice described minor changes, later studies report altered behavior. To date, most functional PrP(c) studies on synaptic plasticity have been performed in vitro. To our knowledge, only one electrophysiological study has been performed in vivo in anesthetized mice, by Curtis and coworkers. They reported no significant differences in paired-pulse facilitation or LTP in the CA1 region after Schaffer collateral/commissural pathway stimulation. Principal Findings: Here we explore the role of PrP(c) expression in neurotransmission and neural excitability using wild-type, Prnp -/- and PrP(c)-overexpressing mice (Tg20 strain). By correlating histopathology with electrophysiology in living behaving mice, we demonstrate that both Prnp -/- mice but, more relevantly Tg20 mice show increased susceptibility to KA, leading to significant cell death in the hippocampus. This finding correlates with enhanced synaptic facilitation in paired-pulse experiments and hippocampal LTP in living behaving mutant mice. Gene expression profiling using Illumina microarrays and Ingenuity pathways analysis showed that 129 genes involved in canonical pathways such as Ubiquitination or Neurotransmission were co-regulated in Prnp -/- and Tg20 mice. Lastly, RT-qPCR of neurotransmission-related genes indicated that subunits of GABA(A) and AMPA-kainate receptors are co-regulated in both Prnp -/- and Tg20 mice. Conclusions/Significance: Present results demonstrate that PrP(c) is necessary for the proper homeostatic functioning of hippocampal circuits, because of its relationships with GABA(A) and AMPA-Kainate neurotransmission. New PrP(c) functions have recently been described, which point to PrP(c) as a target for putative therapies in Alzheimer's disease. However, our results indicate that a "gain of function" strategy in Alzheimer's disease, or a "loss of function" in prionopathies, may impair PrP(c) function, with devastating effects. In conclusion, we believe that present data should be taken into account in the development of future therapies

Role of the cellular prion protein in oligodendrocyte precursor cell proliferation and differentiation in the developing and adult mouse CNS

There are numerous studies describing the signaling mechanisms that mediate oligodendrocyte precursor cell (OPC) proliferation and differentiation, although the contribution of the cellular prion protein (PrPc) to this process remains unclear. PrPc is a glycosyl-phosphatidylinositol (GPI)-anchored glycoprotein involved in diverse cellular processes during the development and maturation of the mammalian central nervous system (CNS). Here we describe how PrPc influences oligodendrocyte proliferation in the developing and adult CNS. OPCs that lack PrPc proliferate more vigorously at the expense of a delay in differentiation, which correlates with changes in the expression of oligodendrocyte lineage markers. In addition, numerous NG2-positive cells were observed in cortical regions of adult PrPc knockout mice, although no significant changes in myelination can be seen, probably due to the death of surplus cells

Dementia with lewy bodies: molecular pathology in the frontal cortex in typical and rapidly progressive forms

Objectives: the goal of this study was to assess mitochondrial function, energy, and purine metabolism, protein synthesis machinery from the nucleolus to the ribosome, inflammation, and expression of newly identified ectopic olfactory receptors (ORs) and taste receptors (TASRs) in the frontal cortex of typical cases of dementia with Lewy bodies (DLB) and cases with rapid clinical course (rpDLB: 2 years or less) compared with middle-aged non-affected individuals, in order to learn about the biochemical abnormalities underlying Lewy body pathology. Methods: real-time quantitative PCR, mitochondrial enzymatic assays, and analysis of β-amyloid, tau, and synuclein species were used. Results: the main alterations in DLB and rpDLB, which are more marked in the rapidly progressive forms, include (i) deregulated expression of several mRNAs and proteins of mitochondrial subunits, and reduced activity of complexes I, II, III, and IV of the mitochondrial respiratory chain; (ii) reduced expression of selected molecules involved in energy metabolism and increased expression of enzymes involved in purine metabolism; (iii) abnormal expression of nucleolar proteins, rRNA18S, genes encoding ribosomal proteins, and initiation factors of the transcription at the ribosome; (iv) discrete inflammation; and (v) marked deregulation of brain ORs and TASRs, respectively. Severe mitochondrial dysfunction involving activity of four complexes, minimal inflammatory responses, and dramatic altered expression of ORs and TASRs discriminate DLB from Alzheimer's disease. Altered solubility and aggregation of α-synuclein, increased β-amyloid bound to membranes, and absence of soluble tau oligomers are common in DLB and rpDLB. Low levels of soluble β-amyloid are found in DLB. However, increased soluble β-amyloid 1-40 and β-amyloid 1-42, and increased TNFα mRNA and protein expression, distinguish rpDLB. Conclusion: molecular alterations in frontal cortex in DLB involve key biochemical pathways such as mitochondria and energy metabolism, protein synthesis, purine metabolism, among others and are accompanied by discrete innate inflammatory response

Aging-related tau astrogliopathy (ARTAG): not only tau phosphorylation in astrocytes

Aging-related tau astrogliopathy (ARTAG) is defined by the presence of two types of tau-bearing astrocytes: thorn-shaped astrocytes (TSAs) and granular/fuzzy astrocytes in the brain of old-aged individuals. The present study is focused on TSAs in rare forms of ARTAG with no neuronal tau pathology or restricted to entorhinal and transentorhinal cortices, to avoid bias from associated tauopathies. TSAs show 4Rtau phosphorylation at several specific sites and abnormal tau conformation, but they lack ubiquitin and they are not immunostained with tau-C3 antibodies which recognize truncated tau at Asp421. Astrocytes in ARTAG have atrophic processes, reduced glial fibrillary acidic protein (GFAP) and increased superoxide dismutase 2 (SOD2) immunoreactivity. Gel electrophoresis and western blotting of sarkosyl-insoluble fractions reveal a pattern of phospho-tau in ARTAG characterized by two bands of 68 and 64 kDa, and several middle bands between 35 and 50 kDa which differ from what is seen in AD. Phosphoproteomics of dissected vulnerable regions identifies an increase of phosphorylation marks in a large number of proteins in ARTAG compared with controls. GFAP, aquaporin 4, several serine-threonine kinases, microtubule associated proteins and other neuronal proteins are among the differentially phosphorylated proteins in ARTAG thus suggesting a hyper-phosphorylation background that affects several molecules, including many kinases and proteins from several cell compartments and various cell types. Finally, present results show for the first time that tau seeding is produced in neurons of the hippocampal complex, astrocytes, oligodendroglia and along fibers of the corpus callosum, fimbria and fornix following inoculation into the hippocampus of wild type mice of sarkosyl-insoluble fractions enriched in hyper-phosphorylated tau from selected ARTAG cases. These findings show astrocytes as crucial players of tau seeding in tauopathies

Exercise management in type 1 diabetes:a consensus statement

Type 1 diabetes is a challenging condition to manage for various physiological and behavioural reasons. Regular exercise is important, but management of different forms of physical activity is particularly difficult for both the individual with type 1 diabetes and the health-care provider. People with type 1 diabetes tend to be at least as inactive as the general population, with a large percentage of individuals not maintaining a healthy body mass nor achieving the minimum amount of moderate to vigorous aerobic activity per week. Regular exercise can improve health and wellbeing, and can help individuals to achieve their target lipid profile, body composition, and fitness and glycaemic goals. However, several additional barriers to exercise can exist for a person with diabetes, including fear of hypoglycaemia, loss of glycaemic control, and inadequate knowledge around exercise management. This Review provides an up-to-date consensus on exercise management for individuals with type 1 diabetes who exercise regularly, including glucose targets for safe and effective exercise, and nutritional and insulin dose adjustments to protect against exercise-related glucose excursions

Evaluation of Cavitation Erosion Behavior of Commercial Steel Grades Used in the Design of Fluid Machinery

The erosion response under cavitation of different steel grades was assessed by studying the erosion rate, the volume removal, the roughness evolution, and the accumulated strain energy. A 20 kHz ltrasonic transducer with a probe diameter of 5 mm and peak-to-peak amplitude of 50 lm was deployed in distilled water to induce damage on the surface of commercial chromium and carbon steel samples. After a relatively short incubation period, cavitation induced the formation of pits, cracks, and craters whose features strongly depended on the hardness and composition of the tested steel. AISI 52100 chromium steel showed the best performance and is, therefore, a promising design candidate for replacing the existing fluid machinery materials that operate within potential cavitating environments

Multiphase phenomena in Diesel fuel injection systems

Fuel Injection Equipment (FIE) are an integral component of modern Internal Combustion Engines (ICE), since they play a crucial role in the fuel atomization process and in the formation of a fuel/air combustible mixture, consequently affecting efficiency and pollutant formation. Advancements and improvements of FIE systems are determined by the complexity of the physical mechanisms taking place; the spatial scales are in the order of millimetres, flow may become locally highly supersonic, leading to very small temporal scales of microseconds or less. The operation of these devices is highly unsteady, involving moving geometries such as needle valves. Additionally, extreme pressure changes imply that many assumptions of traditional fluid mechanics, such as incompressibility, are no longer valid. Furthermore, the description of the fuel properties becomes an issue, since fuel databases are scarce or limited to pure components, whereas actual fuels are commonly hydrocarbon mixtures. Last but not least, complicated phenomena such as phase change or transition from subcritical to transcritical/supercritical state of matter further pose complications in the understanding of the operation of these devices