Plant pathogens as introduced weed biological control agents: Could antagonistic fungi be important factors determining agent success or failure?

Mycoparasitic interactions are common in nature, form part of the microbiota of plants, and are considered significant contributors to fungus-fungus antagonism. Mycoparasites kill plant pathogens, protect the plant from abiotic and biotic stressors, and reduce disease incidence and severity at the plant population level. Their exploitation as biocontrol agents in agriculture is well documented. However, mycoparasites may potentially affect classical fungal biocontrol agents of invasive weed species. Classical biological control, or biocontrol, of invasive weeds involves the intentional introduction of exotic, usually co-evolved plant pathogens and insects, for permanent establishment and long-term control of the target plant. Agent establishment, effectiveness, and safety are the critical elements for a successful weed biocontrol programme. Establishment and effectiveness of agents on the invasive plant often vary throughout the invaded range with about two-thirds of weed biocontrol agents failing to suppress their target weed. There are many documented reasons why weed biocontrol agents do not establish or are ineffective when they do, and the presence and accumulation of natural enemies in the invaded range is one of them. Endophyte-enriched, invasive weeds and those forming mutualistic associations with indigenous, native endophytes could explain the lack of consistency of some classical biological control introductions. However, another variable could be factored into the mix: mycoparasitism, where one fungus parasitises another, the natural enemies of the plant’s natural enemies. In this review article, we introduce the concept of invasive weed biocontrol and the history of using plant pathogens as biocontrol agents. We discuss the success and failure of fungal agent programmes and delve into the patterns of success or failure, with a focus on the potential antagonistic role of endophytes and mycoparasites

Ruling out a host-range expansion as the cause of the unpredicted non-target attack on tagasaste (Chamaecytisus proliferus) by Bruchidius villosus

Scotch broom (Cytisus scoparius) is a woody shrub of European origin that is an invasive weed in New Zealand. Bruchidius villosus was released in New Zealand in 1986 as a biological control agent of Scotch broom, after tests indicated that it was specific to this species. However, in 1999, B. villosus was discovered developing in the seeds of an unpredicted host, tagasaste or tree lucerne (Chamaecytisus proliferus). Although the original choice tests carried out in quarantine failed to predict acceptance of C. proliferus by ovipositing females, the current population in New Zealand clearly finds this species an acceptable host. An investigation of the original host-testing procedures revealed a number of possible limitations in the tests conducted in the 1980s. Concerns that a host-range expansion might have occurred in a weed biological control agent led to this study in which beetles from the original population (Silwood Park, United Kingdom) were reimported and the original handling and host choice tests were replicated. Despite showing a strong preference for Scotch broom, the beetles tested in this study accepted C. proliferus for oviposition. These results allow us to rule out the possibility that a hostrange expansion has occurred

GeneMill: A 21st century platform for innovation

GeneMill officially launched on 4th February 2016 and is an open access academic facility located at The University of Liverpool that has been established for the high-throughput construction and testing of synthetic DNA constructs. GeneMill provides end-to-end design, construction and phenotypic characterization of small to large gene constructs or genetic circuits/pathways for academic and industrial applications. Thus, GeneMill is equipping the scientific community with easy access to the validated tools required to explore the possibilities of Synthetic Biology

Surface code quantum computing by lattice surgery

In recent years, surface codes have become a leading method for quantum error correction in theoretical large scale computational and communications architecture designs. Their comparatively high fault-tolerant thresholds and their natural 2-dimensional nearest neighbour (2DNN) structure make them an obvious choice for large scale designs in experimentally realistic systems. While fundamentally based on the toric code of Kitaev, there are many variants, two of which are the planar- and defect- based codes. Planar codes require fewer qubits to implement (for the same strength of error correction), but are restricted to encoding a single qubit of information. Interactions between encoded qubits are achieved via transversal operations, thus destroying the inherent 2DNN nature of the code. In this paper we introduce a new technique enabling the coupling of two planar codes without transversal operations, maintaining the 2DNN of the encoded computer. Our lattice surgery technique comprises splitting and merging planar code surfaces, and enables us to perform universal quantum computation (including magic state injection) while removing the need for braided logic in a strictly 2DNN design, and hence reduces the overall qubit resources for logic operations. Those resources are further reduced by the use of a rotated lattice for the planar encoding. We show how lattice surgery allows us to distribute encoded GHZ states in a more direct (and overhead friendly) manner, and how a demonstration of an encoded CNOT between two distance 3 logical states is possible with 53 physical qubits, half of that required in any other known construction in 2D.Comment: Published version. 29 pages, 18 figure

Impact of intraspecific variation in insect microbiomes on host phenotype and evolution.

Microbes can be an important source of phenotypic plasticity in insects. Insect physiology, behaviour, and ecology are influenced by individual variation in the microbial communities held within the insect gut, reproductive organs, bacteriome, and other tissues. It is becoming increasingly clear how important the insect microbiome is for insect fitness, expansion into novel ecological niches, and novel environments. These investigations have garnered heightened interest recently, yet a comprehensive understanding of how intraspecific variation in the assembly and function of these insect-associated microbial communities can shape the plasticity of insects is still lacking. Most research focuses on the core microbiome associated with a species of interest and ignores intraspecific variation. We argue that microbiome variation among insects can be an important driver of evolution, and we provide examples showing how such variation can influence fitness and health of insects, insect invasions, their persistence in new environments, and their responses to global environmental changes. A and B are two stages of an individual or a population of the same species. The drivers lead to a shift in the insect associated microbial community, which has consequences for the host. The complex interplay of those consequences affects insect adaptation and evolution and influences insect population resilience or invasion

OrgML - a domain specific language for organisational decision-making

Effective decision-making based on precise understanding of an organisation is critical for modern organisations to stay competitive in a dynamic and uncertain business environment. However, the state-of-the-art technologies that are relevant in this context are not adequate to capture and quantitatively analyse complex organisations. This paper discerns the necessary information for an organisational decision-making from management viewpoint, discusses inadequacy of the existing enterprise modelling and specification techniques, proposes a domain specific language to capture the necessary information in machine processable form, and demonstrates how the collected information can be used for a simulation-based evidence-driven organisational decision-making

Assessing architectural evolution: A case study

This is the post-print version of the Article. The official published can be accessed from the link below - Copyright @ 2011 SpringerThis paper proposes to use a historical perspective on generic laws, principles, and guidelines, like Lehman’s software evolution laws and Martin’s design principles, in order to achieve a multi-faceted process and structural assessment of a system’s architectural evolution. We present a simple structural model with associated historical metrics and visualizations that could form part of an architect’s dashboard. We perform such an assessment for the Eclipse SDK, as a case study of a large, complex, and long-lived system for which sustained effective architectural evolution is paramount. The twofold aim of checking generic principles on a well-know system is, on the one hand, to see whether there are certain lessons that could be learned for best practice of architectural evolution, and on the other hand to get more insights about the applicability of such principles. We find that while the Eclipse SDK does follow several of the laws and principles, there are some deviations, and we discuss areas of architectural improvement and limitations of the assessment approach

Synthetic Biology UK 2015

Abstract GeneMill officially launched on 4th February 2016 and is an open access academic facility located at The University of Liverpool that has been established for the high-throughput construction and testing of synthetic DNA constructs. GeneMill provides end-to-end design, construction and phenotypic characterization of small to large gene constructs or genetic circuits/pathways for academic and industrial applications. Thus, GeneMill is equipping the scientific community with easy access to the validated tools required to explore the possibilities of Synthetic Biology

Towards Quantum Repeaters with Solid-State Qubits: Spin-Photon Entanglement Generation using Self-Assembled Quantum Dots

In this chapter we review the use of spins in optically-active InAs quantum dots as the key physical building block for constructing a quantum repeater, with a particular focus on recent results demonstrating entanglement between a quantum memory (electron spin qubit) and a flying qubit (polarization- or frequency-encoded photonic qubit). This is a first step towards demonstrating entanglement between distant quantum memories (realized with quantum dots), which in turn is a milestone in the roadmap for building a functional quantum repeater. We also place this experimental work in context by providing an overview of quantum repeaters, their potential uses, and the challenges in implementing them.Comment: 51 pages. Expanded version of a chapter to appear in "Engineering the Atom-Photon Interaction" (Springer-Verlag, 2015; eds. A. Predojevic and M. W. Mitchell

Formation of dense partonic matter in relativistic nucleus-nucleus collisions at RHIC: Experimental evaluation by the PHENIX collaboration

Extensive experimental data from high-energy nucleus-nucleus collisions were recorded using the PHENIX detector at the Relativistic Heavy Ion Collider (RHIC). The comprehensive set of measurements from the first three years of RHIC operation includes charged particle multiplicities, transverse energy, yield ratios and spectra of identified hadrons in a wide range of transverse momenta (p_T), elliptic flow, two-particle correlations, non-statistical fluctuations, and suppression of particle production at high p_T. The results are examined with an emphasis on implications for the formation of a new state of dense matter. We find that the state of matter created at RHIC cannot be described in terms of ordinary color neutral hadrons.Comment: 510 authors, 127 pages text, 56 figures, 1 tables, LaTeX. Submitted to Nuclear Physics A as a regular article; v3 has minor changes in response to referee comments. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.htm