Hybrid carbon nanocomposites made of aerospace-grade epoxy showing synergistic effects in electrical properties and high processability

In this work, we investigate the processability and the volumetric electrical properties of nanocomposites made of aerospace-grade RTM6, loaded with different carbon nanoparticles. Nanocomposites with graphene nanoplatelets (GNP), single-walled carbon nanotubes (SWCNT) and hybrid GNP/SWCNT in the ratio 2:8 (GNP2SWCNT8), 5:5 (GNP5SWCNT5) and 8:2 (GNP8SWCNT2) were manufactured and analyzed. The hybrid nanofillers are observed to have synergistic properties as epoxy/hybrid mixtures showed better processability than epoxy/SWCNT, while maintaining high values of electrical conductivity. On the other hand, epoxy/SWCNT nanocomposites present the highest electrical conductivities with the formation of a percolating conductive network at lower filler content, but very large viscosity values and filler dispersion issues, which significantly affect the final quality of the samples. Hybrid nanofiller allows us to overcome the manufacturing issues typically associated with the use of SWCNTs. The combination of low viscosity and high electrical conductivity makes the hybrid nanofiller a good candidate for the fabrication of aerospace-grade nanocomposites with multifunctional properties

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study

Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world. Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231. Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001). Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication

3D printing of radiation shielding polyethylene composites filled with Martian regolith simulant using fused filament fabrication

A highly sought-after objective of Space Agencies is the development of additive manufacturing (AM) technologies and of multifunctional materials, key elements to future exploration and colonization of Moon and Mars. The 3D printing process via fused filament fabrication (FFF) is increasingly viewed as an interesting approach for the in-situ manufacturing of buildings and items using regolith as a feedstock material, enabling the necessary repair and recycling capabilities to ensure crew safety. In this work, we investigate the radiation shielding properties and the FFF 3D printing process of polyethylene-based composites filled with Martian regolith. The on-line tool for the assessment of radiation in space (OLTARIS) software developed by NASA was used to assess the radiation shielding effectiveness of polyethylene (PE)/regolith (RG) composites in the Martian radiation environment. A basalt powder with chemical composition similar to that of Mars soil was used as Martian regolith simulant in the 3D printing process. Differential scanning calorimetry (DSC) was used to determine the melting properties and crystallization degree of PE/RG composites at different RG concentrations, in order to analyze the effect of the simulant on the process parameters of filament extrusion and 3D printing. Low-impact Izod tests were also performed, with all PE/RG composites showing improved impact strength with respect to neat PE. Based on the DSC and Izod tests results, filaments of PE/RG composites were fabricated and used to 3D-print samples for tensile tests and 3-point bending tests. Results demonstrate the radiation shielding effectiveness of PE/RG composites and the capability of 3D-printers based on FFF to successfully manufacture components made of PE/RG composites starting from extruded filaments

Synthesis and Characterization of Alginate Gel Beads with Embedded Zeolite Structures as Carriers of Hydrophobic Curcumin

Alginate-based beads containing a porous zeolite filler were developed as carriers of bioactive compounds with a hydrophobic nature, such as curcumin (Cur). Curcumin, a natural pigment extracted from the turmeric (Curcuma longa) plant, exhibits antioxidant, anti-inflammatory, anticarcinogenic, and antiviral properties. To enhance the bioavailability of the drug, curcumin needs to be encapsulated in a suitable carrier that improves its dispersibility and solubility. Commercial A-type zeolites (Z5A) were used as curcumin-binding agents and they were immobilized within the alginate gel beads by cross-linking in calcium chloride solution during an extrusion dripping process. The process parameters (alginate and CaCl2 concentrations, needle gauge, collecting distance) were optimized to fabricate beads with good sphericity factor and 1.5–1.7 mm diameter in their hydrated state. The chemical structure of the gel beads was assessed using FTIR spectroscopy, while their thermal stability was evaluated through differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). Due to the alginate matrix, the composite Alg/ZA5-Cur beads possess pH-responsive properties. In addition, the gel beads were modified by chitosan (CS) to enhance the stability and control the degradation behavior of the gel matrix. The swelling behavior and the degradation of the beads were analyzed in physiological solutions with different pH values. Results demonstrate the stabilizing and protective effect of the chitosan coating, as well as the reinforcing effect of the zeolite filler. This makes the pH-responsive alginate gel beads good candidates for the delivery of lipophilic drugs to specific inflammatory sites

3D printed polyethylene-based composites filled with Martian regolith simulant using fused filament fabrication

Interplanetary manned missions, for which cargo resupply is not possible, require development of radiation protection materials that can be fabricated in situ to ensure crew safety. The 3D printing process via fused filament fabrication (FFF) enables repair of spacecraft components and fabrication of tools by recycling available materials. In addition, FFF 3D printing is increasingly viewed as an interesting approach for the in situ manufacturing of buildings using regolith as a feedstock material. In this work, we investigate the FFF 3D printing process to fabricate polyethylene-based composites filled with Martian regolith simulant, using a basalt powder with chemical composition similar to that of Mars soil. The basalt powder was integrated in medium density polyethylene (MDPE) at different loadings (up to 60% by weight with respect to the polymer), and customized filaments were produced by extrusion. The thermal properties of MDPE and MDPE/basalt composite powders were investigated by differential scanning calorimetry (DSC), in order to analyse the effect of basalt on the process parameters of filament extrusion and 3D printing. Low-impact Izod tests were performed on molded MDPE and MDPE/basalt specimens. An increase of the absorbed impact energy with respect to the neat MDPE was observed at all investigated basalt concentrations, with the highest values of impact strength achieved at 5% and 10%. The filament extrusion and the FFF 3D printing processes of MDPE and MDPE/basalt composites at filler loadings of 5% and 10% were optimized to produce samples with high surface quality. Morphological investigations of the customized extruded filaments were performed using scanning electron microscopy (SEM). Tensile specimens of MDPE and of MDPE/basalt composites at 5% and 10% basalt loading were 3D-printed, and their tensile strength was comparable to those of traditionally molded samples

Fabrication and characterization of layered UHMWPE coatings on aerospace-grade epoxy resin for space radiation shielding

Due to its high hydrogen content, ultra-high molecular weight polyethylene (UHMWPE) is one of the most effective materials in radiation shielding in space environment. UHMWPE is a chemically stable thermoplastic polymer, easily available and non-toxic, but it has poor mechanical and thermal properties, which make it difficult to use as an aerospace structural material. In this paper, we used UHMWPE to fabricate homogeneous coatings on the surface of an aerospace-grade epoxy resin (Cycom 823), in order to combine the superior mechanical and thermal properties of the selected thermosetting polymer with the radiation shielding capabilities of polyethylene. The coating was realized by mechanical mixing of UHMWPE microspheres in the epoxy, followed by phase segregation of the two polymers upon heating. Different microsphere sizes and loadings of UHMWPE were considered and coatings with different thickness and homogeneity were fabricated. The layered coatings were analyzed using optical microscopy, which showed an optimal degree of coverage of the underlying epoxy substrate. The thermal properties of the UHMWPE-coated epoxy resin were investigated by differential scanning calorimetry (DSC), whereas Izod and bending tests were performed to study the fracture toughness and the flexural properties. Results showed an increase of the absorbed impact energy of the coated epoxy resin, and therefore a higher impact strength with respect to the neat thermosetting resin. The vacuum outgassing characteristics of the UHMWPE-coated epoxy resin were also investigated, and all tested samples showed a total mass loss (TML) lower than 1%. Overall, the experimental results of the morphological, thermal and mechanical analyses showed the promising use of this layered UHMWPE coating in space radiation shields, for example for satellites structures to protect sensitive equipment from radiation

Impact of Proton Irradiation on Medium Density Polyethylene/Carbon Nanocomposites for Space Shielding Applications

The development of novel materials with improved radiation shielding capability is a fundamental step towards the optimization of passive radiation countermeasures. Polyethylene (PE) nanocomposites filled with carbon nanotubes (CNT) or graphene nanoplatelets (GNP) can be a good compromise for maintaining the radiation shielding properties of the hydrogen-rich polymer while endowing the material with multifunctional properties. In this work, nanocomposite materials based on medium-density polyethylene (MDPE) loaded with different amounts of multi-walled carbon nanotubes (MWCNT), GNPs, and hybrid MWCNT/GNP nanofillers were fabricated, and their properties were examined before and after proton exposure. The effects of irradiation were evaluated in terms of modifications in the chemical and physical structure, wettability, and surface morphology of the nanocomposites. The aim of this work was to define and compare the MDPE-based nanocomposite behavior under proton irradiation in order to establish the best system for applications as space shielding materials

Impact of Proton Irradiation on Medium Density Polyethylene/Carbon Nanocomposites for Space Shielding Applications

The development of novel materials with improved radiation shielding capability is a fundamental step towards the optimization of passive radiation countermeasures. Polyethylene (PE) nanocomposites filled with carbon nanotubes (CNT) or graphene nanoplatelets (GNP) can be a good compromise for maintaining the radiation shielding properties of the hydrogen-rich polymer while endowing the material with multifunctional properties. In this work, nanocomposite materials based on medium-density polyethylene (MDPE) loaded with different amounts of multi-walled carbon nanotubes (MWCNT), GNPs, and hybrid MWCNT/GNP nanofillers were fabricated, and their properties were examined before and after proton exposure. The effects of irradiation were evaluated in terms of modifications in the chemical and physical structure, wettability, and surface morphology of the nanocomposites. The aim of this work was to define and compare the MDPE-based nanocomposite behavior under proton irradiation in order to establish the best system for applications as space shielding materials

Electrical resistance tomography for structural health monitoring of nanocomposite materials for spacesuit and crew surface mobility applications

Electrical Impedance Tomography (EIT) is an unobtrusive and portable monitoring method allowing the reconstruction of the electrical conductivity in a 2D domain of interest, from the voltage measurements of electrodes positioned along the boundary of the domain. Electrical conductivity changes can be correlated to damage. EIT has been used in biomedical engineering applications (e.g. to monitor the brain function as a patient loses consciousness from anesthesia) and for structural health of advanced composite materials subject to mechanical damage. More recently, using Electrical Resistance Tomography (ERT), based on DC injection, we have characterized the health of nanocomposite sensors applied onto the surface of carbon fiber-reinforced polymer composites. The films were prepared with graphene nanoplatelets and DNA. The samples were subjected to two levels of UV-C radiation (2.6 and 4.0 mW/cm2), for 24 hours, causing varying levels of damage that were studied also with Scanning Electron Microscopy. We proved that the electrical conductivity changes of the films under UV-C irradiation can be well captured by the ERT maps, with accuracy depending on DC current levels and injection patterns. We plan to adapt these methods to the REVEALS (Radiation Effects on Volatiles and Exploration of Asteroids and Lunar Surfaces) project: in particular, for the health monitoring of nanocomposite samples designed synergistically for radiation resistance and electrical conductivity, to be incorporated in spacesuit and surface mobility applications. We envision the material to be compliant sufficiently to be applied around the body to protect the most important organs. The first materials to be tested will be modified polymers consisting of medium density polyethylene treated with graphene nanoplatelets, which could also be eventually 3D-printed. Different types of damage are envisioned for this study, from mechanical damage to UV-C damage to damage due to other radiation types. Residual mechanical properties will be measured directly with mechanical testing or indirectly with measurements of Shore D hardness