21 research outputs found
Advancing Monitoring Infrastructure for Oregon’s Native Freshwater Turtles with Citizen Science Platforms
Monitoring is a core component of conservation plans as well as an opportunity for local stakeholders to contribute. Our objective was to advance monitoring infrastructure for the protection of native, threatened freshwater turtles in the Pacific Northwest through the creation of a citizen science application. This was done by researching previous designs of citizen science projects over the past ten years and improving the platform based on recommendations by practitioners. Current platforms can be improved by better crediting the work of citizen scientists, improving communication between scientists and users, building in flexibility for scientists, and accommodating for disabilities through ergonomic design. This set the framework to design and build a new multi-platform monitoring application. The final product is a mobile and web application that embodies these concepts and is ready for user-testing in the summer, providing scientists with critical data to help monitor multiple species of conservation concern, while engaging the public in this important task
The barber's pole worm CAP protein superfamily — A basis for fundamental discovery and biotechnology advances
The BioIntelligence Framework: a new computational platform for biomedical knowledge computing
Myelin Gene Regulatory Factor Is a Critical Transcriptional Regulator Required for CNS Myelination
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Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4
Small cell carcinoma of the ovary of hypercalcemic type (SCCOHT) is an extremely rare, aggressive cancer affecting children and young women. We identified germline and somatic inactivating mutations in the SWI/SNF chromatin-remodeling gene SMARCA4 in 75% (9/12) of SCCOHT cases in addition to SMARCA4 protein loss in 82% (14/17) of SCCOHT tumors but in only 0.4% (2/485) of other primary ovarian tumors. These data implicate SMARCA4 in SCCOHT oncogenesis
The Role of Community Involvement in Fostering Investment Behavior in Low-Income Black Adolescents
“Living Here has Changed My Whole Perspective”: How Escaping Inner-City Poverty Shapes Neighborhood and Housing Choice
Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4
Small cell carcinoma of the ovary of hypercalcemic type (SCCOHT) is an extremely rare, aggressive cancer affecting children and young women. We identified germline and somatic inactivating mutations in the SWI/SNF chromatin-remodeling gene SMARCA4 in 69% (9/13) of SCCOHT cases in addition to SMARCA4 protein loss in 82% (14/17) of SCCOHT tumors but in only 0.4% (2/485) of other primary ovarian tumors. These data implicate SMARCA4 in SCCOHT oncogenesis