COMPONENTES DO SANGUE E COAGULAÇÃO SANGUÍNEA

Todas as células do sangue são originadas do interior do osso na medula óssea vermelha e tem como função transporte de gases, nutrientes e hormônios, assim como a realização da coagulação sanguínea, da proteção contra  elementos  estranhos,  da  manutenção  da  temperatura  do  corpo,  da regulação do pH e da osmose

Land-Use and Legislation-Based Methodology for the Implementation of Sustainable Drainage Systems in the Semi-Arid Region of Brazil

This is the final version. Available on open access from MDPI via the DOI in this recordIn developing countries, the urbanisation process occurs with empirical urban management, a high increase of impermeable areas, and a lack of connection between water resource management and planning. In Brazil, concentrated rainfall and ineffective urban drainage systems add to this context and may impact the population with flash floods. Although sustainable drainage systems (SuDS) are widely used for flood mitigation, it is still not very well known how those strategies behave in semi-arid regions, where most of the time the weather is very dry. In Brazil, flood mitigation still mostly involves structural measures such as larger pipes or channels, with limited guidance for SuDS use due to the great resistance to change by citizens and managers. This study sought to analyse the efficacy of SuDS in Campina Grande, a semi-arid region of Brazil. A land-use and legislation-based methodology was developed with physical, climate, hydrological and governance data for three catchments and 312 sub-catchments in 30 applications and simulations. Simulations suggest that these strategies would be appropriate for semi-arid regions, with reductions in the flooded area, flooding volume, and impacts. This study is of relevance for cities with a similar climate to reach a sustainable level of urban drainage services, supporting the integration of urban planning and water resources management.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (Capes

Genome-wide association and functional follow-up reveals new loci for kidney function

Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new loci in association with estimated glomerular filtration rate (eGFR), the primary clinical measure of CKD, in or near MPPED2, DDX1, SLC47A1, CDK12, CASP9, and INO80. Morpholino knockdown of mpped2 and casp9 in zebrafish embryos revealed podocyte and tubular abnormalities with altered dextran clearance, suggesting a role for these genes in renal function. By providing new insights into genes that regulate renal function, these results could further our understanding of the pathogenesis of CKD

Emotional and Behavioral Problems in Children Living With Addicted Family Members: Prevention Challenges in an Underprivileged Suburban Community

Abstract Children living with substance abusers are more likely to experience negative outcomes. Our goal was to compare caregivers' reports on the Child Behavior Checklist (CBCL) and a socioeconomic and risk form of psychological aspects of children exposed to substance abuse assisted versus not assisted by a preventive intervention program in an underprivileged community. This observational intervention study was conducted with 66 caregivers of children who attended the program and 35 caregivers of children from the same community who did not attend. Ages ranged between six and 11 years old. Chi-square and logistic regression tests indicate that children exposed to substance abusers have more mental health problems than the general population and those who did not participate in the preventive intervention program presented worse outcomes, with higher rates of behavioral/emotional problems and exposure to risk situations. Results suggest that preventive actions might be helpful to promote the mental health of children at risk, validating the need for public policies and services

Genome-wide association study identifies 74 loci associated with educational attainment

Educational attainment is strongly influenced by social and other environmental factors, but genetic factors are estimated to account for at least 20% of the variation across individuals1. Here we report the results of a genome-wide association study (GWAS) for educational attainment that extends our earlier discovery sample1,2 of 101,069 individuals to 293,723 individuals, and a replication study in an independent sample of 111,349 individuals from the UK Biobank. We identify 74 genome-wide significant loci associated with the number of years of schooling completed. Single-nucleotide polymorphisms associated with educational attainment are disproportionately found in genomic regions regulating gene expression in the fetal brain. Candidate genes are preferentially expressed in neural tissue, especially during the prenatal period, and enriched for biological pathways involved in neural development. Our findings demonstrate that, even for a behavioural phenotype that is mostly environmentally determined, a well-powered GWAS identifies replicable associated genetic variants that suggest biologically relevant pathways. Because educational attainment is measured in large numbers of individuals, it will continue to be useful as a proxy phenotype in efforts to characterize the genetic influences of related phenotypes, including cognition and neuropsychiatric diseases