Prioriteringer ved bilkøb

For at reducere CO2-emissionen fra biler har man i EU bestemt sig for at indføre Energimærkning af biler. Hensigten med EM-ordningen er at få bilkøbere til at vælge mere energieffektive biler, for derigennem at mindske energiforbruget og miljøbelastningen pr. kørte kilometer. Formålet med nærværende undersøgelse er følgende: at analysere i hvor høj grad bilkøbere der har købt bil før indførslen af E-mærket lagde vægt på bilens brændstofeffektivitet, samt i hvor høj grad dette kan ses på deres valg af bil. Undersøgelsen er baseret på en række telefoninterviews af en stikprøve blandt de private husstande der fik indregistreret en ny bil i perioden 1. januar til 31. oktober 1999. Undersøgelsen er et led i et større EU projekt, som har til formål at evaluere effekten af energimærkning af biler - såvel i Danmark som i andre EU-lande. I løbet af efteråret 2001 vil der blive gennemført en række dybdegående undersøgelser som vil være en del af evalueringsrapporten. Rapporten forventes offentliggjort ultimo 2002

The impact of human resource management practices in innovation culture Case Study: Bank of Palestine in Gaza strip

The purpose of this study is to determine the degree of correlation between HRM practices and innovation culture and the degree of the impact of each HRM practice on the innovation culture. Data of this study are obtained from Bank Of Palestine (BoP), triangulation mixed method is used in this study, by using quantitative and qualitative analysis in order to get three points upon the factors being studied through questionnaires distributed to BoPs' employees in different branches in Gaza strip, and interview with the HR manager of BoP and a focus group with BoP's HR team. The results of this study concluded that there is a correlation between HRM practices and innovation culture. The HRM practices, which include staffing process, compensation, employee and labor relations, training and development, safety and health and communication, and participation, should be implemented in a holistic system and not in isolation in order to best stimulate innovation culture. The study recommended the pre-evaluation tests should be changed to better measure employees' creativity, flexibility and ability to take risks which all lead to a better innovation culture

Irrigation And Risk Of Saline Pollution. Example: Groundwater Of Annaba Plain (North East Of Algeria)

In the Annaba plain (Northeast of Algeria), the anthropogenic activities have imposed serious unfavorable impacts on hydraulic, hydrochemical and biological balances that influence the socio-economic future of this area. A hydrochemical analysis was performed in 29 wells distributed over the whole of the plain region during the period of high water (December 2013) to assess the quality of groundwater for its suitability for irrigation. Several parameters were analyzed such as pH, TDS, Ca +2, Mg +2, Na+ , K+ , HCO3 - , Cl- and SO4 - . Analysis of results suggests that groundwater in the study area has the same qualities; however the observed degradation reflects a change in the water quality, and the SAR values vary from 0.08 to 16 with an average of 1.3. The US salinity laboratory, Wilcox, and percentage Na+ it suggest that the majority of groundwater samples are not good for irrigation

Sex differences in the association between plasma copeptin and incident type 2 diabetes: the Prevention of Renal and Vascular Endstage Disease (PREVEND) study

AIMS/HYPOTHESIS: Vasopressin plays a role in osmoregulation, glucose homeostasis and inflammation. Therefore, plasma copeptin, the stable C-terminal portion of the precursor of vasopressin, has strong potential as a biomarker for the cardiometabolic syndrome and diabetes. Previous results were contradictory, which may be explained by differences between men and women in responsiveness of the vasopressin system. The aim of this study was to evaluate the usefulness of copeptin for prediction of future type 2 diabetes in men and women separately. METHODS: From the Prevention of Renal and Vascular Endstage Disease (PREVEND) study, 4,063 women and 3,909 men without diabetes at baseline were included. A total of 208 women and 288 men developed diabetes during a median follow-up of 7.7 years. RESULTS: In multivariable-adjusted models, we observed a stronger association of copeptin with risk of future diabetes in women (OR 1.49 [95% CI 1.24, 1.79]) than in men (OR 1.01 [95% CI 0.85, 1.19]) (p (interaction) < 0.01). The addition of copeptin to the Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR) clinical model improved the discriminative value (C-statistic,+0.007, p = 0.02) and reclassification (integrated discrimination improvement [IDI] = 0.004, p < 0.01) in women. However, we observed no improvement in men. The additive value of copeptin in women was maintained when other independent predictors, such as glucose, high sensitivity C-reactive protein (hs-CRP) and 24 h urinary albumin excretion (UAE), were included in the model. CONCLUSIONS/INTERPRETATION: The association of plasma copeptin with the risk of developing diabetes was stronger in women than in men. Plasma copeptin alone, and along with existing biomarkers (glucose, hs-CRP and UAE), significantly improved the risk prediction for diabetes in women

Fish sperm motility assessment as a tool for aquaculture research, a historical approach

[EN] Fish sperm motility is nowadays considered the best biomarker for the quality of fish spermatozoa, and sperm motion parameters from more than 300 fish species have been reported in more than 1500 scientific articles covering a wide range of topics, from molecular biology to ecology. The most studied topics have been (i) the sperm storage (involving both the use of chilled¿storage protocols for short¿term periods and sperm cryopreservation techniques for long¿term storage), (ii) the sperm physiology (fathom in the spermatozoa activation process and the whole propulsion machinery of the sperm cells) and (iii) the broodstock management (covering aspects such as rearing conditions, dietary requirements or hormonal induction treatments). In addition, other aquaculture and ecological topics, such as (iv) the knowledge of the breeding cycle of the species, (v) the phenomenon of the sperm competition and (vi) ecotoxicological studies for the evaluation of aquatic environments, have also been approached from the evaluation of sperm motion performance. Therefore, fish sperm motility assessment can serve as a potential tool for aquaculture and ecological purposes, covering key topics of fundamental and applied research. This review gives an overview of the major research areas in which fish sperm motility has been applied successfully.This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement no. 642893 (IMPRESS). VG has a postdoc grant from the UPV (PAID-10-16).Gallego Albiach, V.; Asturiano Nemesio, JF. (2018). Fish sperm motility assessment as a tool for aquaculture research, a historical approach. Reviews in Aquaculture (Online). 1-28. https://doi.org/10.1111/raq.12253S12

Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial

Background: Short-term treatment for people with type 2 diabetes using a low dose of the selective endothelin A receptor antagonist atrasentan reduces albuminuria without causing significant sodium retention. We report the long-term effects of treatment with atrasentan on major renal outcomes. Methods: We did this double-blind, randomised, placebo-controlled trial at 689 sites in 41 countries. We enrolled adults aged 18–85 years with type 2 diabetes, estimated glomerular filtration rate (eGFR)25–75 mL/min per 1·73 m 2 of body surface area, and a urine albumin-to-creatinine ratio (UACR)of 300–5000 mg/g who had received maximum labelled or tolerated renin–angiotensin system inhibition for at least 4 weeks. Participants were given atrasentan 0·75 mg orally daily during an enrichment period before random group assignment. Those with a UACR decrease of at least 30% with no substantial fluid retention during the enrichment period (responders)were included in the double-blind treatment period. Responders were randomly assigned to receive either atrasentan 0·75 mg orally daily or placebo. All patients and investigators were masked to treatment assignment. The primary endpoint was a composite of doubling of serum creatinine (sustained for ≥30 days)or end-stage kidney disease (eGFR <15 mL/min per 1·73 m 2 sustained for ≥90 days, chronic dialysis for ≥90 days, kidney transplantation, or death from kidney failure)in the intention-to-treat population of all responders. Safety was assessed in all patients who received at least one dose of their assigned study treatment. The study is registered with ClinicalTrials.gov, number NCT01858532. Findings: Between May 17, 2013, and July 13, 2017, 11 087 patients were screened; 5117 entered the enrichment period, and 4711 completed the enrichment period. Of these, 2648 patients were responders and were randomly assigned to the atrasentan group (n=1325)or placebo group (n=1323). Median follow-up was 2·2 years (IQR 1·4–2·9). 79 (6·0%)of 1325 patients in the atrasentan group and 105 (7·9%)of 1323 in the placebo group had a primary composite renal endpoint event (hazard ratio [HR]0·65 [95% CI 0·49–0·88]; p=0·0047). Fluid retention and anaemia adverse events, which have been previously attributed to endothelin receptor antagonists, were more frequent in the atrasentan group than in the placebo group. Hospital admission for heart failure occurred in 47 (3·5%)of 1325 patients in the atrasentan group and 34 (2·6%)of 1323 patients in the placebo group (HR 1·33 [95% CI 0·85–2·07]; p=0·208). 58 (4·4%)patients in the atrasentan group and 52 (3·9%)in the placebo group died (HR 1·09 [95% CI 0·75–1·59]; p=0·65). Interpretation: Atrasentan reduced the risk of renal events in patients with diabetes and chronic kidney disease who were selected to optimise efficacy and safety. These data support a potential role for selective endothelin receptor antagonists in protecting renal function in patients with type 2 diabetes at high risk of developing end-stage kidney disease. Funding: AbbVie