Nelumbo Nucifera (Lotus): A Review on Ethanobotany, Phytochemistry and Pharmacology

Nelumbo nucifera Gaertn (Nymphaeaceae), a perennial aquatic plant, has been used as a medicinal herb in China and India. It has been recorded in the most famous medicinal book in China for more than 400 years. Different part of plant (leaves, seeds, flower, and rhizome) can be used in traditional system of medicine. In traditional system of medicine, the different parts of plant is reported to possess beneficial effects as in for the treatment of pharyngopathy, pectoralgia, spermatorrhoea, leucoderma, smallpox, dysentery, cough, haematemesis, epistaxis, haemoptysis, haematuria, metrorrhagia, hyperlipidaemia, fever, cholera, hepatopathy and hyperdipsia. Following the traditional claims for the use of N.nucifera as cure of numerous diseases considerable efforts have been made by researchers to verify it’s utility through scientific pharmacological screenings. The pharmacological studies have shown that N.nucifera posseses various notable pharmacological activities like amti-ischemic, antioxidant, anticancer, antiviral, antiobesity, lipolytic, hypocholestemic, antipyretic, hepatoprotective, hypoglycaemic, antidiarrhoeal, antifungal, antibacterial, antiinflammatory and diuretic activities. A wide variety of phytoprinciples have been isolated from the plant. The present review is an effort to consolidate traditional, ethnobotanic, phytochemical and pharmacological information available on N.nucifera

Space Motions of the Dwarf Spheroidal Galaxies Draco and Sculptor based on HST Proper Motions with ~10-year Time Baseline

We present new proper motion (PM) measurements of the dwarf spheroidal galaxies (dSphs) Draco and Sculptor using multi-epoch images obtained with the Hubble Space Telescope ACS/WFC. Our PM results have uncertainties far lower than previous measurements, even made with the same instrument. The PM results for Draco and Sculptor are (mu_W,mu_N)_Dra = (-0.0562+/-0.0099,-0.1765+/-0.0100) mas/yr and (mu_W,mu_N)_Scl = (-0.0296+/-0.0209,-0.1358 +/-0.0214) mas/yr. The implied Galactocentric velocity vectors for Draco and Sculptor have radial and tangential components: (V_rad,V_tan)_Dra = (-88.6,161.4) +/- (4.4,5.6) km/s; and (V_rad,V_tan)_Scl = (72.6,200.2) +/- (1.3,10.8) km/s. We study the detailed orbital history of both Draco and Sculptor via numerical orbit integrations. Orbital periods of Draco and Sculptor are found to be 1-2 and 2-5 Gyrs, respectively, accounting for uncertainties in the MW mass. We also study the influence of the Large Magellanic Cloud (LMC) on the orbits of Draco and Sculptor. Overall, the inclusion of the LMC increases the scatter in the orbital results. Based on our calculations, Draco shows a rather wide range of orbital parameters depending on the MW mass and inclusion/exclusion of the LMC, but Sculptor's orbit is very well constrained with its most recent pericentric approach to the MW being 0.3-0.4 Gyr ago. Our new PMs imply that the orbital trajectories of both Draco and Sculptor are confined within the Disk of Satellites (DoS), better so than implied by earlier PM measurements, and likely rule out the possibility that these two galaxies were accreted together as part of a tightly bound group.Comment: 17 pages, 8 figures, 6 tables. Accepted for publication in Ap

HST Proper Motions of NGC 147 and NGC 185: Orbital Histories and Test of Dynamically Coherent Andromeda Satellite Plane

We present the first proper motion (PM) measurements for the dwarf elliptical galaxies NGC 147 and NGC 185, two satellite galaxies of M31, using multi-epoch HST imaging data with time baselines of $\sim 8$ years. For each galaxy, we take an error-weighted average of measurements from HST ACS/WFC and WFC3/UVIS to determine the PMs. Our final results for the PMs are $(\mu_\mathrm{W}, \mu_\mathrm{N})_\mathrm{N147} = (-0.0232, 0.0378) \pm (0.0143, 0.0146)\,\mathrm{mas}\,\mathrm{yr}^{-1}$ for NGC 147, and $(\mu_\mathrm{W}, \mu_\mathrm{N})_\mathrm{N185} = (-0.0242, 0.0058) \pm (0.0141, 0.0147)\,\mathrm{mas}\,\mathrm{yr}^{-1}$ for NGC 185. The 2-dimensional direction of motion for NGC 147 about M31 is found to be aligned with its tidal tails. The 3-d positions and velocities of both galaxies are transformed into a common M31-centric coordinate system to study the detailed orbital histories of the combined M31+NGC 147+NGC 185 system via numerical orbit integration. We find that NGC 147 (NGC 185) had its closest passage to M31 0.3-0.5~Gyr ($\gtrsim 1.6$~Gyr) within the past 6 Gyr at distances of $\sim 70$ kpc (70-260 kpc). The pericentric times of NGC 147/NGC 185 correlate qualitatively well with the presence/absence of tidal tails seen around the galaxies. Our PMs show that the orbital poles of NGC 147, and also NGC 185 albeit to a lesser degree, agree within the uncertainties with the normal of the Great Plane of Andromeda (GPoA). These are the first measurements of the 3-d angular momentum vector of any satellite identified as original GPoA members. Our results strengthen the hypothesis that the GPoA may be a dynamically coherent entity. We revisit previous claims that NGC 147 and NGC 185 are binary galaxies and conclude that it is very unlikely the two galaxies were ever gravitationally bound to each other.Comment: 20 pages, 9 figures, 4 tables, accepted for publication in Ap

EFFECTS OF LENGTH OF PROXIMAL FEMORAL NAIL ON INTRAOPERATIVE AND POST-OPERATIVE OUTCOMES OF INTERTROCHANTERIC FRACTURES

Background: Trochanteric femoral fractures are often seen in patients aged they can be caused by high-energy or low energy trauma or may be pathological. Particularly in the elderly, hip fractures are a major cause of increased mortality and morbidity. Because of the decreased physical capacity, concomitant systemic diseases, and increased vulnerability to environmental dangers, even low-energy trauma can cause unstable femoral trochanteric fractures in this age group. Compare the functional outcome of the short proximal femoral nail with a long proximal femoral nail in intertrochanteric fractures. Methods: This randomized control trial was conducted in the Department of Orthopedics, Surat Municipal Institute of Medical Science, Surat. Results: The mean duration of surgery in the long PFN group was 79.84 +7.09 minutes and the short PFN group was 50.72 +7.96 minutes. The two-tailed P value<0.001this difference is considered to be extremely statistically significant. The mean intra operative blood loss in the long PFN group was 330.8+ 31.74 ml and the short PFN group was 170 + 23.10 ml. The two-tailed P value < 0.001, this difference is considered to be statistically significant. The number of cases with limb shortening were more in the Short PFN group than the patients in whom long PFN was use. Conclusion: Both the long and short intramedullary nails are the optional internal fixation choices for femoral intertrochanteric fracture. But the long nail could avoided the refracture of femur and reduced postoperative hip pain whereas the short nail has the advantage of reduced surgical time, blood loss and fluoroscopic time

First Gaia Dynamics of the Andromeda System: DR2 Proper Motions, Orbits, and Rotation of M31 and M33

The 3D velocities of M31 and M33 are important for understanding the evolution and cosmological context of the Local Group. Their most massive stars are detected by Gaia, and we use Data Release 2 (DR2) to determine the galaxy proper motions (PMs). We select galaxy members based on, e.g., parallax, PM, color-magnitude-diagram location, and local stellar density. The PM rotation of both galaxies is confidently detected, consistent with the known line-of-sight rotation curves: $V_{\rm rot} = -206\pm86$ km s$^{-1}$ (counter-clockwise) for M31, and $V_{\rm rot} = 80\pm52$ km s$^{-1}$ (clockwise) for M33. We measure the center-of-mass PM of each galaxy relative to surrounding background quasars in DR2. This yields that $({\mu}_{\alpha*},{\mu}_{\delta})$ equals $(65 \pm 18 , -57 \pm 15)$ $\mu$as yr$^{-1}$ for M31, and $(31 \pm 19 , -29 \pm 16)$ $\mu$as yr$^{-1}$ for M33. In addition to the listed random errors, each component has an additional residual systematic error of 16 $\mu$as yr$^{-1}$. These results are consistent at 0.8$\sigma$ and 1.0$\sigma$ with the (2 and 3 times higher-accuracy) measurements already available from Hubble Space Telescope (HST) optical imaging and VLBA water maser observations, respectively. This lends confidence that all these measurements are robust. The new results imply that the M31 orbit towards the Milky Way is somewhat less radial than previously inferred, $V_{\rm tan, DR2+HST} = 57^{+35}_{-31}$ km s$^{-1}$, and strengthen arguments that M33 may be on its first infall into M31. The results highlight the future potential of Gaia for PM studies beyond the Milky Way satellite system.Comment: 15 pages, 7 figures, ApJ, in pres

Proper Motions and Orbits of Distant Local Group Dwarf Galaxies from a combination of Gaia and Hubble Data

We have determined the proper motions (PMs) of 12 dwarf galaxies in the Local Group (LG), ranging from the outer Milky Way (MW) halo to the edge of the LG. We used HST as the first and Gaia as the second epoch using the GaiaHub software. For Leo A and Sag DIG we also used multi-epoch HST measurements relative to background galaxies. Orbital histories derived using these PMs show that two-thirds of the galaxies in our sample are on first infall with $>$90\% certainty. The observed star formation histories (SFHs) of these first-infall dwarfs are generally consistent with infalling dwarfs in simulations. The remaining four galaxies have crossed the virial radius of either the MW or M31. When we compare their star formation (SF) and orbital histories we find tentative agreement between the inferred pattern of SF with the timing of dynamical events in the orbital histories. For Leo~I, SF activity rises as the dwarf crosses the MW's virial radius, culminating in a burst of SF shortly before pericenter ($\approx1.7$~Gyr ago). The SF then declines after pericenter, but with some smaller bursts before its recent quenching ($\approx0.3$~Gyr ago). This shows that even small dwarfs like Leo~I can hold on to gas reservoirs and avoid quenching for several Gyrs after falling into their host, which is longer than generally found in simulations. Leo~II, NGC~6822, and IC~10 are also qualitatively consistent with this SF pattern in relation to their orbit, but more tentatively due to larger uncertainties.Comment: 27 pages, 9 Figures, 8 Tables, Submitted to Ap

Limited genetic and antigenic diversity within parasite isolates used in a live vaccine against Theileria parva

An infection and treatment protocol is used to vaccinate cattle against Theileria parva infection. Due to incomplete cross-protection between different parasite isolates, a mixture of three isolates, termed the Muguga cocktail, is used for vaccination. While vaccination of cattle in some regions provides high levels of protection, some animals are not protected against challenge with buffalo-derived T. parva. Knowledge of the genetic composition of the Muguga cocktail vaccine is required to understand how vaccination is able to protect against field challenge and to identify the potential limitations of the vaccine. The aim of the current study was to determine the extent of genetic and antigenic diversity within the parasite isolates that constitute the Muguga cocktail. High throughput multi-locus sequencing of antigen-encoding loci was performed in parallel with typing using a panel of micro- and minisatellite loci. The former focused on genes encoding CD8+ T cell antigens, believed to be relevant to protective immunity. The results demonstrate that each of the three component stocks of the cocktail contains limited parasite genotypic diversity, with single alleles detected at many gene/satellite loci and, moreover, that two of the components show a very high level of similarity. Thus, the vaccine incorporates very little of the genetic and antigenic diversity observed in field populations of T. parva. The presence of alleles at low frequency (<10%) within vaccine component populations also points to the possibility of variability in the content of vaccine doses and the potential for loss of allelic diversity during tick passage. The results demonstrate that there is scope to modify the content of the vaccine in order to enhance its diversity and thus its potential for providing broad protection. The ability to accurately quantify genetic diversity in vaccine component stocks will facilitate improved quality control procedures designed to ensure the long-term efficacy of the vaccine

The Orbital Histories of Magellanic Satellites Using Gaia DR2 Proper Motions

With the release of Gaia DR2, it is now possible to measure the proper motions (PMs) of the lowest mass, ultra-faint satellite galaxies in the Milky Way's (MW) halo for the first time. Many of these faint satellites are posited to have been accreted as satellites of the Magellanic Clouds (MCs). Using their 6-dimensional phase space information, we calculate the orbital histories of 13 ultra-faint satellites and five classical dwarf spheroidals in a combined MW+LMC+SMC potential to determine which galaxies are dynamically associated with the MCs. These 18 galaxies are separated into four classes: i.) long-term Magellanic satellites that have been bound to the MCs for at least the last two consecutive orbits around the MCs (Carina 2, Carina 3, Horologium 1, Hydrus 1); ii.) Magellanic satellites that were recently captured by the MCs $<$ 1 Gyr ago (Reticulum 2, Phoenix 2); iii.) MW satellites that have interacted with the MCs (Sculptor 1, Tucana 3, Segue 1); and iv.) MW satellites (Aquarius 2, Canes Venatici 2, Crater 2, Draco 1, Draco 2, Hydra 2, Carina, Fornax, Ursa Minor). Results are reported for a range of MW and LMC masses. Contrary to previous work, we find no dynamical association between Carina, Fornax, and the MCs. Finally, we determine that the addition of the SMC's gravitational potential affects the longevity of satellites as members of the Magellanic system (long-term versus recently captured), but it does not change the total number of Magellanic satellites.Comment: 32 pages, 11 figures. Accepted to Ap

The Hubble Space Telescope Survey of M31 Satellite Galaxies. II. The Star Formation Histories of Ultrafaint Dwarf Galaxies

We present the lifetime star formation histories (SFHs) for six ultrafaint dwarf (UFD; M V > − 7.0, 4.9<log10(M*(z=0)/M⊙)<5.5 ) satellite galaxies of M31 based on deep color–magnitude diagrams constructed from Hubble Space Telescope imaging. These are the first SFHs obtained from the oldest main-sequence turnoff of UFDs outside the halo of the Milky Way (MW). We find that five UFDs formed at least 50% of their stellar mass by z = 5 (12.6 Gyr ago), similar to known UFDs around the MW, but that 10%–40% of their stellar mass formed at later times. We uncover one remarkable UFD, And xiii, which formed only 10% of its stellar mass by z = 5, and 75% in a rapid burst at z ∼ 2–3, a result that is robust to choices of underlying stellar model and is consistent with its predominantly red horizontal branch. This “young” UFD is the first of its kind and indicates that not all UFDs are necessarily quenched by reionization, which is consistent with predictions from several cosmological simulations of faint dwarf galaxies. SFHs of the combined MW and M31 samples suggest reionization did not homogeneously quench UFDs. We find that the least-massive MW UFDs (M *(z = 5) ≲ 5 × 104 M ⊙) are likely quenched by reionization, whereas more-massive M31 UFDs (M *(z = 5) ≳ 105 M ⊙) may only have their star formation suppressed by reionization and quench at a later time. We discuss these findings in the context of the evolution and quenching of UFDs

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research