621 research outputs found
Perspectives on ethnic and racial disparities in Alzheimer\u27s disease and related dementias: Update and areas of immediate need
- Publication venue
- Digital Commons@Becker
- Publication date
- 01/01/2019
- Field of study
The disruption of proteostasis in neurodegenerative diseases
- Author
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- Zolkiewski M
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- Publication venue
- 'American Institute of Mathematical Sciences (AIMS)'
- Publication date
- 01/01/2015
- Field of study
Cells count on surveillance systems to monitor and protect the cellular proteome which, besides being highly heterogeneous, is constantly being challenged by intrinsic and environmental factors. In this context, the proteostasis network (PN) is essential to achieve a stable and functional proteome. Disruption of the PN is associated with aging and can lead to and/or potentiate the occurrence of many neurodegenerative diseases (ND). This not only emphasizes the importance of the PN in health span and aging but also how its modulation can be a potential target for intervention and treatment of human diseases.info:eu-repo/semantics/publishedVersio
Recommended from our members
CheriABI: Enforcing Valid Pointer Provenance and Minimizing Pointer Privilege in the POSIX C Run-time Environment
- Author
- Publication venue
- International Conference on Architectural Support for Programming Languages and Operating Systems - ASPLOS
- Publication date
- 01/01/2019
- Field of study
The CHERI architecture allows pointers to be implemented as capabilities (rather than integer virtual addresses) in a manner that is compatible with, and strengthens, the semantics of the C language. In addition to the spatial protections offered by conventional fat pointers, CHERI capabilities offer strong integrity, enforced provenance validity, and access monotonicity. The stronger guarantees of these architectural capabilities must be reconciled with the real-world behavior of operating systems, run-time environments, and applications. When the process model, user-kernel interactions, dynamic linking, and memory management are all considered, we observe that simple derivation of architectural capabilities is insufficient to describe appropriate access to memory. We bridge this conceptual gap with a notional \emph{abstract capability} that describes the accesses that should be allowed at a given point in execution, whether in the kernel or userspace. To investigate this notion at scale, we describe the first adaptation of a full C-language operating system (FreeBSD) with an enterprise database (PostgreSQL) for complete spatial and referential memory safety. We show that awareness of abstract capabilities, coupled with CHERI architectural capabilities, can provide more complete protection, strong compatibility, and acceptable performance overhead compared with the pre-CHERI baseline and software-only approaches. Our observations also have potentially significant implications for other mitigation techniques.This work was supported by the Defense Advanced Research Projects Agency (DARPA) and the Air Force Research Laboratory (AFRL), under contracts FA8750-10-C-0237 (``CTSRD'') and HR0011-18-C-0016 (``ECATS''). The views, opinions, and/or findings contained in this report are those of the authors and should not be interpreted as representing the official views or policies of the Department of Defense or the U.S. Government. We also acknowledge the EPSRC REMS Programme Grant (EP/K008528/1), the ERC ELVER Advanced Grant (789108), Arm Limited, HP Enterprise, and Google, Inc. Approved for Public Release, Distribution Unlimited
Hsp90 orchestrates transcriptional regulation by Hsf1 and cell wall remodelling by MAPK signalling during thermal adaptation in a pathogenic yeast
- Author
- A Ali
- A Mitchell
- A Plaine
- A Roetzer
- A Roetzer
- A Walther
- A Winkler
- AA Duina
- AE Piispanen
- Alex Andrianopoulos
- Alistair J. P. Brown
- AP Gasch
- B Eisman
- B Enjalbert
- B Enjalbert
- B Enjalbert
- BK Jakobsen
- C Csank
- C Giardina
- C Queitsch
- C San Jose
- CA Munro
- Carol Munro
- CH de Dios
- CJ Nobile
- D Chen
- DA Davis
- DA Smith
- DF Jarosz
- DF Jarosz
- DF Smith
- DM Arana
- DR Wysong
- E Kussell
- E Leberer
- E Nikolaou
- E Roman
- EA Craig
- EA Elion
- ET Burt
- F Estruch
- F Lamoth
- F Navarro-Garcia
- F Navarro-Garcia
- F Navarro-García
- F Sherman
- FA Guhad
- G Degols
- G Wiederrecht
- G Wiederrecht
- GJ Gallo
- H Garreau
- H Lavoie
- HC Causton
- I Tirosh
- IV Ene
- J Chen
- J Zou
- JL Brewster
- JR Blankenship
- K-H Chen
- LA Walker
- LA Walker
- LE Cowen
- Leah E. Cowen
- Louise Walker
- M Ramsdale
- M Taipale
- MD Leach
- MD Leach
- MD Leach
- MD Leach
- ME Feder
- Michelle D. Leach
- MM Bradford
- N Shulga
- P Gónzalez-Párraga
- P Hawle
- PD Cantero
- PK Sorger
- PK Sorger
- R Alonso-Monge
- R Alonso-Monge
- R Diez-Orejas
- RA Monge
- RB Wilson
- RS Hegde
- RS Shapiro
- S Bates
- S Diezmann
- S Kuge
- S Nicholls
- S Nicholls
- S Nicholls
- SD Singh
- SH Millson
- SK Prill
- SL LaFayette
- SL Rutherford
- SM Noble
- SM O'Rourke
- SM Roe
- Susan Budge
- TT Wimalasena
- VM Bruno
- VM Bruno
- WA Fonzi
- WM Toone
- X Zhang
- Y Guo
- Y Kamada
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/12/2012
- Field of study
Acknowledgments We thank Rebecca Shapiro for creating CaLC1819, CaLC1855 and CaLC1875, Gillian Milne for help with EM, Aaron Mitchell for generously providing the transposon insertion mutant library, Jesus Pla for generously providing the hog1 hst7 mutant, and Cathy Collins for technical assistance.Peer reviewedPublisher PD
Measurement of D-s(+) and D-s(*+) production in B meson decays and from continuum e(+)e(-) annihilation at √s=10.6 GeV
- Author
- Abe K
- Abrams GS
- Adam I
- Adye T
- Albert J
- Aleksan R
- Allison J
- Alsmiller JRG
- Andress JC
- Angelini C
- Anjomshoaa A
- Anthony PL
- Anulli F
- Arisaka K
- Aspinwall ML
- Aston D
- Aubert B
- Azzopardi DE
- BABAR Collaboration
- Back JJ
- Bagnasco S
- Baird K
- Baldini-Ferroli R
- Band HR
- Barillari T
- Barlow NR
- Barlow RJ
- Bartoldus R
- Batignani G
- Bauer JM
- Benayoun M
- Berger N
- Beringer J
- Bernard D
- Bernet R
- Best D
- Bettarini S
- Bhimji W
- Bianchi F
- Bionta RM
- Blaylock G
- Blinov VE
- Bloom E
- Bloom P
- Blouw J
- Bona M
- Bondioli M
- Bonneaud GR
- Borean C
- Borgland AW
- Bosisio L
- Boutigny D
- Bowerman DA
- Boyarski AM
- Boyd JT
- Bozzi C
- Brandt T
- Brau B
- Brau J
- Breon AB
- Briand H
- Bright-Thomas PG
- Brigljevic V
- Brochard F
- Brose J
- Brown CM
- Brown D
- Brown DN
- Buchanan C
- Bugg W
- Bukin AD
- Bukin DA
- Bulos F
- Burchat PR
- Button-Shafer J
- Buzykaev AR
- Buzzo A
- Cahn RN
- Calcaterra A
- Calderini G
- Campagnari C
- Carpinelli M
- Carroll M
- Cartaro C
- Cavallo N
- Cavoto G
- Chao M
- Charles E
- Chauveau J
- Chen E
- Chen GP
- Chen JC
- Cheng CH
- Chevalier N
- Christ S
- Chun S
- Clark AR
- Clark PJ
- Cochran J
- Cohen-Tanugi J
- Cohn H
- Colberg T
- Colecchia F
- Contri R
- Convery MR
- Copty N
- Cottingham WN
- Coupal DP
- Cowan G
- Cowan R
- Coward DH
- Crawley HB
- Cremaldi L
- Crosetti G
- Dahmes B
- Dal Corso F
- Dallapiccola C
- Dasu S
- Dauncey PD
- David P
- Davis CL
- De Groot N
- de la Vaissiere C
- de Lesquen A
- de Monchenault GH
- De Nardo G
- de Sangro R
- Del Buono L
- del Re D
- Della Ricca G
- Deppermann T
- Devmal S
- Di Lodovico F
- Dickopp M
- Dima MO
- Dittongo S
- Dixon P
- Dorfan DE
- Dorfan J
- Dorigo A
- Dubitzky RS
- Dubois-Felsmann GP
- Dunwoodie W
- Dvoretskii A
- Dyce N
- Egede U
- Eichenbaum AM
- Eigen G
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- Elmer P
- Emery S
- Eschenburg V
- Eschrich I
- Fabozzi F
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- Gaidot A
- Gaillard JM
- Galeazzi F
- Gamba D
- Gamet R
- Ganzhur SF
- Gatto C
- Geddes NI
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- George M
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- Giorgi MA
- Giraud PF
- Gladney L
- Glanzman T
- Godfrey GL
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- Groysman Y
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- Hamilton R
- Hamon O
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- Harton JL
- Hast C
- Hauke A
- Hawkes CM
- Hearty C
- Henderson R
- Hertzbach SS
- Heusch CA
- Hicheur A
- Himel T
- Hitlin DG
- Hocker A
- Hryn'ova T
- Hu H
- Huffer ME
- Innes WR
- Ivanchenko VN
- Iwasaki M
- Izen JM
- Jackson F
- Jackson PD
- Jacobsen RG
- Jawahery A
- Jayatilleke S
- Jessop C
- Johnson DR
- Johnson JR
- Johnson RP
- Jolly S
- Judd D
- Kadel RW
- Kadyk J
- Karyotakis Y
- Kay M
- Kelsey MH
- Kerth LT
- Khan A
- Kim P
- Kirkby D
- Kitayama I
- Knowles DJ
- Koch H
- Kocian ML
- Kofler R
- Kolomensky YG
- Koptchev VG
- Kordich TMB
- Korol AA
- Kowalewski R
- Kozanecki W
- Kral JF
- Kravchenko EA
- Krishnamurthy M
- Kroeger R
- Kunze M
- Kurup A
- Kuznetsova N
- Lacker HM
- Lafferty GD
- Lamanna E
- Lamsa J
- Lanceri L
- Lange D
- Langenegger U
- Langer M
- Lankford AJ
- Laplace S
- Lavin D
- Le Diberder F
- LeClerc C
- Lees JP
- Leith DWGS
- Leonardi E
- Lepeltier V
- Leruste P
- Levi ME
- Levy SL
- Lewandowski B
- Lillard V
- Lista L
- Liu R
- Lo Vetere M
- Lockman WS
- London GW
- Long O
- LoSecco JM
- Lou XC
- Lu A
- Lu C
- Luitz S
- Lusiani A
- Luth V
- Lutz AM
- Lynch G
- Lynch HL
- MacFarlane DB
- Mackay C
- Macri M
- Mallik U
- Maly E
- Mancinelli G
- Mandelkern M
- Manfredi PF
- Margoni M
- Marker CE
- Marsiske H
- Martin JP
- Martinez-Vidal F
- Mattison TS
- Mayer B
- Mazzoni MA
- McDonald KT
- McGrath P
- McKemey AK
- McKenna JA
- McMahon S
- McMahon TR
- Meadows BT
- Menke S
- Messner R
- Metzler S
- Meyer TI
- Meyer WT
- Michelon G
- Miftakov V
- Milek M
- Moffeit KC
- Monge MR
- Moore TB
- Morandin M
- Morganti M
- Morganti S
- Morii M
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- Mugge M
- Muheim F
- Muller DR
- Muller-Pfefferkorn R
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- Nicholson H
- Nief JY
- O'Grady CP
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- Piemontese L
- Piredda G
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- Playfer S
- Pompili A
- Poropat P
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- Potter RJL
- Prell S
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- Pripstein M
- Pulliam T
- Purohit MV
- Qi ND
- Quinn H
- Rahatlou S
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- Rankin P
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- Reidy J
- Ricciardi S
- Richman JD
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- Robertson SH
- Robutti E
- Rochester LS
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- Wallom D
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- Weidemann AW
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- Yushkov AN
- Zacek V
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- Zhang J
- Zhu RY
- Zhu YS
- Zito M
- Publication venue
- American Physical Society
- Publication date
- 01/01/2002
- Field of study
This is the pre-print version of the Article. The official published version can be accessed from the links below. Copyright @ 2002 APSNew measurements of Ds+ and Ds*+ meson production rates from B decays and from qq̅ continuum events near the Υ(4S) resonance are presented. Using 20.8 fb-1 of data on the Υ(4S) resonance and 2.6 fb-1 off-resonance, we find the inclusive branching fractions B(B⃗Ds+X)=(10.93±0.19±0.58±2.73)% and B(B⃗Ds*+X)=(7.9±0.8±0.7±2.0)%, where the first error is statistical, the second is systematic, and the third is due to the Ds+→φπ+ branching fraction uncertainty. The production cross sections σ(e+e-→Ds+X)×B(Ds+→φπ+)=7.55±0.20±0.34pb and σ(e+e-→Ds*±X)×B(Ds+→φπ+)=5.8±0.7±0.5pb are measured at center-of-mass energies about 40 MeV below the Υ(4S) mass. The branching fractions ΣB(B⃗Ds(*)+D(*))=(5.07±0.14±0.30±1.27)% and ΣB(B⃗Ds*+D(*))=(4.1±0.2±0.4±1.0)% are determined from the Ds(*)+ momentum spectra. The mass difference m(Ds+)-m(D+)=98.4±0.1±0.3MeV/c2 is also measured.This work was supported by DOE and NSF (USA), NSERC (Canada), IHEP (China), CEA and CNRS-IN2P3 (France), BMBF (Germany), INFN (Italy), NFR (Norway), MIST (Russia), and PPARC (United Kingdom). Individuals have received support from the Swiss NSF, A. P. Sloan Foundation, Research Corporation, and Alexander von Humboldt Foundation
Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV
- Author
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- Yilmaz M
- Yoosootiniya R
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- Zarzhitsky P
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- Zhemchugov A
- Zheng S
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- Zsenei A
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- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2013
- Field of study
The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of √s = 7TeV corresponding to an integrated luminosity of 38 pb-1. Jets are reconstructed with the anti-kt algorithm with distance parameters R=0. 4 or R=0. 6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pT≥20 GeV and pseudorapidities {pipe}η{pipe}<4. 5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2. 5 % in the central calorimeter region ({pipe}η{pipe}<0. 8) for jets with 60≤pT<800 GeV, and is maximally 14 % for pT<30 GeV in the most forward region 3. 2≤{pipe}η{pipe}<4. 5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon pT, the sum of the transverse momenta of tracks associated to the jet, or a system of low-pT jets recoiling against a high-pT jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-pT jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined. © 2013 CERN for the benefit of the ATLAS collaboration
Search for the neutral Higgs bosons of the minimal supersymmetric standard model in pp collisions at root s=7 TeV with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdinov O
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- AbouZeid OS
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- Acharya BS
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- Allbrooke BMM
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- Zobernig G
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- zur Nedden M
- Zutshi V
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- Publication venue
- Publication date
- 01/02/2013
- Field of study
A search for neutral Higgs bosons of the Minimal Supersymmetric Standard Model (MSSM) is reported. The analysis is based on a sample of proton-proton collisions at a centre-of-mass energy of 7TeV recorded with the ATLAS detector at the Large Hadron Collider. The data were recorded in 2011 and correspond to an integrated luminosity of 4.7 fb-1 to 4.8 fb-1. Higgs boson decays into oppositely-charged muon or τ lepton pairs are considered for final states requiring either the presence or absence of b-jets. No statistically significant excess over the expected background is observed and exclusion limits at the 95% confidence level are derived. The exclusion limits are for the production cross-section of a generic neutral Higgs boson, φ, as a function of the Higgs boson mass and for h/A/H production in the MSSM as a function of the parameters mA and tan β in the mhmax scenario for mA in the range of 90GeV to 500 GeV. Copyright CERN
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente
Regional differences in portion size consumption behaviour: Insights for the global food industry
- Author
- Aaker JL Benet-Martinez V, Garolera J
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- Almiron-Roig E Tsiountsioura M, Lewis HB, et al.
- Antonuk B Block LG
- Brown PM Cameron LD
- Bryant R Dundes L
- Cafaro PJ Primack RB, Zimdahl RL
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- Coussement K Van den Bossche F, De Bock KW
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- Davey R
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- Dobson PW Gerstner E
- Dubois D Rucker DD, Galinsky AD
- Ello-Martin JA Ledikwe JH, Rolls BJ
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- Hawkes C
- Haws KL Winterich KP
- Hill JO Peters JC
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- McCarty JA Hastak M
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- Morgan K
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- Peñaloza L Gilly MC
- Piernas C Popkin BM
- Popkin BM
- Prentice AM
- Rennie KL Johnson L, Jebb SA
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- Rolls BJ Roe LS, Meengs JS
- Rolls BJ Roe LS, Meengs JS
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- Steenhuis IH Vermeer WH
- Story M Hamm MW, Wallinga D
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- Swinburn BA Caterson I, Seidell JC
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- Vermeer WM Steenhuis IH, Seidell JC
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- Wansink B
- Wansink B Painter JE, North J
- Wansink B van Ittersum K
- Young LR Nestle M
- Young LR Nestle M
- Zlatevska N Dubelaar C, Holden SS
- Zlatevska N Spence MT
- Özsomer A Batra R, Chattopadhyay A, et al.
- Publication venue
- 'American Institute of Mathematical Sciences (AIMS)'
- Publication date
- 01/01/2019
- Field of study
Abstract: Given the influence of globalization on consumer food behaviour across the world, the purpose of this paper is to contribute to the theoretical discourse around food portion size as a global consumption-related symbol and its underlying socio-economic drivers for food industry strategy. Overall, 25,000 global food consumers were surveyed across 24 countries to elicit insight on portion size consumption behaviour as well as consumer perception on eating and drinking small portion size within selected socio-economic classes. The data was quantitatively analysed to answer the pertinent research objectives. In 20 out of the 24 global markets surveyed, large food portion size was statistically established as a prevalent consumption-related symbol. The paper found that there are regional differences in portion size food consumption behaviour, and further disparities exist across age, gender and income status in 24 countries covering all regions, including Australia, China, Mexico, South Africa, United Kingdom and United States of America. The outlined food industry implications reveal that adaptation and standardisation strategies are still relevant in global food and nutrition strategy as revealed by the variations in the preference for food portion sizes across various countries of the world
Thermal and utility properties of amide clay modifying agents
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
- …