Antennas and absorbing materials based on geopolymers

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New NIR spectro-polarimetric modes for the SCExAO instrument

Polarization Differential Imaging (PDI) is one of the most productive modes of current high-contrast imagers. Dozens of new protoplanetary, transition and debris disks were imaged recently for the first time, helping us understand the processes of planet formation, and giving clues on the mass of potential planets inside these disks, even if they cannot be imaged directly. The Subaru Coronagraphic Extreme Adaptive Optics (SCExAO) instrument is equipped with a fast visible dual-camera polarimetric module, VAMPIRES, already producing valuable scientific observations of protoplanetary disks and dust shells. In addition, we recently commissioned two new polarimetric modules in the infrared. The first one is a spectro-polarimetric mode using the CHARIS Integral Field Spectrograph (IFS). A Wollaston prism was added in front of the IFS, reducing the field-of-view to 2x1 arcsec to accommodate for the imaging of both polarizations on the same detector without sacrificing the spectral resolution of the instrument, in any of its spectral modes. The second module, similar to VAMPIRES, uses a low-noise high frame rate C-RED ONE camera combined with a Ferroelectric Liquid Crystal (FLC) device to modulate and record the polarization at high-speed, freezing effectively the atmospheric speckles for higher precision. We present on-sky results of the new polarimetric capabilities taken during the commissioning phase. In addition, we show future capabilities that are already scheduled to increase the performance of these modules, especially the addition of non-redundant masks, as well as a polarimetric vector Apodizing Phase Plate (vAPP) coronagraph

GPS network monitor the Western Alps deformation over a five year period: 1993-1998

GPS surveys in the Western Alps, performed in the time span 1993-2003, estimated the current crustal deformation of this area.Published63-763.2. Tettonica attivaJCR Journalreserve

Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity.

Epidemiological and clinical reports indicate that SARS-CoV-2 virulence hinges upon the triggering of an aberrant host immune response, more so than on direct virus-induced cellular damage. To elucidate the immunopathology underlying COVID-19 severity, we perform cytokine and multiplex immune profiling in COVID-19 patients. We show that hypercytokinemia in COVID-19 differs from the interferon-gamma-driven cytokine storm in macrophage activation syndrome, and is more pronounced in critical versus mild-moderate COVID-19. Systems modelling of cytokine levels paired with deep-immune profiling shows that classical monocytes drive this hyper-inflammatory phenotype and that a reduction in T-lymphocytes correlates with disease severity, with CD8+ cells being disproportionately affected. Antigen presenting machinery expression is also reduced in critical disease. Furthermore, we report that neutrophils contribute to disease severity and local tissue damage by amplification of hypercytokinemia and the formation of neutrophil extracellular traps. Together our findings suggest a myeloid-driven immunopathology, in which hyperactivated neutrophils and an ineffective adaptive immune system act as mediators of COVID-19 disease severity

Cenozoic deformation of Iberia: a model for intraplate mountain building and basin development based on analogue modelling

Inferences from analogue models support lithospheric folding as the primary response to large-scale shortening manifested in the present day topography of Iberia. This process was active from the late Oligocene-early Miocene during the Alpine orogeny and was probably enhanced by reactivation of inherited Variscan faults. The modeling results confirm the dependence of fold wavelength on convergence rate and hence the strength of the layers of the lithosphere such that fold wavelength is longest for fast convergence rates favoring whole lithosphere folding. Folding is associated with the formation of dominantly pop-up type mountain ranges in the brittle crust and thickening of the ductile layers in the synforms of the buckle folds by flow. The mountain ranges are represented by upper crustal pop-ups forming the main topographic relief. The wavelengths of the topographic uplifts, both, in model and nature suggest mechanical decoupling between crust and mantle. Moreover, our modeling results suggest that buckling in Iberia took place under rheological conditions where the lithospheric mantle is stronger than the lower crust. The presence of an indenter, inducing oblique shortening in response to the opening of the King's Trough in the north western corner of the Atlantic Iberian margin controls the spacing and obliquity of structures. This leads to the transfer of the deformation from the moving walls towards the inner part of the model, creating oblique structures in both brittle and ductile layers. The effect of the indenter, together with an increase on the convergence rate produced more complex brittle structures. These results show close similarities to observations on the general shape and distribution of mountain ranges and basins in Iberia, including the Spanish Central System and Toledo Mountains.Peer reviewe

Systems biology of platelet-vessel wall interactions

Platelets are small, anucleated cells that participate in primary hemostasis by forming a hemostatic plug at the site of a blood vessel's breach, preventing blood loss. However, hemostatic events can lead to excessive thrombosis, resulting in life-threatening strokes, emboli, or infarction. Development of multi-scale models coupling processes at several scales and running predictive model simulations on powerful computer clusters can help interdisciplinary groups of researchers to suggest and test new patient-specific treatment strategies

Citrullination regulates pluripotency and histone H1 binding to chromatin.

Citrullination is the post-translational conversion of an arginine residue within a protein to the non-coded amino acid citrulline. This modification leads to the loss of a positive charge and reduction in hydrogen-bonding ability. It is carried out by a small family of tissue-specific vertebrate enzymes called peptidylarginine deiminases (PADIs) and is associated with the development of diverse pathological states such as autoimmunity, cancer, neurodegenerative disorders, prion diseases and thrombosis. Nevertheless, the physiological functions of citrullination remain ill-defined, although citrullination of core histones has been linked to transcriptional regulation and the DNA damage response. PADI4 (also called PAD4 or PADV), the only PADI with a nuclear localization signal, was previously shown to act in myeloid cells where it mediates profound chromatin decondensation during the innate immune response to infection. Here we show that the expression and enzymatic activity of Padi4 are also induced under conditions of ground-state pluripotency and during reprogramming in mouse. Padi4 is part of the pluripotency transcriptional network, binding to regulatory elements of key stem-cell genes and activating their expression. Its inhibition lowers the percentage of pluripotent cells in the early mouse embryo and significantly reduces reprogramming efficiency. Using an unbiased proteomic approach we identify linker histone H1 variants, which are involved in the generation of compact chromatin, as novel PADI4 substrates. Citrullination of a single arginine residue within the DNA-binding site of H1 results in its displacement from chromatin and global chromatin decondensation. Together, these results uncover a role for citrullination in the regulation of pluripotency and provide new mechanistic insights into how citrullination regulates chromatin compaction.Cancer Research UKThis is the author accepted manuscript. The final version is available from the Nature Publishing Group via http://dx.doi.org/10.1038/nature1294

Review and scientific prospects of high-contrast optical stellar interferometry

This is the final version. Available from SPIE via the DOI in this recordSPIE Astronomical Telescopes + Instrumentation conference, 14 - 18 December 2020, Online OnlyHigh-contrast optical stellar interferometry generally refers to instruments able to detect circumstellar emission at least a few hundred times fainter than the host star at high-angular resolution (typically within a few λ/D). While such contrast levels have been enabled by classical modal-filtered interferometric instruments such as VLTI/PIONIER, CHARA/FLUOR, and CHARA/MIRC the development of instruments able to filter out the stellar light has significantly pushed this limit, either by nulling interferometry for on-axis observations (e.g., PFN, LBTI, GLINT) or by off-axis classical interferometry with VLTI/GRAVITY. Achieving such high contrast levels at small angular separation was made possible thanks to significant developments in technology (e.g., adaptive optics, integrated optics), data acquisition (e.g., fringe tracking, phase chopping), and data reduction techniques (e.g., nulling self-calibration). In this paper, we review the current status of high-contrast optical stellar interferometry and present its key scientific results. We then present ongoing activities to improve current ground-based interferometric facilities for high-contrast imaging (e.g., Hi-5/VIKING/BIFROST of the ASGARD instrument suite, GRAVITY+) and the scientific milestones that they would be able to achieve. Finally, we discuss the long-term future of high-contrast stellar interferometry and, in particular, ambitious science cases that would be enabled by space interferometry (e.g., LIFE, space-PFI) and large-scale ground-based projects (PFI).European Research Council (ERC