Cardiac congestive insufficiency in children with Fallot Tetralogy in pre- and postoperative period

Departamentul Pediatrie USMF „Nicolae Testemiţanu”The aim of the research was to study the clinico-evolutive Fallot Tetralogy (FT) features analyzing the cardiac congenital insufficiency (CCI) and pre- postoperative cases. The results of 27 patients with FT due to CCI, divided in two groups, were presented in the study. The patients complaints and clinical manifestation presented in the study, marked an improvement of the patients’ general condition, decreasing the fatigability, dyspnea, cyanosis and postoperative cardiac insufficiency functional class signs (p<0.05). The laboratory analysis underlined the Hb postoperative level decrease (123,06±4,79 g/dl), in comparison with the preoperative group (139,75 ±9,73 g/dl). As a result of the electrocardiography obtained data, in patients who did not have a surgical intervention, signs of the right ventricle and right atrium hypertrophy were present, but these signs decrease is noticed after the operation (surgical intervention). The hemodynamic and structural parameters analysis after the electrocardiography, determined a decreased number of the patients with RV and LV dilatation and hypertrophy after the surgical intervention. Lucrarea prezentă şi-a propus drept scop studierea particularităţilor clinico-evolutive în Tetralogia Fallot (TF) asociată cu insuficienţa cardiacă congestivă pre- şi postoperator. În studiu sunt reflectate rezultatele examinării a 27 de pacienţi cu Tetralogia Fallot pe fundal de insuficienţă cardiacă congestivă, divizaţi în două loturi. În baza studierii acuzelor şi manifestărilor clinice ale pacienţilor s-a notat ameliorarea stării generale a pacienţilor, micşorarea semnelor de fatigabilitate, dispnee, cianoză şi clasa funcţională a insuficienţei cardiace postoperator (p<0,05). Analizele de laborator în dinamică postoperator au evidenţiat scăderea nivelului de hemoglobină (123,06±4,79 g/dl), comparativ cu perioada preoperatorie (139,75 ±9,73 g/dl) (p<0.05). În cadrul analizei datelor electrocardiografice obţinute s-a observat, la pacienţii fără intervenţie chirurgicală prezenţa semnelor de hipertrofie a ventriculului drept şi atriului drept, iar postoperator se observă o scădere a proceselor de remodelare cardiacă. Studiul parametrilor hemodinamici şi a celor structurali în urma examenului ecocardiografic, după intervenţie chirurgicală, a estimat reducerea numărului pacienţilor cu dilatarea şi hipertrofia VD şi al VS

Особенности электрокардио-графического мониторирования постинфарктных больныхс желудочковыми нарушениями ритма в зависимости от некоторых эхокардиографических параметров

Electrocardiographic monitoring changes in postinfarction patients with ventricular arrythmias according to some echocardiography parametersStudiul dat a vizat evidențierea relației dintre diferiți parametri ecocardiografici și rezultatele monitorizării electrocardiografice a pacienților cu disritmi ventriculare dezvoltate la distanță după infarct miocardic. &Icirc;n baza datelor obținute a fost stabilit că at&acirc;t afectarea unor parametrii bine cunoscuți anterior (fracția de ejecție a ventriculului st&acirc;ng), c&acirc;t și a altora mai puțin utilizați a fost asociată cu evenimente ventriculare și modificări ale indicilor variabilității cardiaceОсобенности электрокардио-графического мониторирования постинфарктных больныхс желудочковыми нарушениями ритма в зависимости от некоторых эхокардиографических параметро

Unfavorable prognosis quantification in patients with unstable angina pectoris

Universitatea Stat Medicină şi Farmacie Nicolae Testemiţanu, Catedra Medicină Internă No 5, IMSP Institutul Cardiologie şi SCM Sfănta TreimeThe aim of our study was to evaluate cardiovascular risk in patients with unstable angina pectoris for choosing their appropriate management. Most of the patients with unstable angina pectoris had a high risk of major cardiovascular events for a year, estimated using the Duke score, which correlates with a mortality of> 2% for one year. Cardiovascular risk assessment allows patients to receive adequate treatment and revascularization, which would increase their survival. Scopul studiului a fost de a evalua riscul cardiovascular la pacienţii cu angină pectorală instabilă pentru alegerea managementului corespunzător. Majoritatea pacienţilor cu angină pectorală instabilă au avut un risc ridicat de evenimente cardiovasculare majore pentru un an, estimate folosind scorul Duke, ce corelează cu o mortalitate de> 2%. Evaluarea riscului cardiovascular permite pacienţilor de a beneficia de tratament adecvat şi revascularizare, ceea ce ar creşte supravieţuirea lor

Humoral immunity in community-acquired pneumonia associated with manifestations of bronchial obstruction in children

Departamentul pediatrie, USMF „Nicolae Testemiţanu”The aim of the study was to evaluate the humoral immune status in children with bronchial obstruction syndrome associated with pneumonia. The main group consisted of 200 children with pneumonia and wheezing, the control group included 40 children considered healthy. The increase in IgM concentration in children with pneumonia and wheezing than those considered healthy, causes an immune reation more expressed to them, but not efficient enough for qualitative solving infectious process. In these children with bronchial obstruction the syndrome associated with pneumonia was confirmed by infectious mechanisms involving severe allergic marked by immunopathological mechanisms, exaggerated hyperimmunoglobulinemia E of immunocomplex type. Scopul studiului a fost de a evalua statusul imun umoral la copiii cu pneumonie asociată sindromului bronhoobstructiv. Lotul de bază alcătuit din 200 copii cu pneumonie şi wheezing, lotul de control a inclus 40 de copii consideraţi sănătoşi. Majorarea concentratiei IgM la copiii cu pneumonie şi cu wheezing faţă de cei consideraţi sănătoşi, determină la ei o reacţie imună mai exprimată, dar nu suficient de eficientă pentru o solutionare calitativă a procesului infecţios. La aceşti copii cu pneumonie asociată sindromului bronhoobstructiv a fost confirmată implicarea mecanismelor infecţios-alergice severe marcate prin hiperimunoglobulinemie E şi mecanisme imunopatologice exagerate de tip imunocomplex

Predicting attitudinal and behavioral responses to COVID-19 pandemic using machine learning

At the beginning of 2020, COVID-19 became a global problem. Despite all the efforts to emphasize the relevance of preventive measures, not everyone adhered to them. Thus, learning more about the characteristics determining attitudinal and behavioral responses to the pandemic is crucial to improving future interventions. In this study, we applied machine learning on the multinational data collected by the International Collaboration on the Social and Moral Psychology of COVID-19 (N = 51,404) to test the predictive efficacy of constructs from social, moral, cognitive, and personality psychology, as well as socio-demographic factors, in the attitudinal and behavioral responses to the pandemic. The results point to several valuable insights. Internalized moral identity provided the most consistent predictive contribution—individuals perceiving moral traits as central to their self-concept reported higher adherence to preventive measures. Similar results were found for morality as cooperation, symbolized moral identity, self-control, open-mindedness, and collective narcissism, while the inverse relationship was evident for the endorsement of conspiracy theories. However, we also found a non-neglible variability in the explained variance and predictive contributions with respect to macro-level factors such as the pandemic stage or cultural region. Overall, the results underscore the importance of morality-related and contextual factors in understanding adherence to public health recommendations during the pandemic.Peer reviewe

National identity predicts public health support during a global pandemic (vol 13, 517, 2022) : National identity predicts public health support during a global pandemic (Nature Communications, (2022), 13, 1, (517), 10.1038/s41467-021-27668-9)

Publisher Copyright: © The Author(s) 2022.In this article the author name ‘Agustin Ibanez’ was incorrectly written as ‘Augustin Ibanez’. The original article has been corrected.Peer reviewe

National identity predicts public health support during a global pandemic.

Changing collective behaviour and supporting non-pharmaceutical interventions is an important component in mitigating virus transmission during a pandemic. In a large international collaboration (Study 1, N = 49,968 across 67 countries), we investigated self-reported factors associated with public health behaviours (e.g., spatial distancing and stricter hygiene) and endorsed public policy interventions (e.g., closing bars and restaurants) during the early stage of the COVID-19 pandemic (April-May 2020). Respondents who reported identifying more strongly with their nation consistently reported greater engagement in public health behaviours and support for public health policies. Results were similar for representative and non-representative national samples. Study 2 (N = 42 countries) conceptually replicated the central finding using aggregate indices of national identity (obtained using the World Values Survey) and a measure of actual behaviour change during the pandemic (obtained from Google mobility reports). Higher levels of national identification prior to the pandemic predicted lower mobility during the early stage of the pandemic (r = -0.40). We discuss the potential implications of links between national identity, leadership, and public health for managing COVID-19 and future pandemics

The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase&nbsp;1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation&nbsp;disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age&nbsp; 6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score&nbsp; 652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc&nbsp;= 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N&nbsp;= 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in&nbsp;Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in&nbsp;Asia&nbsp;and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701

Predicting attitudinal and behavioral responses to COVID-19 pandemic using machine learning

At the beginning of 2020, COVID-19 became a global problem. Despite all the efforts to emphasize the relevance of preventive measures, not everyone adhered to them. Thus, learning more about the characteristics determining attitudinal and behavioral responses to the pandemic is crucial to improving future interventions. In this study, we applied machine learning on the multinational data collected by the International Collaboration on the Social and Moral Psychology of COVID-19 (N = 51,404) to test the predictive efficacy of constructs from social, moral, cognitive, and personality psychology, as well as socio-demographic factors, in the attitudinal and behavioral responses to the pandemic. The results point to several valuable insights. Internalized moral identity provided the most consistent predictive contribution—individuals perceiving moral traits as central to their self-concept reported higher adherence to preventive measures. Similar results were found for morality as cooperation, symbolized moral identity, self-control, open-mindedness, and collective narcissism, while the inverse relationship was evident for the endorsement of conspiracy theories. However, we also found a non-neglible variability in the explained variance and predictive contributions with respect to macro-level factors such as the pandemic stage or cultural region. Overall, the results underscore the importance of morality-related and contextual factors in understanding adherence to public health recommendations during the pandemic