133 research outputs found
Bolocam Survey for 1.1 mm Dust Continuum Emission in the c2d Legacy Clouds. II. Ophiuchus
We present a large-scale millimeter continuum map of the Ophiuchus molecular
cloud. Nearly 11 square degrees, including all of the area in the cloud with
visual extinction more than 3 magnitudes, was mapped at 1.1 mm with Bolocam on
the Caltech Submillimeter Observatory (CSO). By design, the map also covers the
region mapped in the infrared with the Spitzer Space Telescope. We detect 44
definite sources, and a few likely sources are also seen along a filament in
the eastern streamer. The map indicates that dense cores in Ophiuchus are very
clustered and often found in filaments within the cloud. Most sources are
round, as measured at the half power point, but elongated when measured at
lower contour levels, suggesting spherical sources lying within filaments. The
masses, for an assumed dust temperature of 10 K, range from 0.24 to 3.9 solar
masses, with a mean value of 0.96 solar masses. The total mass in distinct
cores is 42 solar masses, 0.5 to 2% of the total cloud mass, and the total mass
above 4 sigma is about 80 solar masses. The mean densities in the cores are
quite high, with an average of 1.6 x 10^6 per cc, suggesting short free-fall
times. The core mass distribution can be fitted with a power law with slope of
2.1 plus or minus 0.3 for M>0.5 solar masses, similar to that found in other
regions, but slightly shallower than that of some determinations of the local
IMF. In agreement with previous studies, our survey shows that dense cores
account for a very small fraction of the cloud volume and total mass. They are
nearly all confined to regions with visual extinction at least 9 mag, a lower
threshold than found previously.Comment: 47 pages, 16 figures, accepted for Ap
Current status of Bolocam: a large-format millimeter-wave bolometer camera
We describe the design and performance of Bolocam, a 144-element, bolometric, millimeter-wave camera. Bolocam is currently in its commissioning stage at the Caltech Submillimeter Observatory. We compare the instrument performance measured at the telescope with a detailed sensitivity model, discuss the factors limiting the current sensitivity, and describe our plans for future improvements intended to increase the mapping speed
Hospital admission and risk assessment associated to exposure of fungal bioaerosols at a municipal landfill using statistical models
The object of this research to determine the statistical relationship
and degree of association between variables: hospital admission days and
diagnostic (disease) potentially associated to fungal bioaerosols exposure.
Admissions included acute respiratory infections, atopic dermatitis, pharyngitis
and otitis. Statistical analysis was done using Statgraphics Centurion XVI
software. In addition, was estimated the occupational exposure to fungal aerosols in stages of a landfill using BIOGAVAL method and represented by Golden
Surfer XVI program. Biological risk assessment with sentinel microorganism A.
fumigatus and Penicillium sp, indicated that occupational exposure to fungal
aerosols is Biological action level. Preventive measures should be taken to
reduce the risk of acquiring acute respiratory infections, dermatitis or other skin
infections
Towards onset prevention of cognition decline in adults with Down syndrome (The TOP-COG study): A pilot randomised controlled trial.
BACKGROUND: Dementia is very common in Down syndrome (trisomy 21) adults. Statins may slow brain amyloid β (Aβ, coded on chromosome 21) deposition and, therefore, delay Alzheimer disease onset. One prospective cohort study with Down syndrome adults found participants on statins had reduced risk of incident dementia, but there are no randomised controlled trials (RCTs) on this issue. Evidence is sparse on the best instruments to detect longitudinal cognitive decline in older Down syndrome adults. METHODS: TOP-COG was a feasibility/pilot, double-blind RCT of 12 months simvastatin 40 mg versus placebo for the primary prevention of dementia in Alzheimer disease in Down syndrome adults aged 50 years or older. Group allocation was stratified by age, apolipoprotein E (APOE) ε4 allele status, and cholesterol level. Recruitment was from multiple general community sources over 12 months. Adults with dementia, or simvastatin contraindications, were excluded. Main outcomes were recruitment and retention rates. Cognitive decline was measured with a battery of tests; secondary measures were adaptive behaviour skills, general health, and quality of life. Assessments were conducted pre randomisation and at 12 months post randomisation. Blood Aβ40/Aβ42 levels were investigated as a putative biomarker. Results were analysed on an intention-to-treat basis. A qualitative sub-study was conducted and analysed using the Framework Approach to determine recruitment motivators/barriers, and participation experience. RESULTS: We identified 181 (78 %) of the likely eligible Down syndrome population, and recruited 21 (11.6 %), from an area with a general population size of 3,135,974. Recruitment was highly labour-intensive. Thirteen (62 %) participants completed the full year. Results favoured the simvastatin group. The most appropriate cognitive instrument (regarding ease of completion and detecting change over time) was the Memory for Objects test from the Neuropsychological Assessment of Dementia in Individuals with Intellectual Disabilities battery. Cognitive testing appeared more sensitive than proxy-rated adaptive behaviour, quality of life, or general health scores. Aβ40 levels changed less for the simvastatin group (not statistically significant). People mostly declined to participate because of not wanting to take medication, and not knowing if they would receive simvastatin or placebo. Participants reported enjoying taking part. CONCLUSION: A full-scale RCT is feasible. It will need 37 % UK population coverage to recruit the required 160 participants. Information/education about the importance of RCT participation is needed for this population. TRIAL REGISTRATION: ISRCTN67338640 .This study was funded by the Chief Scientist Office, Scottish Government Health Department (reference: CZH/4/626). JS is funded by the NHS Lothian R&D Directorate.
The study was supported by Down Syndrome Scotland, and we thank them, and all members of the Trial Steering Committee and Data Management and Ethics Committee.This is the final version of the article. It first appeared from BioMed Central via https://doi.org/10.1186/s13063-016-1370-
Genetic Applications in Avian Conservation
A fundamental need in conserving species and their habitats is defining distinct entities that range from individuals to species to ecosystems and beyond (Table 1; Ryder 1986, Moritz 1994, Mayden and Wood 1995, Haig and Avise 1996, Hazevoet 1996, Palumbi and Cipriano 1998, Hebert et al. 2004, Mace 2004, Wheeler et al. 2004, Armstrong and Ball 2005, Baker 2008, Ellis et al. 2010, Winker and Haig 2010). Rapid progression in this interdisciplinary field continues at an exponential rate; thus, periodic updates on theory, techniques, and applications are important for informing practitioners and consumers of genetic information. Here, we outline conservation topics for which genetic information can be helpful, provide examples of where genetic techniques have been used best in avian conservation, and point to current technical bottlenecks that prevent better use of genomics to resolve conservation issues related to birds. We hope this review will provide geneticists and avian ecologists with a mutually beneficial dialogue on how this integrated field can solve current and future problems
Current status of Bolocam: a large-format millimeter-wave bolometer camera
We describe the design and performance of Bolocam, a 144-element, bolometric, millimeter-wave camera. Bolocam is currently in its commissioning stage at the Caltech Submillimeter Observatory. We compare the instrument performance measured at the telescope with a detailed sensitivity model, discuss the factors limiting the current sensitivity, and describe our plans for future improvements intended to increase the mapping speed
Bolocam Survey for 1.1 mm Dust Continuum Emission in the c2d Legacy Clouds
ABSTRACT We have completed a
Towards onset prevention of cognition decline in adults with Down syndrome (The TOP-COG study): A pilot randomised controlled trial
A communal catalogue reveals Earth's multiscale microbial diversity
Our growing awareness of the microbial world's importance and diversity contrasts starkly with our limited understanding of its fundamental structure. Despite recent advances in DNA sequencing, a lack of standardized protocols and common analytical frameworks impedes comparisons among studies, hindering the development of global inferences about microbial life on Earth. Here we present a meta-analysis of microbial community samples collected by hundreds of researchers for the Earth Microbiome Project. Coordinated protocols and new analytical methods, particularly the use of exact sequences instead of clustered operational taxonomic units, enable bacterial and archaeal ribosomal RNA gene sequences to be followed across multiple studies and allow us to explore patterns of diversity at an unprecedented scale. The result is both a reference database giving global context to DNA sequence data and a framework for incorporating data from future studies, fostering increasingly complete characterization of Earth's microbial diversity.Peer reviewe
A communal catalogue reveals Earth’s multiscale microbial diversity
Our growing awareness of the microbial world’s importance and diversity contrasts starkly with our limited understanding of its fundamental structure. Despite recent advances in DNA sequencing, a lack of standardized protocols and common analytical frameworks impedes comparisons among studies, hindering the development of global inferences about microbial life on Earth. Here we present a meta-analysis of microbial community samples collected by hundreds of researchers for the Earth Microbiome Project. Coordinated protocols and new analytical methods, particularly the use of exact sequences instead of clustered operational taxonomic units, enable bacterial and archaeal ribosomal RNA gene sequences to be followed across multiple studies and allow us to explore patterns of diversity at an unprecedented scale. The result is both a reference database giving global context to DNA sequence data and a framework for incorporating data from future studies, fostering increasingly complete characterization of Earth’s microbial diversity
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